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Aliases for PCDHGC4 Gene

Aliases for PCDHGC4 Gene

  • Protocadherin Gamma Subfamily C, 4 2 3
  • PCDH-GAMMA-C4 3 4
  • Protocadherin Gamma-C4 3

External Ids for PCDHGC4 Gene

Previous GeneCards Identifiers for PCDHGC4 Gene

  • GC05P140592
  • GC05P141320
  • GC05P140717
  • GC05P140775
  • GC05P140796
  • GC05P140735
  • GC05P140744
  • GC05P140819
  • GC05P140844
  • GC05P140861
  • GC05P140887
  • GC05P140909
  • GC05P140919
  • GC05P140941
  • GC05P140962
  • GC05P140984
  • GC05P141056
  • GC05P141077
  • GC05P136009
  • GC05P141125
  • GC05P141138
  • GC05P141190
  • GC05P141223
  • GC05P141263
  • GC05P141341
  • GC05P141397

Summaries for PCDHGC4 Gene

Entrez Gene Summary for PCDHGC4 Gene

  • This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PCDHGC4 Gene

PCDHGC4 (Protocadherin Gamma Subfamily C, 4) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding. An important paralog of this gene is PCDHGA11.

UniProtKB/Swiss-Prot for PCDHGC4 Gene

  • Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PCDHGC4 Gene

Genomics for PCDHGC4 Gene

Regulatory Elements for PCDHGC4 Gene

Genomic Location for PCDHGC4 Gene

141,484,997 bp from pter
141,512,979 bp from pter
27,983 bases
Plus strand

Genomic View for PCDHGC4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PCDHGC4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PCDHGC4 Gene

Proteins for PCDHGC4 Gene

  • Protein details for PCDHGC4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protocadherin gamma-C4
    Protein Accession:
    Secondary Accessions:
    • Q495T2
    • Q9Y5C3

    Protein attributes for PCDHGC4 Gene

    938 amino acids
    Molecular mass:
    101214 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for PCDHGC4 Gene


neXtProt entry for PCDHGC4 Gene

Proteomics data for PCDHGC4 Gene at MOPED

Post-translational modifications for PCDHGC4 Gene

  • Glycosylation at Asn265, Asn276, and Asn444
  • Modification sites at PhosphoSitePlus

Other Protein References for PCDHGC4 Gene

No data available for DME Specific Peptides for PCDHGC4 Gene

Domains for PCDHGC4 Gene

Gene Families for PCDHGC4 Gene

  • PCDHC :Cadherins / Protocadherins : Clustered

Protein Domains for PCDHGC4 Gene

Suggested Antigen Peptide Sequences for PCDHGC4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9Y5F7
  • Contains 6 cadherin domains.
genes like me logo Genes that share domains with PCDHGC4: view

Function for PCDHGC4 Gene

Molecular function for PCDHGC4 Gene

UniProtKB/Swiss-Prot Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain

Gene Ontology (GO) - Molecular Function for PCDHGC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with PCDHGC4: view

Animal Model Products

CRISPR Products

miRNA for PCDHGC4 Gene

miRTarBase miRNAs that target PCDHGC4

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHGC4

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for PCDHGC4 Gene

Localization for PCDHGC4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PCDHGC4 Gene

Cell membrane; Single-pass type I membrane protein.

Subcellular locations from

Jensen Localization Image for PCDHGC4 Gene COMPARTMENTS Subcellular localization image for PCDHGC4 gene
Compartment Confidence
plasma membrane 5
cytosol 1
extracellular 1
lysosome 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PCDHGC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with PCDHGC4: view

Pathways for PCDHGC4 Gene

SuperPathways for PCDHGC4 Gene

No Data Available

Interacting Proteins for PCDHGC4 Gene

Gene Ontology (GO) - Biological Process for PCDHGC4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules IEA --
genes like me logo Genes that share ontologies with PCDHGC4: view

No data available for Pathways by source for PCDHGC4 Gene

Compounds for PCDHGC4 Gene

(1) HMDB Compounds for PCDHGC4 Gene

Compound Synonyms Cas Number PubMed IDs
  • Ca
genes like me logo Genes that share compounds with PCDHGC4: view

Transcripts for PCDHGC4 Gene

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PCDHGC4

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PCDHGC4
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PCDHGC4 Gene

No ASD Table

Relevant External Links for PCDHGC4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PCDHGC4 Gene

mRNA expression in normal human tissues for PCDHGC4 Gene

mRNA differential expression in normal tissues according to GTEx for PCDHGC4 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (11.4) and Brain - Cerebellum (8.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PCDHGC4 Gene

genes like me logo Genes that share expressions with PCDHGC4: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for PCDHGC4 Gene

Orthologs for PCDHGC4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for PCDHGC4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 33 (a)
  • 99.68 (n)
  • 99.89 (a)
(Bos Taurus)
Mammalia -- 36
  • 33 (a)
(Canis familiaris)
Mammalia -- 36
  • 31 (a)
(Mus musculus)
Mammalia Pcdhgc4 35
  • 91.22 (n)
  • 98.19 (a)
Pcdhgc4 16
(Gallus gallus)
Aves PCDH10 36
  • 33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491009 35
  • 52.47 (n)
  • 46.63 (a)
(Danio rerio)
Actinopterygii BX119910.3 36
  • 42 (a)
BX119910.4 36
  • 42 (a)
BX119910.4 36
  • 41 (a)
BX119910.6 36
  • 42 (a)
BX119910.9 36
  • 41 (a)
pcdh1g22 36
  • 41 (a)
pcdh1g26 36
  • 43 (a)
pcdh1g32 36
  • 42 (a)
pcdh1gc5 36
  • 39 (a)
zgc:162322 36
  • 42 (a)
Species with no ortholog for PCDHGC4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PCDHGC4 Gene

Gene Tree for PCDHGC4 (if available)
Gene Tree for PCDHGC4 (if available)

Paralogs for PCDHGC4 Gene

genes like me logo Genes that share paralogs with PCDHGC4: view

Variants for PCDHGC4 Gene

Structural Variations from Database of Genomic Variants (DGV) for PCDHGC4 Gene

Variant ID Type Subtype PubMed ID
dgv6352n71 CNV Loss 21882294
nsv462470 CNV Loss 19166990
esv25744 CNV Gain 19812545

Relevant External Links for PCDHGC4 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for PCDHGC4 Gene

Disorders for PCDHGC4 Gene

Relevant External Links for PCDHGC4

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with PCDHGC4: view

No data available for UniProtKB/Swiss-Prot for PCDHGC4 Gene

Publications for PCDHGC4 Gene

  1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PMID: 10380929) Wu Q. … Maniatis T. (Cell 1999) 2 3 4
  2. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PMID: 10716726) Wu Q. … Maniatis T. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3
  3. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PMID: 10817752) Yagi T. … Takeichi M. (Genes Dev. 2000) 3
  4. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PMID: 10835267) Nollet F. … van Roy F. (J. Mol. Biol. 2000) 3
  5. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PMID: 11230163) Wu Q. … Maniatis T. (Genome Res. 2001) 3

Products for PCDHGC4 Gene

Sources for PCDHGC4 Gene

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