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Aliases for PSKH1 Gene

Aliases for PSKH1 Gene

  • Protein Serine Kinase H1 2 3 4
  • EC 2.7.11.1 4 63
  • PSK-H1 3 4
  • Serine/Threonine-Protein Kinase H1 3
  • EC 2.7.11 63

External Ids for PSKH1 Gene

Previous GeneCards Identifiers for PSKH1 Gene

  • GC16P058622
  • GC16P068304
  • GC16P067662
  • GC16P067703
  • GC16P066484
  • GC16P053800

Summaries for PSKH1 Gene

GeneCards Summary for PSKH1 Gene

PSKH1 (Protein Serine Kinase H1) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway. GO annotations related to this gene include protein serine/threonine kinase activity. An important paralog of this gene is DCX.

UniProtKB/Swiss-Prot for PSKH1 Gene

  • May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.

Gene Wiki entry for PSKH1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSKH1 Gene

Genomics for PSKH1 Gene

Regulatory Elements for PSKH1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PSKH1 Gene

Start:
67,893,272 bp from pter
End:
67,929,678 bp from pter
Size:
36,407 bases
Orientation:
Plus strand

Genomic View for PSKH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSKH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSKH1 Gene

Proteins for PSKH1 Gene

  • Protein details for PSKH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11801-KPSH1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase H1
    Protein Accession:
    P11801
    Secondary Accessions:
    • Q9NY19

    Protein attributes for PSKH1 Gene

    Size:
    424 amino acids
    Molecular mass:
    48035 Da
    Quaternary structure:
    • Homodimer

neXtProt entry for PSKH1 Gene

Proteomics data for PSKH1 Gene at MOPED

Post-translational modifications for PSKH1 Gene

Other Protein References for PSKH1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

Domains for PSKH1 Gene

Gene Families for PSKH1 Gene

Suggested Antigen Peptide Sequences for PSKH1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P11801

UniProtKB/Swiss-Prot:

KPSH1_HUMAN :
  • P11801
Domain:
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
genes like me logo Genes that share domains with PSKH1: view

Function for PSKH1 Gene

Molecular function for PSKH1 Gene

GENATLAS Biochemistry:
protein serine/kinase of unknown function
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activity depends on Ca(2+) concentration
UniProtKB/Swiss-Prot Function:
May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing.

Enzyme Numbers (IUBMB) for PSKH1 Gene

Gene Ontology (GO) - Molecular Function for PSKH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 22939624
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with PSKH1: view

Phenotypes for PSKH1 Gene

GenomeRNAi human phenotypes for PSKH1:
genes like me logo Genes that share phenotypes with PSKH1: view

Animal Model Products

miRNA for PSKH1 Gene

miRTarBase miRNAs that target PSKH1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSKH1

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for PSKH1 Gene

Localization for PSKH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSKH1 Gene

Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus speckle. Endoplasmic reticulum membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Cytoplasm. Note=Localized in the brefeldin A-sensitive Golgi compartment, at centrosomes, in the nucleus with a somewhat speckle-like presence, membrane-associated to the endoplasmic reticulum (ER) and the plasma membrane (PM), and more diffusely in the cytoplasm. Found to concentrate in splicing factor compartments (SFCs) within the nucleus of interphase cells. The acylation-negative form may be only cytoplasmic and nuclear. Acylation seems to allow the sequestering to the intracellular membranes. Myristoylation may mediate targeting to the intracellular non-Golgi membranes and palmitoylation may mediate the targeting to the Golgi membranes. Dual acylation is required to stabilize the interaction with Golgi membranes.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSKH1 Gene COMPARTMENTS Subcellular localization image for PSKH1 gene
Compartment Confidence
cytoskeleton 5
endoplasmic reticulum 5
golgi apparatus 5
nucleus 5
plasma membrane 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for PSKH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005634 nucleus --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
genes like me logo Genes that share ontologies with PSKH1: view

Pathways for PSKH1 Gene

SuperPathways for PSKH1 Gene

Superpath Contained pathways
1 mRNA Splicing - Major Pathway
genes like me logo Genes that share pathways with PSKH1: view

Pathways by source for PSKH1 Gene

1 BioSystems pathway for PSKH1 Gene

Gene Ontology (GO) - Biological Process for PSKH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PSKH1: view

Compounds for PSKH1 Gene

(2) HMDB Compounds for PSKH1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
genes like me logo Genes that share compounds with PSKH1: view

Transcripts for PSKH1 Gene

mRNA/cDNA for PSKH1 Gene

Unigene Clusters for PSKH1 Gene

Protein serine kinase H1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PSKH1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PSKH1 Gene

