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Aliases for SLC7A10 Gene

Aliases for SLC7A10 Gene

  • Solute Carrier Family 7 Member 10 2 3 4 5
  • Solute Carrier Family 7 (Neutral Amino Acid Transporter Light Chain, Asc System), Member 10 2 3
  • ASC-1 3 4
  • ASC1 3 4
  • Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 10 3
  • Solute Carrier Family 7, (Neutral Amino Acid Transporter, Y+ System) Member 10 3
  • Asc-Type Amino Acid Transporter 1 3
  • HASC-1 3

External Ids for SLC7A10 Gene

Previous GeneCards Identifiers for SLC7A10 Gene

  • GC19M034317
  • GC19M034148
  • GC19M038375
  • GC19M038391
  • GC19M033699
  • GC19M030201

Summaries for SLC7A10 Gene

Entrez Gene Summary for SLC7A10 Gene

  • SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC7A10 Gene

SLC7A10 (Solute Carrier Family 7 Member 10) is a Protein Coding gene. Diseases associated with SLC7A10 include Cystinuria and Hyperekplexia. Among its related pathways are Response to elevated platelet cytosolic Ca2+ and Differentiation of white and brown adipocyte. Gene Ontology (GO) annotations related to this gene include amino acid transmembrane transporter activity and neutral amino acid transmembrane transporter activity. An important paralog of this gene is SLC7A8.

UniProtKB/Swiss-Prot for SLC7A10 Gene

  • Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.

Gene Wiki entry for SLC7A10 Gene

Additional gene information for SLC7A10 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A10 Gene

Genomics for SLC7A10 Gene

GeneHancer (GH) Regulatory Elements for SLC7A10 Gene

Promoters and enhancers for SLC7A10 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I033226 Promoter 0.7 EPDnew 550.8 +0.0 21 0.1 SIN3A EZH2 SLC7A10 ENSG00000267714
GH19I033225 Enhancer 0.5 ENCODE 550.8 -0.8 -807 1.4 CTCF GATAD2A NFIA POLR2A SCRT2 ZSCAN4 EZH2 SLC7A10 PIR37620
GH19I033175 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE 14.4 +48.7 48710 2.7 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZFP41 LRP3 TRT-AGT1-3 GC19M033175 ENSG00000267054 GPATCH1 CEP89 ZNF507 LSM14A WDR88 PDCD5
GH19I033485 Enhancer 0.7 FANTOM5 ENCODE 2 -261.0 -261006 2 GLIS2 GLIS1 SCRT2 ZIC2 PEPD SLC7A10 GC19P033457 GC19M033516
GH19I033240 Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 -15.5 -15500 1.7 ZFP64 DMAP1 ZNF2 ZBTB7B GLIS2 ARID2 RXRA YY2 REST NFIL3 ZNF507 GPATCH1 LSM14A CEP89 SLC7A10 PIR37620
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around SLC7A10 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the SLC7A10 gene promoter:

Genomic Locations for SLC7A10 Gene

Genomic Locations for SLC7A10 Gene
chr19:33,208,664-33,225,850
(GRCh38/hg38)
Size:
17,187 bases
Orientation:
Minus strand
chr19:33,699,570-33,716,756
(GRCh37/hg19)

Genomic View for SLC7A10 Gene

Genes around SLC7A10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC7A10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC7A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A10 Gene

Proteins for SLC7A10 Gene

  • Protein details for SLC7A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS82-AAA1_HUMAN
    Recommended name:
    Asc-type amino acid transporter 1
    Protein Accession:
    Q9NS82
    Secondary Accessions:
    • B2RE84

    Protein attributes for SLC7A10 Gene

    Size:
    523 amino acids
    Molecular mass:
    56798 Da
    Quaternary structure:
    • Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

neXtProt entry for SLC7A10 Gene

Post-translational modifications for SLC7A10 Gene

No Post-translational modifications

Other Protein References for SLC7A10 Gene

No data available for DME Specific Peptides for SLC7A10 Gene

Domains & Families for SLC7A10 Gene

Gene Families for SLC7A10 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Transporters

Protein Domains for SLC7A10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC7A10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS82

UniProtKB/Swiss-Prot:

AAA1_HUMAN :
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
genes like me logo Genes that share domains with SLC7A10: view

Function for SLC7A10 Gene

Molecular function for SLC7A10 Gene

UniProtKB/Swiss-Prot Function:
Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.

Phenotypes From GWAS Catalog for SLC7A10 Gene

Gene Ontology (GO) - Molecular Function for SLC7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015171 amino acid transmembrane transporter activity IEA --
GO:0015175 neutral amino acid transmembrane transporter activity IDA,IEA 10863037
GO:0015194 L-serine transmembrane transporter activity TAS 10863037
GO:0015297 antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A10: view
genes like me logo Genes that share phenotypes with SLC7A10: view

Animal Models for SLC7A10 Gene

MGI Knock Outs for SLC7A10:

Animal Model Products

miRNA for SLC7A10 Gene

miRTarBase miRNAs that target SLC7A10

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for SLC7A10 Gene

Localization for SLC7A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC7A10 gene
Compartment Confidence
plasma membrane 5
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (1)
  • Nucleus (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for SLC7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS,TAS 10863037
GO:0016020 membrane IEA,TAS 10734121
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC7A10: view

