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Aliases for CTTNBP2NL Gene

Aliases for CTTNBP2NL Gene

  • CTTNBP2 N-Terminal Like 2 3
  • KIAA1433 4

External Ids for CTTNBP2NL Gene

Previous GeneCards Identifiers for CTTNBP2NL Gene

  • GC01P112651
  • GC01P112740
  • GC01P112938
  • GC01P110795

Summaries for CTTNBP2NL Gene

GeneCards Summary for CTTNBP2NL Gene

CTTNBP2NL (CTTNBP2 N-Terminal Like) is a Protein Coding gene. GO annotations related to this gene include protein phosphatase 2A binding. An important paralog of this gene is CTTNBP2.

Gene Wiki entry for CTTNBP2NL Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CTTNBP2NL Gene

Genomics for CTTNBP2NL Gene

Regulatory Elements for CTTNBP2NL Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CTTNBP2NL Gene

Chromosome:
1
Start:
112,396,178 bp from pter
End:
112,463,456 bp from pter
Size:
67,279 bases
Orientation:
Plus strand

Genomic View for CTTNBP2NL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CTTNBP2NL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CTTNBP2NL Gene

Proteins for CTTNBP2NL Gene

  • Protein details for CTTNBP2NL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2B4-CT2NL_HUMAN
    Recommended name:
    CTTNBP2 N-terminal-like protein
    Protein Accession:
    Q9P2B4
    Secondary Accessions:
    • B3KMS5
    • Q96B40

    Protein attributes for CTTNBP2NL Gene

    Size:
    639 amino acids
    Molecular mass:
    70158 Da
    Quaternary structure:
    • Interacts with CTTN/cortactin; this interaction may redistribute CTTN to stress fibers (By similarity). May form homomers. May interact with MOB4, PPP2R1A, PPP2CB, STK24, STK25, STK26, STRN4, STRIP1 and STRIP2.
    SequenceCaution:
    • Sequence=BAA92671.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for CTTNBP2NL Gene

Proteomics data for CTTNBP2NL Gene at MOPED

Post-translational modifications for CTTNBP2NL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CTTNBP2NL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for CTTNBP2NL Gene

Domains & Families for CTTNBP2NL Gene

Protein Domains for CTTNBP2NL Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CTTNBP2NL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CTTNBP2NL: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Function for CTTNBP2NL Gene

Gene Ontology (GO) - Molecular Function for CTTNBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18782753
GO:0051721 protein phosphatase 2A binding IDA 24218568
genes like me logo Genes that share ontologies with CTTNBP2NL: view

Phenotypes for CTTNBP2NL Gene

genes like me logo Genes that share phenotypes with CTTNBP2NL: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTTNBP2NL

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CTTNBP2NL Gene

Localization for CTTNBP2NL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Cytoplasm, cytoskeleton. Note=Colocalizes with stress fibers. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CTTNBP2NL Gene COMPARTMENTS Subcellular localization image for CTTNBP2NL gene
Compartment Confidence
cytoskeleton 4
cytosol 2
nucleus 2

Gene Ontology (GO) - Cellular Components for CTTNBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with CTTNBP2NL: view

Pathways & Interactions for CTTNBP2NL Gene

SuperPathways for CTTNBP2NL Gene

No Data Available

Gene Ontology (GO) - Biological Process for CTTNBP2NL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation IMP 24218568
GO:0032410 negative regulation of transporter activity IMP 24218568
GO:0034763 negative regulation of transmembrane transport IMP 24218568
genes like me logo Genes that share ontologies with CTTNBP2NL: view

No data available for Pathways by source and SIGNOR curated interactions for CTTNBP2NL Gene

Drugs & Compounds for CTTNBP2NL Gene

No Compound Related Data Available

Transcripts for CTTNBP2NL Gene

Unigene Clusters for CTTNBP2NL Gene

CTTNBP2 N-terminal like:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CTTNBP2NL

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CTTNBP2NL Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: - - -
SP2: - -
SP3: - - - -
SP4:

Relevant External Links for CTTNBP2NL Gene

GeneLoc Exon Structure for
CTTNBP2NL
ECgene alternative splicing isoforms for
CTTNBP2NL

Expression for CTTNBP2NL Gene

mRNA expression in normal human tissues for CTTNBP2NL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CTTNBP2NL Gene

This gene is overexpressed in Adrenal (34.1) and Cervix (14.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CTTNBP2NL Gene



SOURCE GeneReport for Unigene cluster for CTTNBP2NL Gene Hs.744100

genes like me logo Genes that share expression patterns with CTTNBP2NL: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CTTNBP2NL Gene

Orthologs for CTTNBP2NL Gene

This gene was present in the common ancestor of animals.

Orthologs for CTTNBP2NL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CTTNBP2NL 35
  • 89.25 (n)
  • 92.02 (a)
CTTNBP2NL 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CTTNBP2NL 35
  • 87.79 (n)
  • 90.61 (a)
CTTNBP2NL 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cttnbp2nl 35
  • 87.04 (n)
  • 89.81 (a)
Cttnbp2nl 16
Cttnbp2nl 36
  • 90 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CTTNBP2NL 35
  • 99.48 (n)
  • 99.37 (a)
CTTNBP2NL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cttnbp2nl 35
  • 86.99 (n)
  • 89.03 (a)
oppossum
(Monodelphis domestica)
Mammalia CTTNBP2NL 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CTTNBP2NL 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves CTTNBP2NL 35
  • 73.26 (n)
  • 78.65 (a)
CTTNBP2NL 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CTTNBP2NL 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cttnbp2nl 35
  • 66.67 (n)
  • 68.2 (a)
zebrafish
(Danio rerio)
Actinopterygii cttnbp2nlb 35
  • 56.97 (n)
  • 55.03 (a)
cttnbp2nl 36
  • 49 (a)
OneToMany
CTTNBP2NL (1 of 2) 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG10915 36
  • 24 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C49H3.6 36
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToMany
Species with no ortholog for CTTNBP2NL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CTTNBP2NL Gene

ENSEMBL:
Gene Tree for CTTNBP2NL (if available)
TreeFam:
Gene Tree for CTTNBP2NL (if available)

Paralogs for CTTNBP2NL Gene

Paralogs for CTTNBP2NL Gene

(3) SIMAP similar genes for CTTNBP2NL Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CTTNBP2NL: view

Variants for CTTNBP2NL Gene

Sequence variations from dbSNP and Humsavar for CTTNBP2NL Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs11035 -- 112,460,067(-) ACTAA(A/T)ATTGT utr-variant-3-prime
rs962401 -- 112,412,144(+) ACCAA(C/G/T)TTGTT intron-variant
rs962402 -- 112,412,372(+) ATGCA(A/G)TTTTA intron-variant
rs1018712 -- 112,413,440(+) aagat(A/G)ttcta intron-variant
rs1018713 -- 112,452,190(+) ggtct(C/T)gctgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CTTNBP2NL Gene

Variant ID Type Subtype PubMed ID
esv27061 CNV Gain+Loss 19812545
nsv831081 CNV Loss 17160897
esv2660196 CNV Deletion 23128226
esv267691 CNV Insertion 20981092
esv273441 CNV Insertion 20981092
nsv159431 CNV Insertion 16902084
nsv159278 CNV Loss 16902084
nsv506955 CNV Insertion 20534489

Variation tolerance for CTTNBP2NL Gene

Residual Variation Intolerance Score: 36.58% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CTTNBP2NL Gene

HapMap Linkage Disequilibrium report
CTTNBP2NL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CTTNBP2NL Gene

Disorders for CTTNBP2NL Gene

Relevant External Links for CTTNBP2NL

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CTTNBP2NL
genes like me logo Genes that share disorders with CTTNBP2NL: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CTTNBP2NL Gene

Publications for CTTNBP2NL Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 67
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 67
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67

Products for CTTNBP2NL Gene

Sources for CTTNBP2NL Gene

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