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Aliases for PROX1 Gene

Aliases for PROX1 Gene

  • Prospero Homeobox 1 2 3 5
  • Homeobox Prospero-Like Protein PROX1 4
  • Prospero-Related Homeobox 1 2
  • PROX-1 4

External Ids for PROX1 Gene

Previous GeneCards Identifiers for PROX1 Gene

  • GC01P212818
  • GC01P209982
  • GC01P210777
  • GC01P211218
  • GC01P210550
  • GC01P212228
  • GC01P214156
  • GC01P184836

Summaries for PROX1 Gene

Entrez Gene Summary for PROX1 Gene

  • The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for PROX1 Gene

PROX1 (Prospero Homeobox 1) is a Protein Coding gene. Diseases associated with PROX1 include Kaposiform Hemangioendothelioma and Angiokeratoma Of Fordyce. Among its related pathways are Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers and Angiogenesis (CST). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is PROX2.

UniProtKB/Swiss-Prot for PROX1 Gene

  • Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Gene Wiki entry for PROX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROX1 Gene

Genomics for PROX1 Gene

Regulatory Elements for PROX1 Gene

Enhancers for PROX1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around PROX1 on UCSC Golden Path with GeneCards custom track

Genomic Location for PROX1 Gene

Chromosome:
1
Start:
213,983,181 bp from pter
End:
214,041,510 bp from pter
Size:
58,330 bases
Orientation:
Plus strand

Genomic View for PROX1 Gene

Genes around PROX1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PROX1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PROX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROX1 Gene

Proteins for PROX1 Gene

  • Protein details for PROX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92786-PROX1_HUMAN
    Recommended name:
    Prospero homeobox protein 1
    Protein Accession:
    Q92786
    Secondary Accessions:
    • A6NK29
    • A8K2B1
    • Q5SW76
    • Q8TB91

    Protein attributes for PROX1 Gene

    Size:
    737 amino acids
    Molecular mass:
    83203 Da
    Quaternary structure:
    • Interacts with RORA and RORG (via AF-2 motif).
    SequenceCaution:
    • Sequence=CAI15309.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PROX1 Gene

neXtProt entry for PROX1 Gene

Proteomics data for PROX1 Gene at MOPED

Post-translational modifications for PROX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROX1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PROX1 (PROX1)

No data available for DME Specific Peptides for PROX1 Gene

Domains & Families for PROX1 Gene

Gene Families for PROX1 Gene

Protein Domains for PROX1 Gene

Suggested Antigen Peptide Sequences for PROX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92786

UniProtKB/Swiss-Prot:

PROX1_HUMAN :
  • The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • Belongs to the Prospero homeobox family.
Domain:
  • The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • Contains 1 Prospero-type homeobox DNA-binding domain.
Family:
  • Belongs to the Prospero homeobox family.
genes like me logo Genes that share domains with PROX1: view

Function for PROX1 Gene

Molecular function for PROX1 Gene

GENATLAS Biochemistry:
prospero-related homeo box 1,chicken homeo domain protein PROX1 homolog,highly expressed in lens,retina,pancreas
UniProtKB/Swiss-Prot Function:
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Gene Ontology (GO) - Molecular Function for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016922 ligand-dependent nuclear receptor binding IPI 15143342
GO:0050693 LBD domain binding IPI 15143342
genes like me logo Genes that share ontologies with PROX1: view
genes like me logo Genes that share phenotypes with PROX1: view

Animal Models for PROX1 Gene

MGI Knock Outs for PROX1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PROX1 Gene

Localization for PROX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROX1 Gene

Nucleus. Note=RORG promotes its nuclear localization. {ECO:0000250 UniProtKB:P48437}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PROX1 Gene COMPARTMENTS Subcellular localization image for PROX1 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 2
cytoskeleton 1

No data available for Gene Ontology (GO) - Cellular Components for PROX1 Gene

Pathways & Interactions for PROX1 Gene

genes like me logo Genes that share pathways with PROX1: view

Pathways by source for PROX1 Gene

1 Cell Signaling Technology pathway for PROX1 Gene

Gene Ontology (GO) - Biological Process for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15205472
GO:0001709 cell fate determination IEA --
GO:0001822 kidney development IEP 8812486
GO:0001889 liver development IEP 11789987
GO:0001938 positive regulation of endothelial cell proliferation IDA 19210544
genes like me logo Genes that share ontologies with PROX1: view

No data available for SIGNOR curated interactions for PROX1 Gene

Drugs & Compounds for PROX1 Gene

(1) Drugs for PROX1 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Atenolol Approved Pharma Antagonist 99

(1) Additional Compounds for PROX1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with PROX1: view

Transcripts for PROX1 Gene

Unigene Clusters for PROX1 Gene

Prospero homeobox 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PROX1 Gene

No ASD Table

Relevant External Links for PROX1 Gene

GeneLoc Exon Structure for
PROX1
ECgene alternative splicing isoforms for
PROX1

Expression for PROX1 Gene

mRNA expression in normal human tissues for PROX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROX1 Gene

This gene is overexpressed in Liver (x13.2).

Protein differential expression in normal tissues from HIPED for PROX1 Gene

This gene is overexpressed in Liver (25.0), Fetal testis (15.2), Fetal ovary (7.7), and Fetal Liver (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PROX1 Gene



SOURCE GeneReport for Unigene cluster for PROX1 Gene Hs.744931

mRNA Expression by UniProt/SwissProt for PROX1 Gene

Q92786-PROX1_HUMAN
Tissue specificity: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with PROX1: view

Primer Products

No data available for Protein tissue co-expression partners for PROX1 Gene

Orthologs for PROX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PROX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PROX1 35
  • 94.93 (n)
  • 98.51 (a)
PROX1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PROX1 35
  • 96.79 (n)
  • 99.32 (a)
PROX1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prox1 35
  • 92.04 (n)
  • 98.37 (a)
Prox1 16
Prox1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PROX1 35
  • 100 (n)
  • 100 (a)
PROX1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prox1 35
  • 92.26 (n)
  • 97.92 (a)
oppossum
(Monodelphis domestica)
Mammalia PROX1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROX1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROX1 35
  • 88.86 (n)
  • 93.75 (a)
PROX1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROX1 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prox1 35
  • 83.61 (n)
  • 88.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1033 35
zebrafish
(Danio rerio)
Actinopterygii prox1 35
prox1a 35
  • 75.94 (n)
  • 83.63 (a)
prox1a 36
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3509 35
fruit fly
(Drosophila melanogaster)
Insecta pros 37
  • 62 (a)
pros 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-26 37
  • 58 (a)
pros-1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for PROX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PROX1 Gene

ENSEMBL:
Gene Tree for PROX1 (if available)
TreeFam:
Gene Tree for PROX1 (if available)

Paralogs for PROX1 Gene

Paralogs for PROX1 Gene

(1) SIMAP similar genes for PROX1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PROX1: view

Variants for PROX1 Gene

Sequence variations from dbSNP and Humsavar for PROX1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs12121210 - 214,005,190(+) CAATC(A/G)CTTGA reference, missense
rs340834 -- 213,999,481(-) CCACC(A/C)ATAGC intron-variant
rs340835 -- 213,990,332(-) CTCTC(C/T)AACCC intron-variant
rs340836 -- 213,989,726(-) GCAGG(A/G)GGAGT intron-variant, utr-variant-5-prime
rs340837 -- 213,989,391(-) CCCGG(A/C)CCGCG intron-variant, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for PROX1 Gene

Variant ID Type Subtype PubMed ID
nsv873164 CNV Gain 21882294
nsv4498 CNV Insertion 18451855

Variation tolerance for PROX1 Gene

Residual Variation Intolerance Score: 4.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROX1 Gene

Human Gene Mutation Database (HGMD)
PROX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROX1 Gene

Disorders for PROX1 Gene

MalaCards: The human disease database

(16) MalaCards diseases for PROX1 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
kaposiform hemangioendothelioma
  • congenital cutaneous multifocal kaposiform hemangioendothelioma
angiokeratoma of fordyce
  • fordyce angiokeratoma
capillary lymphangioma
  • cutaneous lymphangioma
lymphangioma
  • benign lymphangioma
inflammatory breast carcinoma
  • inflammatory carcinoma of breast
- elite association - COSMIC cancer census association via MalaCards
Search PROX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PROX1

Genetic Association Database (GAD)
PROX1
Human Genome Epidemiology (HuGE) Navigator
PROX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROX1
genes like me logo Genes that share disorders with PROX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROX1 Gene

Publications for PROX1 Gene

  1. Structure and chromosomal localization of the human homeobox gene Prox 1. (PMID: 8812486) Zinovieva R.D. … Tomarev S.I. (Genomics 1996) 2 3 4 67
  2. Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1. (PMID: 19901262) Flister M.J. … Ran S. (Blood 2010) 3 23
  3. COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction. (PMID: 19210544) Yamazaki T. … Watabe T. (Genes Cells 2009) 3 23
  4. Sumoylation of Prox1 controls its ability to induce VEGFR3 expression and lymphatic phenotypes in endothelial cells. (PMID: 19706680) Pan M.R. … Hung W.C. (J. Cell. Sci. 2009) 3 23
  5. Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis. (PMID: 19825936) Harada K. … Miyazono K. (J. Cell. Sci. 2009) 3 23

Products for PROX1 Gene

Sources for PROX1 Gene

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