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Aliases for PSMA6 Gene

Aliases for PSMA6 Gene

  • Proteasome Subunit Alpha 6 2 3
  • Proteasome (Prosome, Macropain) Subunit, Alpha Type, 6 2 3
  • Multicatalytic Endopeptidase Complex Iota Chain 3 4
  • 27 KDa Prosomal Protein 3 4
  • Proteasome Iota Chain 3 4
  • Macropain Iota Chain 3 4
  • EC 3.4.25.1 4 63
  • PROS-27 3 4
  • PROS27 3 4
  • P27K 3 4
  • Proteasome Subunit Iota 3
  • Macropain Subunit Iota 3
  • Prosomal P27K Protein 3
  • IOTA 3

External Ids for PSMA6 Gene

Previous GeneCards Identifiers for PSMA6 Gene

  • GC14P033139
  • GC14P029548
  • GC14P033751
  • GC14P034832
  • GC14P035761
  • GC14P015875
  • GC14P035747

Summaries for PSMA6 Gene

Entrez Gene Summary for PSMA6 Gene

  • The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple transcript variants encoding several different isoforms have been found for this gene. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Aug 2013]

GeneCards Summary for PSMA6 Gene

PSMA6 (Proteasome Subunit Alpha 6) is a Protein Coding gene. Diseases associated with PSMA6 include phaeohyphomycosis and myocardial infarction. Among its related pathways are Immune System and Signaling by GPCR. GO annotations related to this gene include RNA binding and NF-kappaB binding.

UniProtKB/Swiss-Prot for PSMA6 Gene

  • The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity

Gene Wiki entry for PSMA6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSMA6 Gene

Genomics for PSMA6 Gene

Regulatory Elements for PSMA6 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSMA6 Gene

Chromosome:
14
Start:
35,278,558 bp from pter
End:
35,317,493 bp from pter
Size:
38,936 bases
Orientation:
Plus strand

Genomic View for PSMA6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSMA6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSMA6 Gene

Proteins for PSMA6 Gene

  • Protein details for PSMA6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P60900-PSA6_HUMAN
    Recommended name:
    Proteasome subunit alpha type-6
    Protein Accession:
    P60900
    Secondary Accessions:
    • B2R7J9
    • B4DQR4
    • B4DXJ9
    • P34062
    • Q6IB60

    Protein attributes for PSMA6 Gene

    Size:
    246 amino acids
    Molecular mass:
    27399 Da
    Quaternary structure:
    • The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. Interacts with ALKBH4.

    Three dimensional structures from OCA and Proteopedia for PSMA6 Gene

    Alternative splice isoforms for PSMA6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSMA6 Gene

Proteomics data for PSMA6 Gene at MOPED

Selected DME Specific Peptides for PSMA6 Gene

Post-translational modifications for PSMA6 Gene

  • Ubiquitination at Lys 30, Lys 45, Lys 55, Lys 59, Lys 102, Lys 104, Lys 116, Lys 164, Lys 171, and Lys 181
  • Glycosylation at Ser 5
  • Modification sites at PhosphoSitePlus

Domains & Families for PSMA6 Gene

Gene Families for PSMA6 Gene

Protein Domains for PSMA6 Gene

Graphical View of Domain Structure for InterPro Entry

P60900

UniProtKB/Swiss-Prot:

PSA6_HUMAN :
  • Belongs to the peptidase T1A family.
Family:
  • Belongs to the peptidase T1A family.
genes like me logo Genes that share domains with PSMA6: view

Function for PSMA6 Gene

Molecular function for PSMA6 Gene

GENATLAS Biochemistry:
multicatalytic proteinase complex (20S) proteasome (prosome,macropain) component,alpha type 6,subunit Pros27 (Iota),27.3 kDa
UniProtKB/Swiss-Prot CatalyticActivity:
Cleavage of peptide bonds with very broad specificity.
UniProtKB/Swiss-Prot Function:
The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity

Enzyme Numbers (IUBMB) for PSMA6 Gene

Gene Ontology (GO) - Molecular Function for PSMA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding NAS 7681138
GO:0004175 endopeptidase activity NAS 7681138
GO:0004298 threonine-type endopeptidase activity IEA --
GO:0005515 protein binding IPI 14733938
GO:0035639 purine ribonucleoside triphosphate binding NAS 7681138
genes like me logo Genes that share ontologies with PSMA6: view
genes like me logo Genes that share phenotypes with PSMA6: view

miRNA for PSMA6 Gene

miRTarBase miRNAs that target PSMA6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMA6

