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Aliases for GRIPAP1 Gene

Aliases for GRIPAP1 Gene

  • GRIP1 Associated Protein 1 2 3 5
  • GRASP-1 3 4
  • GRIP1-Associated Protein 1 3
  • KIAA1167 4

External Ids for GRIPAP1 Gene

Previous GeneCards Identifiers for GRIPAP1 Gene

  • GC0XM047632
  • GC0XM047090
  • GC0XM047876
  • GC0XM048586
  • GC0XM048715
  • GC0XM048830
  • GC0XM046487

Summaries for GRIPAP1 Gene

Entrez Gene Summary for GRIPAP1 Gene

  • This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]

GeneCards Summary for GRIPAP1 Gene

GRIPAP1 (GRIP1 Associated Protein 1) is a Protein Coding gene.

Gene Wiki entry for GRIPAP1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIPAP1 Gene

Genomics for GRIPAP1 Gene

Regulatory Elements for GRIPAP1 Gene

Enhancers for GRIPAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH0XG048890 1.2 Ensembl ENCODE 7.2 +110.9 110850 2.0 AGO1 ARID4B SIN3A ZNF48 GLIS2 SP3 REST ZNF579 SMARCA4 GLIS1 SLC35A2 PIM2 ERAS GLOD5 GRIPAP1 PQBP1 PCSK1N
GH0XG049000 1 ENCODE 7.6 +0.2 156 2.3 PKNOX1 ATF1 ARNT WRNIP1 SIN3A GLI4 BRCA1 YY1 GLIS2 KLF7 USP27X-AS1 ZNF182 RN7SL262P ZNF630 GRIPAP1 KCND1
GH0XG048934 2 FANTOM5 Ensembl ENCODE dbSUPER 3.8 +63.8 63764 9.7 HDGF FOXA2 PKNOX1 ARNT AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 PQBP1 WAS OTUD5 SLC35A2 TIMM17B PIM2 TBC1D25 ENSG00000204620 ENSG00000228343 FOXP3
GH0XG048954 1.6 Ensembl ENCODE dbSUPER 4.6 +43.5 43496 8.1 HDGF PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 GPKOW PIM2 SLC35A2 ENSG00000204620 PCSK1N KCND1 ENSG00000228343 GRIPAP1 OTUD5 RNU6-722P
GH0XG048932 0.7 dbSUPER 6.6 +69.3 69273 0.9 HDGF YBX3 FOXM1 ZNF366 POLR2A ZNF680 MTA2 ZNF740 ZBTB11 ZNF407 PRICKLE3 PLP2 GRIPAP1 ENSG00000228343 ENSG00000279155 PIM2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around GRIPAP1 on UCSC Golden Path with GeneCards custom track

Promoters for GRIPAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000246538 164 2200 PKNOX1 ATF1 ARNT WRNIP1 SIN3A GLI4 BRCA1 YY1 GLIS2 KLF7

Genomic Location for GRIPAP1 Gene

Chromosome:
X
Start:
48,973,720 bp from pter
End:
49,002,264 bp from pter
Size:
28,545 bases
Orientation:
Minus strand

Genomic View for GRIPAP1 Gene

Genes around GRIPAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIPAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIPAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIPAP1 Gene

Proteins for GRIPAP1 Gene

  • Protein details for GRIPAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4V328-GRAP1_HUMAN
    Recommended name:
    GRIP1-associated protein 1
    Protein Accession:
    Q4V328
    Secondary Accessions:
    • A6NL78
    • Q3MJ75
    • Q4V327
    • Q4V330
    • Q5HYG1
    • Q6N046
    • Q96DH8
    • Q9NQ43
    • Q9ULQ3

    Protein attributes for GRIPAP1 Gene

    Size:
    841 amino acids
    Molecular mass:
    95990 Da
    Quaternary structure:
    • Interacts with GRIP1, GRIP2 and AMPA receptors.
    Miscellaneous:
    • Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynauds syndrome and telangiectasias.

