Aliases for PRODH Gene
Aliases for PRODH Gene
- Proline Dehydrogenase 1 2 3 5
- P53-Induced Gene 6 Protein 3 4
- Proline Oxidase 2 3 4
- Proline Oxidase 2 4
- PIG6 3 4
- Proline Dehydrogenase (Proline Oxidase ) 2
- Proline Dehydrogenase 1, Mitochondrial 3
- Tumor Protein P53 Inducible Protein 6 3
- Proline Dehydrogenase (Oxidase) 1 3
- Proline Oxidase, Mitochondrial 3
External Ids for PRODH Gene
- HGNC: 9453
- Entrez Gene: 5625
- Ensembl: ENSG00000100033
- OMIM: 606810
- UniProtKB: O43272
Previous GeneCards Identifiers for PRODH Gene
- GC22M015840
- GC22M017274
- GC22M002522
Summaries for PRODH Gene
-
This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]
GeneCards Summary for PRODH Gene
PRODH (Proline Dehydrogenase 1) is a Protein Coding gene. Diseases associated with PRODH include Hyperprolinemia, Type I and Schizophrenia 4. Among its related pathways are Viral mRNA Translation and Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism. GO annotations related to this gene include FAD binding and proline dehydrogenase activity. An important paralog of this gene is LOC102724788.
UniProtKB/Swiss-Prot for PRODH Gene
-
Converts proline to delta-1-pyrroline-5-carboxylate.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRODH Gene
Genomics for PRODH Gene
Regulatory Elements for PRODH Gene
Enhancers for PRODH Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH22G018923 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 17.5 | +6.4 | 6375 | 13.4 | HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF121 GLIS2 FOS SP5 | DGCR6 PRODH DGCR5 MICAL3 TUBA8 GC22P018950 ENSG00000283809 |
| GH22G018967 | 1.1 | Ensembl ENCODE | 11.3 | -31.4 | -31397 | 1.4 | HDAC1 RB1 TBL1XR1 ARID4B ZBTB40 ZNF2 RAD21 RARA ZNF766 GLIS2 | PRODH DGCR5 ENSG00000280418 |
| GH22G018970 | 0.6 | ENCODE | 11.9 | -33.8 | -33750 | 0.2 | E2F1 CTCF ZFHX2 POLR2A TEAD4 ZFX | PRODH DGCR5 ENSG00000280418 |
| GH22G018947 | 0.4 | dbSUPER | 14.3 | -11.5 | -11548 | 0.8 | POLR2A | PRODH DGCR6 DGCR5 GC22P018956 ENSG00000280418 |
| GH22G018948 | 0.4 | dbSUPER | 14.3 | -11.8 | -11755 | 0.9 | POLR2A | PRODH DGCR6 DGCR5 GC22P018956 ENSG00000280418 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around PRODH on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the PRODH gene promoter:
Regulatory Element Products
Genomic Location for PRODH Gene
- Chromosome:
- 22
- Start:
- 18,912,695 bp from pter
- End:
- 18,936,553 bp from pter
- Size:
- 23,859 bases
- Orientation:
- Minus strand
Genomic View for PRODH Gene
Genes around PRODH on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q11.21 by Ensembl
- 22q11.21 by Entrez Gene
- 22q11.21 by HGNC
PRODH Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for PRODH Gene
Proteins for PRODH Gene
-
Protein details for PRODH Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43272-PROD_HUMAN
- Recommended name:
- Proline dehydrogenase 1, mitochondrial
- Protein Accession:
- O43272
- A6NF53
- O14680
- Q0P507
- Q147W8
- Q504W1
- Q59FI8
- Q6NV86
- Q9UF13
Protein attributes for PRODH Gene
- Size:
- 600 amino acids
- Molecular mass:
- 68002 Da
- Cofactor:
- Name=FAD; Xref=ChEBI:CHEBI:57692;
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAC39529.1; Type=Frameshift; Positions=540, 563, 568, 577, 580, 582; Evidence={ECO:0000305}; Sequence=AAH68260.1; Type=Frameshift; Positions=123; Evidence={ECO:0000305}; Sequence=AAH94736.1; Type=Frameshift; Positions=40; Evidence={ECO:0000305}; Sequence=AAH94736.1; Type=Miscellaneous discrepancy; Note=Artifact. Missing internal sequence that doesnt correspond to an exon-intron boundary.; Evidence={ECO:0000305}; Sequence=BAD92709.1; Type=Miscellaneous discrepancy; Note=Intron retention. Includes intronic sequence at the 5 end.; Evidence={ECO:0000305};
Protein Expression for PRODH Gene
Selected DME Specific Peptides for PRODH Gene
- O43272:
-
- FGQLLGMCD
- GHFVAGE
- MVASHNE
- KLVRGAY
Post-translational modifications for PRODH Gene
