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Aliases for AZU1 Gene

Aliases for AZU1 Gene

  • Azurocidin 1 2 3 5
  • Heparin-Binding Protein 2 3 4
  • Cationic Antimicrobial Protein CAP37 3 4
  • Cationic Antimicrobial Protein 37 2 3
  • Neutrophil Azurocidin 2 3
  • HHBP 3 4
  • HBP 3 4
  • HUMAZUR 3
  • AZAMP 3
  • CAP37 3
  • NAZC 3
  • AZU 3

External Ids for AZU1 Gene

Previous GeneCards Identifiers for AZU1 Gene

  • GC19P000909
  • GC19P000765
  • GC19P000776
  • GC19P000597

Summaries for AZU1 Gene

Entrez Gene Summary for AZU1 Gene

  • Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. This gene encodes a preproprotein that is proteolytically processed to generate a mature azurophil granule antibiotic protein, with monocyte chemotactic and antimicrobial activity. It is also an important multifunctional inflammatory mediator. This encoded protein is a member of the serine protease gene family but it is not a serine proteinase, because the active site serine and histidine residues are replaced. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, Nov 2015]

GeneCards Summary for AZU1 Gene

AZU1 (Azurocidin 1) is a Protein Coding gene. Diseases associated with AZU1 include heparin-induced thrombocytopenia and cornea cancer. GO annotations related to this gene include serine-type endopeptidase activity and toxic substance binding. An important paralog of this gene is ELANE.

UniProtKB/Swiss-Prot for AZU1 Gene

  • This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.

Gene Wiki entry for AZU1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for AZU1 Gene

Genomics for AZU1 Gene

Regulatory Elements for AZU1 Gene

Transcription factor binding sites by QIAGEN in the AZU1 gene promoter:

Genomic Location for AZU1 Gene

Chromosome:
19
Start:
825,097 bp from pter
End:
832,018 bp from pter
Size:
6,922 bases
Orientation:
Plus strand

Genomic View for AZU1 Gene

Genes around AZU1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
AZU1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for AZU1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for AZU1 Gene

Proteins for AZU1 Gene

  • Protein details for AZU1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P20160-CAP7_HUMAN
    Recommended name:
    Azurocidin
    Protein Accession:
    P20160
    Secondary Accessions:
    • P80014
    • Q52LG4
    • Q9UCM1
    • Q9UCT5

    Protein attributes for AZU1 Gene

    Size:
    251 amino acids
    Molecular mass:
    26886 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for AZU1 Gene

neXtProt entry for AZU1 Gene

Proteomics data for AZU1 Gene at MOPED

Post-translational modifications for AZU1 Gene

  • Cleavage of the N-terminal propeptide which is composed of 7 amino acids occurs in two steps. The initial cleavage of 5 amino acids is followed by the cleavage of a dipeptide to produce the mature form.
  • Glycosylation at Asn 126, Asn 140, and Asn 171

Other Protein References for AZU1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for AZU1 (Azurocidin/CAP37/HBP)

No data available for DME Specific Peptides for AZU1 Gene

Domains & Families for AZU1 Gene

Suggested Antigen Peptide Sequences for AZU1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P20160

UniProtKB/Swiss-Prot:

CAP7_HUMAN :
  • Contains 1 peptidase S1 domain.
  • Belongs to the peptidase S1 family. Elastase subfamily.
Domain:
  • Contains 1 peptidase S1 domain.
Family:
  • Belongs to the peptidase S1 family. Elastase subfamily.
genes like me logo Genes that share domains with AZU1: view

No data available for Gene Families for AZU1 Gene

Function for AZU1 Gene

Molecular function for AZU1 Gene

GENATLAS Biochemistry:
azurocidin,37kDa,neutrophil and monocyte derived serine protease homolog,released from azurophilic granules of neutrophiles,oxygen independent phagocytes of Gram- bacteria
UniProtKB/Swiss-Prot Function:
This is a neutrophil granule-derived antibacterial and monocyte- and fibroblast-specific chemotactic glycoprotein. Binds heparin. The cytotoxic action is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. It may play a role in mediating recruitment of monocytes in the second wave of inflammation. Has antibacterial activity against the Gram-nagative bacterium P.aeruginosa, this activity is inhibited by LPS from P.aeruginosa. Acting alone, it does not have antimicrobial activity against the Gram-negative bacteria A.actinomycetemcomitans ATCC 29532, A.actinomycetemcomitans NCTC 9709, A.actinomycetemcomitans FDC-Y4, H.aphrophilus ATCC 13252, E.corrodens ATCC 23834, C.sputigena ATCC 33123, Capnocytophaga sp ATCC 33124, Capnocytophaga sp ATCC 27872 or E.coli ML-35. Has antibacterial activity against C.sputigena ATCC 33123 when acting synergistically with either elastase or cathepsin G.

