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Aliases for PSG4 Gene

Aliases for PSG4 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 4 2 3 5
  • Pregnancy-Specific Beta-1-Glycoprotein 9 3 4
  • Pregnancy-Specific Glycoprotein 4 3 4
  • Pregnancy-Specific Glycoprotein 9 3 4
  • PS-Beta-G-4 3 4
  • PS-Beta-G-9 3 4
  • PSBG-4 3 4
  • PSBG-9 3 4
  • PSG9 3 4
  • Pregnancy-Specific Beta-1-Glycoprotein 4 2
  • Pregnancy-Specific Beta-1-Glycoprotein-4 3
  • CGM4 4

External Ids for PSG4 Gene

Previous GeneCards Identifiers for PSG4 Gene

  • GC19M044343
  • GC19M044088
  • GC19M048372
  • GC19M048388
  • GC19M048124
  • GC19M047918
  • GC19M043696
  • GC19M040126

Summaries for PSG4 Gene

Entrez Gene Summary for PSG4 Gene

  • The protein encoded by this gene is a pregnancy-specific glycoprotein (PSG), one of several encoded by a cluster of similar genes on chromosome 19. This gene is a member of the carcinoembryonic antigen (CEA) gene family and may play a role in regulation of the innate immune system. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PSG4 Gene

PSG4 (Pregnancy Specific Beta-1-Glycoprotein 4) is a Protein Coding gene. An important paralog of this gene is CEACAM8.

Gene Wiki entry for PSG4 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG4 Gene

Genomics for PSG4 Gene

Regulatory Elements for PSG4 Gene

Enhancers for PSG4 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSG4 on UCSC Golden Path with GeneCards custom track

Promoters for PSG4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PSG4 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG4 Gene

43,192,702 bp from pter
43,207,299 bp from pter
14,598 bases
Minus strand

Genomic View for PSG4 Gene

Genes around PSG4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG4 Gene

Proteins for PSG4 Gene

  • Protein details for PSG4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 4
    Protein Accession:
    Secondary Accessions:
    • E7EX79
    • Q13047
    • Q13048
    • Q15234
    • Q15240
    • Q9UQ76

    Protein attributes for PSG4 Gene

    419 amino acids
    Molecular mass:
    47113 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAA60208.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the N-terminal part.; Evidence={ECO:0000305}; Sequence=M32625; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for PSG4 Gene


neXtProt entry for PSG4 Gene

Proteomics data for PSG4 Gene at MOPED

Post-translational modifications for PSG4 Gene

  • Glycosylation at Asn 104, Asn 111, Asn 199, Asn 268, Asn 299, and Asn 303
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for PSG4 Gene

Domains & Families for PSG4 Gene

Protein Domains for PSG4 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG4: view

Function for PSG4 Gene

Molecular function for PSG4 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 4,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Phenotypes for PSG4 Gene

genes like me logo Genes that share phenotypes with PSG4: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for PSG4 Gene

Localization for PSG4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG4 Gene


Subcellular locations from

Jensen Localization Image for PSG4 Gene COMPARTMENTS Subcellular localization image for PSG4 gene
Compartment Confidence
extracellular 5

No data available for Gene Ontology (GO) - Cellular Components for PSG4 Gene

Pathways & Interactions for PSG4 Gene

SuperPathways for PSG4 Gene

No Data Available

Interacting Proteins for PSG4 Gene

Gene Ontology (GO) - Biological Process for PSG4 Gene


No data available for Pathways by source and SIGNOR curated interactions for PSG4 Gene

Drugs & Compounds for PSG4 Gene

(1) Drugs for PSG4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PSG4 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSG4: view

Transcripts for PSG4 Gene

mRNA/cDNA for PSG4 Gene

(8) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(17) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PSG4 Gene

Pregnancy specific beta-1-glycoprotein 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSG4 Gene

No ASD Table

Relevant External Links for PSG4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSG4 Gene

mRNA expression in normal human tissues for PSG4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PSG4 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x7.7) and Skin - Not Sun Exposed (Suprapubic) (x6.5).

Protein differential expression in normal tissues from HIPED for PSG4 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for PSG4 Gene

SOURCE GeneReport for Unigene cluster for PSG4 Gene Hs.711363

genes like me logo Genes that share expression patterns with PSG4: view

Protein tissue co-expression partners for PSG4 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PSG4 Gene

Orthologs for PSG4 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PSG4 35
  • 96.47 (n)
  • 94.23 (a)
PSG4 36
  • 95 (a)
(Bos Taurus)
Mammalia -- 36
  • 26 (a)
  • 34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 27 (a)
(Mus musculus)
Mammalia Ceacam9 36
  • 32 (a)
Species with no ortholog for PSG4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG4 Gene

Gene Tree for PSG4 (if available)
Gene Tree for PSG4 (if available)

