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Aliases for SLC2A9 Gene

Aliases for SLC2A9 Gene

  • Solute Carrier Family 2 Member 9 2 3 5
  • Solute Carrier Family 2 (Facilitated Glucose Transporter), Member 9 2 3
  • Urate Voltage-Driven Efflux Transporter 1 2 3
  • Glucose Transporter Type 9 3 4
  • GLUT-9 3 4
  • GLUT9 3 4
  • Solute Carrier Family 2, Facilitated Glucose Transporter Member 9 3
  • Human Glucose Transporter-Like Protein-9 3
  • UAQTL2 3
  • URATv1 3
  • GLUTX 3

External Ids for SLC2A9 Gene

Previous GeneCards Identifiers for SLC2A9 Gene

  • GC04M009497
  • GC04M009778
  • GC04M009578
  • GC04M009504
  • GC04M009827
  • GC04M009162

Summaries for SLC2A9 Gene

Entrez Gene Summary for SLC2A9 Gene

  • This gene encodes a member of the SLC2A facilitative glucose transporter family. Members of this family play a significant role in maintaining glucose homeostasis. The encoded protein may play a role in the development and survival of chondrocytes in cartilage matrices. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for SLC2A9 Gene

SLC2A9 (Solute Carrier Family 2 Member 9) is a Protein Coding gene. Diseases associated with SLC2A9 include Hypouricemia, Renal, 2 and Hypouricemia, Renal. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Uricosurics Pathway, Pharmacodynamics. GO annotations related to this gene include transmembrane transporter activity and glucose transmembrane transporter activity. An important paralog of this gene is SLC2A5.

UniProtKB/Swiss-Prot for SLC2A9 Gene

  • Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate.

Gene Wiki entry for SLC2A9 Gene

Additional gene information for SLC2A9 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC2A9 Gene

Genomics for SLC2A9 Gene

Regulatory Elements for SLC2A9 Gene

Enhancers for SLC2A9 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H010114 2 FANTOM5 Ensembl ENCODE dbSUPER 21 -64.6 -64643 10.6 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 ZNF207 ENSG00000261490 SLC2A9 WDR1 LOC105374476 PIR57718 PIR45151
GH04H010091 1.7 VISTA Ensembl ENCODE dbSUPER 23.5 -47.1 -47064 20.6 FOXA2 ZSCAN4 EGR1 ZNF366 SCRT2 ZNF548 ATF7 FOS RUNX3 CREM SLC2A9 ENSG00000261490 LOC105374476 GC04M010099 MIR3138
GH04H010179 1.9 FANTOM5 Ensembl ENCODE dbSUPER 17.7 -127.7 -127731 6.2 HNRNPUL1 HDGF PKNOX1 ATF1 ARNT TCF12 GATA2 ELK1 ATF7 RUNX3 ENSG00000261490 SLC2A9 WDR1 LOC105374476 ENSG00000251296 LOC100129344
GH04H010018 1.3 ENCODE dbSUPER 24.2 +34.0 34018 5 HDGF ATF1 MLX ARID4B YY1 ZNF766 ZNF143 ZNF207 ATF7 RUNX3 SLC2A9 LOC105374476
GH04H010167 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -117.2 -117169 8.5 HDGF PKNOX1 ATF1 ARNT TCF12 ZNF766 CBX5 GATA2 ELK1 ATF7 SLC2A9 ZNF518B ENSG00000261490 LOC105374476 ENSG00000251296 LOC100129344
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC2A9 on UCSC Golden Path with GeneCards custom track

Genomic Locations for SLC2A9 Gene

Genomic Locations for SLC2A9 Gene
283,812 bases
Minus strand

Genomic View for SLC2A9 Gene

Genes around SLC2A9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC2A9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC2A9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC2A9 Gene

Proteins for SLC2A9 Gene

  • Protein details for SLC2A9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 9
    Protein Accession:
    Secondary Accessions:
    • Q0VGC4
    • Q4W5D1
    • Q8WV30
    • Q96P00

