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Aliases for CHST7 Gene

Aliases for CHST7 Gene

  • Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 7 2 3
  • Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 5 3 4
  • N-Acetylglucosamine 6-O-Sulfotransferase 4 3 4
  • GlcNAc6ST-4 3 4
  • Gn6st-4 3 4
  • C6ST-2 3 4
  • GST-5 3 4
  • Chondroitin 6-Sulfotransferase-2 3
  • Chondroitin 6-Sulfotransferase 2 4
  • Carbohydrate Sulfotransferase 7 3
  • EC 2.8.2.17 4
  • EC 2.8.2.- 4
  • C6ST2 6

External Ids for CHST7 Gene

Summaries for CHST7 Gene

Entrez Gene Summary for CHST7 Gene

  • This gene is a member of the Gal/GalNAc/GlcNAc (galactose/N-acetylgalactosamine/N-acetylglucosamine) 6-O-sulfotransferase (GST) family. Members of this family encode enzymes that catalyze the specific addition of sulfate groups to distinct hydroxyl and amino groups of carbohydrates. The encoded protein catalyzes the sulfation of 6-hydroxyl group of GalNAc in chondroitin. [provided by RefSeq, Aug 2013]

GeneCards Summary for CHST7 Gene

CHST7 (Carbohydrate (N-Acetylglucosamine 6-O) Sulfotransferase 7) is a Protein Coding gene. Among its related pathways are Disease and Metabolism. GO annotations related to this gene include N-acetylglucosamine 6-O-sulfotransferase activity and chondroitin 6-sulfotransferase activity. An important paralog of this gene is CHST2.

UniProtKB/Swiss-Prot for CHST7 Gene

  • Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.

Gene Wiki entry for CHST7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHST7 Gene

Genomics for CHST7 Gene

Genomic Location for CHST7 Gene

Start:
46,573,687 bp from pter
End:
46,598,496 bp from pter
Size:
24,810 bases
Orientation:
Plus strand

Genomic View for CHST7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHST7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHST7 Gene

Regulatory Elements for CHST7 Gene

Proteins for CHST7 Gene

  • Protein details for CHST7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS84-CHST7_HUMAN
    Recommended name:
    Carbohydrate sulfotransferase 7
    Protein Accession:
    Q9NS84
    Secondary Accessions:
    • O75667

    Protein attributes for CHST7 Gene

    Size:
    486 amino acids
    Molecular mass:
    54266 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHST7 Gene

Proteomics data for CHST7 Gene at MOPED

Post-translational modifications for CHST7 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys272
  • Glycosylation at Asn88, Asn186, and Asn407

Other Protein References for CHST7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CHST7 Gene

Domains for CHST7 Gene

Gene Families for CHST7 Gene

HGNC:
  • SULTM :Sulfotransferases, membrane-bound

Protein Domains for CHST7 Gene

Suggested Antigen Peptide Sequences for CHST7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS84

UniProtKB/Swiss-Prot:

CHST7_HUMAN
Family:
  • Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.:
    • Q9NS84
genes like me logo Genes that share domains with CHST7: view

Function for CHST7 Gene

Molecular function for CHST7 Gene

UniProtKB/Swiss-Prot CatalyticActivity: 3-phosphoadenylyl sulfate + chondroitin = adenosine 3,5-bisphosphate + chondroitin 6-sulfate
UniProtKB/Swiss-Prot Function: Sulfotransferase that utilizes 3-phospho-5-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.

Enzyme Numbers (IUBMB) for CHST7 Gene

Gene Ontology (GO) - Molecular Function for CHST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity IDA 10913333
GO:0008146 sulfotransferase activity --
GO:0008459 chondroitin 6-sulfotransferase activity IDA 10781596
genes like me logo Genes that share ontologies with CHST7: view

miRNA for CHST7 Gene

miRTarBase miRNAs that target CHST7

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CHST7 Gene

Localization for CHST7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHST7 Gene

Golgi apparatus membrane; Single-pass type II membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHST7 Gene COMPARTMENTS Subcellular localization image for CHST7 gene
Compartment Confidence
golgi apparatus 5
endoplasmic reticulum 1
extracellular 1
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CHST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0016021 integral component of membrane TAS 10781596
genes like me logo Genes that share ontologies with CHST7: view

Pathways for CHST7 Gene

genes like me logo Genes that share pathways with CHST7: view

Interacting Proteins for CHST7 Gene

Gene Ontology (GO) - Biological Process for CHST7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005975 carbohydrate metabolic process TAS --
GO:0005976 polysaccharide metabolic process TAS 10781596
GO:0006044 N-acetylglucosamine metabolic process IDA 10913333
GO:0006790 sulfur compound metabolic process IDA 10913333
GO:0030203 glycosaminoglycan metabolic process TAS --
genes like me logo Genes that share ontologies with CHST7: view

