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Aliases for PRPSAP1 Gene

Aliases for PRPSAP1 Gene

  • Phosphoribosyl Pyrophosphate Synthetase-Associated Protein 1 2 3
  • 39 KDa Phosphoribosypyrophosphate Synthase-Associated Protein 3 4
  • PRPP Synthase-Associated Protein 1 3 4
  • PAP39 3 4
  • Phosphoribosyl Pyrophosphate Synthase-Associated Protein 1 3

External Ids for PRPSAP1 Gene

Previous GeneCards Identifiers for PRPSAP1 Gene

  • GC17M074165
  • GC17M077298
  • GC17M074771
  • GC17M074904
  • GC17M071818
  • GC17M074306
  • GC17M069735

Summaries for PRPSAP1 Gene

GeneCards Summary for PRPSAP1 Gene

PRPSAP1 (Phosphoribosyl Pyrophosphate Synthetase-Associated Protein 1) is a Protein Coding gene. GO annotations related to this gene include magnesium ion binding and enzyme inhibitor activity. An important paralog of this gene is PRPS1L1.

UniProtKB/Swiss-Prot for PRPSAP1 Gene

  • Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Gene Wiki entry for PRPSAP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRPSAP1 Gene

Genomics for PRPSAP1 Gene

Regulatory Elements for PRPSAP1 Gene

Genomic Location for PRPSAP1 Gene

Start:
76,309,486 bp from pter
End:
76,384,521 bp from pter
Size:
75,036 bases
Orientation:
Minus strand

Genomic View for PRPSAP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRPSAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRPSAP1 Gene

Proteins for PRPSAP1 Gene

  • Protein details for PRPSAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14558-KPRA_HUMAN
    Recommended name:
    Phosphoribosyl pyrophosphate synthase-associated protein 1
    Protein Accession:
    Q14558
    Secondary Accessions:
    • B2R6M4
    • Q96H06

    Protein attributes for PRPSAP1 Gene

    Size:
    356 amino acids
    Molecular mass:
    39394 Da
    Quaternary structure:
    • Binds to PRPS1 and PRPS2
    SequenceCaution:
    • Sequence=BAG35521.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PRPSAP1 Gene

    Alternative splice isoforms for PRPSAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRPSAP1 Gene

Proteomics data for PRPSAP1 Gene at MOPED

Post-translational modifications for PRPSAP1 Gene

  • Ubiquitination at Lys238
  • Modification sites at PhosphoSitePlus

Other Protein References for PRPSAP1 Gene

No data available for DME Specific Peptides for PRPSAP1 Gene

Domains for PRPSAP1 Gene

Protein Domains for PRPSAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q14558

UniProtKB/Swiss-Prot:

KPRA_HUMAN :
  • Q14558
Family:
  • Belongs to the ribose-phosphate pyrophosphokinase family.
genes like me logo Genes that share domains with PRPSAP1: view

No data available for Gene Families for PRPSAP1 Gene

Function for PRPSAP1 Gene

Molecular function for PRPSAP1 Gene

GENATLAS Biochemistry: phosphoribosylpyrophosphate synthetase-associated protein,39kDa
UniProtKB/Swiss-Prot Function: Seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Gene Ontology (GO) - Molecular Function for PRPSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IEA --
GO:0004749 ribose phosphate diphosphokinase activity IEA --
GO:0004857 enzyme inhibitor activity TAS 8132556
GO:0005515 protein binding IPI 16189514
GO:0019900 kinase binding IEA --
genes like me logo Genes that share ontologies with PRPSAP1: view

Phenotypes for PRPSAP1 Gene

GenomeRNAi human phenotypes for PRPSAP1:
genes like me logo Genes that share phenotypes with PRPSAP1: view

miRNA for PRPSAP1 Gene

miRTarBase miRNAs that target PRPSAP1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PRPSAP1 Gene

Localization for PRPSAP1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRPSAP1 Gene COMPARTMENTS Subcellular localization image for PRPSAP1 gene
Compartment Confidence
mitochondrion 3
cytosol 2

Gene Ontology (GO) - Cellular Components for PRPSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002189 ribose phosphate diphosphokinase complex IEA --
GO:0043234 protein complex --
genes like me logo Genes that share ontologies with PRPSAP1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for PRPSAP1 Gene

Pathways for PRPSAP1 Gene

SuperPathways for PRPSAP1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PRPSAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006139 nucleobase-containing compound metabolic process TAS 8611620
GO:0009165 nucleotide biosynthetic process IEA --
GO:0033673 negative regulation of kinase activity IEA --
genes like me logo Genes that share ontologies with PRPSAP1: view

