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Aliases for PRODH Gene

Aliases for PRODH Gene

  • Proline Dehydrogenase 1 2 3 5
  • P53-Induced Gene 6 Protein 3 4
  • Proline Oxidase 2 3 4
  • Proline Oxidase 2 4
  • PRODH2 3 4
  • PIG6 3 4
  • Proline Dehydrogenase (Proline Oxidase ) 2
  • Proline Dehydrogenase 1, Mitochondrial 3
  • Tumor Protein P53 Inducible Protein 6 3
  • Proline Dehydrogenase (Oxidase) 1 3
  • Proline Oxidase, Mitochondrial 3
  • EC 58
  • EC 4
  • HSPOX2 3
  • PRODH1 3
  • TP53I6 3
  • POX2 4
  • POX 3

External Ids for PRODH Gene

Previous GeneCards Identifiers for PRODH Gene

  • GC22M015840
  • GC22M017274
  • GC22M002522

Summaries for PRODH Gene

Entrez Gene Summary for PRODH Gene

  • This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010]

GeneCards Summary for PRODH Gene

PRODH (Proline Dehydrogenase 1) is a Protein Coding gene. Diseases associated with PRODH include Hyperprolinemia, Type I and Schizophrenia 4. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include FAD binding and proline dehydrogenase activity. An important paralog of this gene is LOC102724788.

UniProtKB/Swiss-Prot for PRODH Gene

  • Converts proline to delta-1-pyrroline-5-carboxylate.

Gene Wiki entry for PRODH Gene

Additional gene information for PRODH Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRODH Gene

Genomics for PRODH Gene

Regulatory Elements for PRODH Gene

Enhancers for PRODH Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H018923 1.8 FANTOM5 Ensembl ENCODE dbSUPER 17.5 +6.4 6375 13.4 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 ZNF121 GLIS2 FOS RUNX3 DGCR6 PRODH DGCR5 MICAL3 TUBA8 GC22P018954 ENSG00000283809
GH22H018967 1.1 Ensembl ENCODE 11.3 -31.4 -31397 1.4 HDAC1 RB1 TBL1XR1 ARID4B ZBTB40 RARA ZNF766 KLF11 NCOA1 USF2 PRODH DGCR5 ENSG00000280418
GH22H018970 0.5 ENCODE 11.9 -33.8 -33750 0.2 E2F1 CTCF ZFHX2 POLR2A ZFX PRODH DGCR5 ENSG00000280418
GH22H018947 0.4 dbSUPER 14.3 -11.7 -11670 1 POLR2A PRODH DGCR6 DGCR5 GC22P018961 ENSG00000280418
GH22H018921 0.5 dbSUPER 10.7 +14.2 14221 1.2 ZFHX2 KLF1 EGR2 DGCR6 PRODH GC22P018954 ENSG00000283809
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRODH on UCSC Golden Path with GeneCards custom track

Promoters for PRODH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000143695 452 600 E2F1 LEF1 MAZ POLR2A PATZ1 SIN3A ZBTB26

Genomic Locations for PRODH Gene

Genomic Locations for PRODH Gene
23,859 bases
Minus strand

Genomic View for PRODH Gene

Genes around PRODH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRODH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRODH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRODH Gene

Proteins for PRODH Gene

  • Protein details for PRODH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Proline dehydrogenase 1, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • A6NF53
    • O14680
    • Q0P507
    • Q147W8
    • Q504W1
    • Q59FI8
    • Q6NV86
    • Q9UF13

    Protein attributes for PRODH Gene

    600 amino acids
    Molecular mass:
    68002 Da
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    No Data Available
    • Sequence=AAC39529.1; Type=Frameshift; Positions=540, 563, 568, 577, 580, 582; Evidence={ECO:0000305}; Sequence=AAH68260.1; Type=Frameshift; Positions=123; Evidence={ECO:0000305}; Sequence=AAH94736.1; Type=Frameshift; Positions=40; Evidence={ECO:0000305}; Sequence=AAH94736.1; Type=Miscellaneous discrepancy; Note=Artifact. Missing internal sequence that doesnt correspond to an exon-intron boundary.; Evidence={ECO:0000305}; Sequence=BAD92709.1; Type=Miscellaneous discrepancy; Note=Intron retention. Includes intronic sequence at the 5 end.; Evidence={ECO:0000305};

    Alternative splice isoforms for PRODH Gene


neXtProt entry for PRODH Gene

Selected DME Specific Peptides for PRODH Gene


Post-translational modifications for PRODH Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for PRODH Gene

Gene Families for PRODH Gene

Human Protein Atlas (HPA):
  • Disease related genes
  • Enzymes
  • Potential drug targets
  • Predicted intracellular proteins

