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Aliases for SLC22A11 Gene

Aliases for SLC22A11 Gene

  • Solute Carrier Family 22 Member 11 2 3
  • Solute Carrier Family 22 (Organic Anion/Urate Transporter), Member 11 2 3 5
  • Organic Anion Transporter 4 3 4
  • OAT4 3 4
  • Solute Carrier Family 22 (Organic Anion/Cation Transporter), Member 11 3
  • HOAT4 3

External Ids for SLC22A11 Gene

Previous GeneCards Identifiers for SLC22A11 Gene

  • GC11P066839
  • GC11P066004
  • GC11P064098
  • GC11P064079
  • GC11P064324
  • GC11P060650

Summaries for SLC22A11 Gene

Entrez Gene Summary for SLC22A11 Gene

  • The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and is found mainly in the kidney and in the placenta, where it may act to prevent potentially harmful organic anions from reaching the fetus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

GeneCards Summary for SLC22A11 Gene

SLC22A11 (Solute Carrier Family 22 Member 11) is a Protein Coding gene. Diseases associated with SLC22A11 include gout and persistent fetal circulation syndrome. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics. GO annotations related to this gene include transmembrane transporter activity and organic anion transmembrane transporter activity. An important paralog of this gene is SLC22A12.

UniProtKB/Swiss-Prot for SLC22A11 Gene

  • Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.

Gene Wiki entry for SLC22A11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC22A11 Gene

Genomics for SLC22A11 Gene

Regulatory Elements for SLC22A11 Gene

Genomic Location for SLC22A11 Gene

Chromosome:
11
Start:
64,555,626 bp from pter
End:
64,572,875 bp from pter
Size:
17,250 bases
Orientation:
Plus strand

Genomic View for SLC22A11 Gene

Genes around SLC22A11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC22A11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC22A11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC22A11 Gene

Proteins for SLC22A11 Gene

  • Protein details for SLC22A11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NSA0-S22AB_HUMAN
    Recommended name:
    Solute carrier family 22 member 11
    Protein Accession:
    Q9NSA0
    Secondary Accessions:
    • A8K426
    • Q53GR2
    • Q6ZP72
    • Q8NBU4

    Protein attributes for SLC22A11 Gene

    Size:
    550 amino acids
    Molecular mass:
    59972 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11483.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC22A11 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for SLC22A11 Gene

Proteomics data for SLC22A11 Gene at MOPED

Post-translational modifications for SLC22A11 Gene

  • N-glycosylated. Contains several complex-type N-glycans.
  • Glycosylation at Asn 39, Asn 56, and Asn 99
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC22A11 Gene

Antibody Products

No data available for DME Specific Peptides for SLC22A11 Gene

Domains & Families for SLC22A11 Gene

Gene Families for SLC22A11 Gene

Protein Domains for SLC22A11 Gene

Suggested Antigen Peptide Sequences for SLC22A11 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NSA0

UniProtKB/Swiss-Prot:

S22AB_HUMAN :
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
Family:
  • Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.
genes like me logo Genes that share domains with SLC22A11: view

Function for SLC22A11 Gene

Molecular function for SLC22A11 Gene

UniProtKB/Swiss-Prot Function:
Mediates saturable uptake of estrone sulfate, dehydroepiandrosterone sulfate and related compounds.

Gene Ontology (GO) - Molecular Function for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008514 organic anion transmembrane transporter activity IDA 15102942
genes like me logo Genes that share ontologies with SLC22A11: view
genes like me logo Genes that share phenotypes with SLC22A11: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for SLC22A11 Gene

Localization for SLC22A11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC22A11 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SLC22A11 Gene COMPARTMENTS Subcellular localization image for SLC22A11 gene
Compartment Confidence
extracellular 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0009897 external side of plasma membrane IDA 15102942
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with SLC22A11: view

Pathways & Interactions for SLC22A11 Gene

genes like me logo Genes that share pathways with SLC22A11: view

Gene Ontology (GO) - Biological Process for SLC22A11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046415 urate metabolic process IMP 19503597
GO:0098656 anion transmembrane transport IDA 15037815
genes like me logo Genes that share ontologies with SLC22A11: view

No data available for SIGNOR curated interactions for SLC22A11 Gene

Drugs & Compounds for SLC22A11 Gene

(37) Drugs for SLC22A11 Gene - From: DrugBank, HMDB, FDA Approved Drugs, PharmGKB, Novoseek, and DGIdb

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Probenecid Approved Pharma Inhibition, Inhibitor, blocker, Target, Transporter, inhibitor 27
Methotrexate Approved Pharma Transporter, substrate Folate antagonist,inhibits DFHR, Cytotoxic agent 1444
Bumetanide Approved Pharma Agonist, Transporter, inhibitor NKCC cotransporter inhibitor, Na+/2Cl-/K+ (NKCC) symporter inhibitor 15
Cefalotin Approved Pharma Transporter, inhibitor 0
Cefamandole Approved Pharma Transporter, inhibitor 0

(3) Additional Compounds for SLC22A11 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4'-Hydroxydiclofenac
  • (O-(2,6-Dichloro-4-hydroxyanilino)phenyl)acetic acid
  • 4'-Hydroxy diclofenac
  • 4'-OH DCF
  • {2-[(2,6-dichloro-4-hydroxyphenyl)amino]phenyl}acetic acid
64118-84-9
5'-Hydroxypiroxicam
77459-78-0
genes like me logo Genes that share compounds with SLC22A11: view

