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Aliases for RAD18 Gene

Aliases for RAD18 Gene

  • RAD18 E3 Ubiquitin Protein Ligase 2 3
  • Postreplication Repair Protein RAD18 3 4
  • RING Finger Protein 73 3 4
  • HRAD18 3 4
  • RNF73 3 4
  • HHR18 3 4
  • Postreplication Repair Protein HRAD18p 3
  • E3 Ubiquitin-Protein Ligase RAD18 3
  • RAD18 Homolog (S. Cerevisiae) 2
  • RAD18, S. Cerevisiae, Homolog 3
  • RAD18 Homolog 3
  • EC 6.3.2.- 4

External Ids for RAD18 Gene

Summaries for RAD18 Gene

Entrez Gene Summary for RAD18 Gene

  • The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAD18 Gene

RAD18 (RAD18 E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control and Cell Cycle / Checkpoint Control. GO annotations related to this gene include ubiquitin protein ligase binding and damaged DNA binding.

UniProtKB/Swiss-Prot for RAD18 Gene

  • E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on Lys-164. Has ssDNA binding activity.

Gene Wiki entry for RAD18 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD18 Gene

Genomics for RAD18 Gene

Genomic Location for RAD18 Gene

Start:
8,775,402 bp from pter
End:
8,963,773 bp from pter
Size:
188,372 bases
Orientation:
Minus strand

Genomic View for RAD18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for RAD18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD18 Gene

Regulatory Elements for RAD18 Gene

Proteins for RAD18 Gene

  • Protein details for RAD18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS91-RAD18_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase RAD18
    Protein Accession:
    Q9NS91
    Secondary Accessions:
    • Q58F55
    • Q9NRT6

    Protein attributes for RAD18 Gene

    Size:
    495 amino acids
    Molecular mass:
    56223 Da
    Quaternary structure:
    • Homodimer. Interacts with UBE2A and UBE2B, one homodimer binding one molecule of UBE2B. Interacts with HLTF and SHPRH. Interacts with SPRTN; leading to enhance chromatin association of RAD18 and RAD18-mediated PCNA ubiquitination and translesion DNA synthesis.

    Three dimensional structures from OCA and Proteopedia for RAD18 Gene

neXtProt entry for RAD18 Gene

Proteomics data for RAD18 Gene at MOPED

Post-translational modifications for RAD18 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys83, Lys102, Lys110, Lys115, Lys151, Lys161, Lys186, Lys197, Lys218, Lys245, Lys261, Lys271, Lys318, Lys328, and Lys370

Other Protein References for RAD18 Gene

No data available for DME Specific Peptides for RAD18 Gene

Domains for RAD18 Gene

Gene Families for RAD18 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

UniProtKB/Swiss-Prot:

RAD18_HUMAN
Domain:
  • Contains 1 SAP domain.:
    • Q9NS91
Family:
  • Belongs to the RAD18 family.:
    • Q9NS91
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q9NS91
  • Contains 1 UBZ-type zinc finger.:
    • Q9NS91
genes like me logo Genes that share domains with RAD18: view

Function for RAD18 Gene

Molecular function for RAD18 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on Lys-164. Has ssDNA binding activity.

Enzyme Numbers (IUBMB) for RAD18 Gene

Gene Ontology (GO) - Molecular Function for RAD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000403 Y-form DNA binding IDA 18363965
GO:0003677 DNA binding --
GO:0003684 damaged DNA binding NAS 10884424
GO:0005515 protein binding IPI 21659603
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with RAD18: view
genes like me logo Genes that share phenotypes with RAD18: view

Animal Models for RAD18 Gene

MGI Knock Outs for RAD18:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for RAD18 Gene

Localization for RAD18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD18 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RAD18 Gene COMPARTMENTS Subcellular localization image for RAD18 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for RAD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin IEA --
GO:0001741 XY body IEA --
GO:0005634 nucleus NAS 10884424
GO:0005654 nucleoplasm TAS --
GO:0005657 replication fork IDA 18363965
genes like me logo Genes that share ontologies with RAD18: view

Pathways for RAD18 Gene

genes like me logo Genes that share pathways with RAD18: view

Pathways by source for RAD18 Gene

2 Cell Signaling Technology pathways for RAD18 Gene

UniProtKB/Swiss-Prot Q9NS91-RAD18_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for RAD18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair TAS --
GO:0006974 cellular response to DNA damage stimulus --
GO:0007283 spermatogenesis IEA --
GO:0009411 response to UV IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with RAD18: view

Compounds for RAD18 Gene

(4) HMDB Compounds for RAD18 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Novoseek inferred chemical compound relationships for RAD18 Gene

