Aliases for BTNL2 Gene
External Ids for BTNL2 Gene
Previous GeneCards Identifiers for BTNL2 Gene
This gene encodes a major histocompatibility complex, class II associated, type I transmembrane protein which belongs to the butyrophilin-like B7 family of immunoregulators. It is thought to be involved in immune surveillance, serving as a negative T-cell regulator by decreasing T-cell proliferation and cytokine release. The encoded protein contains an N-terminal signal peptide, two pairs of immunoglobulin-like domains, separated by a heptad peptide sequence, and a C-terminal transmembrane domain. Naturally occurring mutations in this gene are associated with sarcoidosis, rheumatoid arthritis, ulcerative colitis, inflammatory bowel disease, myositis, type 1 diabetes, systemic lupus erythematosus, acute coronary syndrome, and prostate cancer. [provided by RefSeq, May 2017]
GeneCards Summary for BTNL2 Gene
BTNL2 (Butyrophilin Like 2) is a Protein Coding gene. Diseases associated with BTNL2 include Sarcoidosis 2 and Sarcoidosis, Susceptibility 2. Among its related pathways are T Cell Co-Signaling Pathway: Ligand-Receptor Interactions and Butyrophilin (BTN) family interactions. GO annotations related to this gene include receptor binding. An important paralog of this gene is BTN1A1.
UniProtKB/Swiss-Prot for BTNL2 Gene
Negative regulator of T-cell proliferation.