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Aliases for CTTNBP2NL Gene

Aliases for CTTNBP2NL Gene

  • CTTNBP2 N-Terminal Like 2 3 5
  • KIAA1433 4

External Ids for CTTNBP2NL Gene

Previous GeneCards Identifiers for CTTNBP2NL Gene

  • GC01P112651
  • GC01P112740
  • GC01P112938
  • GC01P110795

Summaries for CTTNBP2NL Gene

GeneCards Summary for CTTNBP2NL Gene

CTTNBP2NL (CTTNBP2 N-Terminal Like) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is CTTNBP2.

Gene Wiki entry for CTTNBP2NL Gene

Additional gene information for CTTNBP2NL Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTTNBP2NL Gene

Genomics for CTTNBP2NL Gene

GeneHancer (GH) Regulatory Elements for CTTNBP2NL Gene

Promoters and enhancers for CTTNBP2NL Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I112393 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 564.6 -0.4 -357 5.6 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 IRF4 YY1 ZNF143 FOS CTTNBP2NL GC01P112397 ST7L LRIG2 ENSG00000243960 WNT2B LOC105378909 GC01P112392
GH01I112617 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.5 +224.1 224135 6.2 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ST7L CAPZA1 LOC100421402 LRIG2 DDX20 LOC100996251 MOV10 ENSG00000225075 RHOC PPM1J
GH01I112714 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 10.1 +319.3 319316 3 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A ZNF2 IRF4 YY1 ZNF143 PPM1J LOC105378910 GC01P112727 MOV10 CTTNBP2NL MAGI3
GH01I112388 Enhancer 1.4 Ensembl ENCODE dbSUPER 14.2 -5.6 -5640 3.5 PKNOX1 ATF1 ARID4B SIN3A DMAP1 ZNF2 IRF4 ZNF48 E2F8 ARID2 GC01P112392 WNT2B CTTNBP2NL RHOC PPM1J ENSG00000238761
GH01I112462 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 9.4 +68.6 68589 5 HDGF PKNOX1 CLOCK FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B WNT2B LOC100421402 DDX20 ST7L LRIG2 CTTNBP2NL MIR4256
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around CTTNBP2NL on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the CTTNBP2NL gene promoter:

Genomic Locations for CTTNBP2NL Gene

Genomic Locations for CTTNBP2NL Gene
chr1:112,396,178-112,463,456
(GRCh38/hg38)
Size:
67,279 bases
Orientation:
Plus strand
chr1:112,938,800-113,006,078
(GRCh37/hg19)

Genomic View for CTTNBP2NL Gene

Genes around CTTNBP2NL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CTTNBP2NL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CTTNBP2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTTNBP2NL Gene

Proteins for CTTNBP2NL Gene

  • Protein details for CTTNBP2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2B4-CT2NL_HUMAN
    Recommended name:
    CTTNBP2 N-terminal-like protein
    Protein Accession:
    Q9P2B4
    Secondary Accessions:
    • B3KMS5
    • Q96B40

    Protein attributes for CTTNBP2NL Gene

    Size:
    639 amino acids
    Molecular mass:
    70158 Da
    Quaternary structure:
    • Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers (By similarity). May form homomers. May interact with MOB4, PPP2R1A, PPP2CB, STK24, STK25, STK26, STRN4, STRIP1 and STRIP2.
    SequenceCaution:
    • Sequence=BAA92671.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CTTNBP2NL Gene

Post-translational modifications for CTTNBP2NL Gene

No Post-translational modifications

Other Protein References for CTTNBP2NL Gene

Antibody Products

No data available for DME Specific Peptides for CTTNBP2NL Gene

Domains & Families for CTTNBP2NL Gene

Gene Families for CTTNBP2NL Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CTTNBP2NL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTTNBP2NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CTTNBP2NL: view

No data available for UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Function for CTTNBP2NL Gene

Phenotypes From GWAS Catalog for CTTNBP2NL Gene

Gene Ontology (GO) - Molecular Function for CTTNBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18782753
GO:0051721 protein phosphatase 2A binding IDA 24218568
genes like me logo Genes that share ontologies with CTTNBP2NL: view
genes like me logo Genes that share phenotypes with CTTNBP2NL: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CTTNBP2NL Gene

Localization for CTTNBP2NL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with stress fibers. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CTTNBP2NL gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CTTNBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with CTTNBP2NL: view

Pathways & Interactions for CTTNBP2NL Gene

SuperPathways for CTTNBP2NL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTTNBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IEA,IMP 24218568
GO:0032410 negative regulation of transporter activity IMP 24218568
GO:0034763 negative regulation of transmembrane transport IMP 24218568
genes like me logo Genes that share ontologies with CTTNBP2NL: view