Other Protein References for PRODH Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for PRODH
-
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-
Cloud-Clone Corp. Antibodies for PRODH
- Invitrogen Antibodies for PRODH
- antibodies-online Antibodies for PRODH: See all 69
- GeneTex PRODH antibody for PRODH
-
Santa Cruz Biotechnology (SCBT) Antibodies for PRODH
Protein Products
-
OriGene Purified Proteins for PRODH
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-
Cloud-Clone Corp. Proteins for PRODH
- antibodies-online Proteins for PRODH: See all 3
- Search antibodies-online for peptides
- Search GeneTex for Proteins for PRODH
Assay Products
- antibodies-online Kits for PRODH: See all 1
Domains & Families for PRODH Gene
Protein Domains for PRODH Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for PRODH Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O43272- Family:
-
- Belongs to the proline oxidase family.
No data available for Gene Families for PRODH Gene
Function for PRODH Gene
Molecular function for PRODH Gene
- GENATLAS Biochemistry:
- proline dehydrogenase,Drosophila sluggish-A homolog,predominantly expressed in lung,skeletal muscle,brain,heart,kidney,proline metabolic pathway,mitochondrial matrix,involved putatively in any psychiatric disorders
- UniProtKB/Swiss-Prot CatalyticActivity:
- L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.
- UniProtKB/Swiss-Prot Function:
- Converts proline to delta-1-pyrroline-5-carboxylate.
- UniProtKB/Swiss-Prot Induction:
- During p53/TP53-induced apoptosis.
Enzyme Numbers (IUBMB) for PRODH Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004657 | proline dehydrogenase activity | IDA | 15662599 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0071949 | FAD binding | IDA | 15662599 |
Phenotypes for PRODH Gene
- MGI mutant phenotypes for PRODH:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for PRODH:
Animal Models for PRODH Gene
- MGI Knock Outs for PRODH:
-
- Prodh tm1b(KOMP)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
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-
-
ViGene Biosciences lentiviral particle packaged cDNA for PRODH gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRODH gene
- Search ViGene Biosciences for PRODH
CRISPR Products
-
OriGene CRISPR knockouts for PRODH
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRODH
- GenScript: Design CRISPR guide RNA sequences for PRODH
miRNA for PRODH Gene
- miRTarBase miRNAs that target PRODH
miRNA Products
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Inhibitory RNA Products
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Clone Products
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-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for PRODH
-
ViGene Biosciences adenoviral particle packaged cDNA for PRODH gene
-
ViGene Biosciences lentiviral particle packaged cDNA for PRODH gene
-
ViGene Biosciences ready-to-package AAV shRNAs for PRODH gene
Flow Cytometry Products
No data available for Transcription Factor Targets and HOMER Transcription for PRODH Gene
Localization for PRODH Gene
Subcellular locations from UniProtKB/Swiss-Prot for PRODH Gene
- Mitochondrion matrix.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| cytosol | 3 |
| extracellular | 2 |
| peroxisome | 2 |
| plasma membrane | 1 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005739 | mitochondrion | IBA,IEA | -- |
| GO:0005743 | mitochondrial inner membrane | TAS | -- |
| GO:0005759 | mitochondrial matrix | IEA | -- |
Pathways & Interactions for PRODH Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Metabolism |
.37
|
|
| 2 | Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism | ||
| 3 | Arginine and proline metabolism | ||
| 4 | Viral mRNA Translation | ||
Pathways by source for PRODH Gene
4 Reactome pathways for PRODH Gene
2 KEGG pathways for PRODH Gene
UniProtKB/Swiss-Prot O43272-PROD_HUMAN
- Pathway: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.
