Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PROX1 Gene

Aliases for PROX1 Gene

  • Prospero Homeobox 1 2 3
  • Homeobox Prospero-Like Protein PROX1 4
  • Prospero-Related Homeobox 1 2
  • PROX-1 4

External Ids for PROX1 Gene

Summaries for PROX1 Gene

Entrez Gene Summary for PROX1 Gene

  • The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for PROX1 Gene

PROX1 (Prospero Homeobox 1) is a Protein Coding gene. Diseases associated with PROX1 include breast angiosarcoma and kaposiform hemangioendothelioma. GO annotations related to this gene include sequence-specific DNA binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is PROX2.

UniProtKB/Swiss-Prot for PROX1 Gene

  • Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Gene Wiki entry for PROX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROX1 Gene

Genomics for PROX1 Gene

Genomic Location for PROX1 Gene

Start:
213,983,181 bp from pter
End:
214,041,510 bp from pter
Size:
58,330 bases
Orientation:
Plus strand

Genomic View for PROX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PROX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROX1 Gene

Regulatory Elements for PROX1 Gene

Proteins for PROX1 Gene

  • Protein details for PROX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92786-PROX1_HUMAN
    Recommended name:
    Prospero homeobox protein 1
    Protein Accession:
    Q92786
    Secondary Accessions:
    • A6NK29
    • A8K2B1
    • Q5SW76
    • Q8TB91

    Protein attributes for PROX1 Gene

    Size:
    737 amino acids
    Molecular mass:
    83203 Da
    Quaternary structure:
    • Interacts with RORA and RORG (via AF-2 motif).
    SequenceCaution:
    • Sequence=CAI15309.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PROX1 Gene

neXtProt entry for PROX1 Gene

Proteomics data for PROX1 Gene at MOPED

Post-translational modifications for PROX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROX1 Gene

No data available for DME Specific Peptides for PROX1 Gene

Domains for PROX1 Gene

Gene Families for PROX1 Gene

HGNC:
  • PROX :Homeoboxes / PROS class

Protein Domains for PROX1 Gene

UniProtKB/Swiss-Prot:

PROX1_HUMAN
Domain:
  • The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.:
    • Q92786
  • Contains 1 Prospero-type homeobox DNA-binding domain.:
    • Q92786
Family:
  • Belongs to the Prospero homeobox family.:
    • Q92786
genes like me logo Genes that share domains with PROX1: view

Function for PROX1 Gene

Molecular function for PROX1 Gene

GENATLAS Biochemistry: prospero-related homeo box 1,chicken homeo domain protein PROX1 homolog,highly expressed in lens,retina,pancreas
UniProtKB/Swiss-Prot Function: Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Gene Ontology (GO) - Molecular Function for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity --
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0003677 DNA binding IMP 18815287
GO:0003700 sequence-specific DNA binding transcription factor activity IC 19210544
GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity ISS --
genes like me logo Genes that share ontologies with PROX1: view
genes like me logo Genes that share phenotypes with PROX1: view

miRNA for PROX1 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for PROX1 Gene

Localization for PROX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROX1 Gene

Nucleus. Note=RORG promotes its nuclear localization. {ECO:0000250 UniProtKB:P48437}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PROX1 Gene COMPARTMENTS Subcellular localization image for PROX1 gene
Compartment Confidence
nucleus 4
cytosol 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11850194
GO:0005737 cytoplasm IDA 11850194
genes like me logo Genes that share ontologies with PROX1: view

Pathways for PROX1 Gene

SuperPathways for PROX1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15205472
GO:0001709 cell fate determination IEA --
GO:0001822 kidney development IEP 8812486
GO:0001889 liver development IEP 11789987
GO:0001938 positive regulation of endothelial cell proliferation IDA 19210544
genes like me logo Genes that share ontologies with PROX1: view

No data available for Pathways by source for PROX1 Gene

Compounds for PROX1 Gene

(1) Novoseek inferred chemical compound relationships for PROX1 Gene

Compound -log(P) Hits PubMed IDs
vegf 34.3 3
genes like me logo Genes that share compounds with PROX1: view

Transcripts for PROX1 Gene

Unigene Clusters for PROX1 Gene

Prospero homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PROX1 Gene

No ASD Table

Relevant External Links for PROX1 Gene

GeneLoc Exon Structure for
PROX1
ECgene alternative splicing isoforms for
PROX1

Expression for PROX1 Gene

mRNA expression in normal human tissues for PROX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROX1 Gene

This gene is overexpressed in Liver (13.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PROX1 Gene

SOURCE GeneReport for Unigene cluster for PROX1 Gene Hs.744931

mRNA Expression by UniProt/SwissProt for PROX1 Gene

Q92786-PROX1_HUMAN
Tissue specificity: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expressions with PROX1: view

Orthologs for PROX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PROX1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PROX1 36
  • 100 (n)
  • 100 (a)
PROX1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PROX1 36
  • 94.93 (n)
  • 98.51 (a)
PROX1 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PROX1 36
  • 96.79 (n)
  • 99.32 (a)
PROX1 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prox1 36
  • 92.04 (n)
  • 98.37 (a)
Prox1 16
Prox1 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PROX1 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROX1 37
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prox1 36
  • 92.26 (n)
  • 97.92 (a)
chicken
(Gallus gallus)
Aves PROX1 36
  • 88.86 (n)
  • 93.75 (a)
PROX1 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROX1 37
  • 93 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.1033 36
tropical clawed frog
(Silurana tropicalis)
Amphibia prox1 36
  • 83.61 (n)
  • 88.86 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3509 36
zebrafish
(Danio rerio)
Actinopterygii prox1 36
prox1a 36
  • 75.94 (n)
  • 83.63 (a)
prox1a 37
  • 82 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta pros 37
  • 11 (a)
OneToMany
pros 38
  • 62 (a)
worm
(Caenorhabditis elegans)
Secernentea pros-1 37
  • 27 (a)
OneToMany
ceh-26 38
  • 58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToMany
Species with no ortholog for PROX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PROX1 Gene

ENSEMBL:
Gene Tree for PROX1 (if available)
TreeFam:
Gene Tree for PROX1 (if available)

Paralogs for PROX1 Gene

Paralogs for PROX1 Gene

Selected SIMAP similar genes for PROX1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PROX1: view

Variants for PROX1 Gene

Sequence variations from dbSNP and Humsavar for PROX1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs340834 -- 213,999,481(-) CCACC(A/C)ATAGC intron-variant
rs366684 -- 214,013,919(-) TTCTT(C/G)CCTTC intron-variant
rs378414 -- 214,014,830(-) AGCTT(A/C)TGACA intron-variant
rs394638 -- 214,012,767(-) ACAGA(C/T)GTTGG intron-variant
rs399887 -- 214,014,370(-) CCATG(G/T)TTTAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROX1 Gene

Variant ID Type Subtype PubMed ID
nsv873164 CNV Gain 21882294
nsv4498 CNV Insertion 18451855

Relevant External Links for PROX1 Gene

HapMap Linkage Disequilibrium report
PROX1

Disorders for PROX1 Gene

(3) University of Copenhagen DISEASES for PROX1 Gene

(9) Novoseek inferred disease relationships for PROX1 Gene

Disease -log(P) Hits PubMed IDs
lymphedema 65 1
lymphangioma 62.9 2
inflammatory breast cancer 54.5 2
hemangioma 28.9 4
metastasis 21.9 2

Relevant External Links for PROX1

Genetic Association Database (GAD)
PROX1
Human Genome Epidemiology (HuGE) Navigator
PROX1
genes like me logo Genes that share disorders with PROX1: view

No data available for UniProtKB/Swiss-Prot for PROX1 Gene

Publications for PROX1 Gene

  1. Structure and chromosomal localization of the human homeobox gene Prox 1. (PMID: 8812486) Zinovieva R.D. … Tomarev S.I. (Genomics 1996) 2 3 4
  2. Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight. (PMID: 20490451) Andersson E.A. … Pedersen O. (Diabetologia 2010) 3 49
  3. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B. … Franks P.W. (Diabetologia 2010) 3 49
  4. Candidate gene analysis in primary lymphedema. (PMID: 18564921) Ferrell R.E. … Finegold D.N. (Lymphat Res Biol 2008) 3 49
  5. Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS. (PMID: 20064070) Herbeck J.T. … Mullins J.I. (J. Infect. Dis. 2010) 3 49

Products for PROX1 Gene

Sources for PROX1 Gene

Back to Top

Content