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Aliases for PRKD1 Gene

Aliases for PRKD1 Gene

  • Protein Kinase D1 2 3
  • PRKCM 3 4 6
  • PKD 3 4 6
  • Protein Kinase C Mu Type 3 4
  • Protein Kinase C, Mu 2 3
  • Protein Kinase D 3 4
  • EC 2.7.11.13 4 63
  • NPKC-D1 3 4
  • NPKC-Mu 3 4
  • Serine/Threonine-Protein Kinase D1 3
  • EC 2.7.11 63
  • PKC-MU 3
  • PKCM 3
  • PKD1 4

External Ids for PRKD1 Gene

Previous HGNC Symbols for PRKD1 Gene

  • PRKCM

Previous GeneCards Identifiers for PRKD1 Gene

  • GC14M029115
  • GC14M030045
  • GC14M010161

Summaries for PRKD1 Gene

Entrez Gene Summary for PRKD1 Gene

  • PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]

GeneCards Summary for PRKD1 Gene

PRKD1 (Protein Kinase D1) is a Protein Coding gene. Among its related pathways are Ras signaling pathway and Development FGFR signaling pathway. GO annotations related to this gene include identical protein binding and phospholipid binding. An important paralog of this gene is PRKD3.

UniProtKB/Swiss-Prot for PRKD1 Gene

  • Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor.

Tocris Summary for PRKD1 Gene

  • The protein kinase D (PKD) family of serine/threonine protein kinases contains three members; PKD1, PKD2 and PKD2. These enzymes occupy a unique position in the signal transduction pathway initiated by diacylglycerol (DAG) and protein kinase C (PKC). PKDs are direct targets of DAG, and also lie downstream of PKC in a novel signal transduction pathway that is implicated in a variety of biological processes. Structurally, PKDs contain an N' terminal cysteine-rich domain (CRD), which binds phorbol esters with high affinity and has a role in mediating PKD translocation to the plasma membrane upon activation. The PH domains have an autoregulatory phosphorylation site (PKD1 and PKD2 only) and the catalytic domains have a high degree of homology to myosin light chain and calmodulin-dependent kinases. In the inactivated state, PKD1 and PKD2 are localized mainly to the cytoplasm, whilst PKD3 is found both in the cytoplasm and nucleus. Kinase activity of these enzymes is repressed by their CRD and PH domains. PKDs are activated by a variety of stimuli including regulatory peptides, lysophosphatidic acid, thrombin, PDGF, IGF-1, oxidative stress, cholecystokinin, Gbetagamma, ATP and more. These stimuli produce a rapid generation of DAG, which induces CRD-mediated PKD translocation from the cytosol to the plasma membrane. Novel PKCs are also recruited to the plasma membrane in response to DAG generation. Novel PKCs are allosterically activated by DAG, and transphosphorylate PKDs. This stabilizes PKD in its active conformation. Activated PKD dissociates from the plasma membrane, translocates to the cytosol and subsequently to the nucleus. PKDs have been implicated in fundamental physiological processes including signal transduction, membrane trafficking, and cell survival, migration, differentiation and proliferation. PKD upregulates the ERK and Ras signaling pathways, and suppresses the JNK signaling pathway. These enzymes regulate the budding of secretory vesicles from the trans-Golgi network and promote integrin recruitment to focal adhesions. In addition, PKDs have a role in regulating apoptosis and have functions in cell survival pathways induced by oxidative stress. They also have a role in immune regulation. Despite the plethora of physiological processes PKDs are involved in, only a few direct targets are known. These include kidins220, an integral membrane protein of neuroendocrine cells, c-Jun and RIN1, a protein that associates with Ras and 14.3.3 and activates the Ras-MEK-ERK pathway.

