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Aliases for CPXM1 Gene

Aliases for CPXM1 Gene

  • Carboxypeptidase X (M14 Family), Member 1 2 3 5
  • Carboxypeptidase-Like Protein X1 2 3
  • Metallocarboxypeptidase CPX-1 3 4
  • CPX1 3 4
  • CPXM 3 4
  • Carboxypeptidase X (M14 Family) 2
  • EC 3.4.17.10 63
  • EC 3.4.17.3 63
  • EC 3.4.17.- 4
  • EC 3.4.17 63

External Ids for CPXM1 Gene

Previous HGNC Symbols for CPXM1 Gene

  • CPXM

Summaries for CPXM1 Gene

Entrez Gene Summary for CPXM1 Gene

  • This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity.[provided by RefSeq, May 2010]

GeneCards Summary for CPXM1 Gene

CPXM1 (Carboxypeptidase X (M14 Family), Member 1) is a Protein Coding gene. GO annotations related to this gene include metallocarboxypeptidase activity. An important paralog of this gene is CPXM2.

UniProtKB/Swiss-Prot for CPXM1 Gene

  • May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).

Gene Wiki entry for CPXM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CPXM1 Gene

Genomics for CPXM1 Gene

Regulatory Elements for CPXM1 Gene

Genomic Location for CPXM1 Gene

Chromosome:
20
Start:
2,794,069 bp from pter
End:
2,800,646 bp from pter
Size:
6,578 bases
Orientation:
Minus strand

Genomic View for CPXM1 Gene

Genes around CPXM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CPXM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CPXM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CPXM1 Gene

Proteins for CPXM1 Gene

  • Protein details for CPXM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96SM3-CPXM1_HUMAN
    Recommended name:
    Probable carboxypeptidase X1
    Protein Accession:
    Q96SM3
    Secondary Accessions:
    • Q6P4G8
    • Q6UW65
    • Q9NUB5

    Protein attributes for CPXM1 Gene

    Size:
    734 amino acids
    Molecular mass:
    81668 Da
    Cofactor:
    Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
    Quaternary structure:
    No Data Available

neXtProt entry for CPXM1 Gene

Proteomics data for CPXM1 Gene at MOPED

Selected DME Specific Peptides for CPXM1 Gene

Post-translational modifications for CPXM1 Gene

  • Glycosylation at Asn 57, Asn 210, Asn 220, Asn 318, Asn 428, and Asn 472
  • Modification sites at PhosphoSitePlus

Other Protein References for CPXM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CPXM1 (Carboxypeptidase X1/CPXM1)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CPXM1

Domains & Families for CPXM1 Gene

Gene Families for CPXM1 Gene

Graphical View of Domain Structure for InterPro Entry

Q96SM3

UniProtKB/Swiss-Prot:

CPXM1_HUMAN :
  • Contains 1 F5/8 type C domain.
  • Belongs to the peptidase M14 family.
Domain:
  • Contains 1 F5/8 type C domain.
Family:
  • Belongs to the peptidase M14 family.
genes like me logo Genes that share domains with CPXM1: view

Function for CPXM1 Gene

Molecular function for CPXM1 Gene

UniProtKB/Swiss-Prot Function:
May be involved in cell-cell interactions. No carboxypeptidase activity was found yet (By similarity).

Enzyme Numbers (IUBMB) for CPXM1 Gene

genes like me logo Genes that share phenotypes with CPXM1: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CPXM1 Gene

Localization for CPXM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CPXM1 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CPXM1 Gene COMPARTMENTS Subcellular localization image for CPXM1 gene
Compartment Confidence
extracellular 4

No data available for Gene Ontology (GO) - Cellular Components for CPXM1 Gene

Pathways & Interactions for CPXM1 Gene

SuperPathways for CPXM1 Gene

No Data Available

Interacting Proteins for CPXM1 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000369979%0d%0a9606.ENSP00000263025%0d%0a9606.ENSP00000278360%0d%0a
Selected Interacting proteins: Q96SM3-CPXM1_HUMAN ENSP00000369979 for CPXM1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CPXM1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CPXM1 Gene