No data available for Pathways by source for PRPSAP1 Gene

Transcripts for PRPSAP1 Gene

Unigene Clusters for PRPSAP1 Gene

Phosphoribosyl pyrophosphate synthetase-associated protein 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRPSAP1 Gene

No ASD Table

Relevant External Links for PRPSAP1 Gene

GeneLoc Exon Structure for
PRPSAP1
ECgene alternative splicing isoforms for
PRPSAP1

Expression for PRPSAP1 Gene

mRNA expression in normal human tissues for PRPSAP1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRPSAP1 Gene

SOURCE GeneReport for Unigene cluster for PRPSAP1 Gene Hs.77498

mRNA Expression by UniProt/SwissProt for PRPSAP1 Gene

Q14558-KPRA_HUMAN
Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with PRPSAP1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for PRPSAP1 Gene

Orthologs for PRPSAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRPSAP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRPSAP1 35
  • 95.63 (n)
  • 95.19 (a)
PRPSAP1 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRPSAP1 35
  • 91.01 (n)
  • 98.6 (a)
PRPSAP1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRPSAP1 35
  • 92.79 (n)
  • 99.72 (a)
PRPSAP1 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prpsap1 35
  • 89.48 (n)
  • 97.86 (a)
Prpsap1 16
Prpsap1 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRPSAP1 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRPSAP1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prpsap1 35
  • 89.13 (n)
  • 97.33 (a)
chicken
(Gallus gallus)
Aves PRPSAP1 35
  • 86.05 (n)
  • 97.47 (a)
PRPSAP1 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRPSAP1 36
  • 95 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC75778 35
prpsap1 35
  • 76.53 (n)
  • 85.63 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11236 35
zebrafish
(Danio rerio)
Actinopterygii prpsap1 35
  • 77.24 (n)
  • 90.08 (a)
PRPSAP1 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG2246 36
  • 57 (a)
OneToMany
CG2246 37
  • 64 (a)
worm
(Caenorhabditis elegans)
Secernentea W04G3.5 36
  • 58 (a)
OneToMany
W04G3.5 37
  • 59 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PRS2 36
  • 42 (a)
ManyToMany
PRS3 36
  • 45 (a)
ManyToMany
PRS4 36
  • 42 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 64 (a)
OneToMany
Species with no ortholog for PRPSAP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRPSAP1 Gene

ENSEMBL:
Gene Tree for PRPSAP1 (if available)
TreeFam:
Gene Tree for PRPSAP1 (if available)

Paralogs for PRPSAP1 Gene

Paralogs for PRPSAP1 Gene

Selected SIMAP similar genes for PRPSAP1 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with PRPSAP1: view

Variants for PRPSAP1 Gene

Sequence variations from dbSNP and Humsavar for PRPSAP1 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs9498 -- 76,311,425(-) ATATC(C/T)TCTTT utr-variant-3-prime
rs10459 -- 76,311,656(-) CTGCA(A/G)TGTCC reference, synonymous-codon
rs171135 -- 76,329,787(+) CCTCA(C/T)TGCTT intron-variant
rs346791 -- 76,328,648(+) caaaa(A/C)caaca intron-variant
rs346792 -- 76,327,449(+) agaga(C/T)cgaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRPSAP1 Gene

Variant ID Type Subtype PubMed ID
nsv833547 CNV Loss 17160897
nsv527075 CNV Gain 19592680
nsv518967 CNV Loss 19592680
esv2668273 CNV Deletion 23128226
esv24990 CNV Loss 19812545

Relevant External Links for PRPSAP1 Gene

HapMap Linkage Disequilibrium report
PRPSAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRPSAP1 Gene

Disorders for PRPSAP1 Gene

(1) University of Copenhagen DISEASES for PRPSAP1 Gene

genes like me logo Genes that share disorders with PRPSAP1: view

No data available for UniProtKB/Swiss-Prot for PRPSAP1 Gene

Publications for PRPSAP1 Gene

  1. The human phosphoribosylpyrophosphate synthetase-associated protein 39 gene (PRPSAP1) is located in the chromosome region 17q24-q25. (PMID: 8660991) Ishizuka T. … Tatibana M. (Genomics 1996) 2 3 23
  2. Cloning and sequencing of human complementary DNA for the phosphoribosylpyrophosphate synthetase-associated protein 39. (PMID: 8611620) Ishizuka T. … Tatibana M. (Biochim. Biophys. Acta 1996) 3 4
  3. Mammalian phosphoribosyl-pyrophosphate synthetase. (PMID: 7572345) Tatibana M. … Ahmad I. (Adv. Enzyme Regul. 1995) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for PRPSAP1 Gene

Sources for PRPSAP1 Gene

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