Gene Wiki entry for PRKD1 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKD1 Gene

Genomics for PRKD1 Gene

Regulatory Elements for PRKD1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKD1 Gene

Start:
29,576,479 bp from pter
End:
30,191,898 bp from pter
Size:
615,420 bases
Orientation:
Minus strand

Genomic View for PRKD1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKD1 Gene

Proteins for PRKD1 Gene

  • Protein details for PRKD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15139-KPCD1_HUMAN
    Recommended name:
    Serine/threonine-protein kinase D1
    Protein Accession:
    Q15139
    Secondary Accessions:
    • A6NL64
    • B2RAF6

    Protein attributes for PRKD1 Gene

    Size:
    912 amino acids
    Molecular mass:
    101704 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • Interacts (via N-terminus) with ADAP1/CENTA1. Interacts with MAPK13 and SRC. Interacts with DAPK1 in an oxidative stress-regulated manner.

neXtProt entry for PRKD1 Gene

Proteomics data for PRKD1 Gene at MOPED

Post-translational modifications for PRKD1 Gene

  • Phosphorylated at Ser-397 and Ser-401 by MAPK13 during regulation of insulin secretion in pancreatic beta cells. Phosphorylated by DAPK1. Phosphorylated by ABL at Tyr-463, which primes the kinase in response to oxidative stress, and promotes a second step activating phosphorylation at Ser-738/Ser-742 by PKRD.
  • Ubiquitination at Lys292
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKD1 Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKD1 (PKD1)

Domains for PRKD1 Gene

Gene Families for PRKD1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for PRKD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15139

UniProtKB/Swiss-Prot:

KPCD1_HUMAN :
  • Q15139
Domain:
  • Contains 1 PH domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKD1: view

Function for PRKD1 Gene

Molecular function for PRKD1 Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by DAG and phorbol esters. Phorbol-ester/DAG-type domain 1 binds DAG with high affinity and appears to play the dominant role in mediating translocation to the cell membrane and trans-Golgi network. Phorbol-ester/DAG-type domain 2 binds phorbol ester with higher affinity. Autophosphorylation of Ser-742 and phosphorylation of Ser-738 by PKC relieves auto-inhibition by the PH domain. Phosphorylation on Tyr-463 by the SRC-ABL1 pathway in response to oxidative stress, is also required for activation. Activated by DAPK1 under oxidative stress.
UniProtKB/Swiss-Prot Function: Serine/threonine-protein kinase that converts transient diacylglycerol (DAG) signals into prolonged physiological effects downstream of PKC, and is involved in the regulation of MAPK8/JNK1 and Ras signaling, Golgi membrane integrity and trafficking, cell survival through NF-kappa-B activation, cell migration, cell differentiation by mediating HDAC7 nuclear export, cell proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced apoptosis and flagellin-stimulated inflammatory response. Phosphorylates the epidermal growth factor receptor (EGFR) on dual threonine residues, which leads to the suppression of epidermal growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to 14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition with RAF1 for binding to GTP-bound form of Ras proteins (NRAS, HRAS and KRAS). Acts downstream of the heterotrimeric G-protein beta/gamma-subunit complex to maintain the structural integrity of the Golgi membranes, and is required for protein transport along the secretory pathway. In the trans-Golgi network (TGN), regulates the fission of transport vesicles that are on their way to the plasma membrane. May act by activating the lipid kinase phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the local synthesis of phosphorylated inositol lipids, which induces a sequential production of DAG, phosphatidic acid (PA) and lyso-PA (LPA) that are necessary for membrane fission and generation of specific transport carriers to the cell surface. Under oxidative stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes to cell survival by activating IKK complex and subsequent nuclear translocation and activation of NFKB1. Involved in cell migration by regulating integrin alpha-5/beta-3 recycling and promoting its recruitment in newly forming focal adhesion. In osteoblast differentiation, mediates the bone morphogenic protein 2 (BMP2)-induced nuclear export of HDAC7, which results in the inhibition of HDAC7 transcriptional repression of RUNX2. In neurons, plays an important role in neuronal polarity by regulating the biogenesis of TGN-derived dendritic vesicles, and is involved in the maintenance of dendritic arborization and Golgi structure in hippocampal cells. May potentiate mitogenesis induced by the neuropeptide bombesin or vasopressin by mediating an increase in the duration of MAPK1/3 (ERK1/2) signaling, which leads to accumulation of immediate-early gene products including FOS that stimulate cell cycle progression. Plays an important role in the proliferative response induced by low calcium in keratinocytes, through sustained activation of MAPK1/3 (ERK1/2) pathway. Downstream of novel PKC signaling, plays a role in cardiac hypertrophy by phosphorylating HDAC5, which in turn triggers XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional activation and induction of downstream target genes that promote myocyte hypertrophy and pathological cardiac remodeling. Mediates cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which results in reduced myofilament calcium sensitivity, and accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway is also involved in angiogenesis by mediating VEGFA-induced specific subset of gene expression, cell migration, and tube formation. In response to VEGFA, is necessary and required for HDAC7 phosphorylation which induces HDAC7 nuclear export and endothelial cell proliferation and migration. During apoptosis induced by cytarabine and other genotoxic agents, PRKD1 is cleaved by caspase-3 at Asp-378, resulting in activation of its kinase function and increased sensitivity of cells to the cytotoxic effects of genotoxic agents. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor.

