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Aliases for MAPK10 Gene

Aliases for MAPK10 Gene

  • Mitogen-Activated Protein Kinase 10 2 3 5
  • Stress-Activated Protein Kinase JNK3 3 4
  • Stress-Activated Protein Kinase 1b 3 4
  • C-Jun N-Terminal Kinase 3 3 4
  • MAP Kinase P49 3F12 3 4
  • MAP Kinase 10 3 4
  • EC 2.7.11.24 4 63
  • MAPK 10 3 4
  • PRKM10 3 4
  • SAPK1b 3 4
  • JNK3A 3 4
  • JNK3 3 4
  • Stress Activated Protein Kinase Beta 3
  • JNK3 Alpha Protein Kinase 3
  • EC 2.7.11 63
  • P54bSAPK 3
  • P493F12 3

External Ids for MAPK10 Gene

Previous HGNC Symbols for MAPK10 Gene

  • PRKM10

Previous GeneCards Identifiers for MAPK10 Gene

  • GC04M086878
  • GC04M087239
  • GC04M087396
  • GC04M087294
  • GC04M087156
  • GC04M082680
  • GC04M086936

Summaries for MAPK10 Gene

Entrez Gene Summary for MAPK10 Gene

  • The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as integration points for multiple biochemical signals and are involved in a wide variety of cellular processes, such as proliferation, differentiation, transcription regulation and development. This kinase is specifically expressed in a subset of neurons in the nervous system and is activated by threonine and tyrosine phosphorylation. Targeted deletion of this gene in mice suggests that it may have a role in stress-induced neuronal apoptosis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015]

GeneCards Summary for MAPK10 Gene

MAPK10 (Mitogen-Activated Protein Kinase 10) is a Protein Coding gene. Diseases associated with MAPK10 include lennox-gastaut syndrome and pertussis. Among its related pathways are Adipocytokine signaling pathway and AGE-RAGE signaling pathway in diabetic complications. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is MAPK11.

UniProtKB/Swiss-Prot for MAPK10 Gene

  • Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).

Tocris Summary for MAPK10 Gene

  • MAPKs (mitogen-activated protein kinases) are serine-threonine kinases that regulate a wide variety of cellular functions.

Gene Wiki entry for MAPK10 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK10 Gene

Genomics for MAPK10 Gene

Regulatory Elements for MAPK10 Gene

Enhancers for MAPK10 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around MAPK10 on UCSC Golden Path with GeneCards custom track

Promoters for MAPK10 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around MAPK10 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the MAPK10 gene promoter:

Genomic Location for MAPK10 Gene

Chromosome:
4
Start:
86,012,299 bp from pter
End:
86,594,131 bp from pter
Size:
581,833 bases
Orientation:
Minus strand

Genomic View for MAPK10 Gene

Genes around MAPK10 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
MAPK10 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for MAPK10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK10 Gene

Proteins for MAPK10 Gene

  • Protein details for MAPK10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P53779-MK10_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 10
    Protein Accession:
    P53779
    Secondary Accessions:
    • A6NFS3
    • A6NG28
    • B3KQ94
    • Q15707
    • Q49AP1

    Protein attributes for MAPK10 Gene

    Size:
    464 amino acids
    Molecular mass:
    52585 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts with MAPKBP1 (By similarity). Binds to at least four scaffolding proteins, MAPK8IP1/JIP-1, MAPK8IP2/JIP-2, MAPK8IP3/JIP-3/JSAP1 and SPAG9/MAPK8IP4/JIP-4. These proteins also bind other components of the JNK signaling pathway. Interacts with HDAC9. Interacts with ARRB2; the interaction enhances MAPK10 activation by MAP3K5. Interacts with SARM1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for MAPK10 Gene

    Alternative splice isoforms for MAPK10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK10 Gene

