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Aliases for EAPP Gene

Aliases for EAPP Gene

  • E2F-Associated Phosphoprotein 2 3
  • C14orf11 3 4
  • Chromosome 14 Open Reading Frame 11 2
  • BM036 3

External Ids for EAPP Gene

Previous HGNC Symbols for EAPP Gene

  • C14orf11

Previous GeneCards Identifiers for EAPP Gene

  • GC14M034055
  • GC14M034985
  • GC14M015103

Summaries for EAPP Gene

Entrez Gene Summary for EAPP Gene

  • This gene encodes a phosphoprotein that interacts with several members of the E2F family of proteins. The protein localizes to the nucleus, and is present throughout the cell cycle except during mitosis. It functions to modulate E2F-regulated transcription and stimulate proliferation. [provided by RefSeq, Jul 2008]

GeneCards Summary for EAPP Gene

EAPP (E2F-Associated Phosphoprotein) is a Protein Coding gene. Among its related pathways are Cell Cycle / Checkpoint Control.

UniProtKB/Swiss-Prot for EAPP Gene

  • May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.

Gene Wiki entry for EAPP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for EAPP Gene

Genomics for EAPP Gene

Regulatory Elements for EAPP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for EAPP Gene

Start:
34,515,929 bp from pter
End:
34,539,737 bp from pter
Size:
23,809 bases
Orientation:
Minus strand

Genomic View for EAPP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for EAPP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for EAPP Gene

Proteins for EAPP Gene

  • Protein details for EAPP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q56P03-EAPP_HUMAN
    Recommended name:
    E2F-associated phosphoprotein
    Protein Accession:
    Q56P03
    Secondary Accessions:
    • Q9BVF4
    • Q9NWV5
    • Q9NZ86

    Protein attributes for EAPP Gene

    Size:
    285 amino acids
    Molecular mass:
    32762 Da
    Quaternary structure:
    • Interacts with E2F1. The C-terminal half binds the N-terminal of E2F1. Also interacts with E2F2 and E2F3, but not E2F4.
    SequenceCaution:
    • Sequence=AAF67623.1; Type=Frameshift; Positions=178, 189, 198, 226; Evidence={ECO:0000305}; Sequence=AAO17041.1; Type=Frameshift; Positions=178, 189, 198, 226; Evidence={ECO:0000305}; Sequence=AAO17042.1; Type=Frameshift; Positions=178, 189, 198, 226; Evidence={ECO:0000305};

neXtProt entry for EAPP Gene

Proteomics data for EAPP Gene at MOPED

Post-translational modifications for EAPP Gene

  • Ubiquitination at Lys93
  • Modification sites at PhosphoSitePlus

Other Protein References for EAPP Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for EAPP (EAPP)

No data available for DME Specific Peptides for EAPP Gene

Domains for EAPP Gene

Protein Domains for EAPP Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for EAPP Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with EAPP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for EAPP Gene

Function for EAPP Gene

Molecular function for EAPP Gene

UniProtKB/Swiss-Prot Function:
May play an important role in the fine-tuning of both major E2F1 activities, the regulation of the cell-cycle and the induction of apoptosis. Promotes S-phase entry, and inhibits p14(ARP) expression.

Phenotypes for EAPP Gene

GenomeRNAi human phenotypes for EAPP:
genes like me logo Genes that share phenotypes with EAPP: view

Animal Model Products

miRNA for EAPP Gene

miRTarBase miRNAs that target EAPP

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EAPP

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for EAPP Gene

Localization for EAPP Gene

Subcellular locations from UniProtKB/Swiss-Prot for EAPP Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for EAPP Gene COMPARTMENTS Subcellular localization image for EAPP gene
Compartment Confidence
nucleus 5
golgi apparatus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for EAPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with EAPP: view

Pathways for EAPP Gene

SuperPathways for EAPP Gene

genes like me logo Genes that share pathways with EAPP: view

Pathways by source for EAPP Gene

1 Cell Signaling Technology pathway for EAPP Gene

Gene Ontology (GO) - Biological Process for EAPP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008284 positive regulation of cell proliferation IDA 15716352
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter IDA 15716352
GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter IDA 15716352
genes like me logo Genes that share ontologies with EAPP: view

Transcripts for EAPP Gene

Unigene Clusters for EAPP Gene

E2F-associated phosphoprotein:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for EAPP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for EAPP Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: - - - - -
SP3: - - -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for EAPP Gene

