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Aliases for PRKCH Gene

Aliases for PRKCH Gene

  • Protein Kinase C Eta 2 3
  • Protein Kinase C, Eta 2 3 5
  • EC 2.7.11.13 4 63
  • NPKC-Eta 3 4
  • PRKCL 3 4
  • PKC-L 3 4
  • PKCL 3 4
  • EC 2.7.11 63

External Ids for PRKCH Gene

Previous HGNC Symbols for PRKCH Gene

  • PRKCL

Previous GeneCards Identifiers for PRKCH Gene

  • GC14P059114
  • GC14P055582
  • GC14P059778
  • GC14P060858
  • GC14P061788
  • GC14P041951
  • GC14P061655

Summaries for PRKCH Gene

Entrez Gene Summary for PRKCH Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. It is a calcium-independent and phospholipids-dependent protein kinase. It is predominantly expressed in epithelial tissues and has been shown to reside specifically in the cell nucleus. This protein kinase can regulate keratinocyte differentiation by activating the MAP kinase MAPK13 (p38delta)-activated protein kinase cascade that targets CCAAT/enhancer-binding protein alpha (CEBPA). It is also found to mediate the transcription activation of the transglutaminase 1 (TGM1) gene. Mutations in this gene are associated with susceptibility to cerebral infarction. [provided by RefSeq, Sep 2015]

GeneCards Summary for PRKCH Gene

PRKCH (Protein Kinase C Eta) is a Protein Coding gene. Diseases associated with PRKCH include stroke, ischemic and glioblastoma. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCH Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization.

Tocris Summary for PRKCH Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCH Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCH Gene

Genomics for PRKCH Gene

Regulatory Elements for PRKCH Gene

Promoters for PRKCH Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKCH on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKCH Gene

Chromosome:
14
Start:
61,187,559 bp from pter
End:
61,550,980 bp from pter
Size:
363,422 bases
Orientation:
Plus strand

Genomic View for PRKCH Gene

Genes around PRKCH on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCH Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCH Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCH Gene

Proteins for PRKCH Gene

  • Protein details for PRKCH Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P24723-KPCL_HUMAN
    Recommended name:
    Protein kinase C eta type
    Protein Accession:
    P24723
    Secondary Accessions:
    • B4DJN5
    • Q16246
    • Q8NE03

    Protein attributes for PRKCH Gene

    Size:
    683 amino acids
    Molecular mass:
    77828 Da
    Quaternary structure:
    • Interacts with FYN and RALA (By similarity). Interacts with DGKQ.

    Three dimensional structures from OCA and Proteopedia for PRKCH Gene

    Alternative splice isoforms for PRKCH Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCH Gene

Proteomics data for PRKCH Gene at MOPED

Post-translational modifications for PRKCH Gene

  • Ubiquitination at Lys 36 and Lys 404
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCH (PKCH)

Domains & Families for PRKCH Gene

Graphical View of Domain Structure for InterPro Entry

P24723

UniProtKB/Swiss-Prot:

KPCL_HUMAN :
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 C2 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKCH: view

Function for PRKCH Gene

Molecular function for PRKCH Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-513 (activation loop of the kinase domain), Thr-656 (turn motif) and Ser-675 (hydrophobic region), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentiation. Associates with the cyclin CCNE1-CDK2-CDKN1B complex and inhibits CDK2 kinase activity, leading to RB1 dephosphorylation and thereby G1 arrest in keratinocytes. In association with RALA activates actin depolymerization, which is necessary for keratinocyte differentiation. In the pre-B cell receptor signaling, functions downstream of BLNK by up-regulating IRF4, which in turn activates L chain gene rearrangement. Regulates epithelial tight junctions (TJs) by phosphorylating occludin (OCLN) on threonine residues, which is necessary for the assembly and maintenance of TJs. In association with PLD2 and via TLR4 signaling, is involved in lipopolysaccharide (LPS)-induced RGS2 down-regulation and foam cell formation. Upon PMA stimulation, mediates glioblastoma cell proliferation by activating the mTOR pathway, the PI3K/AKT pathway and the ERK1-dependent phosphorylation of ELK1. Involved in the protection of glioblastoma cells from irradiation-induced apoptosis by preventing caspase-9 activation. In camptothecin-treated MCF-7 cells, regulates NF-kappa-B upstream signaling by activating IKBKB, and confers protection against DNA damage-induced apoptosis. Promotes oncogenic functions of ATF2 in the nucleus while blocking its apoptotic function at mitochondria. Phosphorylates ATF2 which promotes its nuclear retention and transcriptional activity and negatively regulates its mitochondrial localization.

