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Aliases for PSG1 Gene

Aliases for PSG1 Gene

  • Pregnancy Specific Beta-1-Glycoprotein 1 2 3
  • PSBG1 3 4 6
  • B1G1 3 4 6
  • Fetal Liver Non-Specific Cross-Reactive Antigen 1/2 3 4
  • Pregnancy-Specific Beta-1 Glycoprotein C/D 3 4
  • CD66 Antigen-Like Family Member F 3 4
  • PS-Beta-C/D 3 4
  • PS-Beta-G-1 3 4
  • FL-NCA-1/2 3 4
  • PSBG-1 3 4
  • PSGGA 3 4
  • PSG95 3 4
  • SP1 3 6
  • Pregnancy-Specific Beta-1-Glycoprotein 1 3
  • Pregnancy-Specific B-1 Glycoprotein 3
  • Pregnancy-Specific Glycoprotein 1 4
  • CD66f Antigen 4
  • DHFRP2 3
  • PSGIIA 3
  • CD66f 3
  • PBG1 3

External Ids for PSG1 Gene

Previous Symbols for PSG1 Gene

  • PSBG1

Summaries for PSG1 Gene

Entrez Gene Summary for PSG1 Gene

  • The human placenta is a multihormonal endocrine organ that produces hormones, enzymes, and other molecules that support fetal survival and development. Pregnancy-specific beta-1-glycoprotein (PSBG, PSG) is a major product of the syncytiotrophoblast, reaching concentrations of 100 to 290 mg/l at term in the serum of pregnant women (Horne et al., 1976 [PubMed 971765]). PSG is a member of the immunoglobulin (Ig) superfamily (Watanabe and Chou, 1988 [PubMed 3257488]; Streydio et al., 1988 [PubMed 3260773]).[supplied by OMIM, Oct 2009]

GeneCards Summary for PSG1 Gene

PSG1 (Pregnancy Specific Beta-1-Glycoprotein 1) is a Protein Coding gene. Diseases associated with PSG1 include gestational trophoblastic neoplasm and trophoblastic neoplasm. Among its related pathways are Signaling by GPCR and Disease. An important paralog of this gene is CEACAM8.

Gene Wiki entry for PSG1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PSG1 Gene

Genomics for PSG1 Gene

Genomic Location for PSG1 Gene

Start:
42,866,461 bp from pter
End:
42,879,822 bp from pter
Size:
13,362 bases
Orientation:
Minus strand

Genomic View for PSG1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PSG1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PSG1 Gene

Regulatory Elements for PSG1 Gene

Proteins for PSG1 Gene

  • Protein details for PSG1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11464-PSG1_HUMAN
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 1
    Protein Accession:
    P11464
    Secondary Accessions:
    • O75236
    • P11462
    • P11463
    • Q15231
    • Q15241
    • Q15243
    • Q16660
    • Q6ICR4
    • Q9P1W5
    • Q9UQ79

    Protein attributes for PSG1 Gene

    Size:
    419 amino acids
    Molecular mass:
    47223 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PSG1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PSG1 Gene

Proteomics data for PSG1 Gene at MOPED

Post-translational modifications for PSG1 Gene

  • Glycosylation at Asn61, Asn104, Asn111, Asn199, Asn259, Asn268, and Asn303

No data available for DME Specific Peptides for PSG1 Gene

Domains for PSG1 Gene

Gene Families for PSG1 Gene

HGNC:
  • CD :CD molecules
  • VSET :Immunoglobulin superfamily / V-set domain containing
  • IGD :Immunoglobulin superfamily / Immunoglobulin-like domain containing

Protein Domains for PSG1 Gene

UniProtKB/Swiss-Prot:

PSG1_HUMAN
Domain:
  • Contains 3 Ig-like C2-type (immunoglobulin-like) domains.:
    • P11464
  • Contains 1 Ig-like V-type (immunoglobulin-like) domain.:
    • P11464
Family:
  • Belongs to the immunoglobulin superfamily. CEA family.:
    • P11464
genes like me logo Genes that share domains with PSG1: view

Function for PSG1 Gene

Molecular function for PSG1 Gene

GENATLAS Biochemistry: pregnancy specific beta-1-glycoprotein 1,expressed by placental syncytiotrophoblasts,unknown function,carcinoembryonic antigen (CEA family),immunoglobulin superfamily

Gene Ontology (GO) - Molecular Function for PSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with PSG1: view