Compound -log(P) Hits PubMed IDs
methylmethanesulfonate 70.2 4
genes like me logo Genes that share compounds with RAD18: view

Transcripts for RAD18 Gene

Unigene Clusters for RAD18 Gene

RAD18 homolog (S. cerevisiae):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RAD18 Gene

No ASD Table

Relevant External Links for RAD18 Gene

GeneLoc Exon Structure for
RAD18
ECgene alternative splicing isoforms for
RAD18

Expression for RAD18 Gene

mRNA expression in normal human tissues for RAD18 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for RAD18 Gene

SOURCE GeneReport for Unigene cluster for RAD18 Gene Hs.375684

genes like me logo Genes that share expressions with RAD18: view

Orthologs for RAD18 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAD18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD18 36
  • 99.12 (n)
  • 98.59 (a)
RAD18 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia RAD18 36
  • 87.4 (n)
  • 82.42 (a)
RAD18 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAD18 36
  • 88.93 (n)
  • 84.21 (a)
RAD18 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rad18 36
  • 80.43 (n)
  • 72.55 (a)
Rad18 16
Rad18 37
  • 66 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAD18 37
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD18 37
  • 40 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad18 36
  • 83.37 (n)
  • 77.51 (a)
chicken
(Gallus gallus)
Aves RAD18 36
  • 64.03 (n)
  • 59.4 (a)
RAD18 37
  • 48 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAD18 37
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rad18 36
  • 62.84 (n)
  • 57.76 (a)
Str.19594 36
zebrafish
(Danio rerio)
Actinopterygii rad18 36
  • 53.89 (n)
  • 48.7 (a)
rad18 37
  • 43 (a)
OneToOne
zgc55577 36
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD18 37
  • 22 (a)
OneToOne
RAD18 39
Species with no ortholog for RAD18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAD18 Gene

ENSEMBL:
Gene Tree for RAD18 (if available)
TreeFam:
Gene Tree for RAD18 (if available)

Paralogs for RAD18 Gene

genes like me logo Genes that share paralogs with RAD18: view

No data available for Paralogs for RAD18 Gene

Variants for RAD18 Gene

Sequence variations from dbSNP and Humsavar for RAD18 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs83626 -- 8,887,171(+) ctaaa(G/T)ctact intron-variant
rs124847 -- 8,886,920(+) GAACA(C/T)GAAAA intron-variant
rs166094 -- 8,884,640(+) TTCCA(A/T)GTTTC intron-variant
rs166095 -- 8,887,227(+) aagtc(C/T)tccag intron-variant
rs168186 -- 8,908,585(+) tgaca(C/T)cttga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RAD18 Gene

Variant ID Type Subtype PubMed ID
nsv876514 CNV Gain 21882294
dgv5106n71 CNV Loss 21882294
nsv518352 CNV Loss 19592680
esv275011 CNV Gain+Loss 21479260
nsv520776 CNV Gain 19592680
nsv528867 CNV Loss 19592680

Relevant External Links for RAD18 Gene

HapMap Linkage Disequilibrium report
RAD18

Disorders for RAD18 Gene

(2) University of Copenhagen DISEASES for RAD18 Gene

Relevant External Links for RAD18

Genetic Association Database (GAD)
RAD18
Human Genome Epidemiology (HuGE) Navigator
RAD18
genes like me logo Genes that share disorders with RAD18: view

No data available for UniProtKB/Swiss-Prot for RAD18 Gene

Publications for RAD18 Gene

  1. Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. (PMID: 10884424) Tateishi S. … Yamaizumi M. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4 23
  2. The human RAD18 gene product interacts with HHR6A and HHR6B. (PMID: 10908344) Xin H. … Wang Z. (Nucleic Acids Res. 2000) 2 3 4 23
  3. The association between RAD18 Arg302Gln polymorphism and the risk of human non-small-cell lung cancer. (PMID: 17624554) Kanzaki H. … Shimizu K. (J. Cancer Res. Clin. Oncol. 2008) 3 23 49
  4. Single nucleotide polymorphism in the RAD18 gene and risk of colorectal cancer in the Japanese population. (PMID: 17914568) Kanzaki H. … Shimizu K. (Oncol. Rep. 2007) 3 23 49
  5. RAD18 signals DNA polymerase IOTA to stalled replication forks in cells entering S-phase with DNA damage. (PMID: 18290323) Kakar S. … McGregor W.G. (Adv. Exp. Med. Biol. 2008) 3 23

Products for RAD18 Gene

Sources for RAD18 Gene

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