Compounds for CHST7 Gene

(5) HMDB Compounds for CHST7 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine 3',5'-diphosphate
  • 3,5-Diphosphoadenosine
1053-73-2
Chondroitin
  • Chondroitin-D-glucuronate
9007-27-6
Keratan
  • Kerato sulfate
69992-87-6
N-Acetyllactosamine
  • D-galactopyranosyl
32181-59-2
Phosphoadenosine phosphosulfate
  • 3'-Phospho-5'-adenylyl sulfate
482-67-7

(3) Novoseek inferred chemical compound relationships for CHST7 Gene

Compound -log(P) Hits PubMed IDs
chondroitin 77 4
n-acetylglucosamine 64.8 1
sulfate 52 1
genes like me logo Genes that share compounds with CHST7: view

Transcripts for CHST7 Gene

mRNA/cDNA for CHST7 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(61) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHST7 Gene

Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHST7 Gene

No ASD Table

Relevant External Links for CHST7 Gene

GeneLoc Exon Structure for
CHST7
ECgene alternative splicing isoforms for
CHST7

Expression for CHST7 Gene

mRNA expression in normal human tissues for CHST7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CHST7 Gene

This gene is overexpressed in Ovary (5.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHST7 Gene

SOURCE GeneReport for Unigene cluster for CHST7 Gene Hs.129955

mRNA Expression by UniProt/SwissProt for CHST7 Gene

Q9NS84-CHST7_HUMAN
Tissue specificity: Widely expressed. Highly expressed in heart, spleen, liver and ovary. Expressed at lower level in brain, placenta, thyroid, spinal cord and peripheral blood leukocytes. Not expressed in adult skin.
genes like me logo Genes that share expressions with CHST7: view

Orthologs for CHST7 Gene

This gene was present in the common ancestor of animals.

Orthologs for CHST7 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHST7 35
  • 88.89 (n)
  • 91.98 (a)
CHST7 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHST7 35
  • 90.95 (n)
  • 94.03 (a)
CHST7 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chst7 35
  • 84.16 (n)
  • 87.81 (a)
Chst7 16
Chst7 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHST7 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chst7 35
  • 85.22 (n)
  • 87.01 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 32 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia chst7 35
  • 62.23 (n)
  • 61.88 (a)
Str.16127 35
zebrafish
(Danio rerio)
Actinopterygii CHST7 36
  • 53 (a)
OneToOne
LOC563748 35
  • 60.34 (n)
  • 56.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31637 36
  • 18 (a)
ManyToMany
CG9550 36
  • 21 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 20 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 18 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 33 (a)
ManyToMany
CSA.5535 36
  • 19 (a)
ManyToMany
Species with no ortholog for CHST7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHST7 Gene

ENSEMBL:
Gene Tree for CHST7 (if available)
TreeFam:
Gene Tree for CHST7 (if available)

Paralogs for CHST7 Gene

Paralogs for CHST7 Gene

Selected SIMAP similar genes for CHST7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHST7: view

Variants for CHST7 Gene

Sequence variations from dbSNP and Humsavar for CHST7 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs735716 -- 46,598,351(+) TTTCT(A/G)TCTGG utr-variant-3-prime
rs760697 -- 46,587,909(+) CAGCC(A/G)TTGCA intron-variant
rs1003507 -- 46,575,686(+) CTGCA(C/T)TCCCA intron-variant
rs1117956 -- 46,595,690(+) ggtca(C/T)agtat intron-variant
rs1987792 -- 46,596,031(+) tactc(A/G)ggagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHST7 Gene

Variant ID Type Subtype PubMed ID
esv25002 CNV Loss 19812545

Relevant External Links for CHST7 Gene

HapMap Linkage Disequilibrium report
CHST7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHST7 Gene

Disorders for CHST7 Gene

No disorders were found for CHST7 Gene.

No data available for UniProtKB/Swiss-Prot for CHST7 Gene

Publications for CHST7 Gene

  1. Molecular cloning and expression of a novel chondroitin 6-O- sulfotransferase. (PMID: 10781596) Kitagawa H. … Sugahara K. (J. Biol. Chem. 2000) 2 3 4 23
  2. Sulfation of N-acetylglucosamine by chondroitin 6-sulfotransferase 2 (GST-5). (PMID: 10956661) Bhakta S. … Hemmerich S. (J. Biol. Chem. 2000) 3 4 23
  3. An integrated, functionally annotated gene map of the DXS8026-ELK1 interval on human Xp11.3-Xp11.23: potential hotspot for neurogenetic disorders. (PMID: 11944989) Thiselton D.L. … Meindl A. (Genomics 2002) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 3 4

Products for CHST7 Gene

Sources for CHST7 Gene

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