GeneLoc Exon Structure for
EAPP
ECgene alternative splicing isoforms for
EAPP

Expression for EAPP Gene

mRNA expression in normal human tissues for EAPP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for EAPP Gene

This gene is overexpressed in Lung (30.9), Prostate (13.5), Testis (9.2), and Retina (7.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for EAPP Gene

SOURCE GeneReport for Unigene cluster for EAPP Gene Hs.433269

mRNA Expression by UniProt/SwissProt for EAPP Gene

Q56P03-EAPP_HUMAN
Tissue specificity: Ubiquitously expressed. Highest levels in heart, placenta, skeletal muscle and pancreas. Lower levels in brain, lung and kidney. In the brain, expressed in all regions with high levels in the cerebellum and cerebral cortex. Expressed in COS1 and transformed skin fibroblasts.
genes like me logo Genes that share expressions with EAPP: view

Expression partners for EAPP Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for EAPP Gene

Orthologs for EAPP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for EAPP Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia EAPP 35
  • 89.91 (n)
  • 91.2 (a)
EAPP 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia EAPP 35
  • 90.18 (n)
  • 89.82 (a)
-- 36
  • 87 (a)
OneToMany
-- 36
  • 81 (a)
OneToMany
-- 36
  • 86 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Eapp 35
  • 84.4 (n)
  • 88.57 (a)
Eapp 16
Eapp 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia EAPP 35
  • 99.53 (n)
  • 99.3 (a)
EAPP 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Eapp 35
  • 83.39 (n)
  • 86.74 (a)
oppossum
(Monodelphis domestica)
Mammalia EAPP 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia EAPP 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves EAPP 35
  • 70.24 (n)
  • 70.36 (a)
EAPP 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia EAPP 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia eapp 35
  • 66.9 (n)
  • 65.71 (a)
zebrafish
(Danio rerio)
Actinopterygii eapp 35
  • 64.18 (n)
  • 64.18 (a)
wufd21g02 35
eapp 36
  • 58 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea F48E8.2 36
  • 15 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G08320 35
  • 56.72 (n)
  • 48.39 (a)
rice
(Oryza sativa)
Liliopsida Os02g0635700 35
  • 54.59 (n)
  • 55.12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
OneToOne
Species with no ortholog for EAPP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for EAPP Gene

ENSEMBL:
Gene Tree for EAPP (if available)
TreeFam:
Gene Tree for EAPP (if available)

Paralogs for EAPP Gene

No data available for Paralogs for EAPP Gene

Variants for EAPP Gene

Sequence variations from dbSNP and Humsavar for EAPP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs7766 -- 34,516,300(-) CCCAA(C/G)TGGCA utr-variant-3-prime, downstream-variant-500B
rs7797 -- 34,516,439(-) GCTGC(C/T)GAGAA reference, synonymous-codon, utr-variant-3-prime
rs4368076 -- 34,540,427(+) CAACC(G/T)CTCCT upstream-variant-2KB
rs4403966 -- 34,536,991(+) TCTCT(C/G)TATTA intron-variant
rs4567613 -- 34,537,289(+) tacag(A/G)tgtga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for EAPP Gene

Variant ID Type Subtype PubMed ID
nsv528989 CNV Gain 19592680
nsv901600 CNV Gain 21882294
nsv7251 OTHER Inversion 18451855
nsv92 OTHER Inversion 15895083
nsv9131 CNV Loss 18304495
esv1007795 OTHER Inversion 20482838

Relevant External Links for EAPP Gene

HapMap Linkage Disequilibrium report
EAPP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for EAPP Gene

Disorders for EAPP Gene

(2) University of Copenhagen DISEASES for EAPP Gene

genes like me logo Genes that share disorders with EAPP: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships , Genatlas and External Links for EAPP Gene

Publications for EAPP Gene

  1. EAPP, a novel E2F binding protein that modulates E2F-dependent transcription. (PMID: 15716352) Novy M. … Rotheneder H. (Mol. Biol. Cell 2005) 2 3 4 23
  2. Regulation of the E2F-associated phosphoprotein promoter by GC-box binding proteins. (PMID: 18588995) Schwarzmayr L. … Rotheneder H. (Int. J. Biochem. Cell Biol. 2008) 3 23
  3. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for EAPP Gene

Sources for EAPP Gene

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