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Aliases for GNG12 Gene

Aliases for GNG12 Gene

  • Guanine Nucleotide Binding Protein (G Protein), Gamma 12 2 3

External Ids for GNG12 Gene

Previous GeneCards Identifiers for GNG12 Gene

  • GC01M067098
  • GC01M067524
  • GC01M067537
  • GC01M067879
  • GC01M067939
  • GC01M068167
  • GC01M066277

Summaries for GNG12 Gene

GeneCards Summary for GNG12 Gene

GNG12 (Guanine Nucleotide Binding Protein (G Protein), Gamma 12) is a Protein Coding gene. Among its related pathways are PI3K-Akt signaling pathway and MAPK signaling pathway. GO annotations related to this gene include signal transducer activity. An important paralog of this gene is GNG7.

UniProtKB/Swiss-Prot for GNG12 Gene

  • Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Tocris Summary for GNG12 Gene

  • Heterotrimeric G proteins are membrane bound GTPases that are linked to 7-TM receptors. Each G protein contains an alpha-, beta- and gamma-subunit and is bound to GDP in the 'off' state. Ligand-receptor binding results in detachment of the G protein, switching it to an 'on' state and permitting Galpha activation of second messenger signalling cascades. There are several types of Galpha proteins; in addition, some Gbetagamma subunits have active functions. Gbetagamma coupled to H1 receptors can activate PLA2 and Gbetagamma coupled to M1 receptors can activate KIR channels.

Gene Wiki entry for GNG12 Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for GNG12 Gene

Genomics for GNG12 Gene

Regulatory Elements for GNG12 Gene

Genomic Location for GNG12 Gene

Start:
67,701,466 bp from pter
End:
67,833,472 bp from pter
Size:
132,007 bases
Orientation:
Minus strand

Genomic View for GNG12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for GNG12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for GNG12 Gene

Proteins for GNG12 Gene

  • Protein details for GNG12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBI6-GBG12_HUMAN
    Recommended name:
    Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-12
    Protein Accession:
    Q9UBI6
    Secondary Accessions:
    • Q69YP5
    • Q9BRV5

    Protein attributes for GNG12 Gene

    Size:
    72 amino acids
    Molecular mass:
    8006 Da
    Quaternary structure:
    • G proteins are composed of 3 units, alpha, beta and gamma

neXtProt entry for GNG12 Gene

Proteomics data for GNG12 Gene at MOPED

Post-translational modifications for GNG12 Gene

  • Ubiquitination at Lys34 and Lys64
  • Modification sites at PhosphoSitePlus

Other Protein References for GNG12 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for GNG12 Gene

Domains for GNG12 Gene

Protein Domains for GNG12 Gene

Suggested Antigen Peptide Sequences for GNG12 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UBI6

UniProtKB/Swiss-Prot:

GBG12_HUMAN :
  • Q9UBI6
Family:
  • Belongs to the G protein gamma family.
genes like me logo Genes that share domains with GNG12: view

No data available for Gene Families for GNG12 Gene

Function for GNG12 Gene

Molecular function for GNG12 Gene

UniProtKB/Swiss-Prot Function: Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction

Gene Ontology (GO) - Molecular Function for GNG12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity IEA --
GO:0005515 protein binding IPI 21988832
GO:0030165 PDZ domain binding IDA 23209302
GO:0042301 phosphate ion binding IEA --
genes like me logo Genes that share ontologies with GNG12: view

Phenotypes for GNG12 Gene

genes like me logo Genes that share phenotypes with GNG12: view

miRNA for GNG12 Gene

miRTarBase miRNAs that target GNG12

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for GNG12 Gene

Localization for GNG12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for GNG12 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for GNG12 Gene COMPARTMENTS Subcellular localization image for GNG12 gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 2
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for GNG12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005834 heterotrimeric G-protein complex IEA --
GO:0005884 actin filament IEA --
GO:0005886 plasma membrane TAS --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with GNG12: view

Pathways for GNG12 Gene

SuperPathways for GNG12 Gene

Superpath Contained pathways
1 ADP signalling through P2Y purinoceptor 12
2 Development Angiotensin activation of ERK
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 ERK Signaling
genes like me logo Genes that share pathways with GNG12: view

Gene Ontology (GO) - Biological Process for GNG12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0007165 signal transduction TAS 10819326
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0007268 synaptic transmission TAS --
GO:0021987 cerebral cortex development IEA --
genes like me logo Genes that share ontologies with GNG12: view