Paralogs for PSG4 Gene

genes like me logo Genes that share paralogs with PSG4: view

Variants for PSG4 Gene

Sequence variations from dbSNP and Humsavar for PSG4 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3170216 - 43,204,093(-) CATAC(A/C/G/T)TCTAC upstream-variant-2KB, reference, missense
rs3859474 - 43,195,265(+) CTTGG(A/G/T)CAGCT intron-variant, reference, missense
rs2355442 - 43,195,126(+) GCTTT(A/G)CCCTG intron-variant, reference, missense
rs11883278 - 43,205,504(+) ATGCG(C/G)TGTGT upstream-variant-2KB, reference, missense
rs73548061 - 43,198,175(+) TGGTA(A/C/G)CTTGC intron-variant, reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for PSG4 Gene

Variant ID Type Subtype PubMed ID
dgv1087e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
dgv1089e1 CNV Complex 17122850
dgv141e55 CNV Loss 17911159
dgv3891n71 CNV Gain 21882294
dgv411n27 CNV Loss 19166990
esv2663048 CNV Deletion 23128226
dgv3898n71 CNV Loss 21882294
esv22277 CNV Gain+Loss 19812545
nsv470145 CNV Loss 18288195
dgv565e201 CNV Deletion 23290073
esv2751794 CNV Gain 17911159
dgv3921n71 CNV Loss 21882294
esv2421574 OTHER Complex 20811451
nsv912001 CNV Gain 21882294
dgv1092e1 CNV Complex 17122850
dgv3925n71 CNV Gain 21882294
nsv437832 CNV Loss 16327808
esv2657641 CNV Deletion 23128226
dgv1093e1 CNV Complex 17122850
dgv1094e1 CNV Complex 17122850
dgv3930n71 CNV Gain 21882294
esv2718603 CNV Deletion 23290073
nsv912041 CNV Loss 21882294
nsv912042 CNV Gain+Loss 21882294
nsv912046 CNV Gain+Loss 21882294
dgv3932n71 CNV Gain 21882294
esv2751795 CNV Loss 17911159
dgv3933n71 CNV Gain 21882294
dgv3934n71 CNV Loss 21882294
dgv3937n71 CNV Loss 21882294
esv2671292 CNV Deletion 23128226
dgv3939n71 CNV Loss 21882294
dgv3940n71 CNV Gain+Loss 21882294
dgv3941n71 CNV Loss 21882294
dgv1095e1 CNV Complex 17122850
nsv833838 CNV Gain 17160897
dgv1096e1 CNV Complex 17122850
nsv912096 CNV Gain+Loss 21882294
nsv437833 CNV Loss 16327808
esv2718604 CNV Deletion 23290073
esv7692 CNV Loss 19470904
nsv912105 CNV Gain 21882294
essv22369 CNV CNV 17122850
nsv437182 CNV Loss 16327808
dgv1097e1 CNV Complex 17122850
dgv1098e1 CNV Complex 17122850
nsv458705 CNV Loss 19166990
nsv817848 CNV Loss 17921354
dgv1099e1 CNV Complex 17122850
dgv1100e1 CNV Complex 17122850
dgv1101e1 CNV Complex 17122850
esv34676 CNV Loss 17911159
nsv828557 CNV Loss 20364138
nsv2499 CNV Loss 18451855
dgv590n67 CNV Loss 20364138
esv33039 CNV Gain 17666407
esv2664621 CNV Deletion 23128226
nsv482044 CNV Gain 20164927
nsv435702 CNV Deletion 17901297
esv2659897 CNV Deletion 23128226
dgv645e199 CNV Deletion 23128226
esv6630 CNV Loss 19470904
nsv820547 CNV Deletion 20802225
esv1002165 CNV Gain 20482838
esv2658764 CNV Deletion 23128226
nsv442769 CNV CNV 18776908
dgv1102e1 CNV Complex 17122850
dgv1103e1 CNV Complex 17122850
dgv1104e1 CNV Complex 17122850
dgv1105e1 CNV Complex 17122850

Variation tolerance for PSG4 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.49; 64.43% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSG4 Gene

Disorders for PSG4 Gene

Relevant External Links for PSG4

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for PSG4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PSG4 Gene

Publications for PSG4 Gene

  1. cDNA cloning demonstrates the expression of pregnancy-specific glycoprotein genes, a subgroup of the carcinoembryonic antigen gene family, in fetal liver. (PMID: 2783133) Zimmermann W.A. … Thompson J.A. (Biochem. Biophys. Res. Commun. 1989) 2 3 4 67
  2. A single human cell expresses all messenger ribonucleic acids: the arrow of time in a cell. (PMID: 9645429) Kimoto Y. (Mol. Gen. Genet. 1998) 3 23
  3. Characterization of cDNA encoding novel pregnancy-specific glycoprotein variants. (PMID: 7794280) Teglund S. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1995) 3 23
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  5. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3

Products for PSG4 Gene

Sources for PSG4 Gene