Proteomics data for MAPK10 Gene at MOPED

Post-translational modifications for MAPK10 Gene

  • Dually phosphorylated on Thr-221 and Tyr-223 by MAP2K4 and MAP2K7, which activates the enzyme. MAP2K7 shows a strong preference for Thr-221 while MAP2K4 phosphorylates Tyr-223 preferentially. Weakly autophosphorylated on threonine and tyrosine residues in vitro.
  • Palmitoylation regulates subcellular location and axonal development.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPK10 (JNK3)

Domains & Families for MAPK10 Gene

Graphical View of Domain Structure for InterPro Entry

P53779

UniProtKB/Swiss-Prot:

MK10_HUMAN :
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK10: view

Function for MAPK10 Gene

Molecular function for MAPK10 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by threonine and tyrosine phosphorylation by two dual specificity kinases, MAP2K4 and MAP2K7. MAP2K7 phosphorylates MAPK10 on Thr-221 causing a conformational change and a large increase in Vmax. MAP2K4 then phosphorylates Tyr-223 resulting in a further increase in Vmax. Inhibited by dual specificity phosphatases, such as DUSP1. Inhibited by HDAC9.
UniProtKB/Swiss-Prot Function:
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).

Enzyme Numbers (IUBMB) for MAPK10 Gene

Gene Ontology (GO) - Molecular Function for MAPK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004705 JUN kinase activity ISS 8654373
genes like me logo Genes that share ontologies with MAPK10: view
genes like me logo Genes that share phenotypes with MAPK10: view

Human Phenotype Ontology for MAPK10 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for MAPK10 Gene

MGI Knock Outs for MAPK10:

Animal Model Products

CRISPR Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for MAPK10 Gene

Localization for MAPK10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK10 Gene

Cytoplasm. Membrane; Lipid-anchor. Nucleus. Mitochondrion. Note=Palmitoylation regulates MAPK10 trafficking to cytoskeleton. Recruited to the mitochondria in the presence of SARM1 (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK10 Gene COMPARTMENTS Subcellular localization image for MAPK10 gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
plasma membrane 5
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for MAPK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0005739 mitochondrion ISS --
genes like me logo Genes that share ontologies with MAPK10: view

Pathways & Interactions for MAPK10 Gene

SuperPathways for MAPK10 Gene

Superpath Contained pathways
1 MyD88 cascade initiated on plasma membrane
2 IL-2 Pathway
3 Toll-Like receptor Signaling Pathways
4 4-1BB Pathway
5 GPCR Pathway
genes like me logo Genes that share pathways with MAPK10: view

Pathways by source for MAPK10 Gene

SIGNOR curated interactions for MAPK10 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for MAPK10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 7826642
GO:0002224 toll-like receptor signaling pathway TAS --
GO:0002755 MyD88-dependent toll-like receptor signaling pathway TAS --
GO:0002756 MyD88-independent toll-like receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IEA,ISS --
genes like me logo Genes that share ontologies with MAPK10: view

Drugs & Compounds for MAPK10 Gene

(96) Drugs for MAPK10 Gene - From: DrugBank, ApexBio, DGIdb, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
anisomycin Experimental Pharma JNK, SAPK and p38 activator 0
(3E)-5-fluoro-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-1H-indole-2,3-dione 3-oxime Experimental Pharma Target 0
(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-[(E)-2-phenylethenyl]-1H-indole-2,3-dione 3-oxime Experimental Pharma Target 0
(3Z)-1-[(6-fluoro-4H-1,3-benzodioxin-8-yl)methyl]-4-phenyl-1H-indole-2,3-dione 3-oxime Experimental Pharma Target 0

(72) Additional Compounds for MAPK10 Gene - From: HMDB, Novoseek, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
AEG 3482
63735-71-7
c-JUN peptide
610273-01-3
JIP-1 (153-163)
438567-88-5

(5) Tocris Compounds for MAPK10 Gene

Compound Action Cas Number
AEG 3482 Inhibitor of JNK signaling 63735-71-7
Anisomycin JNK, SAPK and p38 activator 22862-76-6
c-JUN peptide Peptide inhibitor of JNK/c-Jun interaction 610273-01-3
JIP-1 (153-163) JNK-selective inhibitor peptide 438567-88-5
SP 600125 Selective JNK inhibitor 129-56-6