Transcription Factor Targeting for PSG1 Gene

Selected GeneGlobe predicted Target genes for PSG1

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA and HOMER Transcription for PSG1 Gene

Localization for PSG1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PSG1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PSG1 Gene COMPARTMENTS Subcellular localization image for PSG1 gene
Compartment Confidence
extracellular 3
mitochondrion 2
plasma membrane 2
chloroplast 1
cytosol 1

Gene Ontology (GO) - Cellular Components for PSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with PSG1: view

Pathways for PSG1 Gene

genes like me logo Genes that share pathways with PSG1: view

Interacting Proteins for PSG1 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000244296%0d%0a9606.ENSP00000362824%0d%0a
Selected Interacting proteins: ENSP00000244296 P11464-PSG1_HUMAN for PSG1 Gene via STRING UniProtKB I2D

Gene Ontology (GO) - Biological Process for PSG1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007565 female pregnancy TAS 1572651
genes like me logo Genes that share ontologies with PSG1: view

Compounds for PSG1 Gene

(4) Novoseek inferred chemical compound relationships for PSG1 Gene

Compound -log(P) Hits PubMed IDs
oestriol 57 2
progesterone 4.08 2
estradiol 0 5
zinc 0 1
genes like me logo Genes that share compounds with PSG1: view

Transcripts for PSG1 Gene

Unigene Clusters for PSG1 Gene

Pregnancy specific beta-1-glycoprotein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PSG1 Gene

No ASD Table

Relevant External Links for PSG1 Gene

GeneLoc Exon Structure for
PSG1
ECgene alternative splicing isoforms for
PSG1

Expression for PSG1 Gene

mRNA expression in normal human tissues for PSG1 Gene

mRNA differential expression in normal tissues according to GTEx for PSG1 Gene

This gene is overexpressed in Adipose - Subcutaneous (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PSG1 Gene

SOURCE GeneReport for Unigene cluster for PSG1 Gene Hs.709192

genes like me logo Genes that share expressions with PSG1: view

Orthologs for PSG1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for PSG1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100612418 36
  • 95.31 (n)
  • 92.36 (a)
PSG1 37
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia -- 37
  • 26 (a)
ManyToMany
CEACAM1 37
  • 34 (a)
ManyToMany
mouse
(Mus musculus)
Mammalia Ceacam3 37
  • 15 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 26 (a)
ManyToMany
Species with no ortholog for PSG1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for PSG1 Gene

ENSEMBL:
Gene Tree for PSG1 (if available)
TreeFam:
Gene Tree for PSG1 (if available)

Paralogs for PSG1 Gene

Pseudogenes.org Pseudogenes for PSG1 Gene

genes like me logo Genes that share paralogs with PSG1: view

Variants for PSG1 Gene

Sequence variations from dbSNP and Humsavar for PSG1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs707744 - 42,878,222(+) TGGCT(C/G)GGCTT missense, reference, intron-variant
rs707745 - 42,878,216(+) TTTGG(G/T)TGGCT reference, missense, intron-variant
rs707747 -- 42,878,058(-) GCATA(C/T)AGTGG synonymous-codon, reference, intron-variant
rs707748 - 42,878,041(-) AACAG(A/C/T)ATATT missense, reference, intron-variant
rs707753 -- 42,871,954(-) ACTCC(A/G)GACGC reference, synonymous-codon, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PSG1 Gene