Interacting Proteins for PRODH Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006560 | proline metabolic process | TAS | 9385373 |
| GO:0006562 | proline catabolic process | IEA,TAS | -- |
| GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress | NAS | 9305847 |
| GO:0010133 | proline catabolic process to glutamate | IEA | -- |
| GO:0010942 | positive regulation of cell death | IDA | 23743200 |
No data available for SIGNOR curated interactions for PRODH Gene
Drugs & Compounds for PRODH Gene
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 1-Pyrroline-5-carboxylic acid |
|
2906-39-0 |
|
|||
| 4-Hydroxy-L-glutamic acid |
|
2485-33-8 |
|
|||
| 4-Hydroxy-L-proline |
|
30724-02-8 |
|
|||
| Hydrogen Ion |
|
|
||||
| L-4-Hydroxyglutamate semialdehyde |
|
|
Transcripts for PRODH Gene
mRNA/cDNA for PRODH Gene
- (2) REFSEQ mRNAs :
- (9) Additional mRNA sequences :
- (97) Selected AceView cDNA sequences:
- (15) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for PRODH Gene
CRISPR Products
-
OriGene CRISPR knockouts for PRODH
-
Santa Cruz Biotechnology (SCBT) CRISPR for PRODH
- GenScript: Design CRISPR guide RNA sequences for PRODH
miRNA Products
- Search ViGene Biosciences for PRODH
Inhibitory RNA Products
- Origene RNAi, siRNA, and shRNA products in human, mouse, rat for PRODH
- Browse OriGene Inhibitory RNA Products For PRODH
-
ViGene Biosciences ready-to-package AAV shRNAs for PRODH gene
Clone Products
- Sino Biological Human cDNA Clone for PRODH
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for PRODH
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRODH
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
Expression for PRODH Gene
This gene is overexpressed in Bone (14.4), Brain (11.4), Frontal cortex (9.3), Fetal gut (7.4), Breast (7.3), and Spinal cord (6.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRODH Gene
NURSA nuclear receptor signaling pathways regulating expression of PRODH Gene:
PRODHSOURCE GeneReport for Unigene cluster for PRODH Gene:
Hs.517352mRNA Expression by UniProt/SwissProt for PRODH Gene:
O43272-PROD_HUMAN
Tissue specificity:
Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.
Evidence on tissue expression from TISSUES for PRODH Gene
- Nervous system(4.7)
- Kidney(4.4)
- Skin(2.5)
Phenotype-based relationships between genes and organs from Gene ORGANizer for PRODH Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- cardiovascular
- immune
- integumentary
- nervous
- skeletal muscle
- urinary
Organs:
Head and neck:
- brain
- head
Abdomen:
- kidney
Pelvis:
- ureter
- urinary bladder
General:
- blood
- blood vessel
- coagulation system
- skin
Primer Products
-
OriGene qPCR primer pairs for PRODH
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for PRODH Gene
Orthologs for PRODH Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | PRODH 34 35 |
|
||
| chimpanzee (Pan troglodytes) |
Mammalia | PRODH 34 |
|
||
| cow (Bos Taurus) |
Mammalia | PRODH 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Prodh 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Prodh 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | PRODH 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | PRODH 34 35 |
|
||
| lizard (Anolis carolinensis) |
Reptilia | PRODH 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | LOC100494891 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | PRODH (3 of 3) 35 |
|
OneToMany | |
| PRODH (2 of 3) 35 |
|
OneToMany | |||
| LOC100537991 34 |
|
||||
| prodha 35 |
|
OneToMany | |||
| Dr.12460 34 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | slgA 36 34 35 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003860 34 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | CELE_B0513.5 34 |
|
||
| B0513.5 36 35 |
|
||||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | PUT1 35 37 |
|
OneToMany |
- Species where no ortholog for PRODH was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for PRODH Gene
Paralogs for PRODH Gene
(1) SIMAP similar genes for PRODH Gene using alignment to 5 proteins:
Pseudogenes.org Pseudogenes for PRODH Gene
Variants for PRODH Gene
| SNP ID | Clin | Chr 22 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1807467 | Pathogenic, Hyperprolinemia 1 (HYRPRO1) [MIM:239500] | 18,918,380(-) | GTGCG(G/T)CAGAG | reference, missense | |
