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Aliases for MAPK1 Gene

Aliases for MAPK1 Gene

  • Mitogen-Activated Protein Kinase 1 2 3
  • PRKM1 3 4 6
  • ERK2 3 4 6
  • Extracellular Signal-Regulated Kinase 2 3 4
  • Mitogen-Activated Protein Kinase 2 3 4
  • MAP Kinase Isoform P42 3 4
  • MAP Kinase 1 3 4
  • MAP Kinase 2 3 4
  • EC 2.7.11.24 4 63
  • P42-MAPK 3 4
  • MAPK 2 3 4
  • PRKM2 3 4
  • ERK-2 3 4
  • ERT1 3 4
  • Protein Tyrosine Kinase ERK2 3
  • EC 2.7.11 63
  • P42MAPK 3
  • P41mapk 3
  • MAPK 1 4
  • MAPK2 3
  • P40 3
  • P38 3
  • ERK 3
  • P41 3

External Ids for MAPK1 Gene

Previous HGNC Symbols for MAPK1 Gene

  • PRKM2
  • PRKM1

Previous GeneCards Identifiers for MAPK1 Gene

  • GC22M018815
  • GC22M020441
  • GC22M022108
  • GC22M005071

Summaries for MAPK1 Gene

Entrez Gene Summary for MAPK1 Gene

  • This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]

GeneCards Summary for MAPK1 Gene

MAPK1 (Mitogen-Activated Protein Kinase 1) is a Protein Coding gene. Diseases associated with MAPK1 include distal 22q11.2 microdeletion syndrome and retrograde amnesia. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include protein serine/threonine kinase activity and phosphatase binding. An important paralog of this gene is MAPK3.

UniProtKB/Swiss-Prot for MAPK1 Gene

  • Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation

  • Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity

Tocris Summary for MAPK1 Gene

  • Extracellular signal-regulated kinases are a group of mitogen-activated protein kinases (MAPK) that mediate intracellular signaling. ERK1 and ERK2 (MAPK3 and MAPK1) transduce signals from growth factors and phorbol esters. They are expressed in all tissues, at varying levels. Upon activation by MEK, ERK1 and 2 translocate to the nucleus where they phosphorylate transcription factors such as Elk1 and downstream kinases such as p90 RSK

Gene Wiki entry for MAPK1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for MAPK1 Gene

Genomics for MAPK1 Gene

Regulatory Elements for MAPK1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for MAPK1 Gene

Start:
21,754,500 bp from pter
End:
21,867,680 bp from pter
Size:
113,181 bases
Orientation:
Minus strand

Genomic View for MAPK1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for MAPK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for MAPK1 Gene

Proteins for MAPK1 Gene

  • Protein details for MAPK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P28482-MK01_HUMAN
    Recommended name:
    Mitogen-activated protein kinase 1
    Protein Accession:
    P28482
    Secondary Accessions:
    • A8CZ64

    Protein attributes for MAPK1 Gene

    Size:
    360 amino acids
    Molecular mass:
    41390 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Binds both upstream activators and downstream substrates in multimolecular complexes. Binds to HIV-1 Nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity. Interacts with ADAM15, ARHGEF2, ARRB2, DAPK1 (via death domain), HSF4, IER3, IPO7, DUSP6, NISCH, SGK1, and isoform 1 of NEK2. Interacts (phosphorylated form) with CAV2 (Tyr-19-phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with MORG1, PEA15 and MKNK2 (By similarity). MKNK2 isoform 1 binding prevents from dephosphorylation and inactivation (By similarity). Interacts with DCC (By similarity). The phosphorylated form interacts with PML (isoform PML-4). Interacts with STYX.
    SequenceCaution:
    • Sequence=CAA77753.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for MAPK1 Gene

    Alternative splice isoforms for MAPK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for MAPK1 Gene

