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Aliases for MAP2K5 Gene

Aliases for MAP2K5 Gene

  • Mitogen-Activated Protein Kinase Kinase 5 2 3
  • PRKMK5 3 4 6
  • MEK5 3 4 6
  • MAP Kinase Kinase 5 3 4
  • MAPK/ERK Kinase 5 3 4
  • EC 4 63
  • MAPKK 5 3 4
  • MAPKK5 3 6
  • MEK 5 3 4
  • Dual Specificity Mitogen-Activated Protein Kinase Kinase 5 3
  • MAP Kinase Kinase MEK5b 3
  • HsT17454 3
  • MKK5 4

External Ids for MAP2K5 Gene

Previous HGNC Symbols for MAP2K5 Gene

  • PRKMK5

Previous GeneCards Identifiers for MAP2K5 Gene

  • GC15P063628
  • GC15P060933
  • GC15P065413
  • GC15P065550
  • GC15P065622
  • GC15P067835
  • GC15P044669

Summaries for MAP2K5 Gene

Entrez Gene Summary for MAP2K5 Gene

  • The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]

GeneCards Summary for MAP2K5 Gene

MAP2K5 (Mitogen-Activated Protein Kinase Kinase 5) is a Protein Coding gene. Diseases associated with MAP2K5 include developmental coordination disorder. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and protein tyrosine kinase activity. An important paralog of this gene is MAP2K7.

UniProtKB/Swiss-Prot for MAP2K5 Gene

  • Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

Gene Wiki entry for MAP2K5 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAP2K5 Gene

Genomics for MAP2K5 Gene

Regulatory Elements for MAP2K5 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAP2K5 Gene

67,542,683 bp from pter
67,807,123 bp from pter
264,441 bases
Plus strand

Genomic View for MAP2K5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAP2K5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAP2K5 Gene

Proteins for MAP2K5 Gene

  • Protein details for MAP2K5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dual specificity mitogen-activated protein kinase kinase 5
    Protein Accession:
    Secondary Accessions:
    • B4DE43
    • Q92961
    • Q92962

    Protein attributes for MAP2K5 Gene

    448 amino acids
    Molecular mass:
    50112 Da
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). Interacts with Yersinia yopJ.

    Three dimensional structures from OCA and Proteopedia for MAP2K5 Gene

    Alternative splice isoforms for MAP2K5 Gene


neXtProt entry for MAP2K5 Gene

Proteomics data for MAP2K5 Gene at MOPED

Selected DME Specific Peptides for MAP2K5 Gene

Post-translational modifications for MAP2K5 Gene

  • Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases.
  • Yersinia yopJ may acetylate Ser/Thr residues, preventing phosphorylation and activation, thus blocking the MAPK signaling pathway.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAP2K5 Gene

Antibody Products

Domains for MAP2K5 Gene

Gene Families for MAP2K5 Gene

  • MAP2K :Mitogen-activated protein kinase cascade / Kinase kinases

Graphical View of Domain Structure for InterPro Entry



  • Q13163
  • Binds MAP3K2/MAP3K3 and MAPK7 via non-overlapping residues of the PB1 domain. This domain also mediates interactions with SQSTM1 and PARD6A (By similarity).
  • Contains 1 PB1 domain.
  • Contains 1 protein kinase domain.
  • Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily.
genes like me logo Genes that share domains with MAP2K5: view

Function for MAP2K5 Gene

Molecular function for MAP2K5 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis.

Enzyme Numbers (IUBMB) for MAP2K5 Gene

Gene Ontology (GO) - Molecular Function for MAP2K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity TAS 7759517
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004708 MAP kinase kinase activity IBA --
GO:0004713 protein tyrosine kinase activity IEA --
GO:0005515 protein binding IPI 14743216
genes like me logo Genes that share ontologies with MAP2K5: view
genes like me logo Genes that share phenotypes with MAP2K5: view

Animal Model Products

CRISPR Products

miRNA for MAP2K5 Gene

miRTarBase miRNAs that target MAP2K5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP2K5

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for MAP2K5 Gene

Localization for MAP2K5 Gene

Subcellular locations from

Jensen Localization Image for MAP2K5 Gene COMPARTMENTS Subcellular localization image for MAP2K5 gene
Compartment Confidence
cytoskeleton 2
cytosol 2
extracellular 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for MAP2K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA --
GO:0005634 nucleus IEA --
GO:0005819 spindle IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with MAP2K5: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for MAP2K5 Gene

Pathways for MAP2K5 Gene

genes like me logo Genes that share pathways with MAP2K5: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for MAP2K5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter ISS --
GO:0000165 MAPK cascade --
GO:0000187 activation of MAPK activity ISS 20551324
GO:0006468 protein phosphorylation --
GO:0007165 signal transduction TAS 7759517
genes like me logo Genes that share ontologies with MAP2K5: view

Compounds for MAP2K5 Gene

(3) HMDB Compounds for MAP2K5 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
  • adenosindiphosphorsaeure
  • Magnesium

(2) Novoseek inferred chemical compound relationships for MAP2K5 Gene

Compound -log(P) Hits PubMed IDs
pd-184352 88.1 2
pd 98,059 49.7 1
genes like me logo Genes that share compounds with MAP2K5: view

Transcripts for MAP2K5 Gene

Unigene Clusters for MAP2K5 Gene

Mitogen-activated protein kinase kinase 5:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for MAP2K5

