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Aliases for GRIPAP1 Gene

Aliases for GRIPAP1 Gene

  • GRIP1 Associated Protein 1 2 3 5
  • GRASP-1 3 4
  • GRIP1-Associated Protein 1 3
  • KIAA1167 4

External Ids for GRIPAP1 Gene

Previous GeneCards Identifiers for GRIPAP1 Gene

  • GC0XM047632
  • GC0XM047090
  • GC0XM047876
  • GC0XM048586
  • GC0XM048715
  • GC0XM048830
  • GC0XM046487

Summaries for GRIPAP1 Gene

Entrez Gene Summary for GRIPAP1 Gene

  • This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF). The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function. [provided by RefSeq, Aug 2013]

GeneCards Summary for GRIPAP1 Gene

GRIPAP1 (GRIP1 Associated Protein 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for GRIPAP1 Gene

  • Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity).

  • GRASP-1 C-terminal chain: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.

Gene Wiki entry for GRIPAP1 Gene

Additional gene information for GRIPAP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GRIPAP1 Gene

Genomics for GRIPAP1 Gene

GeneHancer (GH) Regulatory Elements for GRIPAP1 Gene

Promoters and enhancers for GRIPAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI049000 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 557.6 +0.2 155 2.3 PKNOX1 ATF1 ARNT SIN3A GLI4 BRCA1 YY1 POLR2B GLIS2 KLF7 GRIPAP1 ENSG00000204620 FTSJ1 ENSG00000270012 RBM3 CCDC22 PQBP1 PLP2 KCND1
GH0XI048954 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 4.6 +43.5 43496 8.1 HDGF PKNOX1 CLOCK SMAD1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 IRF4 OTUD5 RNU6-722P GPKOW PIM2 SLC35A2 PCSK1N ENSG00000228343 KCND1 GRIPAP1
GH0XI048890 Enhancer 1.1 Ensembl ENCODE 7.2 +110.9 110850 2 ARID4B SIN3A ZNF48 GLIS2 ZNF143 ATF7 SP3 REST GMEB1 GLIS1 SLC35A2 PIM2 ERAS GLOD5 GRIPAP1 PQBP1 PCSK1N
GH0XI048834 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 4 +167.1 167083 2.3 ZNF133 ARID4B GLI4 ZNF2 KLF7 SP3 SP5 YY2 MIER2 REST PCSK1N ZNF81 ENSG00000204620 FTSJ1 ENSG00000270012 ZNF182 CCDC120 PRAF2 PQBP1 SYP
GH0XI048933 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 3.8 +63.8 63764 9.7 HDGF FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 YBX1 IRF4 ENSG00000279155 PQBP1 WAS OTUD5 SLC35A2 TIMM17B PIM2 TBC1D25 ENSG00000204620 ENSG00000228343
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around GRIPAP1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the GRIPAP1 gene promoter:

Genomic Locations for GRIPAP1 Gene

Genomic Locations for GRIPAP1 Gene
chrX:48,973,720-49,002,264
(GRCh38/hg38)
Size:
28,545 bases
Orientation:
Minus strand
chrX:48,830,134-48,858,675
(GRCh37/hg19)

Genomic View for GRIPAP1 Gene

Genes around GRIPAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
GRIPAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for GRIPAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GRIPAP1 Gene

Proteins for GRIPAP1 Gene

  • Protein details for GRIPAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q4V328-GRAP1_HUMAN
    Recommended name:
    GRIP1-associated protein 1
    Protein Accession:
    Q4V328
    Secondary Accessions:
    • A6NL78
    • Q3MJ75
    • Q4V327
    • Q4V330
    • Q5HYG1
    • Q6N046
    • Q96DH8
    • Q9NQ43
    • Q9ULQ3

    Protein attributes for GRIPAP1 Gene

    Size:
    841 amino acids
    Molecular mass:
    95990 Da
    Quaternary structure:
    • Interacts with GRIP1, GRIP2 and AMPA receptors (By similarity). Interacts (via C-terminus) with MAPK8/JNK1 and MAP3K1/MEKK1; the interaction promotes MAP3K1-mediated phosphorylation of MAPK8 (PubMed:17761173). Interacts (via N-terminus) with RAB4A (in GTP-bound form) (PubMed:20098723). Interacts (via C-terminus) with STX12 (By similarity).
    Miscellaneous:
    • Antibodies against GRIPAP1 have been found in sera of a patient who developed Raynauds syndrome and telangiectasias.

    Alternative splice isoforms for GRIPAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for GRIPAP1 Gene

Post-translational modifications for GRIPAP1 Gene

  • Proteolytically cleaved by caspase-3. A minor C-terminal proteolytic fragment of 30 kDa is produced. Proteolytic cleavage is required for JNK signaling activation.
  • Ubiquitination at posLast=149149, posLast=249249, and posLast=640640

No data available for DME Specific Peptides for GRIPAP1 Gene

Domains & Families for GRIPAP1 Gene

Gene Families for GRIPAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for GRIPAP1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for GRIPAP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with GRIPAP1: view

No data available for UniProtKB/Swiss-Prot for GRIPAP1 Gene

Function for GRIPAP1 Gene

Molecular function for GRIPAP1 Gene

UniProtKB/Swiss-Prot Function:
Regulates the endosomal recycling back to the neuronal plasma membrane, possibly by connecting early and late recycling endosomal domains and promoting segregation of recycling endosomes from early endosomal membranes. Involved in the localization of recycling endosomes to dendritic spines, thereby playing a role in the maintenance of dendritic spine morphology. Required for the activity-induced AMPA receptor recycling to dendrite membranes and for long-term potentiation and synaptic plasticity (By similarity).
UniProtKB/Swiss-Prot Function:
GRASP-1 C-terminal chain: Functions as a scaffold protein to facilitate MAP3K1/MEKK1-mediated activation of the JNK1 kinase by phosphorylation, possibly by bringing MAP3K1/MEKK1 and JNK1 in close proximity.