No ASD Table

Relevant External Links for PSKH1 Gene

GeneLoc Exon Structure for
PSKH1
ECgene alternative splicing isoforms for
PSKH1

Expression for PSKH1 Gene

mRNA expression in normal human tissues for PSKH1 Gene

Protein differential expression in normal tissues for PSKH1 Gene

This gene is overexpressed in Heart (66.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PSKH1 Gene

SOURCE GeneReport for Unigene cluster for PSKH1 Gene Hs.513683

mRNA Expression by UniProt/SwissProt for PSKH1 Gene

P11801-KPSH1_HUMAN
Tissue specificity: Expressed in all tissues and cell lines tested with the highest level of abundance in testis.
genes like me logo Genes that share expressions with PSKH1: view

Expression partners for PSKH1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PSKH1 Gene

Orthologs for PSKH1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PSKH1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PSKH1 35
  • 90.96 (n)
  • 97.88 (a)
PSKH1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PSKH1 35
  • 91.63 (n)
  • 96.68 (a)
PSKH1 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Pskh1 35
  • 88.36 (n)
  • 97.64 (a)
Pskh1 16
Pskh1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PSKH1 35
  • 99.61 (n)
  • 100 (a)
PSKH1 36
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PSKH1 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PSKH1 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves PSKH1 35
  • 81.54 (n)
  • 89.26 (a)
PSKH1 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PSKH1 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia pskh1 35
  • 70.43 (n)
  • 83.65 (a)
Str.19522 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14987 35
zebrafish
(Danio rerio)
Actinopterygii pskh1 35
  • 72.95 (n)
  • 82.1 (a)
wufc44h10 35
pskh1 36
  • 82 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea R06A10.4 37
  • 42 (a)
R06A10.4 35
  • 54.36 (n)
  • 47.39 (a)
R06A10.4 36
  • 40 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CMK1 36
  • 26 (a)
ManyToMany
CMK2 36
  • 23 (a)
ManyToMany
KSP1 38
barley
(Hordeum vulgare)
Liliopsida Hv.2858 35
rice
(Oryza sativa)
Liliopsida Os.5879 35
corn
(Zea mays)
Liliopsida Zm.6306 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.584 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 63 (a)
OneToMany
Species with no ortholog for PSKH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PSKH1 Gene

ENSEMBL:
Gene Tree for PSKH1 (if available)
TreeFam:
Gene Tree for PSKH1 (if available)

Paralogs for PSKH1 Gene

Pseudogenes.org Pseudogenes for PSKH1 Gene

genes like me logo Genes that share paralogs with PSKH1: view

Variants for PSKH1 Gene

Sequence variations from dbSNP and Humsavar for PSKH1 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1111165 -- 67,927,032(-) CCCCC(C/G)GAACG intron-variant
rs1111166 -- 67,927,027(-) GGAAC(G/T)TGTCC intron-variant
rs2136648 -- 67,912,234(+) TCCCT(A/T)ATACT intron-variant
rs2136649 -- 67,896,636(+) CTCCC(A/G)GGTTC intron-variant
rs2271295 -- 67,893,327(+) GATGG(A/C)CGGCA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PSKH1 Gene

Variant ID Type Subtype PubMed ID
nsv524363 CNV Loss 19592680
nsv522852 CNV Gain 19592680
nsv906813 CNV Loss 21882294
nsv1844 CNV Loss 18451855
nsv906814 CNV Loss 21882294
esv2591720 CNV Deletion 19546169
esv2670395 CNV Deletion 23128226
esv21655 CNV Loss 19812545
nsv442402 CNV CNV 18776908

Relevant External Links for PSKH1 Gene

HapMap Linkage Disequilibrium report
PSKH1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PSKH1 Gene

Disorders for PSKH1 Gene

Relevant External Links for PSKH1

Genetic Association Database (GAD)
PSKH1

No disorders were found for PSKH1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for PSKH1 Gene

Publications for PSKH1 Gene

  1. Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus. (PMID: 14644153) Brede G. … Prydz H. (Exp. Cell Res. 2003) 3 4 23
  2. Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family. (PMID: 2948189) Hanks S.K. (Proc. Natl. Acad. Sci. U.S.A. 1987) 3 4
  3. A tight cluster of five unrelated human genes on chromosome 16q22.1. (PMID: 8268911) Larsen F. … Prydz H. (Hum. Mol. Genet. 1993) 2 3
  4. Characterization of PSKH1, a novel human protein serine kinase with centrosomal, Golgi, and nuclear localization. (PMID: 11087665) Brede G. … Prydz H. (Genomics 2000) 3 4
  5. PSKH1, a novel splice factor compartment-associated serine kinase. (PMID: 12466556) Brede G. … Prydz H. (Nucleic Acids Res. 2002) 3 4

Products for PSKH1 Gene

  • Addgene plasmids for PSKH1

Sources for PSKH1 Gene

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