(2) ApexBio Compounds for MAPK10 Gene

Compound Action Cas Number
JNK-IN-7 Selective JNK inhibitor 1408064-71-0
JNK-IN-8 JNK inhibitor, selective and irreversible 1410880-22-6
genes like me logo Genes that share compounds with MAPK10: view

Drug Products

Transcripts for MAPK10 Gene

Unigene Clusters for MAPK10 Gene

Mitogen-activated protein kinase 10:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK10 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - -
SP6: - - - - -
SP7: - - - - -
SP8: - -
SP9:
SP10:
SP11: -

Relevant External Links for MAPK10 Gene

GeneLoc Exon Structure for
MAPK10
ECgene alternative splicing isoforms for
MAPK10

Expression for MAPK10 Gene

mRNA expression in normal human tissues for MAPK10 Gene

mRNA differential expression in normal tissues according to GTEx for MAPK10 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6), Brain - Cortex (x5.1), and Brain - Anterior cingulate cortex (BA24) (x4.7).

Protein differential expression in normal tissues from HIPED for MAPK10 Gene

This gene is overexpressed in Heart (33.0), Frontal cortex (16.5), Testis (8.6), and Retina (7.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK10 Gene



SOURCE GeneReport for Unigene cluster for MAPK10 Gene Hs.125503

mRNA Expression by UniProt/SwissProt for MAPK10 Gene

P53779-MK10_HUMAN
Tissue specificity: Specific to a subset of neurons in the nervous system. Present in the hippocampus and areas, cerebellum, striatum, brain stem, and weakly in the spinal cord. Very weak expression in testis and kidney.
genes like me logo Genes that share expression patterns with MAPK10: view

Protein tissue co-expression partners for MAPK10 Gene

- Elite partner

In Situ Assay Products

Orthologs for MAPK10 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for MAPK10 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPK10 35
  • 94.13 (n)
  • 100 (a)
MAPK10 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK10 35
  • 93.89 (n)
  • 98.06 (a)
MAPK10 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk10 35
  • 91.74 (n)
  • 99.57 (a)
Mapk10 16
Mapk10 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk10 35
  • 91.67 (n)
  • 99.35 (a)
oppossum
(Monodelphis domestica)
Mammalia MAPK10 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia MAPK10 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPK10 36
  • 100 (a)
OneToOne
MAPK10 35
  • 99.86 (n)
  • 100 (a)
chicken
(Gallus gallus)
Aves MAPK10 35
  • 86.85 (n)
  • 98.28 (a)
MAPK10 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK10 36
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk10 35
  • 85.89 (n)
  • 97.85 (a)
Str.13873 35
zebrafish
(Danio rerio)
Actinopterygii mapk10 35
  • 81.26 (n)
  • 95.45 (a)
mapk10 36
  • 93 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta bsk 37
  • 78 (a)
bsk 36
  • 77 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C49C3.10a 37
  • 32 (a)
C49C3.10b 37
  • 33 (a)
F09C12.2 37
  • 35 (a)
jnk-1 37
  • 70 (a)
Y51B9A.9 37
  • 35 (a)
jnk-1 36
  • 57 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HOG1 36
  • 34 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
OneToMany
Species with no ortholog for MAPK10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK10 Gene

ENSEMBL:
Gene Tree for MAPK10 (if available)
TreeFam:
Gene Tree for MAPK10 (if available)

Paralogs for MAPK10 Gene

Paralogs for MAPK10 Gene

genes like me logo Genes that share paralogs with MAPK10: view

Variants for MAPK10 Gene

Sequence variations from dbSNP and Humsavar for MAPK10 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs958 -- 86,016,721(+) GAGCC(A/C/G/T)TGAGG utr-variant-3-prime
rs1201 -- 86,015,315(+) GAAAG(A/G)AAGTT utr-variant-3-prime
rs1202 -- 86,015,255(+) ACTGG(C/T)ATGGC utr-variant-3-prime
rs3527 -- 86,017,027(-) AATGT(A/G)TATTT utr-variant-3-prime
rs385484 -- 86,109,644(-) ctaaa(C/G)gccca intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for MAPK10 Gene