Proteomics data for MAPK1 Gene at MOPED

Post-translational modifications for MAPK1 Gene

  • ISGylated.
  • Phosphorylated upon KIT and FLT3 signaling (By similarity). Dually phosphorylated on Thr-185 and Tyr-187, which activates the enzyme. Undergoes regulatory phosphorylation on additional residues such as Ser-246 and Ser-248 in the kinase insert domain (KID) These phosphorylations, which are probably mediated by more than one kinase, are important for binding of MAPK1/ERK2 to importin-7 (IPO7) and its nuclear translocation. In addition, autophosphorylation of Thr-190 was shown to affect the subcellular localization of MAPK1/ERK2 as well. Ligand-activated ALK induces tyrosine phosphorylation. Dephosphorylated by PTPRJ at Tyr-187. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. DUSP3 and DUSP6 dephosphorylate specifically MAPK1/ERK2 and MAPK3/ERK1 whereas DUSP9 dephosphorylates a broader range of MAPKs.
  • Ubiquitination at Lys55, Lys203, and Lys292
  • Modification sites at PhosphoSitePlus

Other Protein References for MAPK1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for MAPK1 (ERK2)

Domains for MAPK1 Gene

Gene Families for MAPK1 Gene

Graphical View of Domain Structure for InterPro Entry

P28482

UniProtKB/Swiss-Prot:

MK01_HUMAN :
  • P28482
Domain:
  • The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.
genes like me logo Genes that share domains with MAPK1: view

Function for MAPK1 Gene

Molecular function for MAPK1 Gene

GENATLAS Biochemistry:
mitogen-activated protein kinase 1 (p40,p41),three isoforms,5.5kb highly expressed in forebrain,4.6kb,in skeletal,heart muscle and liver,2.8kb,skeletal,heart muscle,brain,activated and tyrosine phosphorylated in response to insulin NGF and other signals,widely involved in signal transduction,translocated to the nucleus after activation where it phosphorylate nuclear targets
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Phosphorylated by MAP2K1/MEK1 and MAP2K2/MEK2 on Thr-185 and Tyr-187 in response to external stimuli like insulin or NGF. Both phosphorylations are required for activity. This phosphorylation causes dramatic conformational changes, which enable full activation and interaction of MAPK1/ERK2 with its substrates. Phosphorylation on Ser-29 by SGK1 results in its activation by enhancing its interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Dephosphorylated and inactivated by DUSP3, DUSP6 and DUSP9. Inactivated by pyrimidylpyrrole inhibitors.
UniProtKB/Swiss-Prot Function:
Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, DCC, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade. Mediates phosphorylation of TPR in respons to EGF stimulation. May play a role in the spindle assembly checkpoint. Phosphorylates PML and promotes its interaction with PIN1, leading to PML degradation
UniProtKB/Swiss-Prot Function:
Acts as a transcriptional repressor. Binds to a [GC]AAA[GC] consensus sequence. Repress the expression of interferon gamma-induced genes. Seems to bind to the promoter of CCL5, DMP1, IFIH1, IFITM1, IRF7, IRF9, LAMP3, OAS1, OAS2, OAS3 and STAT1. Transcriptional activity is independent of kinase activity

Enzyme Numbers (IUBMB) for MAPK1 Gene

Gene Ontology (GO) - Molecular Function for MAPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001784 phosphotyrosine binding IEA --
GO:0003677 DNA binding IEA --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 15850461
GO:0004707 MAP kinase activity IEA --
genes like me logo Genes that share ontologies with MAPK1: view
genes like me logo Genes that share phenotypes with MAPK1: view

Animal Models for MAPK1 Gene

MGI Knock Outs for MAPK1:

Animal Model Products

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for MAPK1 Gene

Localization for MAPK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for MAPK1 Gene

Cytoplasm, cytoskeleton, spindle. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15-binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for MAPK1 Gene COMPARTMENTS Subcellular localization image for MAPK1 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
endosome 5
golgi apparatus 5
mitochondrion 5
nucleus 5
plasma membrane 5
extracellular 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for MAPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 19565474
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm ISS --
GO:0005739 mitochondrion TAS 19565474
GO:0005769 early endosome TAS 19565474
genes like me logo Genes that share ontologies with MAPK1: view

Pathways for MAPK1 Gene

SuperPathways for MAPK1 Gene

Superpath Contained pathways
1 IL-2 Pathway
2 Signaling by FGFR
3 Insulin receptor signalling cascade
4 Translation Insulin regulation of translation
5 IL-9 Signaling Pathways
genes like me logo Genes that share pathways with MAPK1: view