Transcripts for SLC22A11 Gene

Unigene Clusters for SLC22A11 Gene

Solute carrier family 22 (organic anion/urate transporter), member 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for SLC22A11 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - - - -
SP2: - - - - - -
SP3: - - - -
SP4:
SP5:
SP6: - -

Relevant External Links for SLC22A11 Gene

GeneLoc Exon Structure for
SLC22A11
ECgene alternative splicing isoforms for
SLC22A11

Expression for SLC22A11 Gene

mRNA expression in normal human tissues for SLC22A11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC22A11 Gene

This gene is overexpressed in Kidney - Cortex (x51.0).

Protein differential expression in normal tissues from HIPED for SLC22A11 Gene

This gene is overexpressed in Urine (47.7) and Placenta (17.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for SLC22A11 Gene



SOURCE GeneReport for Unigene cluster for SLC22A11 Gene Hs.220844

mRNA Expression by UniProt/SwissProt for SLC22A11 Gene

Q9NSA0-S22AB_HUMAN
Tissue specificity: Detected in placenta and kidney.
genes like me logo Genes that share expression patterns with SLC22A11: view

Protein tissue co-expression partners for SLC22A11 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for SLC22A11 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC22A11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia SLC22A11 35
  • 99.64 (n)
  • 99.64 (a)
SLC22A11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia SLC22A11 36
  • 69 (a)
OneToOne
SLC22A11 35
  • 79.24 (n)
  • 69.36 (a)
dog
(Canis familiaris)
Mammalia SLC22A11 35
  • 80.72 (n)
  • 73.18 (a)
SLC22A11 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 45 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia SLC22A11 36
  • 48 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8654 37
  • 33 (a)
worm
(Caenorhabditis elegans)
Secernentea K05F1.6 37
  • 27 (a)
ZK455.8a 37
  • 29 (a)
ZK455.8b 37
  • 28 (a)
Species with no ortholog for SLC22A11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC22A11 Gene

ENSEMBL:
Gene Tree for SLC22A11 (if available)
TreeFam:
Gene Tree for SLC22A11 (if available)

Paralogs for SLC22A11 Gene

genes like me logo Genes that share paralogs with SLC22A11: view

Variants for SLC22A11 Gene

Sequence variations from dbSNP and Humsavar for SLC22A11 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12785832 - 64,559,205(+) CCTGG(G/T)GGGCT intron-variant, reference, missense
rs523237 -- 64,562,852(-) GGCCT(G/T)GGGGA intron-variant
rs693591 -- 64,557,597(-) CATGT(C/G)CCCGC intron-variant
rs1056255 -- 64,566,387(+) TAGAA(A/C)AAAGA intron-variant
rs1705364 -- 64,554,431(-) CTGGG(C/T)TTCAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SLC22A11 Gene

Variant ID Type Subtype PubMed ID
nsv897692 CNV Loss 21882294
nsv897693 CNV Loss 21882294
esv2422214 CNV Deletion 17116639
nsv832188 CNV Gain 17160897
nsv825945 CNV Gain 20364138
nsv897694 CNV Loss 21882294

Variation tolerance for SLC22A11 Gene

Residual Variation Intolerance Score: 37.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.95; 36.24% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC22A11 Gene

HapMap Linkage Disequilibrium report
SLC22A11
Human Gene Mutation Database (HGMD)
SLC22A11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC22A11 Gene

Disorders for SLC22A11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for SLC22A11 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
gout
  • articular gout
persistent fetal circulation syndrome
  • congenital alveolar capillary dysplasia with misalignment of pulmonary veins
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for SLC22A11

Genetic Association Database (GAD)
SLC22A11
Human Genome Epidemiology (HuGE) Navigator
SLC22A11
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
SLC22A11
genes like me logo Genes that share disorders with SLC22A11: view

No data available for UniProtKB/Swiss-Prot and Genatlas for SLC22A11 Gene

Publications for SLC22A11 Gene

  1. The role of N-linked glycosylation in protein folding, membrane targeting, and substrate binding of human organic anion transporter hOAT4. (PMID: 15576633) Zhou F. … You G. (Mol. Pharmacol. 2005) 2 3 4 67
  2. Human organic anion transporters mediate the transport of tetracycline. (PMID: 11855680) Babu E. … Endou H. (Jpn. J. Pharmacol. 2002) 3 23 25 26
  3. Molecular cloning and characterization of multispecific organic anion transporter 4 expressed in the placenta. (PMID: 10660625) Cha S.H. … Endou H. (J. Biol. Chem. 2000) 2 3 25 26
  4. Characterization of the renal tubular transport of zonampanel, a novel alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor antagonist, by human organic anion transporters. (PMID: 15377641) Hashimoto T. … Endou H. (Drug Metab. Dispos. 2004) 23 25 26
  5. Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. (PMID: 12023506) Enomoto A. … Endou H. (J. Pharmacol. Exp. Ther. 2002) 3 25 26

Products for SLC22A11 Gene

Sources for SLC22A11 Gene

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