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Aliases for MAPK13 Gene

Aliases for MAPK13 Gene

  • Mitogen-Activated Protein Kinase 13 2 3
  • Mitogen-Activated Protein Kinase P38 Delta 3 4
  • Stress-Activated Protein Kinase 4 3 4
  • MAP Kinase P38 Delta 3 4
  • MAP Kinase 13 3 4
  • EC 2.7.11.24 4 64
  • MAPK 13 3 4
  • PRKM13 3 4
  • SAPK4 3 4
  • EC 2.7.11 64
  • P38delta 3
  • MAPK-13 3

External Ids for MAPK13 Gene

Previous Symbols for MAPK13 Gene

  • PRKM13

Summaries for MAPK13 Gene

Entrez Gene Summary for MAPK13 Gene

  • This gene encodes a member of the mitogen-activated protein (MAP) kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The encoded protein is a p38 MAP kinase and is activated by proinflammatory cytokines and cellular stress. Substrates of the encoded protein include the transcription factor ATF2 and the microtubule dynamics regulator stathmin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

GeneCards Summary for MAPK13 Gene

MAPK13 (Mitogen-Activated Protein Kinase 13) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein serine/threonine kinase activity and MAP kinase activity. An important paralog of this gene is MAPK11.

UniProtKB/Swiss-Prot for MAPK13 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

Gene Wiki entry for MAPK13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK13 Gene

Genomics for MAPK13 Gene

Genomic Location for MAPK13 Gene

Start:
36,127,809 bp from pter
End:
36,144,524 bp from pter
Size:
16,716 bases
Orientation:
Plus strand

Genomic View for MAPK13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPK13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK13 Gene

Regulatory Elements for MAPK13 Gene

Proteins for MAPK13 Gene

  • Protein details for MAPK13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15264-MK13_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 13
    Protein Accession:
    O15264
    Secondary Accessions:
    • O14739
    • O15124
    • Q5U4A5
    • Q6FI46
    • Q9UNU0

    Protein attributes for MAPK13 Gene

    Size:
    365 amino acids
    Molecular mass:
    42090 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MAPK8IP2.

    Three dimensional structures from OCA and Proteopedia for MAPK13 Gene

    Alternative splice isoforms for MAPK13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK13 Gene

Proteomics data for MAPK13 Gene at MOPED

Post-translational modifications for MAPK13 Gene

  • Dually phosphorylated on Thr-180 and Tyr-182 by MAP2K3/MKK3, MAP2K4/MKK4, MAP2K6/MKK6 and MAP2K7/MKK7, which activates the enzyme. Dephosphorylated by dual specificity phosphatase DUSP1.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for MAPK13 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for MAPK13 Gene

Gene Families for MAPK13 Gene

UniProtKB/Swiss-Prot:

MK13_HUMAN
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases:
    • O15264
  • Contains 1 protein kinase domain.:
    • O15264
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.:
    • O15264
genes like me logo Genes that share domains with MAPK13: view

Function for MAPK13 Gene

Molecular function for MAPK13 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on threonine and tyrosine by dual specificity kinases, MAP2K3/MKK3, MAP2K6/MKK6, MAP2K4/MKK4 and MAP2K7/MKK7. Activation by ultraviolet radiation, hyperosmotic shock, anisomycin or by TNF-alpha is mediated by MAP2K3/MKK3. Inhibited by dual specificity phosphatase DUSP1.
UniProtKB/Swiss-Prot Function: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK13 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each. MAPK13 is one of the less studied p38 MAPK isoforms. Some of the targets are downstream kinases such as MAPKAPK2, which are activated through phosphorylation and further phosphorylate additional targets. Plays a role in the regulation of protein translation by phosphorylating and inactivating EEF2K. Involved in cytoskeletal remodeling through phosphorylation of MAPT and STMN1. Mediates UV irradiation induced up-regulation of the gene expression of CXCL14. Plays an important role in the regulation of epidermal keratinocyte differentiation, apoptosis and skin tumor development. Phosphorylates the transcriptional activator MYB in response to stress which leads to rapid MYB degradation via a proteasome-dependent pathway. MAPK13 also phosphorylates and down-regulates PRKD1 during regulation of insulin secretion in pancreatic beta cells.

Enzyme Numbers (IUBMB) for MAPK13 Gene

Gene Ontology (GO) - Molecular Function for MAPK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 12244047
GO:0004707 MAP kinase activity IDA 9218798
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 19135240
genes like me logo Genes that share ontologies with MAPK13: view
genes like me logo Genes that share phenotypes with MAPK13: view

Animal Models for MAPK13 Gene

MGI Knock Outs for MAPK13:

No data available for miRNA , Transcription Factor Targeting and HOMER Transcription for MAPK13 Gene

Localization for MAPK13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK13 Gene COMPARTMENTS Subcellular localization image for MAPK13 gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1
extracellular 1

Gene Ontology (GO) - Cellular Components for MAPK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with MAPK13: view

Pathways for MAPK13 Gene

genes like me logo Genes that share pathways with MAPK13: view

Pathways by source for MAPK13 Gene

Gene Ontology (GO) - Biological Process for MAPK13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006468 protein phosphorylation --
GO:0006950 response to stress IDA 9218798
genes like me logo Genes that share ontologies with MAPK13: view

Compounds for MAPK13 Gene

(3) HMDB Compounds for MAPK13 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4

