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Aliases for PSG4 Gene

Aliases for PSG4 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 4 2 3
  • Pregnancy-Specific Beta-1-Glycoprotein 9 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 4 2 3
  • Pregnancy-Specific Glycoprotein 9 3 4
  • Pregnancy-Specific Glycoprotein 4 3 4
  • PS-Beta-G-9 3 4
  • PS-Beta-G-4 3 4
  • PSBG-9 3 4
  • PSBG-4 3 4
  • PSG9 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein-4 3
  • CGM4 4

External Ids for PSG4 Gene

Summaries for PSG4 Gene

Entrez Gene Summary for PSG4 Gene

  • The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG4 Gene

PSG4 (Pregnancy Specific Beta-1-Glycoprotein 4) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

Gene Wiki entry for PSG4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG4 Gene

Genomics for PSG4 Gene

Genomic Location for PSG4 Gene

Start:
43,192,702 bp from pter
End:
43,207,299 bp from pter
Size:
14,598 bases
Orientation:
Minus strand

Genomic View for PSG4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG4 Gene

Regulatory Elements for PSG4 Gene

Proteins for PSG4 Gene

  • Protein details for PSG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q00888-PSG4_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 4
    Protein Accession:
    Q00888
    Secondary Accessions:
    • E7EX79
    • Q13047
    • Q13048
    • Q15234
    • Q15240
    • Q9UQ76

    Protein attributes for PSG4 Gene

    Size:
    419 amino acids
    Molecular mass:
    47113 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAA60208.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=M32625; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PSG4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSG4 Gene

Proteomics data for PSG4 Gene at MOPED

Post-translational modifications for PSG4 Gene

  • Glycosylation at Asn104, Asn111, Asn199, Asn268, Asn299, and Asn303

No data available for DME Specific Peptides for PSG4 Gene

Domains for PSG4 Gene

Gene Families for PSG4 Gene

HGNC:
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for PSG4 Gene

UniProtKB/Swiss-Prot:

PSG4_HUMAN
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • Q00888
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • Q00888
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.:
    • Q00888
genes like me logo Genes that share domains with PSG4: view

Function for PSG4 Gene

Molecular function for PSG4 Gene

GENATLAS Biochemistry: pregnancy specific beta-1-glycoprotein 4,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Gene Ontology (GO) - Molecular Function for PSG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with PSG4: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for PSG4 Gene

Localization for PSG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSG4 Gene COMPARTMENTS Subcellular localization image for PSG4 gene
Compartment Confidence
extracellular 5
mitochondrion 2
cytosol 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PSG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with PSG4: view

Pathways for PSG4 Gene

SuperPathways for PSG4 Gene

No Data Available

Interacting Proteins for PSG4 Gene

Gene Ontology (GO) - Biological Process for PSG4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS 7794280
genes like me logo Genes that share ontologies with PSG4: view

No data available for Pathways by source for PSG4 Gene

Compounds for PSG4 Gene

(2) Novoseek inferred chemical compound relationships for PSG4 Gene

Compound -log(P) Hits PubMed IDs
pancreozymin 96.2 2
progesterone 37.3 2
genes like me logo Genes that share compounds with PSG4: view

Transcripts for PSG4 Gene

mRNA/cDNA for PSG4 Gene

(7) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSG4 Gene

Pregnancy specific beta-1-glycoprotein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSG4 Gene

No ASD Table

Relevant External Links for PSG4 Gene

GeneLoc Exon Structure for
PSG4
ECgene alternative splicing isoforms for
PSG4

Expression for PSG4 Gene

mRNA expression in normal human tissues for PSG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG4 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (7.7) and Skin - Not Sun Exposed (Suprapubic) (6.5).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for PSG4 Gene

SOURCE GeneReport for Unigene cluster for PSG4 Gene Hs.711363

genes like me logo Genes that share expressions with PSG4: view

Orthologs for PSG4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PSG4 36
  • 96.47 (n)
  • 94.23 (a)
PSG4 37
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 26 (a)
ManyToMany
CEACAM1 37
  • 34 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam9 37
  • 32 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 27 (a)
ManyToMany
Species with no ortholog for PSG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG4 Gene

ENSEMBL:
Gene Tree for PSG4 (if available)
TreeFam:
Gene Tree for PSG4 (if available)

Paralogs for PSG4 Gene

genes like me logo Genes that share paralogs with PSG4: view

Variants for PSG4 Gene

Sequence variations from dbSNP and Humsavar for PSG4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs8603 -- 43,193,077(-) ttaac(C/T)gtcct utr-variant-3-prime
rs12426 -- 43,192,823(-) AATTA(C/T)AGTAG utr-variant-3-prime
rs1058718 - 43,195,184(-) AGAGT(A/G)AGAAC reference, missense, intron-variant
rs1136228 -- 43,193,165(-) GATAA(C/G)AAGTT utr-variant-3-prime, downstream-variant-500B
rs1804229 -- 43,193,127(-) ccaaa(A/G)atgtc utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for PSG4 Gene