Enzyme Numbers (IUBMB) for PRKD1 Gene

Gene Ontology (GO) - Molecular Function for PRKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity TAS 8119958
GO:0004697 protein kinase C activity IDA 12637538
GO:0004713 protein tyrosine kinase activity --
GO:0005515 protein binding IPI 10831594
genes like me logo Genes that share ontologies with PRKD1: view

Phenotypes for PRKD1 Gene

genes like me logo Genes that share phenotypes with PRKD1: view

Animal Models for PRKD1 Gene

MGI Knock Outs for PRKD1:

Animal Model Products

CRISPR Products

miRNA for PRKD1 Gene

miRTarBase miRNAs that target PRKD1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKD1

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PRKD1 Gene

Localization for PRKD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKD1 Gene

Cytoplasm. Cell membrane. Golgi apparatus, trans-Golgi network. Note=Translocation to the cell membrane is required for kinase activation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKD1 Gene COMPARTMENTS Subcellular localization image for PRKD1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
golgi apparatus 3
endoplasmic reticulum 2
extracellular 2
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for PRKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA 11239398
GO:0005802 trans-Golgi network IDA 19211839
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRKD1: view

Pathways for PRKD1 Gene

genes like me logo Genes that share pathways with PRKD1: view

Gene Ontology (GO) - Biological Process for PRKD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001525 angiogenesis IEA --
GO:0001938 positive regulation of endothelial cell proliferation IGI 20497126
GO:0006468 protein phosphorylation --
GO:0006665 sphingolipid metabolic process TAS --
GO:0006915 apoptotic process IEA --
genes like me logo Genes that share ontologies with PRKD1: view

Compounds for PRKD1 Gene

Compound Products

(4) Tocris Compounds for PRKD1 Gene

Compound Action Cas Number
CID 2011756 Pan protein kinase D (PKD) inhibitor; cell permeable [638156-11-3]
CID 755673 Selective protein kinase D inhibitor [521937-07-5]
CRT 0066101 Potent protein kinase D (PKD) inhibitor
kb NB 142-70 Selective PKD inhibitor; analog of CID 755673 (Cat. No. 3327) [1233533-04-4]

(4) ApexBio Compounds for PRKD1 Gene

Compound Action Cas Number
CID 2011756 novel and potent inhibitor of PKD1 [638156-11-3]
CID 755673 Selective PKD inhibitor [521937-07-5]
CRT 0066101 Potent inhibitor of PKD
kb NB 142-70 selective PKD inhibitor [1233533-04-4]

(847) HMDB Compounds for PRKD1 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Aldosterone
  • (+)-Aldosterone
52-39-1
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available

(35) Novoseek inferred chemical compound relationships for PRKD1 Gene

Compound -log(P) Hits PubMed IDs
pkcs 86.5 19
syntide-2 85.2 5
threonine 74.8 39
go 6983 74.3 2
serine 71.2 55
genes like me logo Genes that share compounds with PRKD1: view

Transcripts for PRKD1 Gene

mRNA/cDNA for PRKD1 Gene

(3) Additional mRNA sequences :
(4) REFSEQ mRNAs :
(1) Selected AceView cDNA sequences:
(10) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for PRKD1 Gene

Protein kinase D1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKD1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for PRKD1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKD1 Gene

No ASD Table

Relevant External Links for PRKD1 Gene

GeneLoc Exon Structure for
PRKD1
ECgene alternative splicing isoforms for
PRKD1

Expression for PRKD1 Gene

mRNA expression in normal human tissues for PRKD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKD1 Gene

SOURCE GeneReport for Unigene cluster for PRKD1 Gene Hs.508999

genes like me logo Genes that share expressions with PRKD1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRKD1 Gene