Enzyme Numbers (IUBMB) for PRKCH Gene

Gene Ontology (GO) - Molecular Function for PRKCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004697 protein kinase C activity TAS 1986216
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with PRKCH: view
genes like me logo Genes that share phenotypes with PRKCH: view

Animal Models for PRKCH Gene

MGI Knock Outs for PRKCH:

Animal Model Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCH Gene

Localization for PRKCH Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCH Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCH Gene COMPARTMENTS Subcellular localization image for PRKCH gene
Compartment Confidence
cytosol 5
extracellular 5
plasma membrane 5
mitochondrion 2
cytoskeleton 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for PRKCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 15632189
GO:0005911 cell-cell junction IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with PRKCH: view

Pathways & Interactions for PRKCH Gene

genes like me logo Genes that share pathways with PRKCH: view

SIGNOR curated interactions for PRKCH Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PRKCH Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IMP 22304920
GO:0010744 positive regulation of macrophage derived foam cell differentiation ISS --
GO:0035556 intracellular signal transduction IEA,IBA --
GO:0070528 protein kinase C signaling IEA --
GO:2000810 regulation of bicellular tight junction assembly IMP 19114660
genes like me logo Genes that share ontologies with PRKCH: view

Drugs & Compounds for PRKCH Gene

(15) Drugs for PRKCH Gene - From: Novoseek, HMDB, DGIdb, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Ingenol Mebutate Approved Pharma 0
Adenosine triphosphate Approved Nutra 0
Staurosporine Experimental Pharma Positive, Allosteric regulator Protein kinase inhibitor,potent and cell permeable 21
(-)-Epigallocatechin gallate (EGCG) Pharma Antioxidant, antiangiogenic and antitumor agent 0
Ro 31-8220 Mesylate Pharma Pan-PKC inhibitor 0

(9) Additional Compounds for PRKCH Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCH Gene

Compound Action Cas Number
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8
PKC fragment (530-558) Potent activator of protein kinase C 122613-29-0
Pseudo RACK1 Protein kinase C activator peptide (attached to cell permeable vector)
SC-10 Protein kinase C activator 102649-79-6
SC-9 Protein kinase C activator 102649-78-5

(4) ApexBio Compounds for PRKCH Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
genes like me logo Genes that share compounds with PRKCH: view

Drug Products

Transcripts for PRKCH Gene

Unigene Clusters for PRKCH Gene

Protein kinase C, eta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCH Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b
SP1: - - - - - - -
SP2: - -
SP3:
SP4: -
SP5:
SP6: - - - -
SP7: - - -
SP8:

Relevant External Links for PRKCH Gene

GeneLoc Exon Structure for
PRKCH
ECgene alternative splicing isoforms for
PRKCH

Expression for PRKCH Gene

mRNA expression in normal human tissues for PRKCH Gene

mRNA differential expression in normal tissues according to GTEx for PRKCH Gene

This gene is overexpressed in Whole Blood (x4.4).

Protein differential expression in normal tissues from HIPED for PRKCH Gene

This gene is overexpressed in CD8 Tcells (22.4), Tlymphocyte (13.7), Lung (12.1), and Placenta (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCH Gene



SOURCE GeneReport for Unigene cluster for PRKCH Gene Hs.333907

mRNA Expression by UniProt/SwissProt for PRKCH Gene

P24723-KPCL_HUMAN
Tissue specificity: Most abundant in lung, less in heart and skin.
genes like me logo Genes that share expression patterns with PRKCH: view