(6) Novoseek inferred chemical compound relationships for MAPK13 Gene

Compound -log(P) Hits PubMed IDs
pyridinylimidazole 88.2 1
sb 203580 54.2 2
12-o-tetradecanoylphorbol 13-acetate 41.2 1
okadaic acid 32.8 2
serine 17.1 1
genes like me logo Genes that share compounds with MAPK13: view

Transcripts for MAPK13 Gene

Unigene Clusters for MAPK13 Gene

Mitogen-activated protein kinase 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK13 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d ^ 14
SP1: - - -
SP2: - - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - - - - -
SP6: - - - -
SP7:
SP8: - - -
SP9:

Relevant External Links for MAPK13 Gene

GeneLoc Exon Structure for
MAPK13
ECgene alternative splicing isoforms for
MAPK13

Expression for MAPK13 Gene

mRNA expression in normal human tissues for MAPK13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for MAPK13 Gene

This gene is overexpressed in Esophagus - Mucosa (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK13 Gene

SOURCE GeneReport for Unigene cluster for MAPK13 Gene Hs.178695

mRNA Expression by UniProt/SwissProt for MAPK13 Gene

O15264-MK13_HUMAN
Tissue specificity: Expressed in testes, pancreas, small intestine, lung and kidney. Abundant in macrophages, also present in neutrophils, CD4+ T-cells, and endothelial cells.
genes like me logo Genes that share expressions with MAPK13: view

Orthologs for MAPK13 Gene

This gene was present in the common ancestor of animals.

Orthologs for MAPK13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia MAPK13 36
  • 99.73 (n)
  • 99.72 (a)
MAPK13 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MAPK13 36
  • 92.24 (n)
  • 95.07 (a)
MAPK13 37
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK13 36
  • 91.96 (n)
  • 94.25 (a)
MAPK13 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk13 36
  • 88.13 (n)
  • 93.15 (a)
Mapk13 16
Mapk13 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia MAPK13 37
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK13 37
  • 84 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk13 36
  • 88.13 (n)
  • 92.6 (a)
chicken
(Gallus gallus)
Aves MAPK13 36
  • 76.26 (n)
  • 79.45 (a)
MAPK13 37
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK13 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk13 36
  • 68.5 (n)
  • 76.1 (a)
Str.3065 36
zebrafish
(Danio rerio)
Actinopterygii mapk13 36
  • 65.63 (n)
  • 66.76 (a)
mapk13 37
  • 66 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Mpk2 38
  • 57 (a)
p38b 38
  • 58 (a)
p38c 38
  • 42 (a)
worm
(Caenorhabditis elegans)
Secernentea Y51B9A.9 38
  • 31 (a)
pmk-3 38
  • 38 (a)
C49C3.10a 38
  • 28 (a)
F09C12.2 38
  • 40 (a)
pmk-1 38
  • 56 (a)
C49C3.10b 38
  • 30 (a)
Species with no ortholog for MAPK13:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK13 Gene

ENSEMBL:
Gene Tree for MAPK13 (if available)
TreeFam:
Gene Tree for MAPK13 (if available)

Paralogs for MAPK13 Gene

Paralogs for MAPK13 Gene

genes like me logo Genes that share paralogs with MAPK13: view

Variants for MAPK13 Gene

Sequence variations from dbSNP and Humsavar for MAPK13 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs763096 -- 36,132,892(-) AGCAC(C/T)CCACA intron-variant
rs1059227 -- 36,130,633(+) AAGAC(A/C)GCCTG reference, synonymous-codon, nc-transcript-variant
rs1136549 -- 36,139,966(+) GGCCC(A/C)CCCTA utr-variant-3-prime, nc-transcript-variant
rs1476031 -- 36,136,706(-) ACCAC(A/G)TAGCC reference, synonymous-codon, nc-transcript-variant
rs2007683 -- 36,133,785(-) TCAAT(A/G)CTATC intron-variant

Relevant External Links for MAPK13 Gene

HapMap Linkage Disequilibrium report
MAPK13

No data available for Structural Variations from Database of Genomic Variants (DGV) for MAPK13 Gene

Disorders for MAPK13 Gene

(2) Novoseek inferred disease relationships for MAPK13 Gene

Disease -log(P) Hits PubMed IDs
inflammation 23 2
tumors 0 2

Relevant External Links for MAPK13

Genetic Association Database (GAD)
MAPK13
Human Genome Epidemiology (HuGE) Navigator
MAPK13
genes like me logo Genes that share disorders with MAPK13: view

No data available for UniProtKB/Swiss-Prot for MAPK13 Gene

Publications for MAPK13 Gene

  1. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. (PMID: 9218798) Goedert M. … Cohen P. (EMBO J. 1997) 2 3 4 23
  2. Molecular cloning and characterization of a novel p38 mitogen- activated protein kinase. (PMID: 9295308) Wang X.S. … Yao Z. (J. Biol. Chem. 1997) 2 3 4 23
  3. Characterization of the structure and function of the fourth member of p38 group mitogen-activated protein kinases, p38delta. (PMID: 9374491) Jiang Y. … Han J. (J. Biol. Chem. 1997) 3 4 23
  4. Murine p38-delta mitogen-activated protein kinase, a developmentally regulated protein kinase that is activated by stress and proinflammatory cytokines. (PMID: 10066767) Hu M.C.-T. … Tan T.-H. (J. Biol. Chem. 1999) 3 4 23
  5. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages. (PMID: 10201954) Hale K.K. … Manthey C.L. (J. Immunol. 1999) 3 4 23

Products for MAPK13 Gene

Sources for MAPK13 Gene

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