Orthologs for PRKD1 Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKD1 35
  • 99.49 (n)
  • 99.45 (a)
PRKD1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKD1 35
  • 92.64 (n)
  • 96.64 (a)
PRKD1 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKD1 35
  • 93.24 (n)
  • 96.64 (a)
PRKD1 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkd1 35
  • 87.99 (n)
  • 93.52 (a)
Prkd1 16
Prkd1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKD1 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKD1 36
  • 90 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkd1 35
  • 87.77 (n)
  • 93.96 (a)
chicken
(Gallus gallus)
Aves PRKD1 35
  • 81.25 (n)
  • 90.39 (a)
PRKD1 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKD1 36
  • 82 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9234 35
tropical clawed frog
(Silurana tropicalis)
Amphibia prkd1 35
  • 74.22 (n)
  • 84.3 (a)
zebrafish
(Danio rerio)
Actinopterygii prkd1 35
  • 73.71 (n)
  • 83.22 (a)
PRKD1 36
  • 82 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea dkf-2 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
OneToOne
Species with no ortholog for PRKD1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKD1 Gene

ENSEMBL:
Gene Tree for PRKD1 (if available)
TreeFam:
Gene Tree for PRKD1 (if available)

Paralogs for PRKD1 Gene

Paralogs for PRKD1 Gene

genes like me logo Genes that share paralogs with PRKD1: view

Variants for PRKD1 Gene

Sequence variations from dbSNP and Humsavar for PRKD1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11984 -- 29,576,772(-) TGAAT(A/G)AGGAG utr-variant-3-prime
rs16895 -- 29,605,117(+) GGTTC(A/G)AGCCC intron-variant
rs753216 -- 29,588,625(+) AAATA(C/T)GACCA intron-variant
rs873949 -- 29,774,643(+) TTATT(C/G)TGCAT intron-variant
rs875677 -- 29,602,115(+) CAGTA(C/T)GGGTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKD1 Gene

Variant ID Type Subtype PubMed ID
nsv526536 CNV Gain 19592680
nsv901579 CNV Loss 21882294
esv2748535 CNV Deletion 23290073
nsv518869 CNV Loss 19592680
esv1921382 CNV Deletion 18987734
esv2748536 CNV Deletion 23290073
esv2748537 CNV Deletion 23290073
esv2740903 CNV Deletion 23290073
dgv289e201 CNV Deletion 23290073
esv1587594 CNV Deletion 17803354
nsv832761 CNV Loss 17160897
nsv456195 CNV Loss 19166990
nsv518206 CNV Loss 19592680

Relevant External Links for PRKD1 Gene

HapMap Linkage Disequilibrium report
PRKD1
Human Gene Mutation Database (HGMD)
PRKD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKD1 Gene

Disorders for PRKD1 Gene

(14) Novoseek inferred disease relationships for PRKD1 Gene

Disease -log(P) Hits PubMed IDs
arpkd 40.4 1
cardiac hypertrophy 37.1 1
adpkd 36.9 1
prostate cancer 33 15
pancreatic carcinoma 17.7 1

Relevant External Links for PRKD1

Genetic Association Database (GAD)
PRKD1
Human Genome Epidemiology (HuGE) Navigator
PRKD1
genes like me logo Genes that share disorders with PRKD1: view

No data available for UniProtKB/Swiss-Prot for PRKD1 Gene

Publications for PRKD1 Gene

  1. PKCmu is a novel, atypical member of the protein kinase C family. (PMID: 8119958) Johannes F.-J. … Pfizenmaier K. (J. Biol. Chem. 1994) 2 3 4 23
  2. Cell-type specific phosphorylation of threonines T654 and T669 by PKD defines the signal capacity of the EGF receptor. (PMID: 10523301) Bagowski C.P. … Ullrich A. (EMBO J. 1999) 3 4 23
  3. Protein kinase D: an intracellular traffic regulator on the move. (PMID: 11978539) Van Lint J. … Seufferlein T. (Trends Cell Biol. 2002) 3 4 23
  4. Tyrosine phosphorylation of protein kinase D in the pleckstrin homology domain leads to activation. (PMID: 12637538) Storz P. … Toker A. (J. Biol. Chem. 2003) 3 4 23
  5. Protein kinase D mediates a stress-induced NF-kappaB activation and survival pathway. (PMID: 12505989) Storz P. … Toker A. (EMBO J. 2003) 3 4 23

Products for PRKD1 Gene

  • Addgene plasmids for PRKD1

Sources for PRKD1 Gene

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