Pathways & Interactions for SLC7A10 Gene

genes like me logo Genes that share pathways with SLC7A10: view

Gene Ontology (GO) - Biological Process for SLC7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IEA --
GO:0006810 transport IEA --
GO:0006865 amino acid transport TAS --
GO:0015804 neutral amino acid transport IEA,IDA 10863037
GO:0015825 L-serine transport IEA --
genes like me logo Genes that share ontologies with SLC7A10: view

No data available for SIGNOR curated interactions for SLC7A10 Gene

Drugs & Compounds for SLC7A10 Gene

(2) Drugs for SLC7A10 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
D-serine Approved, Experimental, Investigational Pharma Agonist 0

(1) Additional Compounds for SLC7A10 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
sodium
  • Sodium
  • Sodium ion
7440-23-5
genes like me logo Genes that share compounds with SLC7A10: view

Transcripts for SLC7A10 Gene

Unigene Clusters for SLC7A10 Gene

Solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:

Relevant External Links for SLC7A10 Gene

GeneLoc Exon Structure for
SLC7A10
ECgene alternative splicing isoforms for
SLC7A10

Expression for SLC7A10 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC7A10 Gene

mRNA differential expression in normal tissues according to GTEx for SLC7A10 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (x10.0), Adipose - Subcutaneous (x4.6), and Brain - Caudate (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for SLC7A10 Gene

This gene is overexpressed in Testis (49.0), Frontal cortex (11.1), and Fetal Brain (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC7A10 Gene



Protein tissue co-expression partners for SLC7A10 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of SLC7A10 Gene:

SLC7A10

SOURCE GeneReport for Unigene cluster for SLC7A10 Gene:

Hs.58679

mRNA Expression by UniProt/SwissProt for SLC7A10 Gene:

Q9NS82-AAA1_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.

Evidence on tissue expression from TISSUES for SLC7A10 Gene

  • Kidney(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with SLC7A10: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC7A10 Gene

Orthologs for SLC7A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC7A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC7A10 33 34
  • 99.11 (n)
cow
(Bos Taurus)
Mammalia SLC7A10 34
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC7A10 33 34
  • 91.91 (n)
rat
(Rattus norvegicus)
Mammalia Slc7a10 33
  • 88.66 (n)
mouse
(Mus musculus)
Mammalia Slc7a10 33 16 34
  • 88.34 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia SLC7A10 34
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC7A10 34
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves SLC7A10 33 34
  • 77.26 (n)
lizard
(Anolis carolinensis)
Reptilia SLC7A10 34
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc7a10 33
  • 68.9 (n)
zebrafish
(Danio rerio)
Actinopterygii slc7a10b 33 34
  • 73.14 (n)
slc7a10a 34
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta mnd 35 34
  • 49 (a)
JhI-21 35 34
  • 43 (a)
CG6070 35
  • 42 (a)
gb 34
  • 41 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea aat-2 34
  • 44 (a)
OneToMany
F07C3.7 35
  • 42 (a)
F27C8.1 35
  • 42 (a)
F52H2.2 35
  • 38 (a)
Y53H1C.1 35
  • 33 (a)
T13A10.10 35
  • 32 (a)
C55C2.5a 35
  • 30 (a)
C55C2.5b 35
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 49 (a)
OneToMany
Species where no ortholog for SLC7A10 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC7A10 Gene

ENSEMBL:
Gene Tree for SLC7A10 (if available)
TreeFam:
Gene Tree for SLC7A10 (if available)

Paralogs for SLC7A10 Gene

Paralogs for SLC7A10 Gene

(13) SIMAP similar genes for SLC7A10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC7A10: view

Variants for SLC7A10 Gene

Sequence variations from dbSNP and Humsavar for SLC7A10 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000020126 -- 33,220,022(-) C/T intron_variant
rs1000269239 -- 33,214,788(-) A/G intron_variant
rs1000269834 -- 33,221,801(-) A/C intron_variant
rs1000307483 -- 33,225,872(-) C/T upstream_transcript_variant
rs1000473195 -- 33,209,628(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A10 Gene

Variant ID Type Subtype PubMed ID
esv1069310 CNV insertion 17803354
nsv833808 CNV loss 17160897
nsv953277 CNV deletion 24416366

Variation tolerance for SLC7A10 Gene

Residual Variation Intolerance Score: 58.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.38; 63.53% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for SLC7A10 Gene

Human Gene Mutation Database (HGMD)
SLC7A10
SNPedia medical, phenotypic, and genealogical associations of SNPs for
SLC7A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A10 Gene

Disorders for SLC7A10 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC7A10 Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
cystinuria
  • csnu
hyperekplexia
  • congenital stiff man syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for SLC7A10

genes like me logo Genes that share disorders with SLC7A10: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC7A10 Gene

Publications for SLC7A10 Gene

  1. Cloning and characterization of a human brain Na(+)-independent transporter for small neutral amino acids that transports D-serine with high affinity. (PMID: 10863037) Nakauchi J … Kanai Y (Neuroscience letters 2000) 2 3 4 22 58
  2. Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria? (PMID: 11509015) Leclerc D … Rozen R (Molecular genetics and metabolism 2001) 3 4 22 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The amino acid transporter asc-1 is not involved in cystinuria. (PMID: 15458438) Pineda M … Palacín M (Kidney international 2004) 3 22 58
  5. Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids. (PMID: 10734121) Fukasawa Y … Kanai Y (The Journal of biological chemistry 2000) 2 3 58

Products for SLC7A10 Gene

Sources for SLC7A10 Gene

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