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Aliases for MMP26 Gene

Aliases for MMP26 Gene

  • Matrix Metallopeptidase 26 2 3
  • Matrix Metalloproteinase 26 2 3
  • Matrilysin 2 2 3
  • Matrilysin-2 3 4
  • Endometase 3 4
  • MMP-26 3 4
  • Matrix Metalloproteinase-26 3
  • EC 3.4.24.- 4

External Ids for MMP26 Gene

Previous GeneCards Identifiers for MMP26 Gene

  • GC11P005575
  • GC11P005311
  • GC11P004968
  • GC11P004973
  • GC11P004966
  • GC11P004745
  • GC11P004726
  • GC11P004669

Summaries for MMP26 Gene

Entrez Gene Summary for MMP26 Gene

  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The encoded protein degrades type IV collagen, fibronectin, fibrinogen, casein, vitronectin, alpha 1-antitrypsin, alpha 2-macroglobulin, and insulin-like growth factor-binding protein 1, and activates MMP9 by cleavage. The protein differs from most MMP family members in that it lacks a conserved C-terminal protein domain. [provided by RefSeq, Jul 2008]

GeneCards Summary for MMP26 Gene

MMP26 (Matrix Metallopeptidase 26) is a Protein Coding gene. Diseases associated with MMP26 include endometrial cancer and arthritis. Among its related pathways are GPCR Pathway and Integrin Pathway. GO annotations related to this gene include metalloendopeptidase activity. An important paralog of this gene is MMP2.

UniProtKB/Swiss-Prot for MMP26 Gene

  • May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B

Tocris Summary for MMP26 Gene

  • Matrix metalloproteases (matrix metalloproteinase, MMPs), also called matrixins, are zinc-dependent endopeptidases that are the major proteases involved in ECM degradation. MMPs are capable of degrading a wide range of extracellular molecules and a number of bioactive molecules. 24 matrixin genes have been identified in humans, which can be organized into six groups based on domain organization and substrate preference: Collagenases (MMP-1, -8 and -13), Gelatinases (MMP-2 and MMP-9), Stromelysins (MMP-3, -10 and -11), Matrilysin (MMP-7 and MMP-26), Membrane-type (MT)-MMPs (MMP-14, -15, -16, -17, -24 and -25) and others (MMP-12, -19, -20, -21, -23, -27 and -28). MMP activity is regulated by two major endogenous inhibitors: alpha2-macroglobulin and tissue inhibitors of metalloproteases (TIMPs). MMPs play a central role in cell proliferation, migration, differentiation, angiogenesis, apoptosis and host defences. Dysregulatoin of MMPs has been implicated in many diseases including arthritis, chronic ulcers, encephalomyelitis and cancer. Tumour metastasis is a multistep process involving the dessemination of tumor cells from the primary tumor to secondarys at a distant organ or tissue. One of the first steps in metastasis is the degradation of the basement membrane, a process in which MMPs have been implicated. MMPs are secreted by tumor cells themselves or by surrounding stromal cells stimulated by the nearby tumor. Numerous studies have linked altered MMP expression in different human cancers with poor disease prognosis. MMP-1, -2, -3, -7, -9, -13 and -14 all have elevated expression in primary tumors and/or metastases. Synthetic or natural inhibitors of MMPs result in inhibition of metastasis, while up-regulation of MMPs led to enhanced cancer cell invasion.

Gene Wiki entry for MMP26 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MMP26 Gene

Genomics for MMP26 Gene

Regulatory Elements for MMP26 Gene

Genomic Location for MMP26 Gene

4,704,927 bp from pter
4,992,429 bp from pter
287,503 bases
Plus strand

Genomic View for MMP26 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MMP26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MMP26 Gene

Proteins for MMP26 Gene

  • Protein details for MMP26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Matrix metalloproteinase-26
    Protein Accession:
    Secondary Accessions:
    • Q3MJ78
    • Q9GZS2
    • Q9NR87

    Protein attributes for MMP26 Gene

    261 amino acids
    Molecular mass:
    29708 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
    Quaternary structure:
    No Data Available

neXtProt entry for MMP26 Gene

Proteomics data for MMP26 Gene at MOPED

Post-translational modifications for MMP26 Gene

  • Glycosylation at Asn64 and Asn221
  • Modification sites at PhosphoSitePlus

Other Protein References for MMP26 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for MMP26 Gene

Domains for MMP26 Gene

Protein Domains for MMP26 Gene

Suggested Antigen Peptide Sequences for MMP26 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9NRE1
  • The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme
  • Belongs to the peptidase M10A family.
genes like me logo Genes that share domains with MMP26: view

Function for MMP26 Gene

Molecular function for MMP26 Gene

UniProtKB/Swiss-Prot Function:
May hydrolyze collagen type IV, fibronectin, fibrinogen, beta-casein, type I gelatin and alpha-1 proteinase inhibitor. Is also able to activate progelatinase B

Enzyme Numbers (IUBMB) for MMP26 Gene

Gene Ontology (GO) - Molecular Function for MMP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004222 metalloendopeptidase activity IEA --
GO:0008237 metallopeptidase activity --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with MMP26: view

Animal Model Products

CRISPR Products

miRNA for MMP26 Gene

miRTarBase miRNAs that target MMP26

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP26

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for MMP26 Gene

Localization for MMP26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MMP26 Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

Jensen Localization Image for MMP26 Gene COMPARTMENTS Subcellular localization image for MMP26 gene
Compartment Confidence
extracellular 5
plasma membrane 3
endoplasmic reticulum 1
lysosome 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MMP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005578 proteinaceous extracellular matrix NAS 10801841
GO:0031012 extracellular matrix --
genes like me logo Genes that share ontologies with MMP26: view