Variant ID Type Subtype PubMed ID
esv2422471 CNV Deletion 17116639
dgv15e196 CNV Deletion 17116639
dgv1086e1 CNV Complex 17122850
dgv1087e1 CNV Complex 17122850
dgv1088e1 CNV Complex 17122850
dgv140e55 CNV Gain 17911159
nsv516973 CNV Gain+Loss 19592680
nsv9730 CNV Gain+Loss 18304495
dgv564e201 CNV Deletion 23290073
nsv833835 CNV Gain 17160897
nsv428364 CNV Gain+Loss 18775914
nsv911809 CNV Gain 21882294
dgv3890n71 CNV Gain 21882294
dgv1089e1 CNV Complex 17122850
dgv141e55 CNV Loss 17911159
dgv3891n71 CNV Gain 21882294
dgv3892n71 CNV Gain 21882294
esv33217 CNV Loss 17666407
dgv1090e1 CNV Complex 17122850
nsv828554 CNV Gain 20364138
dgv3893n71 CNV Loss 21882294
dgv3894n71 CNV Gain 21882294
dgv3895n71 CNV Loss 21882294
nsv2497 CNV Loss 18451855
nsv470143 CNV Gain 18288195
dgv409n27 CNV Loss 19166990
dgv410n27 CNV Gain 19166990
dgv411n27 CNV Loss 19166990
dgv142e55 CNV Loss 17911159
esv2663048 CNV Deletion 23128226
nsv911820 CNV Gain+Loss 21882294
dgv3896n71 CNV Loss 21882294
dgv3897n71 CNV Gain+Loss 21882294
nsv911839 CNV Gain+Loss 21882294
dgv3898n71 CNV Loss 21882294
dgv589n67 CNV Loss 20364138
nsv442766 CNV CNV 18776908
dgv1091e1 CNV Complex 17122850
dgv3899n71 CNV Loss 21882294
dgv3900n71 CNV Gain 21882294
esv22277 CNV Gain+Loss 19812545
esv2421673 OTHER Complex 20811451
dgv3901n71 CNV Loss 21882294
esv2668472 CNV Deletion 23128226
esv2718595 CNV Deletion 23290073
nsv817841 CNV Gain 17921354
nsv817842 CNV Gain+Loss 17921354
nsv817843 CNV Gain 17921354
nsv470145 CNV Loss 18288195
dgv3902n71 CNV Loss 21882294
dgv3903n71 CNV Loss 21882294
essv17365 CNV CNV 17122850
dgv3904n71 CNV Gain+Loss 21882294
dgv3905n71 CNV Gain 21882294
dgv3906n71 CNV Loss 21882294
esv2718597 CNV Deletion 23290073
dgv3907n71 CNV Gain 21882294
esv2718598 CNV Deletion 23290073
dgv3908n71 CNV Loss 21882294
dgv565e201 CNV Deletion 23290073
nsv911910 CNV Gain 21882294
dgv3909n71 CNV Gain+Loss 21882294
dgv3910n71 CNV Loss 21882294
dgv3911n71 CNV Gain+Loss 21882294
dgv3912n71 CNV Loss 21882294
dgv3913n71 CNV Loss 21882294
nsv471409 CNV Duplication 19718026
nsv482039 CNV Gain 20164927
dgv412n27 CNV Gain 19166990
dgv413n27 CNV Loss 19166990
dgv414n27 CNV Gain 19166990
dgv415n27 CNV Gain 19166990
dgv416n27 CNV Loss 19166990
dgv3914n71 CNV Loss 21882294

Relevant External Links for PSG1 Gene

HapMap Linkage Disequilibrium report
PSG1

Disorders for PSG1 Gene

(1) University of Copenhagen DISEASES for PSG1 Gene

(18) Novoseek inferred disease relationships for PSG1 Gene

Disease -log(P) Hits PubMed IDs
hydatidiform mole 52.4 2
down syndrome 50.1 10
gestational trophoblastic disease 49.3 1
carcinoma large cell 45.8 1
trisomy 39.4 7
genes like me logo Genes that share disorders with PSG1: view

No data available for UniProtKB/Swiss-Prot for PSG1 Gene

Publications for PSG1 Gene

  1. Linkage of two human pregnancy-specific beta 1-glycoprotein genes: one is associated with hydatidiform mole. (PMID: 2377620) Leslie K.K. … Chou J.Y. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 4 23
  2. Pregnancy-specific {beta}-1-glycoprotein 1 and human leukocyte antigen-E mRNA in human sperm: differential expression in fertile and infertile men and evidence of a possible functional role during early development. (PMID: 18987160) AvendaA+o C. … Oehninger S. (Hum. Reprod. 2009) 3 23
  3. First trimester maternal serum pregnancy-specific beta-1-glycoprotein (SP1) as a marker of adverse pregnancy outcome. (PMID: 19911417) Pihl K. … Christiansen M. (Prenat. Diagn. 2009) 3 23
  4. Characterization of cDNAs of the human pregnancy-specific beta-1- glycoprotein family, a new subfamily of the immunoglobulin gene superfamily. (PMID: 2346748) Zheng Q.-X. … Chan W.-Y. (Biochemistry 1990) 3 23
  5. Carcinoembryonic antigen gene family members in submandibular salivary gland: demonstration of pregnancy-specific glycoproteins by cDNA cloning. (PMID: 2350345) Zoubir F. … Hammarstroem S. (Biochem. Biophys. Res. Commun. 1990) 3 4

Products for PSG1 Gene

Sources for PSG1 Gene

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