Gene Ontology (GO) - Molecular Function for GRIPAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 21988832
genes like me logo Genes that share ontologies with GRIPAP1: view
genes like me logo Genes that share phenotypes with GRIPAP1: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for GRIPAP1 Gene

Localization for GRIPAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GRIPAP1 Gene

Early endosome membrane; Peripheral membrane protein. Recycling endosome membrane; Peripheral membrane protein. Cell projection, axon. Cell projection, dendrite. Cell junction, synapse. Note=Localizes to recycling endosomal tubules that are emanating from early endosomes. {ECO:0000250 UniProtKB:Q9JHZ4}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for GRIPAP1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
endosome 4
golgi apparatus 2
plasma membrane 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for GRIPAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005768 endosome IEA --
GO:0005829 cytosol IDA --
GO:0016020 membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with GRIPAP1: view

Pathways & Interactions for GRIPAP1 Gene

SuperPathways for GRIPAP1 Gene

No Data Available

Interacting Proteins for GRIPAP1 Gene

Gene Ontology (GO) - Biological Process for GRIPAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008150 biological_process ND --
GO:0015031 protein transport IEA --
GO:0098887 neurotransmitter receptor transport, endosome to postsynaptic membrane IEA --
GO:1905244 regulation of modification of synaptic structure IEA --
genes like me logo Genes that share ontologies with GRIPAP1: view

No data available for Pathways by source and SIGNOR curated interactions for GRIPAP1 Gene

Drugs & Compounds for GRIPAP1 Gene

No Compound Related Data Available

Transcripts for GRIPAP1 Gene

Unigene Clusters for GRIPAP1 Gene

GRIP1 associated protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for GRIPAP1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^
SP1: - - -
SP2:
SP3: -
SP4:
SP5: -
SP6:
SP7:

ExUns: 21 ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25 ^ 26 ^ 27
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:
SP6:
SP7:

Relevant External Links for GRIPAP1 Gene

GeneLoc Exon Structure for
GRIPAP1
ECgene alternative splicing isoforms for
GRIPAP1

Expression for GRIPAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for GRIPAP1 Gene

Protein differential expression in normal tissues from HIPED for GRIPAP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (18.7), Brain (8.7), Heart (7.6), and Lymph node (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for GRIPAP1 Gene



Protein tissue co-expression partners for GRIPAP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of GRIPAP1 Gene:

GRIPAP1

SOURCE GeneReport for Unigene cluster for GRIPAP1 Gene:

Hs.109929

Evidence on tissue expression from TISSUES for GRIPAP1 Gene

  • Nervous system(4.5)
  • Eye(4.4)
  • Liver(4.3)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with GRIPAP1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for GRIPAP1 Gene

Orthologs for GRIPAP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GRIPAP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia GRIPAP1 33 34
  • 91.87 (n)
dog
(Canis familiaris)
Mammalia GRIPAP1 33 34
  • 90.88 (n)
rat
(Rattus norvegicus)
Mammalia Gripap1 33
  • 89.01 (n)
mouse
(Mus musculus)
Mammalia Gripap1 33 16 34
  • 88.96 (n)
oppossum
(Monodelphis domestica)
Mammalia GRIPAP1 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia GRIPAP1 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia GRIPAP1 34
  • 69 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.4626 33
zebrafish
(Danio rerio)
Actinopterygii gripap1 33 34
  • 67.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10814 34
  • 34 (a)
OneToOne
Species where no ortholog for GRIPAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GRIPAP1 Gene

ENSEMBL:
Gene Tree for GRIPAP1 (if available)
TreeFam:
Gene Tree for GRIPAP1 (if available)

Paralogs for GRIPAP1 Gene

No data available for Paralogs for GRIPAP1 Gene

Variants for GRIPAP1 Gene

Sequence variations from dbSNP and Humsavar for GRIPAP1 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs782702449 uncertain-significance, not specified 48,985,339(-) C/G coding_sequence_variant, missense_variant
rs1000308434 -- 48,986,292(-) T/C intron_variant
rs1000458796 -- 48,976,542(-) G/C intron_variant
rs1000721860 -- 48,996,334(-) G/A intron_variant
rs1001127767 -- 48,999,283(-) T/C 5_prime_UTR_variant, coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for GRIPAP1 Gene

Variant ID Type Subtype PubMed ID
dgv2289e212 CNV loss 25503493
esv32909 CNV gain+loss 17666407
esv3573947 CNV loss 25503493
nsv528292 CNV gain 19592680

Variation tolerance for GRIPAP1 Gene

Residual Variation Intolerance Score: 11.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.12% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for GRIPAP1 Gene

Human Gene Mutation Database (HGMD)
GRIPAP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
GRIPAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GRIPAP1 Gene

Disorders for GRIPAP1 Gene

Additional Disease Information for GRIPAP1

No disorders were found for GRIPAP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for GRIPAP1 Gene

Publications for GRIPAP1 Gene

  1. Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes. (PMID: 20098723) Hoogenraad CC … van der Sluijs P (PLoS biology 2010) 3 4 58
  2. GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway. (PMID: 17761173) Ye B … Huganir RL (FEBS letters 2007) 3 4 58
  3. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  4. Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes. (PMID: 15897011) Stinton LM … Fritzler MJ (Clinical immunology (Orlando, Fla.) 2005) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for GRIPAP1 Gene

Sources for GRIPAP1 Gene

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