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Aliases for APOM Gene

Aliases for APOM Gene

  • Apolipoprotein M 2 3
  • Protein G3a 3 4
  • Apo-M 3 4
  • NG20 3 4
  • G3a 3 4
  • Alternative Name: G3a, NG20 3
  • NG20-Like Protein 3
  • HSPC336 3
  • ApoM 4

External Ids for APOM Gene

Summaries for APOM Gene

Entrez Gene Summary for APOM Gene

  • The protein encoded by this gene is an apolipoprotein and member of the lipocalin protein family. It is found associated with high density lipoproteins and to a lesser extent with low density lipoproteins and triglyceride-rich lipoproteins. The encoded protein is secreted through the plasma membrane but remains membrane-bound, where it is involved in lipid transport. Alternate splicing results in both coding and non-coding variants of this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for APOM Gene

APOM (Apolipoprotein M) is a Protein Coding gene. Diseases associated with APOM include critical limb ischemia and limb ischemia. Among its related pathways are Ca, cAMP and Lipid Signaling. GO annotations related to this gene include phospholipid binding and lipid transporter activity.

UniProtKB/Swiss-Prot for APOM Gene

  • Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.

Gene Wiki entry for APOM Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for APOM Gene

Genomics for APOM Gene

Genomic Location for APOM Gene

Start:
31,652,410 bp from pter
End:
31,658,210 bp from pter
Size:
5,801 bases
Orientation:
Plus strand

Genomic View for APOM Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for APOM Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

Regulatory Elements for APOM Gene

Proteins for APOM Gene

  • Protein details for APOM Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O95445-APOM_HUMAN
    Recommended name:
    Apolipoprotein M
    Protein Accession:
    O95445
    Secondary Accessions:
    • B0UX98
    • Q5SRP4
    • Q9P046
    • Q9UMP6

    Protein attributes for APOM Gene

    Size:
    188 amino acids
    Molecular mass:
    21253 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for APOM Gene

    Alternative splice isoforms for APOM Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for APOM Gene

Proteomics data for APOM Gene at MOPED

Post-translational modifications for APOM Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn135

Other Protein References for APOM Gene

No data available for DME Specific Peptides for APOM Gene

Domains for APOM Gene

Gene Families for APOM Gene

HGNC:

Protein Domains for APOM Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for APOM Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O95445

UniProtKB/Swiss-Prot:

APOM_HUMAN
Family:
  • Belongs to the calycin superfamily. Lipocalin family. Highly divergent.:
    • O95445
genes like me logo Genes that share domains with APOM: view

Function for APOM Gene

Molecular function for APOM Gene

UniProtKB/Swiss-Prot Function: Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.

Gene Ontology (GO) - Molecular Function for APOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity IDA 16682745
GO:0005543 phospholipid binding IDA 22204862
GO:0016209 antioxidant activity IDA 22204862
genes like me logo Genes that share ontologies with APOM: view

Phenotypes for APOM Gene

MGI mutant phenotypes for APOM:
inferred from 2 alleles
GenomeRNAi human phenotypes for APOM:
genes like me logo Genes that share phenotypes with APOM: view

Animal Models for APOM Gene

MGI Knock Outs for APOM:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for APOM Gene

Localization for APOM Gene

Subcellular locations from UniProtKB/Swiss-Prot for APOM Gene

Secreted. Note=Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins (LDL).

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for APOM Gene COMPARTMENTS Subcellular localization image for APOM gene
Compartment Confidence
extracellular 5
plasma membrane 4
cytosol 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for APOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space --
GO:0005887 integral component of plasma membrane TAS 10531326
GO:0034361 very-low-density lipoprotein particle IDA 17154273
GO:0034362 low-density lipoprotein particle IDA 16682745
genes like me logo Genes that share ontologies with APOM: view

Pathways for APOM Gene

SuperPathways for APOM Gene

genes like me logo Genes that share pathways with APOM: view

Pathways by source for APOM Gene

1 Cell Signaling Technology pathway for APOM Gene

Interacting Proteins for APOM Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365081%0d%0a9606.ENSP00000321320%0d%0a
Selected Interacting proteins: O95445-APOM_HUMAN ENSP00000365081 for APOM Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for APOM Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001523 retinoid metabolic process TAS --
GO:0007603 phototransduction, visible light TAS --
GO:0009749 response to glucose IEA --
GO:0033344 cholesterol efflux IMP 15793583
GO:0034375 high-density lipoprotein particle remodeling IMP 18006500
genes like me logo Genes that share ontologies with APOM: view

