Free for academic non-profit institutions. Other users need a Commercial license

Aliases for PRKCG Gene

Aliases for PRKCG Gene

  • Protein Kinase C, Gamma 2 3
  • PKC-Gamma 2 3 4
  • PKCG 3 4 6
  • EC 2.7.11.13 4 63
  • SCA14 3 6
  • PKCC 3 6
  • Protein Kinase C Gamma Type 3
  • EC 2.7.11 63

External Ids for PRKCG Gene

Previous HGNC Symbols for PRKCG Gene

  • PKCG
  • SCA14

Previous GeneCards Identifiers for PRKCG Gene

  • GC19P055031
  • GC19P054810
  • GC19P059061
  • GC19P059077
  • GC19P054382
  • GC19P050704

Summaries for PRKCG Gene

Entrez Gene Summary for PRKCG Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCG Gene

PRKCG (Protein Kinase C, Gamma) is a Protein Coding gene. Diseases associated with PRKCG include spinocerebellar ataxia 14 and spinocerebellar ataxia type14. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein kinase activity and calcium-dependent protein kinase C activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCG Gene

  • Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity).

Tocris Summary for PRKCG Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCG Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCG Gene

Genomics for PRKCG Gene

Regulatory Elements for PRKCG Gene

Genomic Location for PRKCG Gene

Start:
53,879,190 bp from pter
End:
53,907,652 bp from pter
Size:
28,463 bases
Orientation:
Plus strand

Genomic View for PRKCG Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCG Gene

Proteins for PRKCG Gene

  • Protein details for PRKCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05129-KPCG_HUMAN
    Recommended name:
    Protein kinase C gamma type
    Protein Accession:
    P05129
    Secondary Accessions:
    • B7Z8Q0

    Protein attributes for PRKCG Gene

    Size:
    697 amino acids
    Molecular mass:
    78448 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.;
    Quaternary structure:
    • Interacts with GRIA4 (By similarity). Interacts with CDCP1. Interacts with TP53INP1 and p53/TP53. Interacts with ARNTL/BMAL1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for PRKCG Gene

    Alternative splice isoforms for PRKCG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCG Gene

Proteomics data for PRKCG Gene at MOPED

Post-translational modifications for PRKCG Gene

Other Protein References for PRKCG Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCG (PKCG)

Domains for PRKCG Gene

Graphical View of Domain Structure for InterPro Entry

P05129

UniProtKB/Swiss-Prot:

KPCG_HUMAN :
  • P05129
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 C2 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKCG: view

Function for PRKCG Gene

Molecular function for PRKCG Gene

GENATLAS Biochemistry: protein kinase C,gamma polypeptide
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full activation
UniProtKB/Swiss-Prot Function: Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity).

Enzyme Numbers (IUBMB) for PRKCG Gene

Gene Ontology (GO) - Molecular Function for PRKCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 15808853
GO:0004674 protein serine/threonine kinase activity --
GO:0004697 protein kinase C activity TAS 3755548
GO:0004698 calcium-dependent protein kinase C activity IEA --
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
genes like me logo Genes that share ontologies with PRKCG: view
genes like me logo Genes that share phenotypes with PRKCG: view

Animal Models for PRKCG Gene

MGI Knock Outs for PRKCG:

Animal Model Products

CRISPR Products

miRNA for PRKCG Gene

miRTarBase miRNAs that target PRKCG

No data available for Transcription Factor Targeting and HOMER Transcription for PRKCG Gene

Localization for PRKCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCG Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell projection, dendrite. Note=Translocates to synaptic membranes on stimulation. {ECO:0000250 UniProtKB:P63318}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCG Gene COMPARTMENTS Subcellular localization image for PRKCG gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRKCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS --
GO:0005911 cell-cell junction IEA --
genes like me logo Genes that share ontologies with PRKCG: view

Pathways for PRKCG Gene

SuperPathways for PRKCG Gene

Superpath Contained pathways
1 Signaling by FGFR
2 Ca-dependent events
3 IL-2 Pathway
4 Circadian entrainment
5 fMLP Pathway
genes like me logo Genes that share pathways with PRKCG: view

Pathways by source for PRKCG Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for PRKCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 3755548
GO:0006950 response to stress --
GO:0007165 signal transduction TAS --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0007202 activation of phospholipase C activity TAS --
genes like me logo Genes that share ontologies with PRKCG: view

Compounds for PRKCG Gene

Compound Products

(5) Tocris Compounds for PRKCG Gene

Compound Action Cas Number
GF 109203X Protein kinase C inhibitor [133052-90-1]
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
Phorbol 12-myristate 13-acetate Protein kinase C activator [16561-29-8]
ZIP Cell-permeable inhibitor of atypical PKC isozyme PKMzeta [863987-12-6]