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAP2K5 Gene

No ASD Table

Relevant External Links for MAP2K5 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for MAP2K5 Gene

mRNA expression in normal human tissues for MAP2K5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAP2K5 Gene

SOURCE GeneReport for Unigene cluster for MAP2K5 Gene Hs.114198

mRNA Expression by UniProt/SwissProt for MAP2K5 Gene

Tissue specificity: Expressed in many adult tissues. Abundant in heart and skeletal muscle
genes like me logo Genes that share expressions with MAP2K5: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for MAP2K5 Gene

Orthologs for MAP2K5 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAP2K5 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia MAP2K5 35
  • 99.85 (n)
  • 100 (a)
MAP2K5 36
  • 100 (a)
(Bos Taurus)
Mammalia MAP2K5 35
  • 95.24 (n)
  • 98.88 (a)
MAP2K5 36
  • 99 (a)
(Canis familiaris)
Mammalia MAP2K5 35
  • 95.83 (n)
  • 98.66 (a)
MAP2K5 36
  • 96 (a)
(Mus musculus)
Mammalia Map2k5 35
  • 91.07 (n)
  • 97.77 (a)
Map2k5 16
Map2k5 36
  • 98 (a)
(Monodelphis domestica)
Mammalia MAP2K5 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia MAP2K5 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Map2k5 35
  • 91.37 (n)
  • 98.21 (a)
(Gallus gallus)
Aves MAP2K5 35
  • 85 (n)
  • 94.3 (a)
MAP2K5 36
  • 78 (a)
(Anolis carolinensis)
Reptilia MAP2K5 36
  • 91 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13316 35
tropical clawed frog
(Silurana tropicalis)
Amphibia map2k5 35
  • 77.35 (n)
  • 85.2 (a)
Str.18661 35
(Danio rerio)
Actinopterygii map2k5 35
  • 72 (n)
  • 78.83 (a)
map2k5 36
  • 78 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MKK1 38
PBS2 36
  • 24 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 46 (a)
Species with no ortholog for MAP2K5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for MAP2K5 Gene

Gene Tree for MAP2K5 (if available)
Gene Tree for MAP2K5 (if available)

Paralogs for MAP2K5 Gene

Paralogs for MAP2K5 Gene

genes like me logo Genes that share paralogs with MAP2K5: view

Variants for MAP2K5 Gene

Sequence variations from dbSNP and Humsavar for MAP2K5 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs14429 -- 67,806,716(+) GGCGC(A/T)GGAGG missense, reference
rs737226 -- 67,548,435(-) CTGGA(A/G)TATTA upstream-variant-2KB, intron-variant
rs737227 -- 67,548,571(-) TCACT(G/T)TCCTC upstream-variant-2KB, intron-variant
rs745212 -- 67,767,841(+) CCTGC(A/G)TGTAA intron-variant
rs745213 -- 67,768,051(+) TTCGG(G/T)GTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for MAP2K5 Gene

Variant ID Type Subtype PubMed ID
esv2749801 CNV Deletion 23290073
esv2671430 CNV Deletion 23128226
nsv827374 CNV Loss 20364138
esv27062 CNV Loss 19812545
esv2571443 CNV Insertion 19546169
esv2749802 CNV Deletion 23290073
nsv94879 CNV Loss 16902084
esv2749803 CNV Deletion 23290073
esv1090385 CNV Deletion 17803354
esv1001492 CNV Deletion 20482838
nsv1576 CNV Loss 18451855
esv2749804 CNV Deletion 23290073
esv2749805 CNV Deletion 23290073
esv2352022 CNV Deletion 18987734
esv2749806 CNV Deletion 23290073
esv991898 CNV Deletion 20482838
esv2749809 CNV Deletion 23290073
esv1065122 CNV Deletion 17803354

Relevant External Links for MAP2K5 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAP2K5 Gene

Disorders for MAP2K5 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for MAP2K5 Gene including...

Search for MAP2K5 Gene in MalaCards »

(1) University of Copenhagen DISEASES for MAP2K5 Gene

(6) Novoseek inferred disease relationships for MAP2K5 Gene

Disease -log(P) Hits PubMed IDs
prostate cancer 24 11
breast cancer 17.5 3
metastasis 13.3 1
breast carcinoma 13.3 5
tumors 11.8 2

Relevant External Links for MAP2K5

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with MAP2K5: view

No data available for UniProtKB/Swiss-Prot for MAP2K5 Gene

Publications for MAP2K5 Gene

  1. Components of a new human protein kinase signal transduction pathway. (PMID: 7759517) Zhou G. … Dixon J.E. (J. Biol. Chem. 1995) 2 3 4 23
  2. Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray. (PMID: 12219026) Weldon C.B. … Burow M.E. (Surgery 2002) 3 23
  3. MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion. (PMID: 12618764) Mehta P.B. … Leung H.Y. (Oncogene 2003) 3 23
  4. Mutations in protein kinase subdomain X differentially affect MEKK2 and MEKK1 activity. (PMID: 12659851) Huang J. … Lee F.S. (Biochem. Biophys. Res. Commun. 2003) 3 23
  5. Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. (PMID: 12813044) Lamark T. … Johansen T. (J. Biol. Chem. 2003) 3 23

Products for MAP2K5 Gene

Sources for MAP2K5 Gene

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