No data available for Pathways by source and SIGNOR curated interactions for CTTNBP2NL Gene

Drugs & Compounds for CTTNBP2NL Gene

No Compound Related Data Available

Transcripts for CTTNBP2NL Gene

Unigene Clusters for CTTNBP2NL Gene

CTTNBP2 N-terminal like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CTTNBP2NL Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: - - - -
SP4:

Relevant External Links for CTTNBP2NL Gene

GeneLoc Exon Structure for
CTTNBP2NL
ECgene alternative splicing isoforms for
CTTNBP2NL

Expression for CTTNBP2NL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CTTNBP2NL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTTNBP2NL Gene

This gene is overexpressed in Adrenal (34.1) and Cervix (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CTTNBP2NL Gene



NURSA nuclear receptor signaling pathways regulating expression of CTTNBP2NL Gene:

CTTNBP2NL

SOURCE GeneReport for Unigene cluster for CTTNBP2NL Gene:

Hs.744100

Evidence on tissue expression from TISSUES for CTTNBP2NL Gene

  • Nervous system(4.7)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with CTTNBP2NL: view

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CTTNBP2NL Gene

Orthologs for CTTNBP2NL Gene

This gene was present in the common ancestor of animals.

Orthologs for CTTNBP2NL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CTTNBP2NL 33 34
  • 99.48 (n)
cow
(Bos Taurus)
Mammalia CTTNBP2NL 33 34
  • 89.25 (n)
dog
(Canis familiaris)
Mammalia CTTNBP2NL 33 34
  • 87.79 (n)
mouse
(Mus musculus)
Mammalia Cttnbp2nl 33 16 34
  • 87.04 (n)
rat
(Rattus norvegicus)
Mammalia Cttnbp2nl 33
  • 86.99 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CTTNBP2NL 34
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CTTNBP2NL 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTTNBP2NL 33 34
  • 73.26 (n)
lizard
(Anolis carolinensis)
Reptilia CTTNBP2NL 34
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cttnbp2nl 33
  • 66.67 (n)
zebrafish
(Danio rerio)
Actinopterygii cttnbp2nlb 33
  • 56.97 (n)
CTTNBP2NL (1 of 2) 34
  • 50 (a)
OneToMany
cttnbp2nl 34
  • 49 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10915 34
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C49H3.6 34
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToMany
Species where no ortholog for CTTNBP2NL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTTNBP2NL Gene

ENSEMBL:
Gene Tree for CTTNBP2NL (if available)
TreeFam:
Gene Tree for CTTNBP2NL (if available)

Paralogs for CTTNBP2NL Gene

Paralogs for CTTNBP2NL Gene

(3) SIMAP similar genes for CTTNBP2NL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CTTNBP2NL: view

Variants for CTTNBP2NL Gene

Sequence variations from dbSNP and Humsavar for CTTNBP2NL Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000028394 -- 112,410,087(+) A/G intron_variant
rs1000117710 -- 112,439,208(+) G/A intron_variant
rs1000121557 -- 112,456,799(+) G/A coding_sequence_variant, missense_variant
rs1000218693 -- 112,453,184(+) T/G intron_variant
rs1000224854 -- 112,460,359(+) A/C 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for CTTNBP2NL Gene

Variant ID Type Subtype PubMed ID
esv2660196 CNV deletion 23128226
esv27061 CNV gain+loss 19812545
esv3587211 CNV loss 21293372
nsv159278 CNV deletion 16902084
nsv159431 CNV insertion 16902084
nsv506955 OTHER sequence alteration 20534489
nsv831081 CNV loss 17160897

Variation tolerance for CTTNBP2NL Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.04% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for CTTNBP2NL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CTTNBP2NL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Disorders for CTTNBP2NL Gene

Additional Disease Information for CTTNBP2NL

No disorders were found for CTTNBP2NL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTTNBP2NL Gene

Publications for CTTNBP2NL Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 58
  2. A PP2A phosphatase high density interaction network identifies a novel striatin-interacting phosphatase and kinase complex linked to the cerebral cavernous malformation 3 (CCM3) protein. (PMID: 18782753) Goudreault M … Gingras AC (Molecular & cellular proteomics : MCP 2009) 3 4 58
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  4. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil SA … Gygi SP (Nature biotechnology 2006) 3 4 58
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58

Products for CTTNBP2NL Gene

Sources for CTTNBP2NL Gene

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