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Aliases for CENPN Gene

Aliases for CENPN Gene

  • Centromere Protein N 2 3 5
  • Interphase Centromere Complex Protein 32 3 4
  • C16orf60 3 4
  • CENP-N 3 4
  • ICEN32 3 4
  • Chromosome 16 Open Reading Frame 60 2
  • BM039 3

External Ids for CENPN Gene

Previous HGNC Symbols for CENPN Gene

  • C16orf60

Previous GeneCards Identifiers for CENPN Gene

  • GC16P079598
  • GC16P081040
  • GC16P066796

Summaries for CENPN Gene

Entrez Gene Summary for CENPN Gene

  • The protein encoded by this gene forms part of the nucleosome-associated complex and is important for kinetochore assembly. It is bound to kinetochores during S phase and G2 and recruits other proteins to the centromere. Pseudogenes of this gene are located on chromosome 2. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

GeneCards Summary for CENPN Gene

CENPN (Centromere Protein N) is a Protein Coding gene. Among its related pathways are Chromosome Maintenance and Mitotic Metaphase and Anaphase.

UniProtKB/Swiss-Prot for CENPN Gene

  • Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.

Gene Wiki entry for CENPN Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CENPN Gene

Genomics for CENPN Gene

Regulatory Elements for CENPN Gene

Enhancers for CENPN Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G080935 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.4 -68.7 -68683 4.5 TBP PKNOX1 INSM2 SIN3A BRCA1 ZEB1 ZNF121 GATA2 FOS SP3 ENSG00000260213 ATMIN CENPN GC16P080969 LINC02170
GH16G080991 1.8 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -13.5 -13508 3.9 ATF1 FOXA2 ARNT YY1 TCF12 ZNF121 GATA2 FOS DEK SMARCA4 ENSG00000260213 ATMIN CENPN CMC2 ENSG00000278985
GH16G081003 1.4 ENCODE dbSUPER 7.3 -0.3 -341 5.6 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 ENSG00000260213 ATMIN CMC2 CENPN GCSH ENSG00000278985
GH16G081873 1 ENCODE dbSUPER 6.6 +867.6 867590 2.4 CTCF RB1 JUN TEAD4 RAD21 YY1 TEAD3 GATA3 GATA2 ZNF143 PLCG2 CENPN GC16M081818 GC16P081959
GH16G080803 1.6 FANTOM5 Ensembl ENCODE 3.1 -199.6 -199585 7.4 SIN3A FEZF1 GLIS2 GATA2 CBX5 FOS ZNF263 SP3 YY2 JUNB CDYL2 GCSH CENPN CMC2 ATMIN LINC02170
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CENPN on UCSC Golden Path with GeneCards custom track

Promoters for CENPN Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088402 702 2401 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21

Genomic Location for CENPN Gene

Chromosome:
16
Start:
81,006,498 bp from pter
End:
81,033,114 bp from pter
Size:
26,617 bases
Orientation:
Plus strand

Genomic View for CENPN Gene

Genes around CENPN on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CENPN Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CENPN Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CENPN Gene

Proteins for CENPN Gene

  • Protein details for CENPN Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96H22-CENPN_HUMAN
    Recommended name:
    Centromere protein N
    Protein Accession:
    Q96H22
    Secondary Accessions:
    • A8MZE6
    • B3KN53
    • B4DJD1
    • B4DPY7
    • C9JJM5
    • D3DUK8
    • E7ES30
    • E7ETS3
    • Q9NZ83

    Protein attributes for CENPN Gene

    Size:
    339 amino acids
    Molecular mass:
    39555 Da
    Quaternary structure:
    • Component of the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU (PubMed:16622420, PubMed:16622419). The CENPA-NAC complex interacts with the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. Interacts directly with CENPA (PubMed:19543270). Identified in a centromere complex containing histones H2A, H2B and H4, and at least CENPA, CENPB, CENPC, CENPT, CENPN, HJURP, SUPT16H, SSRP1 and RSF1 (PubMed:27499292).

    Alternative splice isoforms for CENPN Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CENPN Gene

Post-translational modifications for CENPN Gene

  • Ubiquitination at Lys10, Lys207, and Lys276
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CENPN Gene

Domains & Families for CENPN Gene

Protein Domains for CENPN Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CENPN Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CENPN: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CENPN Gene

Function for CENPN Gene

Molecular function for CENPN Gene

UniProtKB/Swiss-Prot Function:
Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation. The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres. CENPN is the first protein to bind specifically to CENPA nucleosomes and the direct binding of CENPA nucleosomes by CENPN is required for centromere assembly. Required for chromosome congression and efficiently align the chromosomes on a metaphase plate.