Variant ID Type Subtype PubMed ID
esv1427548 CNV Insertion 17803354
nsv511259 CNV Loss 21212237
esv2727930 CNV Deletion 23290073
esv2670758 CNV Deletion 23128226
nsv517318 CNV Loss 19592680
nsv10529 CNV Loss 18304495
esv2422128 CNV Deletion 20811451
nsv442912 CNV CNV 18776908
nsv513143 CNV Loss 21212237
esv2727931 CNV Deletion 23290073
esv2678617 CNV Deletion 23128226
nsv471766 CNV Loss 16327809
esv26690 CNV Loss 19812545
nsv514230 CNV Loss 21397061
dgv660n27 CNV Loss 19166990
nsv818248 CNV Loss 17921354
nsv879521 CNV Loss 21882294
nsv820309 CNV Gain 19587683
nsv4408 CNV Insertion 18451855
dgv25e194 CNV Deletion 18987734
esv2727932 CNV Deletion 23290073
esv5249 CNV Deletion 18987735
nsv291104 CNV Loss 16902084
esv2727933 CNV Deletion 23290073
dgv1648e1 CNV Complex 17122850
essv19743 CNV CNV 17122850
nsv515925 CNV Loss 19592680
esv29871 CNV Gain 19812545
nsv461574 CNV Loss 19166990

Variation tolerance for MAPK10 Gene

Residual Variation Intolerance Score: 27.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for MAPK10 Gene

HapMap Linkage Disequilibrium report
MAPK10
Human Gene Mutation Database (HGMD)
MAPK10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK10 Gene

Disorders for MAPK10 Gene

MalaCards: The human disease database

(6) MalaCards diseases for MAPK10 Gene - From: GeneTests, Orphanet, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
lennox-gastaut syndrome
  • lennox syndrome
pertussis
  • bordetella infection
opioid abuse
colon adenoma
  • adenomatous polyp of colon
breast cancer
  • breast cancer, invasive ductal
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

MK10_HUMAN
  • Note=A chromosomal aberration involving MAPK10 has been found in a single patient with pharmacoresistant epileptic encephalopathy. Translocation t(Y;4)(q11.2;q21) which causes MAPK10 truncation. {ECO:0000269 PubMed:16249883}.

Relevant External Links for MAPK10

Genetic Association Database (GAD)
MAPK10
Human Genome Epidemiology (HuGE) Navigator
MAPK10
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
MAPK10
genes like me logo Genes that share disorders with MAPK10: view

No data available for Genatlas for MAPK10 Gene

Publications for MAPK10 Gene

  1. Selective interaction of JNK protein kinase isoforms with transcription factors. (PMID: 8654373) Gupta S. … Davis R.J. (EMBO J. 1996) 2 3 4 23 67
  2. Cone arrestin binding to JNK3 and Mdm2: conformational preference and localization of interaction sites. (PMID: 17680991) Song X. … Gurevich V.V. (J. Neurochem. 2007) 3 23
  3. Truncation of the CNS-expressed JNK3 in a patient with a severe developmental epileptic encephalopathy. (PMID: 16249883) Shoichet S.A. … Kalscheuer V.M. (Hum. Genet. 2006) 3 23
  4. Head-to-head juxtaposition of Fas-associated phosphatase-1 (FAP-1) and c-Jun NH2-terminal kinase 3 (JNK3) genes: genomic structure and seven polymorphisms of the FAP-1 gene. (PMID: 12436199) Yoshida S. … Emi M. (J. Hum. Genet. 2002) 2 3
  5. Identification of a motif in the carboxyl terminus of beta -arrestin2 responsible for activation of JNK3. (PMID: 11356842) Miller W.E. … Lefkowitz R.J. (J. Biol. Chem. 2001) 3 23

Products for MAPK10 Gene

Sources for MAPK10 Gene

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