Pathways by source for MAPK1 Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for MAPK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000165 MAPK cascade TAS --
GO:0000186 activation of MAPKK activity TAS --
GO:0000187 activation of MAPK activity TAS --
GO:0000189 MAPK import into nucleus IEA --
GO:0002224 toll-like receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with MAPK1: view

Compounds for MAPK1 Gene

Compound Products

(4) Tocris Compounds for MAPK1 Gene

Compound Action Cas Number
FR 180204 Selective ERK inhibitor [865362-74-9]
Pluripotin Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal [839707-37-8]
TCS ERK 11e Potent and selective ERK2 inhibitor [896720-20-0]
XMD 8-92 Selective ERK5/BMK1 inhibitor [1234480-50-2]

(2) ApexBio Compounds for MAPK1 Gene

Compound Action Cas Number
FR 180204 ERK inhibitor [865362-74-9]
Piperine MAPK inhibitor [94-62-2]

(4) HMDB Compounds for MAPK1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Magnesium
  • Magnesium
7439-95-4
Sumatriptan
  • Imigran
103628-46-2

(138) Novoseek inferred chemical compound relationships for MAPK1 Gene

Compound -log(P) Hits PubMed IDs
pd 98,059 96.1 159
sb 203580 93.9 137
sp 600125 90.2 103
ly294002 86.8 107
tyrosine 85.9 235
genes like me logo Genes that share compounds with MAPK1: view

Transcripts for MAPK1 Gene

Unigene Clusters for MAPK1 Gene

Mitogen-activated protein kinase 1:
Representative Sequences:

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for MAPK1 Gene

No ASD Table

Relevant External Links for MAPK1 Gene

GeneLoc Exon Structure for
MAPK1
ECgene alternative splicing isoforms for
MAPK1

Expression for MAPK1 Gene

mRNA expression in normal human tissues for MAPK1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for MAPK1 Gene

This gene is overexpressed in Brain (8.7) and Frontal cortex (6.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for MAPK1 Gene

SOURCE GeneReport for Unigene cluster for MAPK1 Gene Hs.431850

genes like me logo Genes that share expressions with MAPK1: view

Expression partners for MAPK1 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for MAPK1 Gene

Orthologs for MAPK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for MAPK1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia MAPK1 35
  • 92.31 (n)
  • 99.72 (a)
MAPK1 36
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia MAPK1 35
  • 94.81 (n)
  • 100 (a)
MAPK1 36
  • 100 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Mapk1 35
  • 92.62 (n)
  • 99.44 (a)
Mapk1 16
Mapk1 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia MAPK1 35
  • 100 (n)
  • 100 (a)
MAPK1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Mapk1 35
  • 91.97 (n)
  • 99.44 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 90 (a)
OneToMany
-- 36
  • 98 (a)
OneToMany
chicken
(Gallus gallus)
Aves MAPK1 35
  • 86.57 (n)
  • 99.43 (a)
MAPK1 36
  • 99 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia MAPK1 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia mapk1 35
  • 83.81 (n)
  • 97.99 (a)
Str.19446 35
zebrafish
(Danio rerio)
Actinopterygii mapk1 35
  • 79.12 (n)
  • 95.11 (a)
mapk1 36
  • 91 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2326 35
fruit fly
(Drosophila melanogaster)
Insecta CG18732 37
  • 86 (a)
rl 37
  • 81 (a)
rl 35
  • 66.09 (n)
  • 81.98 (a)
rl 36
  • 76 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009207 35
  • 70.32 (n)
  • 86.52 (a)
worm
(Caenorhabditis elegans)
Secernentea C05D10.2a 37
  • 40 (a)
C05D10.2c 37
  • 40 (a)
C49C3.10b 37
  • 29 (a)
F09C12.2 37
  • 40 (a)
mpk-1 37
  • 81 (a)
Y51B9A.9 37
  • 31 (a)
mpk-1 35
  • 68.04 (n)
  • 81.18 (a)
mpk-1 36
  • 63 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACL191C 35
  • 56.21 (n)
  • 54.25 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A02497g 35
  • 54.84 (n)
  • 54.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KSS1 35
  • 56.86 (n)
  • 53.82 (a)
FUS3 36
  • 49 (a)
ManyToMany
KSS1 36
  • 48 (a)
ManyToMany
FUS3 38
thale cress
(Arabidopsis thaliana)
eudicotyledons MPK6 35
  • 56.21 (n)
  • 52.49 (a)
rice
(Oryza sativa)
Liliopsida Os06g0154500 35
  • 57.52 (n)
  • 53.1 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4298 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9711 36
  • 83 (a)
OneToMany
Species with no ortholog for MAPK1:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for MAPK1 Gene