Protein tissue co-expression partners for PRKCH Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for PRKCH Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCH Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRKCH 35
  • 92.42 (n)
  • 98.09 (a)
PRKCH 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCH 35
  • 93.07 (n)
  • 97.66 (a)
PRKCH 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkch 35
  • 90.03 (n)
  • 97.8 (a)
Prkch 16
Prkch 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKCH 35
  • 99.61 (n)
  • 99.85 (a)
PRKCH 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkch 35
  • 90.09 (n)
  • 97.36 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKCH 36
  • 94 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCH 36
  • 80 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCH 35
  • 79.31 (n)
  • 86.45 (a)
PRKCH 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCH 36
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkch 35
  • 72.1 (n)
  • 77.48 (a)
zebrafish
(Danio rerio)
Actinopterygii prkcha 35
  • 66.22 (n)
  • 67.9 (a)
prkcha 36
  • 63 (a)
OneToMany
prkchb 36
  • 62 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pkc98E 37
  • 53 (a)
Pkcdgr 37
  • 47 (a)
Pkc98E 36
  • 51 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea R12G8.1 37
  • 46 (a)
pkc-1 36
  • 51 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2703 36
  • 48 (a)
OneToMany
Species with no ortholog for PRKCH:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCH Gene

ENSEMBL:
Gene Tree for PRKCH (if available)
TreeFam:
Gene Tree for PRKCH (if available)

Paralogs for PRKCH Gene

Paralogs for PRKCH Gene

Pseudogenes.org Pseudogenes for PRKCH Gene

genes like me logo Genes that share paralogs with PRKCH: view

Variants for PRKCH Gene

Sequence variations from dbSNP and Humsavar for PRKCH Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs2230500 - 61,457,521(+) CAAGA(A/G)TAAAA reference, missense
rs55645551 - 61,322,157(+) TGAGG(C/T)AGTGG reference, missense
rs55737090 - 61,322,295(+) CAACA(A/G)ACCCA reference, missense
rs55848048 - 61,443,129(+) AGACC(A/G)GATCT reference, missense
rs55818778 - 61,457,291(+) CATCC(A/G)AGTGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PRKCH Gene

Variant ID Type Subtype PubMed ID
nsv902005 CNV Gain 21882294
esv1002305 CNV Loss 20482838
esv2657744 CNV Deletion 23128226
nsv514743 CNV Loss 21397061
nsv1297 CNV Insertion 18451855
nsv442341 CNV CNV 18776908
esv2422159 CNV Deletion 20811451
nsv517729 CNV Loss 19592680
nsv902006 CNV Loss 21882294
esv2663429 CNV Deletion 23128226
nsv470650 CNV Loss 18288195
nsv517477 CNV Loss 19592680

Variation tolerance for PRKCH Gene

Residual Variation Intolerance Score: 7.67% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.21; 62.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCH Gene

HapMap Linkage Disequilibrium report
PRKCH
Human Gene Mutation Database (HGMD)
PRKCH

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCH Gene

Disorders for PRKCH Gene

MalaCards: The human disease database

(3) MalaCards diseases for PRKCH Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
stroke, ischemic
  • ischemic stroke
glioblastoma
  • glioblastoma multiforme
myofibrillar myopathy
  • desminopathy
- elite association - COSMIC cancer census association via MalaCards
Search PRKCH in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

KPCL_HUMAN
  • Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. {ECO:0000269 PubMed:17206144}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for PRKCH

Genetic Association Database (GAD)
PRKCH
Human Genome Epidemiology (HuGE) Navigator
PRKCH
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCH
genes like me logo Genes that share disorders with PRKCH: view

No data available for Genatlas for PRKCH Gene

Publications for PRKCH Gene

  1. Isolation and characterization of PKC-L, a new member of the protein kinase C-related gene family specifically expressed in lung, skin, and heart. (PMID: 1545821) Bacher N. … Livneh E. (Mol. Cell. Biol. 1992) 2 3 4 67
  2. The 1425G/A SNP in PRKCH is associated with ischemic stroke and cerebral hemorrhage in a Chinese population. (PMID: 19520989) Wu L. … Wang X. (Stroke 2009) 3 23
  3. Analysing the expression of protein kinase C eta in human hepatocellular carcinoma. (PMID: 20001341) Lu H.C. … Chang J.G. (Pathology 2009) 3 23
  4. Association between PRKCH gene polymorphisms and subcortical silent brain infarction. (PMID: 18164711) Serizawa M. … Kato N. (Atherosclerosis 2008) 3 23
  5. [Genetic risk factors of ischemic stroke identified by a genome-wide association study]. (PMID: 19069168) Kubo M. (Brain Nerve 2008) 3 23

Products for PRKCH Gene

Sources for PRKCH Gene