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Aliases for PSG1 Gene

Aliases for PSG1 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 1 2 3 5
  • Fetal Liver Non-Specific Cross-Reactive Antigen 1/2 3 4
  • Pregnancy-Specific Beta-1 Glycoprotein C/D 3 4
  • CD66 Antigen-Like Family Member F 3 4
  • PS-Beta-C/D 3 4
  • PS-Beta-G-1 3 4
  • FL-NCA-1/2 3 4
  • PSBG-1 3 4
  • PSBG1 3 4
  • PSG95 3 4
  • PSGGA 3 4
  • B1G1 3 4
  • Pregnancy-Specific B-1 Glycoprotein 3
  • Pregnancy-Specific Glycoprotein 1 4
  • CD66f Antigen 4
  • DHFRP2 3
  • PSGIIA 3
  • CD66f 3
  • PBG1 3
  • SP1 3

External Ids for PSG1 Gene

Previous HGNC Symbols for PSG1 Gene

  • PSBG1

Previous GeneCards Identifiers for PSG1 Gene

  • GC19M044018
  • GC19M043762
  • GC19M048024
  • GC19M048062
  • GC19M048063
  • GC19M047923
  • GC19M043348
  • GC19M039800

Summaries for PSG1 Gene

Entrez Gene Summary for PSG1 Gene

  • The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG1 Gene

PSG1 (Pregnancy Specific Beta-1-Glycoprotein 1) is a Protein Coding gene. Diseases associated with PSG1 include Gestational Trophoblastic Neoplasm and Non-Gestational Choriocarcinoma. An important paralog of this gene is CEACAM8.

Gene Wiki entry for PSG1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG1 Gene

Genomics for PSG1 Gene

Regulatory Elements for PSG1 Gene

Enhancers for PSG1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PSG1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PSG1 Gene

42,866,461 bp from pter
42,879,822 bp from pter
13,362 bases
Minus strand

Genomic View for PSG1 Gene

Genes around PSG1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PSG1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG1 Gene

Proteins for PSG1 Gene

  • Protein details for PSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 1
    Protein Accession:
    Secondary Accessions:
    • O75236
    • P11462
    • P11463
    • Q15231
    • Q15241
    • Q15243
    • Q16660
    • Q6ICR4
    • Q9P1W5
    • Q9UQ79

    Protein attributes for PSG1 Gene

    419 amino acids
    Molecular mass:
    47223 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PSG1 Gene


neXtProt entry for PSG1 Gene

Proteomics data for PSG1 Gene at MOPED

Post-translational modifications for PSG1 Gene

  • Glycosylation at Asn 61, Asn 104, Asn 111, Asn 199, Asn 259, Asn 268, and Asn 303
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for PSG1

No data available for DME Specific Peptides for PSG1 Gene

Domains & Families for PSG1 Gene

Protein Domains for PSG1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. CEA family.
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.
  • Belongs to the immunoglobulin superfamily. CEA family.
genes like me logo Genes that share domains with PSG1: view

Function for PSG1 Gene

Molecular function for PSG1 Gene

GENATLAS Biochemistry:
pregnancy specific beta-1-glycoprotein 1,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Phenotypes for PSG1 Gene

GenomeRNAi human phenotypes for PSG1:
genes like me logo Genes that share phenotypes with PSG1: view

Human Phenotype Ontology for PSG1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Transcription Factor Targets for PSG1 Gene

Selected GeneGlobe predicted Target genes for PSG1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA and HOMER Transcription for PSG1 Gene

Localization for PSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG1 Gene


Subcellular locations from

Jensen Localization Image for PSG1 Gene COMPARTMENTS Subcellular localization image for PSG1 gene
Compartment Confidence
extracellular 3
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for PSG1 Gene

Pathways & Interactions for PSG1 Gene

SuperPathways for PSG1 Gene

No Data Available

Interacting Proteins for PSG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000244296 P11464-PSG1_HUMAN for PSG1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for PSG1 Gene


No data available for Pathways by source and SIGNOR curated interactions for PSG1 Gene

Drugs & Compounds for PSG1 Gene

(3) Drugs for PSG1 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for PSG1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PSG1: view

Transcripts for PSG1 Gene

Unigene Clusters for PSG1 Gene

Pregnancy specific beta-1-glycoprotein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSG1 Gene

No ASD Table

Relevant External Links for PSG1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PSG1 Gene

mRNA expression in normal human tissues for PSG1 Gene

mRNA differential expression in normal tissues according to GTEx for PSG1 Gene

This gene is overexpressed in Adipose - Subcutaneous (x5.1).

Protein differential expression in normal tissues from HIPED for PSG1 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (56.7) and Placenta (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for PSG1 Gene

SOURCE GeneReport for Unigene cluster for PSG1 Gene Hs.709192

genes like me logo Genes that share expression patterns with PSG1: view

Protein tissue co-expression partners for PSG1 Gene

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for PSG1 Gene

Orthologs for PSG1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia LOC100612418 35
  • 95.31 (n)
  • 92.36 (a)
PSG1 36
  • 94 (a)
(Bos Taurus)
Mammalia -- 36
  • 26 (a)
  • 34 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 26 (a)
(Mus musculus)
Mammalia Ceacam3 36
  • 15 (a)
Species with no ortholog for PSG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG1 Gene

Gene Tree for PSG1 (if available)
Gene Tree for PSG1 (if available)