Variant ID Type Subtype PubMed ID
dgv1087e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
dgv1089e1 CNV Complex 17122850
dgv141e55 CNV Loss 17911159
dgv3891n71 CNV Gain 21882294
dgv411n27 CNV Loss 19166990
esv2663048 CNV Deletion 23128226
dgv3898n71 CNV Loss 21882294
esv22277 CNV Gain+Loss 19812545
nsv470145 CNV Loss 18288195
dgv565e201 CNV Deletion 23290073
esv2751794 CNV Gain 17911159
dgv3921n71 CNV Loss 21882294
esv2421574 OTHER Complex 20811451
nsv912001 CNV Gain 21882294
dgv1092e1 CNV Complex 17122850
dgv3925n71 CNV Gain 21882294
nsv437832 CNV Loss 16327808
esv2657641 CNV Deletion 23128226
dgv1093e1 CNV Complex 17122850
dgv1094e1 CNV Complex 17122850
dgv3930n71 CNV Gain 21882294
esv2718603 CNV Deletion 23290073
nsv912041 CNV Loss 21882294
nsv912042 CNV Gain+Loss 21882294
nsv912046 CNV Gain+Loss 21882294
dgv3932n71 CNV Gain 21882294
esv2751795 CNV Loss 17911159
dgv3933n71 CNV Gain 21882294
dgv3934n71 CNV Loss 21882294
dgv3937n71 CNV Loss 21882294
esv2671292 CNV Deletion 23128226
dgv3939n71 CNV Loss 21882294
dgv3940n71 CNV Gain+Loss 21882294
dgv3941n71 CNV Loss 21882294
dgv1095e1 CNV Complex 17122850
nsv833838 CNV Gain 17160897
dgv1096e1 CNV Complex 17122850
nsv912096 CNV Gain+Loss 21882294
nsv437833 CNV Loss 16327808
esv2718604 CNV Deletion 23290073
esv7692 CNV Loss 19470904
nsv912105 CNV Gain 21882294
essv22369 CNV CNV 17122850
nsv437182 CNV Loss 16327808
dgv1097e1 CNV Complex 17122850
dgv1098e1 CNV Complex 17122850
nsv458705 CNV Loss 19166990
nsv817848 CNV Loss 17921354
dgv1099e1 CNV Complex 17122850
dgv1100e1 CNV Complex 17122850
dgv1101e1 CNV Complex 17122850
esv34676 CNV Loss 17911159
nsv828557 CNV Loss 20364138
nsv2499 CNV Loss 18451855
dgv590n67 CNV Loss 20364138
esv33039 CNV Gain 17666407
esv2664621 CNV Deletion 23128226
nsv482044 CNV Gain 20164927
nsv435702 CNV Deletion 17901297
esv2659897 CNV Deletion 23128226
dgv645e199 CNV Deletion 23128226
esv6630 CNV Loss 19470904
nsv820547 CNV Deletion 20802225
esv1002165 CNV Gain 20482838
esv2658764 CNV Deletion 23128226
nsv442769 CNV CNV 18776908
dgv1102e1 CNV Complex 17122850
dgv1103e1 CNV Complex 17122850
dgv1104e1 CNV Complex 17122850
dgv1105e1 CNV Complex 17122850

Relevant External Links for PSG4 Gene

HapMap Linkage Disequilibrium report
PSG4

Disorders for PSG4 Gene

No disorders were found for PSG4 Gene.

No data available for UniProtKB/Swiss-Prot for PSG4 Gene

Publications for PSG4 Gene

  1. cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. (PMID: 2783133) Zimmermann W.A. … Thompson J.A. (Biochem. Biophys. Res. Commun. 1989) 2 3 4
  2. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PMID: 7794280) Teglund S. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1995) 3 4 23
  3. A single human cell expresses all messenger ribonucleic acids: the arrow of time in a cell. (PMID: 9645429) Kimoto Y. (Mol. Gen. Genet. 1998) 3 23
  4. The human pregnancy-specific glycoprotein genes are tightly linked on the long arm of chromosome 19 and are coordinately expressed. (PMID: 1690992) Thompson J. … Hardman N. (Biochem. Biophys. Res. Commun. 1990) 3 4
  5. Characterization of new members of the pregnancy-specific beta 1- glycoprotein family. (PMID: 1922019) Chan W.Y. … Tease L.A. (Mol. Cell. Biochem. 1991) 3 4

Products for PSG4 Gene

Sources for PSG4 Gene

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