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Aliases for NKRF Gene

Aliases for NKRF Gene

  • NFKB Repressing Factor 2 3 5
  • Transcription Factor NRF 3 4
  • ITBA4 3 4
  • NRF 3 4
  • NF-Kappa-B-Repressing Factor 3
  • NF-KappaB Repressing Factor 2
  • NFkB-Repressing Factor 4
  • Protein ITBA4 4

External Ids for NKRF Gene

Previous GeneCards Identifiers for NKRF Gene

  • GC0XM118504
  • GC0XM118606
  • GC0XM118722
  • GC0XM108215

Summaries for NKRF Gene

Entrez Gene Summary for NKRF Gene

  • This gene encodes a transcriptional repressor that interacts with specific negative regulatory elements to mediate transcriptional repression of certain nuclear factor kappa B responsive genes. The protein localizes predominantly to the nucleolus with a small fraction found in the nucleoplasm and cytoplasm. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

GeneCards Summary for NKRF Gene

NKRF (NFKB Repressing Factor) is a Protein Coding gene. Diseases associated with NKRF include Cardiomyopathy, Familial Hypertrophic, 2. Gene Ontology (GO) annotations related to this gene include nucleic acid binding. An important paralog of this gene is CDKN2AIP.

UniProtKB/Swiss-Prot for NKRF Gene

  • Interacts with a specific negative regulatory element (NRE) 5-AATTCCTCTGA-3 to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.

Gene Wiki entry for NKRF Gene

Additional gene information for NKRF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NKRF Gene

Genomics for NKRF Gene

GeneHancer (GH) Regulatory Elements for NKRF Gene

Promoters and enhancers for NKRF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI119604 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.4 355 2.7 HDGF PKNOX1 SMAD1 ATF1 ARID4B SIN3A GLI4 BRCA1 YY1 POLR2B NKRF CXorf56 GC0XP119576 GC0XP119575
GH0XI119593 Promoter 0.5 EPDnew 550.4 +13.3 13313 0.1 NKRF CXorf56 MIR766 GC0XP119575 GC0XP119576
GH0XI119674 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 14.5 -78.3 -78269 20.2 HDGF PKNOX1 SMAD1 ARNT ZFP64 ARID4B FEZF1 IRF4 YY1 POLR2B SEPT6 NKAPP1 EEF1A1P30 CUL4B UPF3B NKAP NKRF MIR766 CXorf56 LINC01402
GH0XI119941 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 5.7 -336.7 -336723 2.7 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 ZNF766 NKAP RHOXF1P3 CUL4B RHOXF1-AS1 NKRF RHOXF1
GH0XI119729 Enhancer 0.9 Ensembl ENCODE 13.2 -123.7 -123664 0.6 CTCF LEF1 RB1 CEBPG RAD21 GTF3C2 CC2D1A SCRT2 ZNF143 SMC3 NKRF PIR44405 ENSG00000279601
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around NKRF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the NKRF gene promoter:

Genomic Locations for NKRF Gene

Genomic Locations for NKRF Gene
chrX:119,588,337-119,606,435
(GRCh38/hg38)
Size:
18,099 bases
Orientation:
Minus strand
chrX:118,722,300-118,739,858
(GRCh37/hg19)

Genomic View for NKRF Gene

Genes around NKRF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
NKRF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for NKRF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NKRF Gene

Proteins for NKRF Gene

  • Protein details for NKRF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15226-NKRF_HUMAN
    Recommended name:
    NF-kappa-B-repressing factor
    Protein Accession:
    O15226
    Secondary Accessions:
    • G3V1N1
    • Q4VC41
    • Q9UJ91

    Protein attributes for NKRF Gene

    Size:
    690 amino acids
    Molecular mass:
    77673 Da
    Quaternary structure:
    • Interacts with NF-kappa-B. Interacts with XRN2 (PubMed:24462208).
    SequenceCaution:
    • Sequence=AL539002; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAB56459.1; Type=Frameshift; Positions=378, 405, 410, 441, 502, 516, 588, 599, 601, 681; Evidence={ECO:0000305};

    Alternative splice isoforms for NKRF Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for NKRF Gene

Post-translational modifications for NKRF Gene

No Post-translational modifications

Other Protein References for NKRF Gene

No data available for DME Specific Peptides for NKRF Gene

Domains & Families for NKRF Gene

Gene Families for NKRF Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with NKRF: view

No data available for UniProtKB/Swiss-Prot for NKRF Gene

Function for NKRF Gene

Molecular function for NKRF Gene

UniProtKB/Swiss-Prot Function:
Interacts with a specific negative regulatory element (NRE) 5-AATTCCTCTGA-3 to mediate transcriptional repression of certain NK-kappa-B responsive genes. Involved in the constitutive silencing of the interferon beta promoter, independently of the virus-induced signals, and in the inhibition of the basal and cytokine-induced iNOS promoter activity. Also involved in the regulation of IL-8 transcription.