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for PSMA6 Gene

Localization for PSMA6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSMA6 Gene

Cytoplasm. Nucleus. Cytoplasm, P-body. Note=Colocalizes with TRIM5 in the cytoplasmic bodies. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSMA6 Gene COMPARTMENTS Subcellular localization image for PSMA6 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 4
cytoskeleton 2
endosome 2
endoplasmic reticulum 1
golgi apparatus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PSMA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IDA 17323924
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005634 nucleus IDA 7681138
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with PSMA6: view

Pathways & Interactions for PSMA6 Gene

SuperPathways for PSMA6 Gene

Superpath Contained pathways
1 CDK-mediated phosphorylation and removal of Cdc6
.78
2 Interleukin receptor SHC signaling
3 Chks in Checkpoint Regulation
4 Infectious disease
.53
5 Immune System
genes like me logo Genes that share pathways with PSMA6: view

Gene Ontology (GO) - Biological Process for PSMA6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000209 protein polyubiquitination TAS --
GO:0000278 mitotic cell cycle TAS --
genes like me logo Genes that share ontologies with PSMA6: view

No data available for SIGNOR curated interactions for PSMA6 Gene

Drugs & Compounds for PSMA6 Gene

(3) Drugs for PSMA6 Gene - From: DrugBank and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bortezomib Approved, Experimental, Investigational Pharma inhibitor, other, Target Proteosome and NF-kappaB inhibitor, Other, Proteasome inhibitors 758
carfilzomib Approved Pharma other, Inhibitor Other, 20S Proteasome Inhibitor 0
(3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE Experimental Pharma Target 0
genes like me logo Genes that share compounds with PSMA6: view

Transcripts for PSMA6 Gene

Unigene Clusters for PSMA6 Gene

Proteasome (prosome, macropain) subunit, alpha type, 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSMA6

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSMA6 Gene

No ASD Table

Relevant External Links for PSMA6 Gene

GeneLoc Exon Structure for
PSMA6
ECgene alternative splicing isoforms for
PSMA6

Expression for PSMA6 Gene

mRNA expression in normal human tissues for PSMA6 Gene

mRNA differential expression in normal tissues according to GTEx for PSMA6 Gene

This gene is overexpressed in Muscle - Skeletal (x4.1).

Protein differential expression in normal tissues from HIPED for PSMA6 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.8) and Liver, secretome (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PSMA6 Gene



SOURCE GeneReport for Unigene cluster for PSMA6 Gene Hs.446260

genes like me logo Genes that share expression patterns with PSMA6: view

Protein tissue co-expression partners for PSMA6 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PSMA6 Gene

Orthologs for PSMA6 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSMA6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSMA6 35
  • 96.34 (n)
  • 100 (a)
PSMA6 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSMA6 35
  • 96.61 (n)
  • 99.59 (a)
PSMA6 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Psma6 35
  • 93.63 (n)
  • 99.59 (a)
Psma6 16
Psma6 36
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSMA6 35
  • 99.59 (n)
  • 100 (a)
PSMA6 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Psma6 35
  • 94.31 (n)
  • 100 (a)
oppossum
(Monodelphis domestica)
Mammalia PSMA6 36
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSMA6 36
  • 97 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSMA6 35
  • 86.99 (n)
  • 96.75 (a)
PSMA6 36
  • 96 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSMA6 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76321 35
psma6 35
  • 80.76 (n)
  • 92.68 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15878 35
zebrafish
(Danio rerio)
Actinopterygii psma6a 35
zgc:92716 35
  • 77.91 (n)
  • 91.06 (a)
psma6a 36
  • 90 (a)
OneToMany
psma6b 36
  • 91 (a)
OneToMany
psma6l 36
  • 69 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Prosalpha6 37
  • 64 (a)
Prosalpha1 35
  • 60.38 (n)
  • 67.21 (a)
CG30382 36
  • 67 (a)
OneToMany
Prosalpha1 36
  • 67 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003935 35
  • 64.5 (n)
  • 73.58 (a)
worm
(Caenorhabditis elegans)
Secernentea pas-1 35
  • 56.37 (n)
  • 56.5 (a)
pas-1 36
  • 56 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AGL089W 35
  • 54.03 (n)
  • 55.42 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A05027g 35
  • 55.14 (n)
  • 55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SCL1 35
  • 58.09 (n)
  • 56.02 (a)
SCL1 36
  • 52 (a)
OneToOne
SCL1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons PAA1 35
  • 61.25 (n)
  • 64.23 (a)
soybean
(Glycine max)
eudicotyledons Gma.17539 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.7441 35
barley
(Hordeum vulgare)
Liliopsida Hv.6366 35
rice
(Oryza sativa)
Liliopsida Os.3704 35
Os03g0180400 35
  • 60.43 (n)
  • 60.57 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.6475 35
corn
(Zea mays)
Liliopsida Zm.3422 35
bread mold
(Neurospora crassa)
Ascomycetes NCU10061 35
  • 57.88 (n)
  • 62.76 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC646.16 35
  • 59.38 (n)
  • 59.24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8137 36
  • 74 (a)
OneToOne
Species with no ortholog for PSMA6:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for PSMA6 Gene