    Protein attributes for SLC2A9 Gene

    540 amino acids
    Molecular mass:
    58702 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for SLC2A9 Gene


neXtProt entry for SLC2A9 Gene

Post-translational modifications for SLC2A9 Gene

  • Glycosylation at isoforms=290
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for SLC2A9 Gene

Domains & Families for SLC2A9 Gene

Gene Families for SLC2A9 Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Potential drug targets
  • Predicted membrane proteins
  • Transporters

Suggested Antigen Peptide Sequences for SLC2A9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
  • Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.
genes like me logo Genes that share domains with SLC2A9: view

Function for SLC2A9 Gene

Molecular function for SLC2A9 Gene

UniProtKB/Swiss-Prot Function:
Transport urate and fructose. May have a role in the urate reabsorption by proximal tubules. Also transports glucose at low rate.

Phenotypes From GWAS Catalog for SLC2A9 Gene

Gene Ontology (GO) - Molecular Function for SLC2A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005351 sugar:proton symporter activity NAS 10860667
GO:0005355 glucose transmembrane transporter activity IEA --
GO:0015143 urate transmembrane transporter activity IDA 18327257
GO:0022857 transmembrane transporter activity TAS --
GO:0022891 substrate-specific transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC2A9: view
genes like me logo Genes that share phenotypes with SLC2A9: view

Human Phenotype Ontology for SLC2A9 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC2A9 Gene

MGI Knock Outs for SLC2A9:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for SLC2A9 Gene

Localization for SLC2A9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC2A9 Gene

Isoform 1: Basolateral cell membrane; Multi-pass membrane protein.
Isoform 2: Apical cell membrane; Multi-pass membrane protein. Basolateral cell membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC2A9 gene
Compartment Confidence
plasma membrane 5
peroxisome 2

Gene Ontology (GO) - Cellular Components for SLC2A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane NAS 10860667
GO:0016323 basolateral plasma membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with SLC2A9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for SLC2A9 Gene

Pathways & Interactions for SLC2A9 Gene

genes like me logo Genes that share pathways with SLC2A9: view

Interacting Proteins for SLC2A9 Gene

Gene Ontology (GO) - Biological Process for SLC2A9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0008643 carbohydrate transport IEA --
GO:0008645 hexose transport TAS --
GO:0015711 organic anion transport IEA --
GO:0015758 glucose transport NAS 10860667
genes like me logo Genes that share ontologies with SLC2A9: view

No data available for SIGNOR curated interactions for SLC2A9 Gene

Drugs & Compounds for SLC2A9 Gene

(9) Drugs for SLC2A9 Gene - From: DrugBank, ClinicalTrials, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
glucose Approved, Vet_approved Pharma Transporter, substrate 0
Fludeoxyglucose F-18 Approved Pharma Transporter, substrate 0
Losartan Approved Pharma Antagonist, Transporter, inhibitor 289
Probenecid Approved Pharma Inhibition, Inhibitor, Transporter, inhibitor 30
Canagliflozin Approved Pharma Inhibition, Inhibitor SGLT2 inhibitor,potent and selective 113

(1) Additional Compounds for SLC2A9 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with SLC2A9: view

Transcripts for SLC2A9 Gene

Unigene Clusters for SLC2A9 Gene

Solute carrier family 2 (facilitated glucose transporter), member 9:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC2A9 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16
SP1: - - - -
SP2: - - -
SP4: -

Relevant External Links for SLC2A9 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC2A9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC2A9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC2A9 Gene

This gene is overexpressed in Kidney - Cortex (x9.4).

Protein differential expression in normal tissues from HIPED for SLC2A9 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.7), Urine (18.9), Fetal Liver (13.4), and Kidney (12.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC2A9 Gene

Protein tissue co-expression partners for SLC2A9 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC2A9 Gene:


SOURCE GeneReport for Unigene cluster for SLC2A9 Gene:


mRNA Expression by UniProt/SwissProt for SLC2A9 Gene:

Tissue specificity: Most strongly expressed in basolateral membranes of proximal renal tubular cells, liver and placenta. Also detected in lung, blood leukocytes, heart skeletal muscle and chondrocytes from articular cartilage. Isoform 2 is only detected in the apical membranes of polarized renal tubular cells and placenta. Isoform 1 and isoform 2 are detected in kidney membrane (at protein level).