Phenotypes for AZU1 Gene

genes like me logo Genes that share phenotypes with AZU1: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for AZU1 Gene

Localization for AZU1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for AZU1 Gene

Cytoplasmic granule membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to azurophil granules of neutrophil granulocytes. Also called primary granules, these specialized lysosomes of the neutrophil formed early during promyelocyte development store antibacterial proteins and peptides. {ECO:0000269 PubMed:2312733, ECO:0000269 PubMed:2501794}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for AZU1 Gene COMPARTMENTS Subcellular localization image for AZU1 gene
Compartment Confidence
extracellular 5
lysosome 5
vacuole 5
cytosol 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for AZU1 Gene

Pathways & Interactions for AZU1 Gene

SuperPathways for AZU1 Gene

No Data Available

Interacting Proteins for AZU1 Gene

Gene Ontology (GO) - Biological Process for AZU1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation IEP 12465046
GO:0006508 proteolysis IEA,IDA 21550830
GO:0010628 positive regulation of gene expression IMP 24008408
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IDA 24008408
GO:0016485 protein processing IBA --
genes like me logo Genes that share ontologies with AZU1: view

No data available for Pathways by source and SIGNOR curated interactions for AZU1 Gene

Drugs & Compounds for AZU1 Gene

(14) Drugs for AZU1 Gene - From: Novoseek and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Heparin Approved, Investigational Pharma Antagonist 719,239

(18) Additional Compounds for AZU1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with AZU1: view

Transcripts for AZU1 Gene

mRNA/cDNA for AZU1 Gene

Unigene Clusters for AZU1 Gene

Azurocidin 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for AZU1 Gene

No ASD Table

Relevant External Links for AZU1 Gene

GeneLoc Exon Structure for
AZU1
ECgene alternative splicing isoforms for
AZU1

Expression for AZU1 Gene

mRNA expression in normal human tissues for AZU1 Gene

mRNA differential expression in normal tissues according to GTEx for AZU1 Gene

This gene is overexpressed in Whole Blood (x43.3).

Protein differential expression in normal tissues from HIPED for AZU1 Gene

This gene is overexpressed in Neutrophil (49.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for AZU1 Gene



SOURCE GeneReport for Unigene cluster for AZU1 Gene Hs.72885

genes like me logo Genes that share expression patterns with AZU1: view

Protein tissue co-expression partners for AZU1 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for AZU1 Gene

Orthologs for AZU1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for AZU1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AZU1 35
  • 98.27 (n)
  • 98.4 (a)
AZU1 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia AZU1 36
  • 71 (a)
OneToOne
AZU1 35
  • 79.18 (n)
  • 78.9 (a)
Species with no ortholog for AZU1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for AZU1 Gene

ENSEMBL:
Gene Tree for AZU1 (if available)
TreeFam:
Gene Tree for AZU1 (if available)

Paralogs for AZU1 Gene

Paralogs for AZU1 Gene

(28) SIMAP similar genes for AZU1 Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for AZU1 Gene

genes like me logo Genes that share paralogs with AZU1: view

Variants for AZU1 Gene

Sequence variations from dbSNP and Humsavar for AZU1 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs595844 -- 830,854(+) AGGTT(C/T)GTCAA reference, synonymous-codon
rs618168 -- 828,059(+) GCGGA(C/T)GGTGT intron-variant
rs678976 -- 829,723(+) GTGCC(A/G)CCTGT intron-variant
rs687077 -- 829,408(+) TGGAA(A/G)GTCTC intron-variant
rs6510980 -- 829,824(+) tggcg(C/T)gcacc intron-variant

Structural Variations from Database of Genomic Variants (DGV) for AZU1 Gene

Variant ID Type Subtype PubMed ID
nsv470101 CNV Loss 18288195
dgv3508n71 CNV Loss 21882294
dgv3513n71 CNV Loss 21882294
dgv3516n71 CNV Loss 21882294
nsv910224 CNV Loss 21882294
nsv910260 CNV Loss 21882294
dgv3548n71 CNV Loss 21882294
dgv3549n71 CNV Loss 21882294
dgv3550n71 CNV Loss 21882294
dgv3551n71 CNV Loss 21882294
dgv3552n71 CNV Loss 21882294
nsv910292 CNV Loss 21882294
dgv3553n71 CNV Loss 21882294
dgv3554n71 CNV Loss 21882294
nsv910310 CNV Loss 21882294
dgv3555n71 CNV Loss 21882294
nsv458321 CNV Loss 19166990
nsv910318 CNV Loss 21882294
dgv3558n71 CNV Loss 21882294
esv2717794 CNV Deletion 23290073
esv2668045 CNV Deletion 23128226
esv2743058 CNV Deletion 23290073
nsv910320 CNV Loss 21882294

Variation tolerance for AZU1 Gene

Residual Variation Intolerance Score: 85.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.12; 51.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for AZU1 Gene

HapMap Linkage Disequilibrium report
AZU1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for AZU1 Gene

Disorders for AZU1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for AZU1 Gene - From: DISEASES and GeneCards

- elite association - COSMIC cancer census association via MalaCards
Search AZU1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for AZU1

Genetic Association Database (GAD)
AZU1
Human Genome Epidemiology (HuGE) Navigator
AZU1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
AZU1
genes like me logo Genes that share disorders with AZU1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for AZU1 Gene

Publications for AZU1 Gene

  1. Cloning of the cDNA for the serine protease homolog CAP37/azurocidin, a microbicidal and chemotactic protein from human granulocytes. (PMID: 1919011) Morgan J.G. … Larrick J.L. (J. Immunol. 1991) 2 3 4 23 67
  2. Erysipelas caused by group A streptococcus activates the contact system and induces the release of heparin-binding protein. (PMID: 20107486) Linder A. … Akesson P. (J. Invest. Dermatol. 2010) 3 23
  3. Leukotriene B4-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin). (PMID: 19151333) Di Gennaro A. … HaeggstrAPm J.Z. (FASEB J. 2009) 3 23
  4. Possible involvement of heparin-binding protein in transfusion-related acute lung injury. (PMID: 18346022) Yasui K. … Hirayama F. (Transfusion 2008) 3 23
  5. Neutrophil-derived heparin-binding protein (HBP/CAP37) deposited on endothelium enhances monocyte arrest under flow conditions. (PMID: 15879141) Soehnlein O. … Lindbom L. (J. Immunol. 2005) 3 23

Products for AZU1 Gene

Sources for AZU1 Gene

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