Compounds for APOM Gene

(1) Drugbank Compounds for APOM Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
MYRISTIC ACID
carrier

(5) Novoseek inferred chemical compound relationships for APOM Gene

Compound -log(P) Hits PubMed IDs
cholesterol 57.9 23
lipid 32 2
phospholipid 17.8 2
acth 14.7 2
glucose 7.6 1
genes like me logo Genes that share compounds with APOM: view

Transcripts for APOM Gene

Unigene Clusters for APOM Gene

Apolipoprotein M:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for APOM Gene

No ASD Table

Relevant External Links for APOM Gene

GeneLoc Exon Structure for
APOM
ECgene alternative splicing isoforms for
APOM

Expression for APOM Gene

mRNA expression in normal human tissues for APOM Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for APOM Gene

This gene is overexpressed in Liver (29.6) and Kidney - Cortex (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for APOM Gene

SOURCE GeneReport for Unigene cluster for APOM Gene Hs.534468

mRNA Expression by UniProt/SwissProt for APOM Gene

O95445-APOM_HUMAN
Tissue specificity: Plasma protein. Expressed in liver and kidney
genes like me logo Genes that share expressions with APOM: view

Orthologs for APOM Gene

This gene was present in the common ancestor of chordates.

Orthologs for APOM Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia APOM 35
  • 99.29 (n)
  • 98.94 (a)
APOM 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia APOM 35
  • 91.13 (n)
  • 89.89 (a)
APOM 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia APOM 35
  • 89.18 (n)
  • 86.7 (a)
APOM 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Apom 35
  • 84.4 (n)
  • 81.38 (a)
Apom 16
Apom 36
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia APOM 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Apom 35
  • 83.51 (n)
  • 82.45 (a)
lizard
(Anolis carolinensis)
Reptilia APOM 36
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia apom 35
  • 53.48 (n)
  • 45.99 (a)
zebrafish
(Danio rerio)
Actinopterygii apom 36
  • 19 (a)
OneToOne
Species with no ortholog for APOM:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for APOM Gene

ENSEMBL:
Gene Tree for APOM (if available)
TreeFam:
Gene Tree for APOM (if available)

Paralogs for APOM Gene

No data available for Paralogs for APOM Gene

Variants for APOM Gene

Structural Variations from Database of Genomic Variants (DGV) for APOM Gene

Variant ID Type Subtype PubMed ID
nsv830627 CNV Loss 17160897
nsv884418 CNV Gain 21882294
nsv462871 CNV Loss 19166990
dgv6581n71 CNV Loss 21882294

Relevant External Links for APOM Gene

HapMap Linkage Disequilibrium report
APOM
Human Gene Mutation Database (HGMD)
APOM

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for APOM Gene

Disorders for APOM Gene

(1) Novoseek inferred disease relationships for APOM Gene

Disease -log(P) Hits PubMed IDs
atherosclerosis 22.8 7

Relevant External Links for APOM

Genetic Association Database (GAD)
APOM
Human Genome Epidemiology (HuGE) Navigator
APOM
genes like me logo Genes that share disorders with APOM: view

No data available for UniProtKB/Swiss-Prot for APOM Gene

Publications for APOM Gene

  1. A novel human apolipoprotein (apoM). (PMID: 10531326) Xu N. … Dahlbaeck B. (J. Biol. Chem. 1999) 2 3 4 23
  2. Proposed lipocalin fold for apolipoprotein M based on bioinformatics and site-directed mutagenesis. (PMID: 11418126) Duan J. … Villoutreix B.O. (FEBS Lett. 2001) 2 3 4 23
  3. Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population. (PMID: 15172102) Kabbara A. … Lambert J.C. (Neurosci. Lett. 2004) 3 23 48
  4. Single nucleotide polymorphisms in the proximal promoter region of apolipoprotein M gene (apoM) confer the susceptibility to development of type 2 diabetes in Han Chinese. (PMID: 16572495) Niu N. … Liu Y. (Diabetes Metab. Res. Rev. 2007) 3 23 48
  5. A prospective evaluation of apolipoprotein M gene T-778C polymorphism in relation to coronary artery disease in Han Chinese. (PMID: 17674965) Jiao G.Q. … Xiao M.D. (Clin. Biochem. 2007) 3 23 48

Products for APOM Gene

Sources for APOM Gene

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