ENSEMBL:
Gene Tree for PSMA6 (if available)
TreeFam:
Gene Tree for PSMA6 (if available)

Paralogs for PSMA6 Gene

genes like me logo Genes that share paralogs with PSMA6: view

No data available for Paralogs for PSMA6 Gene

Variants for PSMA6 Gene

Sequence variations from dbSNP and Humsavar for PSMA6 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs4665 -- 35,313,047(+) TTTGA(A/G)CAGAC reference, synonymous-codon, intron-variant
rs13393 -- 35,314,450(+) CCTAA(A/G)TTCAG reference, synonymous-codon, nc-transcript-variant
rs743225 -- 35,305,975(+) AATCC(C/T)ATCAC intron-variant
rs743226 -- 35,306,355(-) ggtct(C/T)gaact intron-variant
rs743227 -- 35,306,479(-) tgatc(C/T)gcctg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSMA6 Gene

Variant ID Type Subtype PubMed ID
nsv456205 CNV Loss 19166990
esv2661597 CNV Deletion 23128226

Variation tolerance for PSMA6 Gene

Residual Variation Intolerance Score: 34.28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.06; 1.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PSMA6 Gene

HapMap Linkage Disequilibrium report
PSMA6
Human Gene Mutation Database (HGMD)
PSMA6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSMA6 Gene

Disorders for PSMA6 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PSMA6 Gene - From: OMIM, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
phaeohyphomycosis
  • infection by dematiacious fungi
myocardial infarction
  • myocardial infarction, protection against
clostridium difficile colitis
  • pseudomembranous colitis
eye accommodation disease
craniometaphyseal dysplasia
  • craniometaphyseal dysplasia, autosomal dominant
- elite association
Search PSMA6 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSMA6

Genetic Association Database (GAD)
PSMA6
Human Genome Epidemiology (HuGE) Navigator
PSMA6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PSMA6
genes like me logo Genes that share disorders with PSMA6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSMA6 Gene

Publications for PSMA6 Gene

  1. [Expression of genes psma6 and slc25a4 in patients with acute monocytic leukemia]. (PMID: 19840444) Chen Y.X. … Ma X.R. (Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009) 23 67
  2. Identification of an intronic TG repeat polymorphism in the human proteasome core particle PROS-27K gene. (PMID: 12391723) Sjakste T. … Sjakste N. (DNA Seq. 2002) 23 67
  3. Increased prosomal proteins in breast cancer cells and in neighboring normal cells in Parsi and non-Parsi populations. (PMID: 9654195) Bhui-Kaur A. … Bureau J.P. (J. Cancer Res. Clin. Oncol. 1998) 23 67
  4. Structure and functions of the 20S and 26S proteasomes. (PMID: 8811196) Coux O. … Goldberg A.L. (Annu. Rev. Biochem. 1996) 2 67
  5. The prosomal RNA-binding protein p27K is a member of the alpha-type human prosomal gene family. (PMID: 7681138) Bey F. … Scherrer K. (Mol. Gen. Genet. 1993) 23 67

Products for PSMA6 Gene

Sources for PSMA6 Gene

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