Protein Domains for PRODH Gene

Suggested Antigen Peptide Sequences for PRODH Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the proline oxidase family.
  • Belongs to the proline oxidase family.
genes like me logo Genes that share domains with PRODH: view

Function for PRODH Gene

Molecular function for PRODH Gene

GENATLAS Biochemistry:
proline dehydrogenase,Drosophila sluggish-A homolog,predominantly expressed in lung,skeletal muscle,brain,heart,kidney,proline metabolic pathway,mitochondrial matrix,involved putatively in any psychiatric disorders
UniProtKB/Swiss-Prot CatalyticActivity:
L-proline + a quinone = (S)-1-pyrroline-5-carboxylate + a quinol.
UniProtKB/Swiss-Prot Function:
Converts proline to delta-1-pyrroline-5-carboxylate.
UniProtKB/Swiss-Prot Induction:
During p53/TP53-induced apoptosis.

Enzyme Numbers (IUBMB) for PRODH Gene

Phenotypes From GWAS Catalog for PRODH Gene

Gene Ontology (GO) - Molecular Function for PRODH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004657 proline dehydrogenase activity IDA 15662599
GO:0016491 oxidoreductase activity IEA --
GO:0071949 FAD binding IDA 15662599
genes like me logo Genes that share ontologies with PRODH: view
genes like me logo Genes that share phenotypes with PRODH: view

Human Phenotype Ontology for PRODH Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRODH Gene

MGI Knock Outs for PRODH:

miRNA for PRODH Gene

miRTarBase miRNAs that target PRODH

Clone Products

No data available for Transcription Factor Targets and HOMER Transcription for PRODH Gene

Localization for PRODH Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRODH Gene

Mitochondrion matrix.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRODH gene
Compartment Confidence
mitochondrion 5
cytosol 3
extracellular 2
peroxisome 2
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for PRODH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IBA --
GO:0005743 mitochondrial inner membrane TAS --
GO:0005759 mitochondrial matrix IEA --
genes like me logo Genes that share ontologies with PRODH: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for PRODH Gene

Pathways & Interactions for PRODH Gene

genes like me logo Genes that share pathways with PRODH: view

UniProtKB/Swiss-Prot O43272-PROD_HUMAN

  • Pathway: Amino-acid degradation; L-proline degradation into L-glutamate; L-glutamate from L-proline: step 1/2.

Gene Ontology (GO) - Biological Process for PRODH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006560 proline metabolic process IEA,TAS 9385373
GO:0006562 proline catabolic process IEA,TAS --
GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress NAS 9305847
GO:0010133 proline catabolic process to glutamate IEA --
GO:0010942 positive regulation of cell death IDA 23743200
genes like me logo Genes that share ontologies with PRODH: view

No data available for SIGNOR curated interactions for PRODH Gene

Drugs & Compounds for PRODH Gene

(9) Drugs for PRODH Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Proline Approved Nutra Target, Enzyme, substrate 0
Betaine Approved Nutra Enzyme, inhibitor 34
FAD Approved Pharma 0
Water Approved Pharma 0
NAD Pharma Full agonist, Agonist 0

(8) Additional Compounds for PRODH Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
1-Pyrroline-5-carboxylic acid
  • (S)-1-pyrroline-5-carboxylate
  • 1-Pyrroline-5-carboxylate
  • 1-Pyrroline-5-carboxylic acid
  • 3,4-Dihydro-2h-pyrrole-2-carboxylate
  • 3,4-Dihydro-2h-pyrrole-2-carboxylic acid
4-Hydroxy-L-glutamic acid
  • (2S)-2-amino-4-hydroxypentanedioate
  • (2S)-2-amino-4-hydroxypentanedioic acid
  • 4-Hydroxy-L-glutamate
  • 4-Hydroxy-L-glutamic acid
  • Erythro-4-hydroxyglutamate
  • (2S)-4-hydroxypyrrolidine-2-carboxylic acid
  • (4S)-4-hydroxy-L-Proline
  • 4-Hydroxy-L-Proline
  • Allo-4-Hydroxy-L-proline
  • Allo-4-Hydroxyproline
Hydrogen Ion
  • Hydrogen cation
  • Hydron
  • Proton
L-4-Hydroxyglutamate semialdehyde
genes like me logo Genes that share compounds with PRODH: view

Transcripts for PRODH Gene

Unigene Clusters for PRODH Gene

Proline dehydrogenase (oxidase) 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRODH Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15
SP1: - - -
SP2: - - - -
SP3: - - -
SP4: - - - - -
SP6: - - - -

Relevant External Links for PRODH Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRODH Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for PRODH Gene

Protein differential expression in normal tissues from HIPED for PRODH Gene

This gene is overexpressed in Bone (14.4), Brain (11.4), Frontal cortex (9.3), Fetal gut (7.4), Breast (7.3), and Spinal cord (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for PRODH Gene

NURSA nuclear receptor signaling pathways regulating expression of PRODH Gene:


SOURCE GeneReport for Unigene cluster for PRODH Gene:


mRNA Expression by UniProt/SwissProt for PRODH Gene:

Tissue specificity: Expressed in lung, skeletal muscle and brain, to a lesser extent in heart and kidney, and weakly in liver, placenta and pancreas.

Evidence on tissue expression from TISSUES for PRODH Gene

  • Nervous system(4.7)
  • Kidney(4.4)
  • Skin(2.5)

Phenotype-based relationships between genes and organs from Gene ORGANizer for PRODH Gene

Germ Layers:
  • ectoderm
  • mesoderm
  • cardiovascular
  • immune
  • integumentary
  • nervous
  • skeletal muscle
  • urinary
Head and neck:
  • brain
  • head
  • kidney
  • ureter
  • urinary bladder
  • blood
  • blood vessel
  • coagulation system
  • skin
genes like me logo Genes that share expression patterns with PRODH: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for PRODH Gene

Orthologs for PRODH Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRODH Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia PRODH 33 34
  • 86.73 (n)
(Pan troglodytes)
Mammalia PRODH 33
  • 85.37 (n)
(Bos Taurus)
Mammalia PRODH 33 34
  • 84.2 (n)
(Mus musculus)
Mammalia Prodh 33 16 34
  • 82.47 (n)
(Rattus norvegicus)
Mammalia Prodh 33
  • 81.75 (n)
(Ornithorhynchus anatinus)
Mammalia PRODH 34
  • 71 (a)
(Gallus gallus)
Aves PRODH 33 34
  • 77.49 (n)
(Anolis carolinensis)
Reptilia PRODH 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494891 33
  • 67.03 (n)
(Danio rerio)
Actinopterygii PRODH (3 of 3) 34
  • 75 (a)
PRODH (2 of 3) 34
  • 69 (a)
LOC100537991 33
  • 67.99 (n)
prodha 34
  • 54 (a)
Dr.12460 33
fruit fly
(Drosophila melanogaster)
Insecta slgA 35 33 34
  • 56.11 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003860 33
  • 54.46 (n)
(Caenorhabditis elegans)
Secernentea CELE_B0513.5 33
  • 51.63 (n)
B0513.5 35 34
  • 45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PUT1 34 36
  • 20 (a)
Species where no ortholog for PRODH was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRODH Gene

Gene Tree for PRODH (if available)
Gene Tree for PRODH (if available)

Paralogs for PRODH Gene

Paralogs for PRODH Gene

(1) SIMAP similar genes for PRODH Gene using alignment to 5 proteins: Pseudogenes for PRODH Gene

genes like me logo Genes that share paralogs with PRODH: view

Variants for PRODH Gene

Sequence variations from dbSNP and Humsavar for PRODH Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1807467 Pathogenic, Hyperprolinemia 1 (HYRPRO1) [MIM:239500] 18,918,380(-) GTGCG(G/T)CAGAG reference, missense
rs2238731 Hyperprolinemia 1 (HYRPRO1) [MIM:239500], Schizophrenia 4 (SCZD4) [MIM:600850] 18,918,464(+) CTCCA(C/T)GTCCA reference, missense
rs2870983 Hyperprolinemia 1 (HYRPRO1) [MIM:239500], Schizophrenia 4 (SCZD4) [MIM:600850] 18,918,329(+) CATGG(C/T)GTTGG reference, missense
rs2870984 other, Schizophrenia 4 (SCZD4) [MIM:600850] 18,918,346(+) CGTAC(A/G)TGGGG reference, missense
rs2904551 Pathogenic, Hyperprolinemia 1 (HYRPRO1) [MIM:239500], Schizophrenia 4 (SCZD4) [MIM:600850] 18,918,421(+) GCACC(A/G)GCTTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PRODH Gene

