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Aliases for SLC7A10 Gene

Aliases for SLC7A10 Gene

  • Solute Carrier Family 7 (Neutral Amino Acid Transporter Light Chain, Asc System), Member 10 2 3
  • Solute Carrier Family 7 Member 10 3 4
  • ASC-1 3 4
  • ASC1 3 4
  • Solute Carrier Family 7, (Cationic Amino Acid Transporter, Y+ System) Member 10 3
  • Solute Carrier Family 7, (Neutral Amino Acid Transporter, Y+ System) Member 10 3
  • Asc-Type Amino Acid Transporter 1 3
  • HASC-1 3

External Ids for SLC7A10 Gene

Previous GeneCards Identifiers for SLC7A10 Gene

  • GC19M034317
  • GC19M034148
  • GC19M038375
  • GC19M038391
  • GC19M033699
  • GC19M030201

Summaries for SLC7A10 Gene

Entrez Gene Summary for SLC7A10 Gene

  • SLC7A10, in association with 4F2HC (SLC3A2; MIM 158070), mediates high-affinity transport of D-serine and several other neutral amino acids (Nakauchi et al., 2000 [PubMed 10863037]).[supplied by OMIM, Mar 2008]

GeneCards Summary for SLC7A10 Gene

SLC7A10 (Solute Carrier Family 7 (Neutral Amino Acid Transporter Light Chain, Asc System), Member 10) is a Protein Coding gene. Diseases associated with SLC7A10 include cystinuria. Among its related pathways are Hemostasis and Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. GO annotations related to this gene include neutral amino acid transmembrane transporter activity and L-serine transmembrane transporter activity. An important paralog of this gene is SLC7A7.

UniProtKB/Swiss-Prot for SLC7A10 Gene

  • Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.

Gene Wiki entry for SLC7A10 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC7A10 Gene

Genomics for SLC7A10 Gene

Regulatory Elements for SLC7A10 Gene

Genomic Location for SLC7A10 Gene

Start:
33,208,664 bp from pter
End:
33,225,850 bp from pter
Size:
17,187 bases
Orientation:
Minus strand

Genomic View for SLC7A10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SLC7A10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC7A10 Gene

Proteins for SLC7A10 Gene

  • Protein details for SLC7A10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NS82-AAA1_HUMAN
    Recommended name:
    Asc-type amino acid transporter 1
    Protein Accession:
    Q9NS82
    Secondary Accessions:
    • B2RE84

    Protein attributes for SLC7A10 Gene

    Size:
    523 amino acids
    Molecular mass:
    56798 Da
    Quaternary structure:
    • Disulfide-linked heterodimer with the amino acid transport protein SLC3A2/4F2hc.

neXtProt entry for SLC7A10 Gene

Proteomics data for SLC7A10 Gene at MOPED

Post-translational modifications for SLC7A10 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for SLC7A10 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for SLC7A10 Gene

Domains for SLC7A10 Gene

Gene Families for SLC7A10 Gene

HGNC:
  • SLC :Solute carriers
IUPHAR :

Protein Domains for SLC7A10 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for SLC7A10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NS82

UniProtKB/Swiss-Prot:

AAA1_HUMAN :
  • Q9NS82
Family:
  • Belongs to the amino acid-polyamine-organocation (APC) superfamily.
genes like me logo Genes that share domains with SLC7A10: view

Function for SLC7A10 Gene

Molecular function for SLC7A10 Gene

UniProtKB/Swiss-Prot Function: Sodium-independent, high affinity transport of small neutral D- and L-amino acids. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse.

Gene Ontology (GO) - Molecular Function for SLC7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0015171 amino acid transmembrane transporter activity --
GO:0015175 neutral amino acid transmembrane transporter activity IDA 10863037
GO:0015194 L-serine transmembrane transporter activity TAS 10863037
GO:0015297 antiporter activity IBA --
genes like me logo Genes that share ontologies with SLC7A10: view
genes like me logo Genes that share phenotypes with SLC7A10: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for SLC7A10 Gene

Localization for SLC7A10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC7A10 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC7A10 Gene COMPARTMENTS Subcellular localization image for SLC7A10 gene
Compartment Confidence
plasma membrane 5
nucleus 1

Gene Ontology (GO) - Cellular Components for SLC7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane NAS 10863037
GO:0016020 membrane TAS 10734121
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with SLC7A10: view

Pathways for SLC7A10 Gene

genes like me logo Genes that share pathways with SLC7A10: view

Gene Ontology (GO) - Biological Process for SLC7A10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003333 amino acid transmembrane transport IBA --
GO:0006810 transport --
GO:0006811 ion transport TAS --
GO:0006865 amino acid transport TAS --
GO:0007596 blood coagulation TAS --
genes like me logo Genes that share ontologies with SLC7A10: view

Compounds for SLC7A10 Gene

(2) HMDB Compounds for SLC7A10 Gene

Compound Synonyms Cas Number PubMed IDs
D-Serine
  • (2R)-2-amino-3-hydroxypropanoate
312-84-5
Sodium
  • Sodium
7440-23-5

(1) Novoseek inferred chemical compound relationships for SLC7A10 Gene

Compound -log(P) Hits PubMed IDs
serine 48.2 9
genes like me logo Genes that share compounds with SLC7A10: view

Transcripts for SLC7A10 Gene

Unigene Clusters for SLC7A10 Gene

Solute carrier family 7 (neutral amino acid transporter light chain, asc system), member 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC7A10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
SP1: -
SP2:

Relevant External Links for SLC7A10 Gene

GeneLoc Exon Structure for
SLC7A10
ECgene alternative splicing isoforms for
SLC7A10

Expression for SLC7A10 Gene

mRNA expression in normal human tissues for SLC7A10 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC7A10 Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (10.0), Adipose - Subcutaneous (4.6), and Brain - Caudate (basal ganglia) (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SLC7A10 Gene

SOURCE GeneReport for Unigene cluster for SLC7A10 Gene Hs.58679

mRNA Expression by UniProt/SwissProt for SLC7A10 Gene

Q9NS82-AAA1_HUMAN
Tissue specificity: Expressed in brain, heart, kidney, liver, lung, pancreas, placenta, and skeletal muscle.
genes like me logo Genes that share expressions with SLC7A10: view

Orthologs for SLC7A10 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC7A10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC7A10 35
  • 99.11 (n)
  • 98.47 (a)
SLC7A10 36
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC7A10 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SLC7A10 35
  • 91.91 (n)
  • 94.41 (a)
SLC7A10 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Slc7a10 35
  • 88.34 (n)
  • 92.93 (a)
Slc7a10 16
Slc7a10 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia SLC7A10 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SLC7A10 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Slc7a10 35
  • 88.66 (n)
  • 92.93 (a)
chicken
(Gallus gallus)
Aves SLC7A10 35
  • 77.26 (n)
  • 85.34 (a)
SLC7A10 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SLC7A10 36
  • 78 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia slc7a10 35
  • 68.9 (n)
  • 77.82 (a)
zebrafish
(Danio rerio)
Actinopterygii slc7a10a 36
  • 70 (a)
OneToMany
slc7a10b 35
  • 73.14 (n)
  • 75.95 (a)
slc7a10b 36
  • 70 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta gb 36
  • 41 (a)
ManyToMany
JhI-21 36
  • 41 (a)
ManyToMany
mnd 36
  • 45 (a)
ManyToMany
mnd 37
  • 49 (a)
JhI-21 37
  • 43 (a)
CG6070 37
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea aat-2 36
  • 44 (a)
OneToMany
C55C2.5a 37
  • 30 (a)
C55C2.5b 37
  • 30 (a)
Y53H1C.1 37
  • 33 (a)
F27C8.1 37
  • 42 (a)
T13A10.10 37
  • 32 (a)
F07C3.7 37
  • 42 (a)
F52H2.2 37
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 49 (a)
OneToMany
Species with no ortholog for SLC7A10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for SLC7A10 Gene

ENSEMBL:
Gene Tree for SLC7A10 (if available)
TreeFam:
Gene Tree for SLC7A10 (if available)

Paralogs for SLC7A10 Gene

Paralogs for SLC7A10 Gene

Selected SIMAP similar genes for SLC7A10 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC7A10: view

Variants for SLC7A10 Gene

Sequence variations from dbSNP and Humsavar for SLC7A10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs726822 -- 33,226,343(+) GTGCC(C/T)CCTGA upstream-variant-2KB
rs889101 -- 33,210,012(-) agtga(C/G)cggtg intron-variant
rs1009175 -- 33,224,849(-) AGGCC(C/T)TGGAC intron-variant
rs1465424 -- 33,226,515(-) CCGTG(C/T)CCAGG upstream-variant-2KB
rs1974807 -- 33,222,152(-) CAGAG(G/T)GTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for SLC7A10 Gene

Variant ID Type Subtype PubMed ID
nsv833808 CNV Loss 17160897
nsv911579 CNV Loss 21882294
dgv3839n71 CNV Loss 21882294
dgv3840n71 CNV Loss 21882294
dgv3841n71 CNV Loss 21882294
dgv3842n71 CNV Loss 21882294
esv1069310 CNV Insertion 17803354
dgv3843n71 CNV Loss 21882294

Relevant External Links for SLC7A10 Gene

HapMap Linkage Disequilibrium report
SLC7A10
Human Gene Mutation Database (HGMD)
SLC7A10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC7A10 Gene

Disorders for SLC7A10 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for SLC7A10 Gene including...

Search for SLC7A10 Gene in MalaCards »

(1) University of Copenhagen DISEASES for SLC7A10 Gene

(1) Novoseek inferred disease relationships for SLC7A10 Gene

Disease -log(P) Hits PubMed IDs
cystinuria 86.8 9

Relevant External Links for SLC7A10

Genetic Association Database (GAD)
SLC7A10
genes like me logo Genes that share disorders with SLC7A10: view

No data available for UniProtKB/Swiss-Prot for SLC7A10 Gene

Publications for SLC7A10 Gene

  1. Cloning and characterization of a human brain Na+-independent transporter for small neutral amino acids that transports D-serine with high affinity. (PMID: 10863037) Nakauchi J. … Kanai Y. (Neurosci. Lett. 2000) 2 3 4 23
  2. Is the SLC7A10 gene on chromosome 19 a candidate locus for cystinuria? (PMID: 11509015) Leclerc D. … Rozen R. (Mol. Genet. Metab. 2001) 3 4 23
  3. The amino acid transporter asc-1 is not involved in cystinuria. (PMID: 15458438) Pineda M. … PalacA-n M. (Kidney Int. 2004) 3 23
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids. (PMID: 10734121) Fukasawa Y. … Kanai Y. (J. Biol. Chem. 2000) 2 3

Products for SLC7A10 Gene

Sources for SLC7A10 Gene

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