| rs2238731 | Hyperprolinemia 1 (HYRPRO1) [MIM:239500], Schizophrenia 4 (SCZD4) [MIM:600850] | 18,918,464(+) | CTCCA(C/T)GTCCA | reference, missense | |
| rs2870983 | Hyperprolinemia 1 (HYRPRO1) [MIM:239500], Schizophrenia 4 (SCZD4) [MIM:600850] | 18,918,329(+) | CATGG(C/T)GTTGG | reference, missense | |
| rs2870984 | other, Schizophrenia 4 (SCZD4) [MIM:600850] | 18,918,346(+) | CGTAC(A/G)TGGGG | reference, missense | |
| rs2904551 | Pathogenic, Hyperprolinemia 1 (HYRPRO1) [MIM:239500], Schizophrenia 4 (SCZD4) [MIM:600850] | 18,918,421(+) | GCACC(A/G)GCTTG | reference, missense |
Residual Variation Intolerance Score:
95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
9.32;
88.30% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for PRODH Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRODH Gene
Disorders for PRODH Gene
(15) MalaCards diseases for PRODH Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hyperprolinemia, type i |
|
|
| schizophrenia 4 |
|
|
| hyperprolinemia |
|
|
| schizophrenia |
|
|
| primary hyperoxaluria |
|
|
Search PRODH in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
PROD_HUMAN- Hyperprolinemia 1 (HYRPRO1) [MIM:239500]: An inborn error of proline metabolism resulting in elevated levels of proline in the plasma and urine. The disorder is generally benign and most affected individuals are clinically asymptomatic. Some patients, however, have neurologic manifestations, including epilepsy and mental retardation. Association with certain forms of schizophrenia have been reported. {ECO:0000269 PubMed:12217952, ECO:0000269 PubMed:15662599, ECO:0000269 PubMed:17135275}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Schizophrenia 4 (SCZD4) [MIM:600850]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:11891283, ECO:0000269 PubMed:15662599}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
Relevant External Links for PRODH
No data available for Genatlas for PRODH Gene
Publications for PRODH Gene
- Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. (PMID: 11891283) Liu H. … Karayiorgou M. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 4 22 46 64
- PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. (PMID: 12217952) Jacquet H. … Frebourg T. (Hum. Mol. Genet. 2002) 3 4 22 46 64
- The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. (PMID: 10192398) Gogos J.A. … Karayiorgou M. (Nat. Genet. 1999) 2 3 4 22 64
- Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia. (PMID: 17504246) Zinkstok J. … Linszen D. (Genes Brain Behav. 2008) 3 22 46 64
- Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome. (PMID: 17135275) Raux G. … Campion D. (Hum. Mol. Genet. 2007) 3 4 22 64
Products for PRODH Gene
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- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for PRODH
- Sino Biological Human cDNA Clone for PRODH
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Proteins
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for PRODH
- Novus Biologicals proteins and lysates for PRODH
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Cloud-Clone Corp. Antibodies for PRODH
- Cloud-Clone Corp. Proteins for PRODH
- Browse Assay Kits at Cloud-Clone Corp.
- antibodies-online Antibodies for PRODH: See all 69
- antibodies-online Kits for PRODH: See all 1
- antibodies-online Proteins for PRODH: See all 3
- Search antibodies-online for peptides
- GeneTex PRODH antibody for PRODH
- Search GeneTex for Proteins for PRODH
- ViGene Biosciences adenoviral particle packaged cDNA for PRODH gene
- ViGene Biosciences lentiviral particle packaged cDNA for PRODH gene
- ViGene Biosciences ready-to-package AAV shRNAs for PRODH gene
- Search ViGene Biosciences for PRODH
- Santa Cruz Biotechnology (SCBT) Antibodies for PRODH
- Search Santa Cruz Biotechnology (SCBT) for PRODH siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for PRODH
- Horizon Cell Lines for PRODH
- Cyagen custom Knockout/knockin (KOKI) mouse models for PRODH
- VectorBuilder custom plasmid, inducible vectors for PRODH
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for PRODH
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for PRODH Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer