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Aliases for BTNL2 Gene

Aliases for BTNL2 Gene

  • Butyrophilin-Like 2 2 3
  • Butyrophilin-Like 2 (MHC Class II Associated) 2 3
  • BTL-II 3 4
  • SS2 3 6
  • Butyrophilin-Like Protein 2 3
  • HSBLMHC1 3
  • BTN7 3

External Ids for BTNL2 Gene

Previous GeneCards Identifiers for BTNL2 Gene

  • GC06M032389
  • GC06M032133
  • GC06M032433
  • GC06M032470

Summaries for BTNL2 Gene

GeneCards Summary for BTNL2 Gene

BTNL2 (Butyrophilin-Like 2) is a Protein Coding gene. Diseases associated with BTNL2 include sarcoidosis 2 and sarcoidosis 1. An important paralog of this gene is BTNL9.

UniProtKB/Swiss-Prot for BTNL2 Gene

  • Negative regulator of T-cell proliferation.

Gene Wiki entry for BTNL2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for BTNL2 Gene

Genomics for BTNL2 Gene

Regulatory Elements for BTNL2 Gene

Genomic Location for BTNL2 Gene

32,393,963 bp from pter
32,407,128 bp from pter
13,166 bases
Minus strand

Genomic View for BTNL2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for BTNL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Proteins for BTNL2 Gene

  • Protein details for BTNL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Butyrophilin-like protein 2
    Protein Accession:
    Secondary Accessions:
    • A0PJV5
    • B0UYW9
    • B0V0N6
    • O98261
    • Q08E96
    • Q58R22
    • Q58R23
    • Q5JYF9
    • Q5MP42
    • Q5MP43
    • Q5RIF8
    • Q5SP08
    • Q5SP09
    • Q5SRW3
    • Q5SRW4
    • Q5SU36
    • Q95HK0

    Protein attributes for BTNL2 Gene

    455 amino acids
    Molecular mass:
    50436 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for BTNL2 Gene

neXtProt entry for BTNL2 Gene

Proteomics data for BTNL2 Gene at MOPED

Post-translational modifications for BTNL2 Gene

  • Glycosylation at Asn210 and Asn427
  • Modification sites at PhosphoSitePlus

Other Protein References for BTNL2 Gene

No data available for DME Specific Peptides for BTNL2 Gene

Domains for BTNL2 Gene

Gene Families for BTNL2 Gene

  • BTN :Butyrophilins
  • C2SET :Immunoglobulin superfamily / C2-set domain containing
  • VSET :Immunoglobulin superfamily / V-set domain containing

Protein Domains for BTNL2 Gene

Graphical View of Domain Structure for InterPro Entry



  • Q9UIR0
  • Contains 3 Ig-like V-type (immunoglobulin-like) domains.
  • Belongs to the immunoglobulin superfamily. BTN/MOG family.
genes like me logo Genes that share domains with BTNL2: view

Function for BTNL2 Gene

Molecular function for BTNL2 Gene

GENATLAS Biochemistry:
butyrophilin-like 7,B box family of proteins,involved in cell proliferation and development
UniProtKB/Swiss-Prot Function:
Negative regulator of T-cell proliferation.
UniProtKB/Swiss-Prot Induction:
By proinflammatory cytokines such as TNF and IL1B/interleukin-1 beta.

Gene Ontology (GO) - Molecular Function for BTNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding --
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with BTNL2: view

Phenotypes for BTNL2 Gene

GenomeRNAi human phenotypes for BTNL2:
genes like me logo Genes that share phenotypes with BTNL2: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTNL2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for BTNL2 Gene

Localization for BTNL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for BTNL2 Gene

Membrane; Single-pass type II membrane protein. Note=Isoform 2 is present in the nuclear, vesicle and plasma membranes, isoform 3 is found in cytoplasmic vesicle structures and is not membrane bound.

Subcellular locations from

Jensen Localization Image for BTNL2 Gene COMPARTMENTS Subcellular localization image for BTNL2 gene
Compartment Confidence
plasma membrane 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for BTNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with BTNL2: view

Pathways for BTNL2 Gene

SuperPathways for BTNL2 Gene

No Data Available

Interacting Proteins for BTNL2 Gene

Gene Ontology (GO) - Biological Process for BTNL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042102 positive regulation of T cell proliferation --
GO:0050860 negative regulation of T cell receptor signaling pathway --
GO:1900042 positive regulation of interleukin-2 secretion --
genes like me logo Genes that share ontologies with BTNL2: view

No data available for Pathways by source for BTNL2 Gene

Transcripts for BTNL2 Gene

mRNA/cDNA for BTNL2 Gene

(19) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for BTNL2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for BTNL2 Gene

No ASD Table

Relevant External Links for BTNL2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for BTNL2 Gene

mRNA expression in normal human tissues for BTNL2 Gene

Protein differential expression in normal tissues for BTNL2 Gene

This gene is overexpressed in Plasma (59.3) and Adipocyte (9.7).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for BTNL2 Gene

SOURCE GeneReport for Unigene cluster for BTNL2 Gene Hs.534471

mRNA Expression by UniProt/SwissProt for BTNL2 Gene

Tissue specificity: Expressed in brain, heart, kidney, liver, pancreas, ovary, leukocyte, small intestine, testis and thymus.
genes like me logo Genes that share expressions with BTNL2: view

Expression partners for BTNL2 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for BTNL2 Gene

Orthologs for BTNL2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for BTNL2 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia BTNL2 35
  • 80.43 (n)
  • 73.95 (a)
-- 36
  • 71 (a)
BTNL2 36
  • 66 (a)
(Canis familiaris)
Mammalia BTNL2 35
  • 81.82 (n)
  • 75.06 (a)
BTNL2 36
  • 73 (a)
(Mus musculus)
Mammalia Btnl2 35
  • 74.93 (n)
  • 63.94 (a)
Btnl2 16
Btnl2 36
  • 58 (a)
(Rattus norvegicus)
Mammalia Btnl2 35
  • 75.22 (n)
  • 65.93 (a)
(Monodelphis domestica)
Mammalia BTNL2 36
  • 27 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 22 (a)
-- 36
  • 32 (a)
-- 36
  • 17 (a)
-- 36
  • 37 (a)
-- 36
  • 13 (a)
-- 36
  • 21 (a)
-- 36
  • 14 (a)
-- 36
  • 32 (a)
-- 36
  • 18 (a)
-- 36
  • 34 (a)
-- 36
  • 22 (a)
-- 36
  • 33 (a)
-- 36
  • 41 (a)
-- 36
  • 39 (a)
-- 36
  • 35 (a)
-- 36
  • 42 (a)
-- 36
  • 22 (a)
-- 36
  • 19 (a)
-- 36
  • 16 (a)
-- 36
  • 33 (a)
-- 36
  • 15 (a)
-- 36
  • 37 (a)
-- 36
  • 14 (a)
-- 36
  • 32 (a)
-- 36
  • 28 (a)
Species with no ortholog for BTNL2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for BTNL2 Gene

Gene Tree for BTNL2 (if available)
Gene Tree for BTNL2 (if available)

Paralogs for BTNL2 Gene

Paralogs for BTNL2 Gene Pseudogenes for BTNL2 Gene

genes like me logo Genes that share paralogs with BTNL2: view

Variants for BTNL2 Gene

Sequence variations from dbSNP and Humsavar for BTNL2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1980493 -- 32,395,438(-) ATGGG(A/G)GCGCA intron-variant
rs2076526 -- 32,396,509(-) TGACC(C/T)TGAGC intron-variant
rs2076527 -- 32,396,437(-) ACATT(A/G)TTGGT intron-variant
rs2076528 -- 32,396,417(-) ATTCT(G/T)TCATT intron-variant
rs2076529 -- 32,396,178(-) ACTGT(A/G)CTGGT reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for BTNL2 Gene

Variant ID Type Subtype PubMed ID
nsv830630 CNV Loss 17160897
nsv7882 CNV Loss 18304495
dgv1011n67 CNV Loss 20364138
nsv884740 CNV Loss 21882294
nsv884741 CNV Loss 21882294
esv33644 CNV Loss 17666407
esv2731830 CNV Deletion 23290073
dgv1012n67 CNV Loss 20364138
dgv1930e1 CNV Complex 17122850
dgv1931e1 CNV Complex 17122850
nsv428142 CNV Gain+Loss 18775914

Relevant External Links for BTNL2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for BTNL2 Gene

Disorders for BTNL2 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for BTNL2 Gene in MalaCards »

(4) Diseases for BTNL2 Gene including...

(1) OMIM Diseases for BTNL2 Gene (606000)


  • Sarcoidosis 2 (SS2) [MIM:612387]: An idiopathic, systemic, inflammatory disease characterized by the formation of immune granulomas in involved organs. Granulomas predominantly invade the lungs and the lymphatic system, but also skin, liver, spleen, eyes and other organs may be involved. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry. A nucleotide transition affecting a splice donor site results in the use of an alternative splice site and the production of isoform 3. Individuals expressing isoform 3 have a higher risk for sarcoidosis.

(1) University of Copenhagen DISEASES for BTNL2 Gene

(1) Novoseek inferred disease relationships for BTNL2 Gene

Disease -log(P) Hits PubMed IDs
sarcoidosis 69.4 9

Relevant External Links for BTNL2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with BTNL2: view

No data available for Genatlas for BTNL2 Gene

Publications for BTNL2 Gene

  1. Sarcoidosis is associated with a truncating splice site mutation in BTNL2. (PMID: 15735647) Valentonyte R. … Schreiber S. (Nat. Genet. 2005) 2 3 4 23 48
  2. BTL-II: a polymorphic locus with homology to the butyrophilin gene family, located at the border of the major histocompatibility complex class II and class III regions in human and mouse. (PMID: 10803852) Stammers M. … Beck S. (Immunogenetics 2000) 2 3 4 23
  3. Confirmation of the novel association at the BTNL2 locus with ulcerative colitis. (PMID: 19659809) Pathan S. … Jewell D.P. (Tissue Antigens 2009) 3 23 48
  4. BTNL2 gene polymorphisms may be associated with susceptibility to Kawasaki disease and formation of coronary artery lesions in Taiwanese children. (PMID: 19882345) Hsueh K.C. … Tsai F.J. (Eur. J. Pediatr. 2010) 3 23 48
  5. Butyrophilin-like 2 gene is associated with ulcerative colitis in the Japanese under strong linkage disequilibrium with HLA-DRB1*1502. (PMID: 17610417) Mochida A. … Shimosegawa T. (Tissue Antigens 2007) 3 23 48

Products for BTNL2 Gene

Sources for BTNL2 Gene

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