Gene Ontology (GO) - Molecular Function for NKRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10562553
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10562553
GO:0003676 nucleic acid binding IEA --
GO:0003677 DNA binding IEA --
GO:0003723 RNA binding HDA,IDA 22658674
genes like me logo Genes that share ontologies with NKRF: view

Phenotypes for NKRF Gene

genes like me logo Genes that share phenotypes with NKRF: view

Animal Models for NKRF Gene

MGI Knock Outs for NKRF:

Animal Model Products

CRISPR Products

miRNA for NKRF Gene

miRTarBase miRNAs that target NKRF

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for NKRF Gene

Localization for NKRF Gene

Subcellular locations from UniProtKB/Swiss-Prot for NKRF Gene

Nucleus, nucleolus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for NKRF gene
Compartment Confidence
nucleus 5
mitochondrion 2
endoplasmic reticulum 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for NKRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 10562553
GO:0005730 nucleolus IDA,IEA --
genes like me logo Genes that share ontologies with NKRF: view

Pathways & Interactions for NKRF Gene

No Data Available

Gene Ontology (GO) - Biological Process for NKRF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0045892 negative regulation of transcription, DNA-templated IDA 10562553
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 10562553
genes like me logo Genes that share ontologies with NKRF: view

No data available for Pathways by source and SIGNOR curated interactions for NKRF Gene

Drugs & Compounds for NKRF Gene

No Compound Related Data Available

Transcripts for NKRF Gene

Unigene Clusters for NKRF Gene

NFKB repressing factor:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for NKRF Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c
SP1: -
SP2: - -
SP3:

Relevant External Links for NKRF Gene

GeneLoc Exon Structure for
NKRF
ECgene alternative splicing isoforms for
NKRF

Expression for NKRF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for NKRF Gene

Protein differential expression in normal tissues from HIPED for NKRF Gene

This gene is overexpressed in Lung (24.2), Monocytes (15.6), Saliva (8.5), Esophagus (7.5), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for NKRF Gene



NURSA nuclear receptor signaling pathways regulating expression of NKRF Gene:

NKRF

SOURCE GeneReport for Unigene cluster for NKRF Gene:

Hs.437084

mRNA Expression by UniProt/SwissProt for NKRF Gene:

O15226-NKRF_HUMAN
Tissue specificity: Widely and constitutively expressed. Expressed at lower level in colon, peripheral blood lymphocytes, lung and kidney.

Evidence on tissue expression from TISSUES for NKRF Gene

  • Nervous system(4.5)
  • Skin(4.3)
  • Pancreas(4)
genes like me logo Genes that share expression patterns with NKRF: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for NKRF Gene

Orthologs for NKRF Gene

This gene was present in the common ancestor of animals.

Orthologs for NKRF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NKRF 33 34
  • 99.86 (n)
dog
(Canis familiaris)
Mammalia NKRF 33 34
  • 94.16 (n)
cow
(Bos Taurus)
Mammalia NKRF 33 34
  • 93.86 (n)
mouse
(Mus musculus)
Mammalia Nkrf 33 16 34
  • 91.16 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 76 (a)
OneToMany
-- 34
  • 69 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia NKRF 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves NKRF 33 34
  • 69.42 (n)
lizard
(Anolis carolinensis)
Reptilia NKRF 34
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia nkrf 33
  • 61.19 (n)
Str.6073 33
zebrafish
(Danio rerio)
Actinopterygii nkrf 33 34
  • 56.7 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31301 34
  • 20 (a)
OneToMany
Species where no ortholog for NKRF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NKRF Gene

ENSEMBL:
Gene Tree for NKRF (if available)
TreeFam:
Gene Tree for NKRF (if available)

Paralogs for NKRF Gene

Paralogs for NKRF Gene

(1) SIMAP similar genes for NKRF Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with NKRF: view

Variants for NKRF Gene

Sequence variations from dbSNP and Humsavar for NKRF Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000043587 -- 119,600,451(-) G/A genic_upstream_transcript_variant, intron_variant
rs1000352141 -- 119,608,287(-) G/A upstream_transcript_variant
rs1000538369 -- 119,589,136(-) A/G 3_prime_UTR_variant
rs1000596210 -- 119,604,545(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000898079 -- 119,601,171(-) T/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for NKRF Gene

Variant ID Type Subtype PubMed ID
nsv476108 CNV novel sequence insertion 20440878

Variation tolerance for NKRF Gene

Residual Variation Intolerance Score: 14.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.62; 13.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for NKRF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
NKRF

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for NKRF Gene

Disorders for NKRF Gene

MalaCards: The human disease database

(1) MalaCards diseases for NKRF Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, familial hypertrophic, 2
  • cmh2
- elite association - COSMIC cancer census association via MalaCards
Search NKRF in MalaCards View complete list of genes associated with diseases

Additional Disease Information for NKRF

genes like me logo Genes that share disorders with NKRF: view

No data available for UniProtKB/Swiss-Prot and Genatlas for NKRF Gene

Publications for NKRF Gene

  1. Constitutive silencing of IFN-beta promoter is mediated by NRF (NF-kappaB-repressing factor), a nuclear inhibitor of NF-kappaB. (PMID: 10562553) Nourbakhsh M … Hauser H (The EMBO journal 1999) 2 3 4 22 58
  2. Identification of a negative response element in the human inducible nitric-oxide synthase (hiNOS) promoter: The role of NF-kappa B-repressing factor (NRF) in basal repression of the hiNOS gene. (PMID: 12381793) Feng X … Geller DA (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 4 22 58
  3. Neutrophil elastase represses IL-8/CXCL8 synthesis in human airway smooth muscle cells through induction of NF-kappa B repressing factor. (PMID: 19542452) Ho SC … Kuo HP (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 22 58
  4. NRF IRES activity is mediated by RNA binding protein JKTBP1 and a 14-nt RNA element. (PMID: 17592041) Reboll MR … Nourbakhsh M (RNA (New York, N.Y.) 2007) 3 22 58
  5. NF-kappaB-repressing factor inhibits elongation of human immunodeficiency virus type 1 transcription by DRB sensitivity-inducing factor. (PMID: 16107696) Dreikhausen U … Nourbakhsh M (Molecular and cellular biology 2005) 3 22 58

Products for NKRF Gene

Sources for NKRF Gene

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