Pathways for MMP26 Gene

genes like me logo Genes that share pathways with MMP26: view

Pathways by source for MMP26 Gene

Gene Ontology (GO) - Biological Process for MMP26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis NAS 10987280
GO:0030574 collagen catabolic process IEA --
GO:0050728 negative regulation of inflammatory response IMP 23569462
genes like me logo Genes that share ontologies with MMP26: view

Compounds for MMP26 Gene

(5) Tocris Compounds for MMP26 Gene

Compound Action Cas Number
Batimastat Potent, broad spectrum MMP inhibitor [130370-60-4]
GI 254023X Selective ADAM10 metalloprotease inhibitor [260264-93-5]
GM 6001 Broad spectrum MMP inhibitor [142880-36-2]
Ro 32-3555 Potent, collagenase-selective MMP inhibitor [190648-49-8]
WAY 170523 Potent and selective inhibitor of MMP-13 [307002-73-9]

(1) HMDB Compounds for MMP26 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca

(1) Drugbank Compounds for MMP26 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
154039-60-8 target inhibitor

(6) Novoseek inferred chemical compound relationships for MMP26 Gene

Compound -log(P) Hits PubMed IDs
estrogen 36.1 11
progesterone 13.9 2
estradiol 11.2 2
retinoic acid 2.16 1
fibrinogen 0.41 2
genes like me logo Genes that share compounds with MMP26: view

Transcripts for MMP26 Gene

mRNA/cDNA for MMP26 Gene

(14) Selected AceView cDNA sequences:
(2) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for MMP26 Gene

Matrix metallopeptidase 26:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MMP26

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MMP26 Gene

No ASD Table

Relevant External Links for MMP26 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MMP26 Gene

mRNA expression in normal human tissues for MMP26 Gene

mRNA differential expression in normal tissues according to GTEx for MMP26 Gene

This gene is overexpressed in Uterus (26.4), Prostate (17.0), and Testis (5.2).

SOURCE GeneReport for Unigene cluster for MMP26 Gene Hs.204732

mRNA Expression by UniProt/SwissProt for MMP26 Gene

Tissue specificity: Expressed specifically in uterus and placenta. Is also widely expressed in malignant tumors from different sources as well as in diverse tumor cell lines
genes like me logo Genes that share expressions with MMP26: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for MMP26 Gene

Orthologs for MMP26 Gene

This gene was present in the common ancestor of animals.

Orthologs for MMP26 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia MMP26 35
  • 78.67 (n)
  • 67.05 (a)
MMP26 36
  • 67 (a)
(Pan troglodytes)
Mammalia MMP26 35
  • 98.98 (n)
  • 97.32 (a)
MMP26 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 43 (a)
-- 36
  • 34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
(Danio rerio)
Actinopterygii MMP26 36
  • 37 (a)
(Caenorhabditis elegans)
Secernentea H19M22.3 36
  • 13 (a)
zmp-1 36
  • 9 (a)
Species with no ortholog for MMP26:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for MMP26 Gene

Gene Tree for MMP26 (if available)
Gene Tree for MMP26 (if available)

Paralogs for MMP26 Gene

Paralogs for MMP26 Gene

Selected SIMAP similar genes for MMP26 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with MMP26: view

Variants for MMP26 Gene

Sequence variations from dbSNP and Humsavar for MMP26 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs1463369 -- 4,990,265(+) ATTTA(C/T)GTAGA intron-variant
rs1973075 -- 4,991,027(+) ATGCT(A/G/T)TTCAA intron-variant
rs2442422 -- 4,988,650(-) CCTTG(A/C)TCTCT intron-variant
rs2499946 -- 4,989,423(+) GTTAT(A/T)GTTTA intron-variant
rs2499953 - 4,989,675(+) TGACC(A/G)AGAAG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for MMP26 Gene

Variant ID Type Subtype PubMed ID
dgv340e1 CNV Complex 17122850
nsv526998 CNV Loss 19592680
nsv510237 CNV Loss 20534489

Relevant External Links for MMP26 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MMP26 Gene

Disorders for MMP26 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for MMP26 Gene in MalaCards »

(3) Diseases for MMP26 Gene including...

(22) Novoseek inferred disease relationships for MMP26 Gene

Disease -log(P) Hits PubMed IDs
endometrial hyperplasia 40.7 1
squamous cell cancer 40.1 1
hyperplasia 34.6 4
cancer 34.2 20
endometrial carcinoma 33.9 7

Relevant External Links for MMP26

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MMP26: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for MMP26 Gene

Publications for MMP26 Gene

  1. Identification and characterization of Homo sapiens endometase (matrix metalloproteinase-26) from endometrial tumor. (PMID: 10801841) Park H.I. … Sang Q.-X.A. (J. Biol. Chem. 2000) 2 3 4 23
  2. Cloning of MMP-26 A novel matrilysin-like proteinase. (PMID: 10824119) Begnoit de Coignac A. … Gauchat J.-F. (Eur. J. Biochem. 2000) 2 3 4 23
  3. Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity. (PMID: 10987280) Uria J.A. … Lopez-Otin C. (Cancer Res. 2000) 3 4 23
  4. Characterization of matrix metalloproteinase-26, a novel metalloproteinase widely expressed in cancer cells of epithelial origin. (PMID: 11389678) Marchenko G.N. … Strongin A.Y. (Biochem. J. 2001) 3 4 23
  5. Unconventional activation mechanisms of MMP-26, a human matrix metalloproteinase with a unique PHCGXXD cysteine-switch motif. (PMID: 11889136) Marchenko N.D. … Strongin A.Y. (J. Biol. Chem. 2002) 3 23

Products for MMP26 Gene

Sources for MMP26 Gene

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