Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PROX1 Gene

Aliases for PROX1 Gene

  • Prospero Homeobox 1 2 3
  • Homeobox Prospero-Like Protein PROX1 4
  • Prospero-Related Homeobox 1 2
  • PROX-1 4

External Ids for PROX1 Gene

Previous GeneCards Identifiers for PROX1 Gene

  • GC01P212818
  • GC01P209982
  • GC01P210777
  • GC01P211218
  • GC01P210550
  • GC01P212228
  • GC01P214156
  • GC01P184836

Summaries for PROX1 Gene

Entrez Gene Summary for PROX1 Gene

  • The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]

GeneCards Summary for PROX1 Gene

PROX1 (Prospero Homeobox 1) is a Protein Coding gene. Diseases associated with PROX1 include kaposiform hemangioendothelioma and angiokeratoma of fordyce. Among its related pathways are Angiogenesis (CST). GO annotations related to this gene include transcription factor activity, sequence-specific DNA binding and transcription regulatory region DNA binding. An important paralog of this gene is PROX2.

UniProtKB/Swiss-Prot for PROX1 Gene

  • Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Gene Wiki entry for PROX1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PROX1 Gene

Genomics for PROX1 Gene

Regulatory Elements for PROX1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PROX1 Gene

Chromosome:
1
Start:
213,983,181 bp from pter
End:
214,041,510 bp from pter
Size:
58,330 bases
Orientation:
Plus strand

Genomic View for PROX1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PROX1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PROX1 Gene

Proteins for PROX1 Gene

  • Protein details for PROX1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92786-PROX1_HUMAN
    Recommended name:
    Prospero homeobox protein 1
    Protein Accession:
    Q92786
    Secondary Accessions:
    • A6NK29
    • A8K2B1
    • Q5SW76
    • Q8TB91

    Protein attributes for PROX1 Gene

    Size:
    737 amino acids
    Molecular mass:
    83203 Da
    Quaternary structure:
    • Interacts with RORA and RORG (via AF-2 motif).
    SequenceCaution:
    • Sequence=CAI15309.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for PROX1 Gene

neXtProt entry for PROX1 Gene

Proteomics data for PROX1 Gene at MOPED

Post-translational modifications for PROX1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PROX1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PROX1 (PROX1)

No data available for DME Specific Peptides for PROX1 Gene

Domains & Families for PROX1 Gene

Gene Families for PROX1 Gene

Protein Domains for PROX1 Gene

Suggested Antigen Peptide Sequences for PROX1 Gene

Graphical View of Domain Structure for InterPro Entry

Q92786

UniProtKB/Swiss-Prot:

PROX1_HUMAN :
  • The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • Belongs to the Prospero homeobox family.
Domain:
  • The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.
  • Contains 1 Prospero-type homeobox DNA-binding domain.
Family:
  • Belongs to the Prospero homeobox family.
genes like me logo Genes that share domains with PROX1: view

Function for PROX1 Gene

Molecular function for PROX1 Gene

GENATLAS Biochemistry:
prospero-related homeo box 1,chicken homeo domain protein PROX1 homolog,highly expressed in lens,retina,pancreas
UniProtKB/Swiss-Prot Function:
Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.

Gene Ontology (GO) - Molecular Function for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding --
GO:0001046 core promoter sequence-specific DNA binding ISS --
GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding IBA --
GO:0003677 DNA binding IMP 18815287
GO:0003700 transcription factor activity, sequence-specific DNA binding IC 19210544
genes like me logo Genes that share ontologies with PROX1: view
genes like me logo Genes that share phenotypes with PROX1: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PROX1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for PROX1 Gene

Localization for PROX1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PROX1 Gene

Nucleus. Note=RORG promotes its nuclear localization. {ECO:0000250 UniProtKB:P48437}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PROX1 Gene COMPARTMENTS Subcellular localization image for PROX1 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2
extracellular 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm IDA 11850194
genes like me logo Genes that share ontologies with PROX1: view

Pathways & Interactions for PROX1 Gene

SuperPathways for PROX1 Gene

Superpath Contained pathways
1 Angiogenesis (CST)
genes like me logo Genes that share pathways with PROX1: view

Pathways by source for PROX1 Gene

1 Cell Signaling Technology pathway for PROX1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for PROX1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 15205472
GO:0001709 cell fate determination IEA --
GO:0001822 kidney development IEP 8812486
GO:0001889 liver development IEP 11789987
GO:0001938 positive regulation of endothelial cell proliferation IDA 19210544
genes like me logo Genes that share ontologies with PROX1: view

No data available for SIGNOR curated interactions for PROX1 Gene

Drugs & Compounds for PROX1 Gene

(1) Additional Compounds for PROX1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
VEGF
genes like me logo Genes that share compounds with PROX1: view

Transcripts for PROX1 Gene

Unigene Clusters for PROX1 Gene

Prospero homeobox 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PROX1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PROX1 Gene

No ASD Table

Relevant External Links for PROX1 Gene

GeneLoc Exon Structure for
PROX1
ECgene alternative splicing isoforms for
PROX1

Expression for PROX1 Gene

mRNA expression in normal human tissues for PROX1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PROX1 Gene

This gene is overexpressed in Liver (x13.2).