Paralogs for PSG1 Gene Pseudogenes for PSG1 Gene

genes like me logo Genes that share paralogs with PSG1: view

Variants for PSG1 Gene

Sequence variations from dbSNP and Humsavar for PSG1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs707744 - 42,878,222(+) TGGCT(C/G/T)GGCTT reference, missense
rs707745 - 42,878,216(+) TTTGG(G/T)TGGCT reference, missense
rs1058956 - 42,878,204(-) TTTCC(A/G)AGGGG reference, missense
rs1064479 - 42,878,156(-) ATCTT(A/G/T)CCGGC reference, missense
rs1064480 - 42,878,125(-) AATGA(A/C/G)GGACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PSG1 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV Deletion 17116639
dgv15e196 CNV Deletion 17116639
dgv1086e1 CNV Complex 17122850
dgv1087e1 CNV Complex 17122850
dgv1088e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
nsv833835 CNV Gain 17160897
nsv428364 CNV Gain+Loss 18775914
nsv911809 CNV Gain 21882294
dgv3890n71 CNV Gain 21882294
dgv1089e1 CNV Complex 17122850
dgv141e55 CNV Loss 17911159
dgv3891n71 CNV Gain 21882294
dgv3892n71 CNV Gain 21882294
esv33217 CNV Loss 17666407
dgv1090e1 CNV Complex 17122850
nsv828554 CNV Gain 20364138
dgv3893n71 CNV Loss 21882294
dgv3894n71 CNV Gain 21882294
dgv3895n71 CNV Loss 21882294
nsv2497 CNV Loss 18451855
nsv470143 CNV Gain 18288195
dgv409n27 CNV Loss 19166990
dgv410n27 CNV Gain 19166990
dgv411n27 CNV Loss 19166990
dgv142e55 CNV Loss 17911159
esv2663048 CNV Deletion 23128226
nsv911820 CNV Gain+Loss 21882294
dgv3896n71 CNV Loss 21882294
dgv3897n71 CNV Gain+Loss 21882294
nsv911839 CNV Gain+Loss 21882294
dgv3898n71 CNV Loss 21882294
dgv589n67 CNV Loss 20364138
nsv442766 CNV CNV 18776908
dgv1091e1 CNV Complex 17122850
dgv3899n71 CNV Loss 21882294
dgv3900n71 CNV Gain 21882294
esv22277 CNV Gain+Loss 19812545
esv2421673 OTHER Complex 20811451
dgv3901n71 CNV Loss 21882294
esv2668472 CNV Deletion 23128226
esv2718595 CNV Deletion 23290073
nsv817841 CNV Gain 17921354
nsv817842 CNV Gain+Loss 17921354
nsv817843 CNV Gain 17921354
nsv470145 CNV Loss 18288195
dgv3902n71 CNV Loss 21882294
dgv3903n71 CNV Loss 21882294
essv17365 CNV CNV 17122850
dgv3904n71 CNV Gain+Loss 21882294
dgv3905n71 CNV Gain 21882294
dgv3906n71 CNV Loss 21882294
esv2718597 CNV Deletion 23290073
dgv3907n71 CNV Gain 21882294
esv2718598 CNV Deletion 23290073
dgv3908n71 CNV Loss 21882294
dgv565e201 CNV Deletion 23290073
nsv911910 CNV Gain 21882294
dgv3909n71 CNV Gain+Loss 21882294
dgv3910n71 CNV Loss 21882294
dgv3911n71 CNV Gain+Loss 21882294
dgv3912n71 CNV Loss 21882294
dgv3913n71 CNV Loss 21882294
nsv471409 CNV Duplication 19718026
nsv482039 CNV Gain 20164927
dgv412n27 CNV Gain 19166990
dgv413n27 CNV Loss 19166990
dgv414n27 CNV Gain 19166990
dgv415n27 CNV Gain 19166990
dgv416n27 CNV Loss 19166990
dgv3914n71 CNV Loss 21882294

Variation tolerance for PSG1 Gene

Residual Variation Intolerance Score: 99.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.28; 76.45% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for PSG1 Gene

Disorders for PSG1 Gene

MalaCards: The human disease database

(6) MalaCards diseases for PSG1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gestational trophoblastic neoplasm
  • hydatidiform mole, recurrent, 1
non-gestational choriocarcinoma
  • choriocarcinoma, non-gestational
orofaciodigital syndrome viii
  • edwards syndrome
  • pineal germinoma
rh isoimmunization
  • rh incompatibility affecting management of mother
- elite association - COSMIC cancer census association via MalaCards
Search PSG1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PSG1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PSG1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PSG1 Gene

Publications for PSG1 Gene

  1. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PMID: 2377620) Leslie K.K. … Chou J.Y. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23 67
  2. Pregnancy-specific {beta}-1-glycoprotein 1 and human leukocyte antigen-E mRNA in human sperm: differential expression in fertile and infertile men and evidence of a possible functional role during early development. (PMID: 18987160) AvendaA+o C. … Oehninger S. (Hum. Reprod. 2009) 3 23
  3. First trimester maternal serum pregnancy-specific beta-1-glycoprotein (SP1) as a marker of adverse pregnancy outcome. (PMID: 19911417) Pihl K. … Christiansen M. (Prenat. Diagn. 2009) 3 23
  4. Characterization of cDNAs of the human pregnancy-specific beta-1- glycoprotein family, a new subfamily of the immunoglobulin gene superfamily. (PMID: 2346748) Zheng Q.-X. … Chan W.-Y. (Biochemistry 1990) 3 23
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3

Products for PSG1 Gene

Sources for PSG1 Gene