ENSEMBL:
Gene Tree for MAPK1 (if available)
TreeFam:
Gene Tree for MAPK1 (if available)

Paralogs for MAPK1 Gene

Paralogs for MAPK1 Gene

genes like me logo Genes that share paralogs with MAPK1: view

Variants for MAPK1 Gene

Sequence variations from dbSNP and Humsavar for MAPK1 Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs6928 -- 21,760,715(-) TTTAT(C/G)CGTGT utr-variant-3-prime
rs9340 -- 21,761,064(-) ACATA(C/T)GCACA utr-variant-3-prime
rs12682 -- 21,761,233(-) ACGAG(C/G)GGTTT utr-variant-3-prime
rs13058 -- 21,763,213(-) ATTCT(G/T)TTTCC utr-variant-3-prime
rs13515 -- 21,761,597(-) GACAC(A/G)GAACA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for MAPK1 Gene

Variant ID Type Subtype PubMed ID
nsv7350 OTHER Inversion 18451855
nsv510804 CNV Loss 20534489
dgv4883n71 CNV Loss 21882294
nsv3564 CNV Insertion 18451855
esv2675107 CNV Deletion 23128226
dgv20e196 CNV Duplication 17116639
esv2422374 CNV Duplication 17116639
dgv256n21 CNV Loss 19592680
dgv22e196 CNV Deletion 17116639
nsv527816 CNV Loss 19592680
esv2422338 CNV Deletion 17116639
dgv23e196 CNV Deletion 17116639

Relevant External Links for MAPK1 Gene

HapMap Linkage Disequilibrium report
MAPK1
Human Gene Mutation Database (HGMD)
MAPK1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for MAPK1 Gene

Disorders for MAPK1 Gene

(1) University of Copenhagen DISEASES for MAPK1 Gene

(94) Novoseek inferred disease relationships for MAPK1 Gene

Disease -log(P) Hits PubMed IDs
tumors 71.1 176
necrosis 66.6 105
cancer 66.3 118
inflammation 59.1 59
colon cancer 57.4 33

Relevant External Links for MAPK1

Genetic Association Database (GAD)
MAPK1
Human Genome Epidemiology (HuGE) Navigator
MAPK1
genes like me logo Genes that share disorders with MAPK1: view

No data available for OMIM , UniProtKB/Swiss-Prot and Genatlas for MAPK1 Gene

Publications for MAPK1 Gene

  1. Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway. (PMID: 10224087) Todd J.L. … Denu J.M. (J. Biol. Chem. 1999) 3 4 23
  2. IEX-1: a new ERK substrate involved in both ERK survival activity and ERK activation. (PMID: 12356731) Garcia J. … Porteu F. (EMBO J. 2002) 3 4 23
  3. MCL1 is phosphorylated in the PEST region and stabilized upon ERK activation in viable cells, and at additional sites with cytotoxic okadaic acid or taxol. (PMID: 15241487) Domina A.M. … Craig R.W. (Oncogene 2004) 3 4 23
  4. ERK1/2 phosphorylate GEF-H1 to enhance its guanine nucleotide exchange activity toward RhoA. (PMID: 18211802) Fujishiro S.H. … Kohno M. (Biochem. Biophys. Res. Commun. 2008) 3 4 23
  5. Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. (PMID: 18794356) Vomastek T. … Nandicoori V.K. (Mol. Cell. Biol. 2008) 3 4 23

Products for MAPK1 Gene

  • Addgene plasmids for MAPK1

Sources for MAPK1 Gene

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