Evidence on tissue expression from TISSUES for SLC2A9 Gene

  • Kidney(4.6)
  • Liver(4.3)
  • Lung(4.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC2A9 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • nervous
  • skeletal muscle
  • skeleton
  • urinary
Head and neck:
  • brain
  • ear
  • head
  • heart
  • duodenum
  • intestine
  • kidney
  • large intestine
  • pancreas
  • small intestine
  • stomach
  • rectum
genes like me logo Genes that share expression patterns with SLC2A9: view

Orthologs for SLC2A9 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC2A9 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC2A9 33 34
  • 99.1 (n)
(Canis familiaris)
Mammalia SLC2A9 33 34
  • 86.47 (n)
(Bos Taurus)
Mammalia SLC2A9 33 34
  • 83.54 (n)
(Rattus norvegicus)
Mammalia Slc2a9 33
  • 83 (n)
(Mus musculus)
Mammalia Slc2a9 33 16 34
  • 82.34 (n)
(Ornithorhynchus anatinus)
Mammalia SLC2A9 34
  • 77 (a)
(Monodelphis domestica)
Mammalia SLC2A9 34
  • 73 (a)
(Gallus gallus)
Aves SLC2A9 33 34
  • 68.8 (n)
(Anolis carolinensis)
Reptilia SLC2A9 34
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia slc2a9 33
  • 63.22 (n)
Str.17199 33
(Danio rerio)
Actinopterygii slc2a15a 34
  • 45 (a)
fruit fly
(Drosophila melanogaster)
Insecta sut2 35
  • 27 (a)
sut3 35
  • 26 (a)
(Caenorhabditis elegans)
Secernentea K08F9.1 35
  • 25 (a)
Y61A9LA.1 35
  • 24 (a)
Y37A1A.3 35
  • 23 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 27 (a)
Species where no ortholog for SLC2A9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC2A9 Gene

Gene Tree for SLC2A9 (if available)
Gene Tree for SLC2A9 (if available)

Paralogs for SLC2A9 Gene

(11) SIMAP similar genes for SLC2A9 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with SLC2A9: view

Variants for SLC2A9 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for SLC2A9 Gene

Genetic variations in SLC2A9 influence the variance in serum uric acid concentrations and define the serum uric acid concentration quantitative trait locus 2 (UAQTL2) [MIM:612076]. Excess serum accumulation of uric acid can lead to the development of gout.

Sequence variations from dbSNP and Humsavar for SLC2A9 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs121908321 Pathogenic, Hypouricemia renal 2 (RHUC2) [MIM:612076] 9,890,687(-) TGGGA(A/C/T)GGAGA intron-variant, nc-transcript-variant, reference, missense
rs121908322 Pathogenic, Hypouricemia renal 2 (RHUC2) [MIM:612076] 9,980,681(-) AGATC(C/T)GTGGC nc-transcript-variant, reference, missense
rs181509591 Pathogenic, Hypouricemia renal 2 (RHUC2) [MIM:612076] 9,996,817(+) TTAAC(A/C/G)TCCCC intron-variant, nc-transcript-variant, reference, missense
rs776127501 Pathogenic, Hypouricemia renal 2 (RHUC2) [MIM:612076] 9,985,693(+) GAAGC(A/G)TCCCA nc-transcript-variant, reference, missense
rs863225072 Pathogenic, Hypouricemia renal 2 (RHUC2) [MIM:612076] 10,019,000(-) CAACC(G/T)GTCGG nc-transcript-variant, reference, missense, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for SLC2A9 Gene