Drugs & Compounds for CPXM1 Gene

No Compound Related Data Available

Transcripts for CPXM1 Gene

mRNA/cDNA for CPXM1 Gene

Unigene Clusters for CPXM1 Gene

Carboxypeptidase X (M14 family), member 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CPXM1 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13 ^ 14
SP1: -
SP2: - - -
SP3: -
SP4: - -
SP5: -
SP6:

Relevant External Links for CPXM1 Gene

GeneLoc Exon Structure for
CPXM1
ECgene alternative splicing isoforms for
CPXM1

Expression for CPXM1 Gene

mRNA expression in normal human tissues for CPXM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CPXM1 Gene

This gene is overexpressed in Cervix - Ectocervix (x7.1), Adipose - Visceral (Omentum) (x5.8), Uterus (x5.2), and Adipose - Subcutaneous (x4.1).

Protein differential expression in normal tissues from HIPED for CPXM1 Gene

This gene is overexpressed in Uterus (13.1), Placenta (12.3), Gallbladder (7.6), Ovary (7.5), and Peripheral blood mononuclear cells (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CPXM1 Gene



SOURCE GeneReport for Unigene cluster for CPXM1 Gene Hs.659346

genes like me logo Genes that share expression patterns with CPXM1: view

Protein tissue co-expression partners for CPXM1 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CPXM1 Gene

Orthologs for CPXM1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CPXM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CPXM1 35
  • 88.04 (n)
  • 88.49 (a)
CPXM1 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CPXM1 35
  • 86.64 (n)
  • 87.69 (a)
CPXM1 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cpxm1 35
  • 84.21 (n)
  • 86.29 (a)
Cpxm1 16
Cpxm1 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CPXM1 35
  • 97.12 (n)
  • 95.75 (a)
CPXM1 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cpxm1 35
  • 83.84 (n)
  • 87.12 (a)
oppossum
(Monodelphis domestica)
Mammalia CPXM1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CPXM1 36
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves CPXM1 36
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CPXM1 36
  • 59 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cpxm1 35
  • 65.83 (n)
  • 65.93 (a)
Str.17581 35
zebrafish
(Danio rerio)
Actinopterygii si:dkey-19p15.7 35
  • 64.24 (n)
  • 64.57 (a)
CPXM1 (1 of 2) 36
  • 55 (a)
OneToMany
CU469518.1 36
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for CPXM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CPXM1 Gene

ENSEMBL:
Gene Tree for CPXM1 (if available)
TreeFam:
Gene Tree for CPXM1 (if available)

Paralogs for CPXM1 Gene

Paralogs for CPXM1 Gene

(7) SIMAP similar genes for CPXM1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CPXM1: view

Variants for CPXM1 Gene

Sequence variations from dbSNP and Humsavar for CPXM1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs127076 -- 2,797,429(-) ACAGT(A/G)AGCTT intron-variant
rs127078 -- 2,794,686(-) AGCAC(A/G)TTATC intron-variant
rs215537 -- 2,793,959(+) CAATG(C/T)GTCCA downstream-variant-500B
rs215538 -- 2,793,983(+) GAGAG(A/T)GTGCA downstream-variant-500B
rs215539 -- 2,794,037(+) CGGGG(A/G)GAGGA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CPXM1 Gene

Variant ID Type Subtype PubMed ID
nsv833895 CNV Loss 17160897
nsv522009 CNV Gain 19592680
nsv510780 CNV Loss 20534489

Variation tolerance for CPXM1 Gene

Residual Variation Intolerance Score: 27.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.44; 54.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CPXM1 Gene

HapMap Linkage Disequilibrium report
CPXM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CPXM1 Gene

Disorders for CPXM1 Gene

Relevant External Links for CPXM1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CPXM1

No disorders were found for CPXM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CPXM1 Gene

Publications for CPXM1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 2 3 4 67
  2. Protein interaction data set highlighted with human Ras-MAPK/PI3K signaling pathways. (PMID: 18624398) Wang J. … He F. (J. Proteome Res. 2008) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. An unappreciated role for RNA surveillance. (PMID: 14759258) Hillman R.T. … Brenner S.E. (Genome Biol. 2004) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for CPXM1 Gene

Sources for CPXM1 Gene

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