    Alternative splice isoforms for GRIPAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIPAP1 Gene

Post-translational modifications for GRIPAP1 Gene

  • Proteolytically cleaved by caspase-3.
  • Ubiquitination at posLast=149149, isoforms=2, 3, 4249, and posLast=640640
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for GRIPAP1 Gene

Domains & Families for GRIPAP1 Gene

Protein Domains for GRIPAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRIPAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRIPAP1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for GRIPAP1 Gene

Function for GRIPAP1 Gene

Gene Ontology (GO) - Molecular Function for GRIPAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with GRIPAP1: view
genes like me logo Genes that share phenotypes with GRIPAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRIPAP1 Gene

Localization for GRIPAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIPAP1 Gene

Early endosome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIPAP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endosome 4
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for GRIPAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with GRIPAP1: view

Pathways & Interactions for GRIPAP1 Gene

SuperPathways for GRIPAP1 Gene

No Data Available

Interacting Proteins for GRIPAP1 Gene

Gene Ontology (GO) - Biological Process for GRIPAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane IEA --
GO:1905244 regulation of modification of synaptic structure IEA --
genes like me logo Genes that share ontologies with GRIPAP1: view

No data available for Pathways by source and SIGNOR curated interactions for GRIPAP1 Gene

Transcripts for GRIPAP1 Gene

Unigene Clusters for GRIPAP1 Gene

GRIP1 associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIPAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for GRIPAP1 Gene

GeneLoc Exon Structure for
GRIPAP1
ECgene alternative splicing isoforms for
GRIPAP1

Expression for GRIPAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIPAP1 Gene

Protein differential expression in normal tissues from HIPED for GRIPAP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.7), Brain (8.7), Heart (7.6), and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRIPAP1 Gene



Protein tissue co-expression partners for GRIPAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRIPAP1 Gene:

GRIPAP1

SOURCE GeneReport for Unigene cluster for GRIPAP1 Gene:

Hs.109929

Evidence on tissue expression from TISSUES for GRIPAP1 Gene

  • Nervous system(4.5)
  • Eye(4.4)
  • Liver(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with GRIPAP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIPAP1 Gene

Orthologs for GRIPAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GRIPAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRIPAP1 34 35
  • 91.87 (n)
dog
(Canis familiaris)
Mammalia GRIPAP1 34 35
  • 90.88 (n)
rat
(Rattus norvegicus)
Mammalia Gripap1 34
  • 89.01 (n)
mouse
(Mus musculus)
Mammalia Gripap1 34 16 35
  • 88.96 (n)
oppossum
(Monodelphis domestica)
Mammalia GRIPAP1 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIPAP1 35
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIPAP1 35
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4626 34
zebrafish
(Danio rerio)
Actinopterygii gripap1 34 35
  • 67.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10814 35
  • 34 (a)
OneToOne
Species where no ortholog for GRIPAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRIPAP1 Gene

ENSEMBL:
Gene Tree for GRIPAP1 (if available)
TreeFam:
Gene Tree for GRIPAP1 (if available)

Paralogs for GRIPAP1 Gene

No data available for Paralogs for GRIPAP1 Gene

Variants for GRIPAP1 Gene

Sequence variations from dbSNP and Humsavar for GRIPAP1 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs782702449 Uncertain significance 48,985,339(+) CAACT(C/G)AGCTG reference, missense
rs1000308434 -- 48,986,292(+) ACCTA(C/T)AATCC intron-variant
rs1000458796 -- 48,976,542(+) AAATG(C/G)GGGTA intron-variant
rs1000721860 -- 48,996,334(+) GGCGC(A/G)GTGGC intron-variant
rs1001127767 -- 48,999,283(+) TTCTG(C/T)CGAAG reference, synonymous-codon, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for GRIPAP1 Gene

Variant ID Type Subtype PubMed ID
dgv2289e212 CNV loss 25503493
esv32909 CNV gain+loss 17666407
esv3573947 CNV loss 25503493
nsv528292 CNV gain 19592680

Variation tolerance for GRIPAP1 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for GRIPAP1 Gene

Human Gene Mutation Database (HGMD)
GRIPAP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIPAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIPAP1 Gene

Disorders for GRIPAP1 Gene

Relevant External Links for GRIPAP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
GRIPAP1

No disorders were found for GRIPAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIPAP1 Gene

Publications for GRIPAP1 Gene

  1. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4 64
  2. Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes. (PMID: 15897011) Stinton L.M. … Fritzler M.J. (Clin. Immunol. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex. (PMID: 10896157) Ye B. … Huganir R.L. (Neuron 2000) 2 3 64
  5. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4 64

Products for GRIPAP1 Gene

Sources for GRIPAP1 Gene

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