Variant ID Type Subtype PubMed ID
nsv954404 CNV deletion 24416366
nsv829857 CNV gain 17160897
nsv593691 CNV loss 21841781
nsv593690 CNV loss 21841781
nsv527211 CNV loss 19592680
nsv527147 CNV gain 19592680
nsv525177 CNV loss 19592680
nsv524654 CNV loss 19592680
nsv519519 CNV loss 19592680
nsv469621 CNV loss 16826518
nsv461259 CNV loss 19166990
nsv433443 CNV loss 18776910
nsv290026 CNV deletion 16902084
nsv1153967 CNV deletion 26484159
nsv1146296 CNV deletion 26484159
nsv1139215 CNV deletion 24896259
nsv1126683 CNV deletion 24896259
nsv1111264 CNV tandem duplication 24896259
nsv10449 CNV gain 18304495
nsv1014335 CNV gain 25217958
nsv1013487 CNV gain 25217958
nsv1005698 CNV gain 25217958
nsv1003496 CNV loss 25217958
esv3893873 CNV loss 25118596
esv3599598 CNV gain 21293372
esv3599597 CNV loss 21293372
esv3599596 CNV loss 21293372
esv3599595 CNV loss 21293372
esv3599593 CNV gain 21293372
esv3599589 CNV gain 21293372
esv3569284 CNV loss 25503493
esv3569283 CNV loss 25503493
esv3378984 CNV insertion 20981092
esv2763339 CNV gain 21179565
esv2759222 CNV gain+loss 17122850
esv2757 CNV loss 18987735
esv2752052 CNV gain 17911159
esv2727161 CNV deletion 23290073
esv2727160 CNV deletion 23290073
esv2727159 CNV deletion 23290073
esv2727158 CNV deletion 23290073
esv2727157 CNV deletion 23290073
esv2727156 CNV deletion 23290073
esv2669053 CNV deletion 23128226
esv25020 CNV loss 19812545
esv2470501 CNV deletion 19546169
esv24465 CNV loss 19812545
esv2425297 CNV insertion 19546169
esv2217569 CNV deletion 18987734
esv2162646 CNV deletion 18987734
dgv5119n100 CNV loss 25217958
dgv5118n100 CNV gain 25217958
dgv5117n100 CNV gain 25217958
dgv5108n100 CNV gain 25217958
dgv313e215 CNV deletion 23714750
dgv312e215 CNV deletion 23714750
dgv2736n106 CNV deletion 24896259
dgv135n6 CNV deletion 16902084

Variation tolerance for SLC2A9 Gene

Residual Variation Intolerance Score: 41.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.85; 96.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC2A9 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

Disorders for SLC2A9 Gene

MalaCards: The human disease database

(8) MalaCards diseases for SLC2A9 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
hypouricemia, renal, 2
  • uric acid concentration, serum, qtl 2
hypouricemia, renal
  • renal hypouricemia
  • articular gout
  • nephrolithiasis, calcium oxalate
acquired polycythemia
  • polycythemia, secondary
- elite association - COSMIC cancer census association via MalaCards


  • Hypouricemia renal 2 (RHUC2) [MIM:612076]: A disorder characterized by impaired uric acid reabsorption at the apical membrane of proximal renal tubule cells, and high urinary urate excretion. Patients often appear asymptomatic, but may be subject to exercise-induced acute renal failure, chronic renal dysfunction and nephrolithiasis. {ECO:0000269 PubMed:19026395, ECO:0000269 PubMed:19926891, ECO:0000269 PubMed:21810765}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC2A9

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC2A9: view

No data available for Genatlas for SLC2A9 Gene

Publications for SLC2A9 Gene

  1. Cloning and expression analysis of a novel member of the facilitative glucose transporter family, SLC2A9 (GLUT9). (PMID: 10860667) Phay JE … Moley JF (Genomics 2000) 2 3 4 22 60
  2. Homozygous SLC2A9 mutations cause severe renal hypouricemia. (PMID: 19926891) Dinour D … Holtzman EJ (Journal of the American Society of Nephrology : JASN 2010) 3 4 22 60
  3. Association of nephrolithiasis and gene for glucose transporter type 9 (SLC2A9): study of 145 patients. (PMID: 20162745) Polasek O … Lauc G (Croatian medical journal 2010) 3 22 45 60
  4. SLC2A9 influences uric acid concentrations with pronounced sex-specific effects. (PMID: 18327256) Döring A … Meisinger C (Nature genetics 2008) 3 4 45 60
  5. SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. (PMID: 18327257) Vitart V … Wright AF (Nature genetics 2008) 3 4 45 60

Products for SLC2A9 Gene

Sources for SLC2A9 Gene

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