Aliases for DNAJC3 Gene
- DnaJ (Hsp40) Homolog, Subfamily C, Member 3 2 3
- PRKRI 3 4 6
- Interferon-Induced, Double-Stranded RNA-Activated Protein Kinase Inhibitor 3 4
- Endoplasmic Reticulum DNA J Domain-Containing Protein 6 3 4
- Protein Kinase Inhibitor Of 58 KDa 3 4
- Protein Kinase Inhibitor P58 3 4
- ER-Resident Protein ERdj6 3 4
- P58IPK 3 4
External Ids for DNAJC3 Gene
Previous Symbols for DNAJC3 Gene
This gene encodes a protein with multiple tetratricopeptide repeat (TPR) motifs as well as the highly conserved J domain found in DNAJ chaperone family members. It is a member of the tetratricopeptide repeat family of proteins and acts as an inhibitor of the interferon-induced, dsRNA-activated protein kinase (PKR). [provided by RefSeq, Jul 2010]
GeneCards Summary for DNAJC3 Gene
DNAJC3 (DnaJ (Hsp40) Homolog, Subfamily C, Member 3) is a Protein Coding gene. Diseases associated with DNAJC3 include ataxia, combined cerebellar and peripheral, with hearing loss and diabetes mellitus. Among its related pathways are Disease and Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein. GO annotations related to this gene include protein kinase inhibitor activity. An important paralog of this gene is DNAJC7.
UniProtKB/Swiss-Prot for DNAJC3 Gene
Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.