Compounds for GNG12 Gene

(5) Tocris Compounds for GNG12 Gene

Compound Action Cas Number
8-Bromo-cGMP, sodium salt cGMP analog; activates PKG [51116-01-9]
CCG 50014 Potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein [883050-24-6]
Gallein Inhibitor of betagamma signaling [2103-64-2]
Pertussis Toxin Catalyzes ADP-ribosylation of Gi, Go and Gt [70323-44-3]
SCH 202676 hydrobromide Inhibitor of ligand binding to G-protein-coupled receptors [265980-25-4]

(3) HMDB Compounds for GNG12 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine diphosphate
  • 5'-GDP
146-91-8
Guanosine monophosphate
  • 5'-GMP
85-32-5
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with GNG12: view

Transcripts for GNG12 Gene

mRNA/cDNA for GNG12 Gene

Unigene Clusters for GNG12 Gene

Guanine nucleotide binding protein (G protein), gamma 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for GNG12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c · 9d · 9e
SP1: - - - -
SP2: - - - - -
SP3: - - - -
SP4: - - -
SP5: -
SP6:

Relevant External Links for GNG12 Gene

GeneLoc Exon Structure for
GNG12
ECgene alternative splicing isoforms for
GNG12

Expression for GNG12 Gene

mRNA expression in normal human tissues for GNG12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for GNG12 Gene

SOURCE GeneReport for Unigene cluster for GNG12 Gene Hs.431101

genes like me logo Genes that share expressions with GNG12: view

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for GNG12 Gene

Orthologs for GNG12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for GNG12 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia GNG12 35
  • 100 (n)
  • 100 (a)
GNG12 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia GNG12 35
  • 89.35 (n)
  • 94.44 (a)
GNG12 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia GNG12 35
  • 91.2 (n)
  • 98.61 (a)
GNG12 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Gng12 35
  • 86.57 (n)
  • 97.22 (a)
Gng12 16
Gng12 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia GNG12 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Gng12 35
  • 86.11 (n)
  • 95.83 (a)
chicken
(Gallus gallus)
Aves GNG12 35
  • 78.24 (n)
  • 87.5 (a)
GNG12 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia gng12 35
  • 79.63 (n)
  • 83.33 (a)
zebrafish
(Danio rerio)
Actinopterygii GNG12 (2 of 2) 36
  • 78 (a)
OneToMany
gng12a 36
  • 72 (a)
OneToMany
LOC100331581 35
  • 72.69 (n)
  • 77.78 (a)
Species with no ortholog for GNG12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for GNG12 Gene

ENSEMBL:
Gene Tree for GNG12 (if available)
TreeFam:
Gene Tree for GNG12 (if available)

Paralogs for GNG12 Gene

Paralogs for GNG12 Gene

Selected SIMAP similar genes for GNG12 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with GNG12: view

Variants for GNG12 Gene

Sequence variations from dbSNP and Humsavar for GNG12 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2198 -- 67,709,409(+) AGAGT(C/T)CCTGG intron-variant
rs7419 -- 67,701,808(-) ACTTG(A/G)TTACT utr-variant-3-prime
rs9549 -- 67,704,572(-) GATAG(G/T)CACCT utr-variant-3-prime
rs15471 -- 67,704,576(+) GCCTA(A/T)CCCTA utr-variant-3-prime
rs15472 -- 67,704,373(+) GGGGA(A/G)GGTAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for GNG12 Gene

Variant ID Type Subtype PubMed ID
esv1336934 CNV Deletion 17803354
esv1542404 CNV Deletion 17803354
esv273176 CNV Insertion 20981092
nsv830104 CNV Gain 17160897

Relevant External Links for GNG12 Gene

HapMap Linkage Disequilibrium report
GNG12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for GNG12 Gene

Disorders for GNG12 Gene

No disorders were found for GNG12 Gene.

No data available for UniProtKB/Swiss-Prot for GNG12 Gene

Publications for GNG12 Gene

  1. Genomic characterization of the human heterotrimeric G protein alpha, beta, and gamma subunit genes. (PMID: 10819326) Hurowitz E.H. … Shizuya H. (DNA Res. 2000) 2 3 4
  2. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu R.-M. … Chen J.-L. (Proc. Natl. Acad. Sci. U.S.A. 2000) 3 4
  3. Identification of a region in G protein gamma subunits conserved across species but hypervariable among subunit isoforms. (PMID: 11714923) Cook L.A. … Hildebrandt J.D. (Protein Sci. 2001) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for GNG12 Gene

  • antibodies-online proteins for GNG12
  • antibodies-online antibodies for GNG12
  • antibodies-online kits for GNG12

Sources for GNG12 Gene

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