Variant ID Type Subtype PubMed ID
nsv588166 CNV loss 21841781
nsv588196 CNV gain 21841781
nsv588201 CNV loss 21841781
nsv588203 CNV gain+loss 21841781
nsv953020 CNV deletion 24416366
nsv979632 CNV duplication 23825009
nsv588165 CNV gain 21841781
nsv588155 CNV gain 21841781
nsv516997 CNV gain+loss 19592680
nsv471180 CNV loss 18288195
nsv471179 CNV gain 18288195
nsv459336 CNV loss 19166990
nsv442503 CNV gain 18776908
nsv1160726 CNV duplication 26073780
nsv1067175 CNV loss 25217958
nsv1063432 CNV loss 25217958
esv3893433 CNV gain 25118596
esv3893432 CNV gain 25118596
esv3893431 CNV gain+loss 25118596
esv3647250 CNV gain 21293372
esv3647249 CNV loss 21293372
esv3584485 CNV gain 24956385
esv3584483 CNV gain 24956385
esv3575418 CNV gain 25503493
esv3568246 CNV loss 25503493
esv32687 CNV gain+loss 17666407
esv2758824 CNV gain+loss 17122850
esv2751935 CNV loss 17911159
esv22247 CNV gain+loss 19812545
dgv99e203 CNV gain+loss 21179565
dgv7977n54 CNV gain 21841781
dgv7976n54 CNV gain 21841781
dgv7975n54 CNV loss 21841781
dgv7973n54 CNV gain 21841781
dgv7972n54 CNV gain+loss 21841781
dgv7971n54 CNV gain 21841781
dgv7969n54 CNV gain 21841781
dgv543n27 CNV gain 19166990
dgv542n27 CNV loss 19166990
dgv541n27 CNV gain 19166990
dgv4476n100 CNV gain 25217958
dgv4475n100 CNV gain 25217958
dgv4474n100 CNV gain 25217958
dgv4473n100 CNV gain+loss 25217958
dgv4472n100 CNV loss 25217958
dgv4471n100 CNV gain 25217958
dgv4469n100 CNV gain 25217958
dgv4468n100 CNV gain+loss 25217958
dgv4467n100 CNV gain 25217958
dgv4466n100 CNV gain+loss 25217958
dgv42e213 CNV gain 24956385
dgv174e55 CNV gain 17911159
dgv173e55 CNV gain 17911159
dgv169n111 CNV duplication 26073780
dgv1285e212 CNV loss 25503493
dgv1284e212 CNV gain 25503493
dgv1283e212 CNV gain 25503493

Variation tolerance for PRODH Gene

Residual Variation Intolerance Score: 95.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.32; 88.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRODH Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRODH Gene

Disorders for PRODH Gene

MalaCards: The human disease database

(16) MalaCards diseases for PRODH Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hyperprolinemia, type i
  • hyperprolinemia type 1
schizophrenia 4
  • schizophrenia susceptibility locus, chromosome 22q11-related
  • hyperprolinemia type 1
schizoaffective disorder
variola minor
  • alastrim
- elite association - COSMIC cancer census association via MalaCards
Search PRODH in MalaCards View complete list of genes associated with diseases


  • Hyperprolinemia 1 (HYRPRO1) [MIM:239500]: An inborn error of proline metabolism resulting in elevated levels of proline in the plasma and urine. The disorder is generally benign and most affected individuals are clinically asymptomatic. Some patients, however, have neurologic manifestations, including epilepsy and mental retardation. Association with certain forms of schizophrenia have been reported. {ECO:0000269 PubMed:12217952, ECO:0000269 PubMed:15662599, ECO:0000269 PubMed:17135275}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Schizophrenia 4 (SCZD4) [MIM:600850]: A complex, multifactorial psychotic disorder or group of disorders characterized by disturbances in the form and content of thought (e.g. delusions, hallucinations), in mood (e.g. inappropriate affect), in sense of self and relationship to the external world (e.g. loss of ego boundaries, withdrawal), and in behavior (e.g bizarre or apparently purposeless behavior). Although it affects emotions, it is distinguished from mood disorders in which such disturbances are primary. Similarly, there may be mild impairment of cognitive function, and it is distinguished from the dementias in which disturbed cognitive function is considered primary. Some patients manifest schizophrenic as well as bipolar disorder symptoms and are often given the diagnosis of schizoaffective disorder. {ECO:0000269 PubMed:11891283, ECO:0000269 PubMed:15662599}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for PRODH

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with PRODH: view

No data available for Genatlas for PRODH Gene

Publications for PRODH Gene

  1. Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. (PMID: 11891283) Liu H … Karayiorgou M (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 4 22 45 60
  2. PRODH mutations and hyperprolinemia in a subset of schizophrenic patients. (PMID: 12217952) Jacquet H … Frébourg T (Human molecular genetics 2002) 3 4 22 45 60
  3. The gene encoding proline dehydrogenase modulates sensorimotor gating in mice. (PMID: 10192398) Gogos JA … Karayiorgou M (Nature genetics 1999) 2 3 4 22 60
  4. Genetic variation in COMT and PRODH is associated with brain anatomy in patients with schizophrenia. (PMID: 17504246) Zinkstok J … Linszen D (Genes, brain, and behavior 2008) 3 22 45 60
  5. Involvement of hyperprolinemia in cognitive and psychiatric features of the 22q11 deletion syndrome. (PMID: 17135275) Raux G … Campion D (Human molecular genetics 2007) 3 4 22 60

Products for PRODH Gene

Sources for PRODH Gene

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