Protein differential expression in normal tissues from HIPED for PROX1 Gene

This gene is overexpressed in Liver (25.0), Fetal testis (15.2), Fetal ovary (7.7), and Fetal Liver (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PROX1 Gene



SOURCE GeneReport for Unigene cluster for PROX1 Gene Hs.744931

mRNA Expression by UniProt/SwissProt for PROX1 Gene

Q92786-PROX1_HUMAN
Tissue specificity: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.
genes like me logo Genes that share expression patterns with PROX1: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for PROX1 Gene

Orthologs for PROX1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PROX1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PROX1 35
  • 94.93 (n)
  • 98.51 (a)
PROX1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PROX1 35
  • 96.79 (n)
  • 99.32 (a)
PROX1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prox1 35
  • 92.04 (n)
  • 98.37 (a)
Prox1 16
Prox1 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PROX1 35
  • 100 (n)
  • 100 (a)
PROX1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prox1 35
  • 92.26 (n)
  • 97.92 (a)
oppossum
(Monodelphis domestica)
Mammalia PROX1 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PROX1 36
  • 90 (a)
OneToOne
chicken
(Gallus gallus)
Aves PROX1 35
  • 88.86 (n)
  • 93.75 (a)
PROX1 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PROX1 36
  • 93 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prox1 35
  • 83.61 (n)
  • 88.86 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.1033 35
zebrafish
(Danio rerio)
Actinopterygii prox1 35
prox1a 35
  • 75.94 (n)
  • 83.63 (a)
prox1a 36
  • 82 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3509 35
fruit fly
(Drosophila melanogaster)
Insecta pros 37
  • 62 (a)
pros 36
  • 11 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea ceh-26 37
  • 58 (a)
pros-1 36
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToMany
Species with no ortholog for PROX1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PROX1 Gene

ENSEMBL:
Gene Tree for PROX1 (if available)
TreeFam:
Gene Tree for PROX1 (if available)

Paralogs for PROX1 Gene

Paralogs for PROX1 Gene

(1) SIMAP similar genes for PROX1 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with PROX1: view

Variants for PROX1 Gene

Sequence variations from dbSNP and Humsavar for PROX1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs188444142 -- 214,012,215(+) TGGTA(C/T)GATAA intron-variant
rs188234505 -- 214,018,303(+) TAATT(C/T)ACAAT intron-variant
rs188226653 -- 213,997,447(+) GACCC(A/C)GGACA reference, synonymous-codon
rs188185945 -- 214,016,757(+) CTAGG(G/T)GGTGG intron-variant
rs188177419 -- 214,017,481(+) TGTGA(A/G)ATGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PROX1 Gene

Variant ID Type Subtype PubMed ID
nsv873164 CNV Gain 21882294
nsv4498 CNV Insertion 18451855

Variation tolerance for PROX1 Gene

Residual Variation Intolerance Score: 4.63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PROX1 Gene

HapMap Linkage Disequilibrium report
PROX1
Human Gene Mutation Database (HGMD)
PROX1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PROX1 Gene

Disorders for PROX1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for PROX1 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
kaposiform hemangioendothelioma
  • congenital cutaneous multifocal kaposiform hemangioendothelioma
angiokeratoma of fordyce
  • fordyce angiokeratoma
capillary lymphangioma
lymphangiosarcoma
  • lymphangiosarcoma of stewart and treves
interstitial emphysema
- elite association
Search PROX1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for PROX1

Genetic Association Database (GAD)
PROX1
Human Genome Epidemiology (HuGE) Navigator
PROX1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PROX1
genes like me logo Genes that share disorders with PROX1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PROX1 Gene

Publications for PROX1 Gene

  1. Role of tumor-associated lymphatic endothelial cells in metastasis: a study of epithelial ovarian tumor in vitro. (PMID: 20028387) Yang S. … Wang Z. (Cancer Sci. 2010) 23 67
  2. The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells. (PMID: 20360386) Srinivasan R.S. … Oliver G. (Genes Dev. 2010) 23 67
  3. Absence of lymphatic vessels in human dental pulp: a morphological study. (PMID: 20486999) Gerli R. … Lorenzini G. (Eur. J. Oral Sci. 2010) 23 67
  4. Inflammation induces lymphangiogenesis through up-regulation of VEGFR-3 mediated by NF-kappaB and Prox1. (PMID: 19901262) Flister M.J. … Ran S. (Blood 2010) 23 67
  5. Colorectal tumor derived fibronectin alternatively spliced EDA domain exserts lymphangiogenic effect on human lymphatic endothelial cells. (PMID: 20023414) Ou J.J. … Liang H.J. (Cancer Biol. Ther. 2010) 23 67

Products for PROX1 Gene

Sources for PROX1 Gene

Back to Top

Content