Phenotypes for CENPN Gene

genes like me logo Genes that share phenotypes with CENPN: view

Animal Model Products

CRISPR Products

miRNA for CENPN Gene

miRTarBase miRNAs that target CENPN

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CENPN Gene

Localization for CENPN Gene

Subcellular locations from UniProtKB/Swiss-Prot for CENPN Gene

Nucleus. Chromosome, centromere, kinetochore. Note=Localizes exclusively in the kinetochore domain of centromeres. Kinetochore-bound levels decrease when cells enter mitosis and increase again when cells exit mitosis.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CENPN gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for CENPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000776 kinetochore IEA --
GO:0000777 condensed chromosome kinetochore IEA --
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
GO:0005694 chromosome IEA --
genes like me logo Genes that share ontologies with CENPN: view

Pathways & Interactions for CENPN Gene

genes like me logo Genes that share pathways with CENPN: view

Gene Ontology (GO) - Biological Process for CENPN Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle IEA --
GO:0007059 chromosome segregation IEA --
GO:0007062 sister chromatid cohesion TAS --
GO:0007067 mitotic nuclear division IEA --
GO:0034080 CENP-A containing nucleosome assembly TAS --
genes like me logo Genes that share ontologies with CENPN: view

No data available for SIGNOR curated interactions for CENPN Gene

Transcripts for CENPN Gene

Unigene Clusters for CENPN Gene

Centromere protein N:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CENPN Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12
SP1: - - - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - -
SP6: -
SP7:

Relevant External Links for CENPN Gene

GeneLoc Exon Structure for
CENPN
ECgene alternative splicing isoforms for
CENPN

Expression for CENPN Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CENPN Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CENPN Gene

This gene is overexpressed in Prostate (x5.2).

Protein differential expression in normal tissues from HIPED for CENPN Gene

This gene is overexpressed in Placenta (52.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CENPN Gene



Protein tissue co-expression partners for CENPN Gene

NURSA nuclear receptor signaling pathways regulating expression of CENPN Gene:

CENPN

SOURCE GeneReport for Unigene cluster for CENPN Gene:

Hs.726537

Evidence on tissue expression from TISSUES for CENPN Gene

  • Bone marrow(4.3)
  • Intestine(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with CENPN: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CENPN Gene

Orthologs for CENPN Gene

This gene was present in the common ancestor of chordates.

Orthologs for CENPN Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CENPN 34 35
  • 99.41 (n)
dog
(Canis familiaris)
Mammalia CENPN 34 35
  • 87.22 (n)
rat
(Rattus norvegicus)
Mammalia Cenpn 34
  • 79.65 (n)
mouse
(Mus musculus)
Mammalia Cenpn 34 16 35
  • 79.03 (n)
cow
(Bos Taurus)
Mammalia CENPN 35
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CENPN 35
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CENPN 35
  • 54 (a)
OneToOne
chicken
(Gallus gallus)
Aves CENPN 34 35
  • 66.17 (n)
lizard
(Anolis carolinensis)
Reptilia CENPN 35
  • 45 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cenpn 34
  • 62.87 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.13228 34
zebrafish
(Danio rerio)
Actinopterygii cenpn 34 35
  • 51.64 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 20 (a)
OneToOne
Species where no ortholog for CENPN was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CENPN Gene

ENSEMBL:
Gene Tree for CENPN (if available)
TreeFam:
Gene Tree for CENPN (if available)

Paralogs for CENPN Gene

(1) SIMAP similar genes for CENPN Gene using alignment to 4 proteins:

Pseudogenes.org Pseudogenes for CENPN Gene

genes like me logo Genes that share paralogs with CENPN: view

No data available for Paralogs for CENPN Gene

Variants for CENPN Gene

Sequence variations from dbSNP and Humsavar for CENPN Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000100660 -- 81,022,280(+) TGACT(A/G)ATATT intron-variant, nc-transcript-variant
rs1000176981 -- 81,007,757(+) TCCAC(A/G)GATCT intron-variant, upstream-variant-2KB
rs1000359233 -- 81,012,341(+) AAAAA(A/C)AGTAC intron-variant
rs1000407108 -- 81,021,960(+) CACCA(C/T)GTTGC intron-variant, downstream-variant-500B
rs1000455764 -- 81,008,244(+) CGGAA(C/T)AAATC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CENPN Gene

Variant ID Type Subtype PubMed ID
esv2422360 CNV duplication 17116639
esv3639306 CNV gain 21293372
nsv1062724 CNV gain 25217958
nsv1897 CNV deletion 18451855
nsv522168 CNV gain 19592680
nsv573338 CNV loss 21841781

Variation tolerance for CENPN Gene

Residual Variation Intolerance Score: 51.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.04; 37.50% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CENPN Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CENPN

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CENPN Gene

Disorders for CENPN Gene

Relevant External Links for CENPN

Genetic Association Database (GAD)
CENPN
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CENPN

No disorders were found for CENPN Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CENPN Gene

Publications for CENPN Gene

  1. The human CENP-A centromeric nucleosome-associated complex. (PMID: 16622419) Foltz D.R. … Cleveland D.W. (Nat. Cell Biol. 2006) 2 3 4 64
  2. Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N. (PMID: 19543270) Carroll C.W. … Straight A.F. (Nat. Cell Biol. 2009) 3 4 64
  3. The CENP-H-I complex is required for the efficient incorporation of newly synthesized CENP-A into centromeres. (PMID: 16622420) Okada M. … Fukagawa T. (Nat. Cell Biol. 2006) 3 4 64
  4. Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. (PMID: 16716197) Izuta H. … Yoda K. (Genes Cells 2006) 3 4 64
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64

Products for CENPN Gene

Sources for CENPN Gene

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