(10) ApexBio Compounds for PRKCG Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor [1009820-21-6]
Dequalinium Chloride PKC inhibitor [522-51-0]
Enzastaurin (LY317615) potent PKC beta inhibitor [170364-57-5]
GF 109203X Very potent and selective inhibitor of PKC [133052-90-1]
Go 6976 PKC inhibitor [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
K-252c PKC inhibitor [85753-43-1]
Ro 31-8220 cell-permeable inhibitor of PKC [125314-64-9]
Sotrastaurin (AEB071) Potent and specific inhibitor of PKC [425637-18-9]
Staurosporine (CGP 41251) inhibitor of a broad spectrum of protein kinases [62996-74-1]

(846) HMDB Compounds for PRKCG Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(19) Novoseek inferred chemical compound relationships for PRKCG Gene

Compound -log(P) Hits PubMed IDs
pkcs 83.6 3
aristolochic acid 50.5 1
gf 109203x 44.9 1
phorbol 12,13-dibutyrate 44.8 4
phosphatidylserine 42.5 3
genes like me logo Genes that share compounds with PRKCG: view

Transcripts for PRKCG Gene

Unigene Clusters for PRKCG Gene

Protein kinase C, gamma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKCG

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCG Gene

No ASD Table

Relevant External Links for PRKCG Gene

GeneLoc Exon Structure for
PRKCG
ECgene alternative splicing isoforms for
PRKCG

Expression for PRKCG Gene

mRNA expression in normal human tissues for PRKCG Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCG Gene

This gene is overexpressed in Brain - Hippocampus (8.5), Brain - Nucleus accumbens (basal ganglia) (8.1), Brain - Cortex (6.1), Brain - Anterior cingulate cortex (BA24) (5.5), Brain - Amygdala (4.6), Brain - Caudate (basal ganglia) (4.6), and Brain - Frontal Cortex (BA9) (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for PRKCG Gene

SOURCE GeneReport for Unigene cluster for PRKCG Gene Hs.631564

mRNA Expression by UniProt/SwissProt for PRKCG Gene

P05129-KPCG_HUMAN
Tissue specificity: Expressed in Purkinje cells of the cerebellar cortex.
genes like me logo Genes that share expressions with PRKCG: view

In Situ Assay Products

Orthologs for PRKCG Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCG Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCG 35
  • 99.4 (n)
  • 99.25 (a)
PRKCG 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCG 35
  • 91.77 (n)
  • 98.13 (a)
PRKCG 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 99 (a)
OneToMany
LOC100855828 35
  • 91.87 (n)
  • 98.57 (a)
mouse
(Mus musculus)
Mammalia Prkcg 35
  • 89.48 (n)
  • 99 (a)
Prkcg 16
Prkcg 36
  • 99 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCG 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcg 35
  • 89.96 (n)
  • 99 (a)
lizard
(Anolis carolinensis)
Reptilia PRKCG 36
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkcg 35
  • 74.3 (n)
  • 83.11 (a)
zebrafish
(Danio rerio)
Actinopterygii prkcg 35
  • 67.44 (n)
  • 70.96 (a)
prkcg 36
  • 69 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta inaC 36
  • 48 (a)
ManyToMany
Pkc53E 36
  • 63 (a)
ManyToMany
Pkc53E 37
  • 64 (a)
inaC 37
  • 51 (a)
worm
(Caenorhabditis elegans)
Secernentea pkc-2 36
  • 46 (a)
OneToMany
R12G8.1 37
  • 43 (a)
pkc-2 37
  • 62 (a)
Species with no ortholog for PRKCG:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCG Gene

ENSEMBL:
Gene Tree for PRKCG (if available)
TreeFam:
Gene Tree for PRKCG (if available)

Paralogs for PRKCG Gene

Paralogs for PRKCG Gene

genes like me logo Genes that share paralogs with PRKCG: view

Variants for PRKCG Gene

Sequence variations from dbSNP and Humsavar for PRKCG Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs307941 -- 53,881,850(+) GAACC(C/T)TAGCG upstream-variant-2KB
rs307942 -- 53,882,183(+) CCCCC(A/C)ACCCG upstream-variant-2KB
rs307943 -- 53,901,222(+) AAGTG(G/T)ACTGG intron-variant
rs307944 -- 53,891,047(-) ATTgc(C/T)gggca intron-variant
rs307945 -- 53,889,572(+) ATAAA(A/C)GGGCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCG Gene

Variant ID Type Subtype PubMed ID
esv2718812 CNV Deletion 23290073
nsv833876 CNV Loss 17160897
nsv2541 CNV Loss 18451855
esv2718846 CNV Deletion 23290073

Relevant External Links for PRKCG Gene

HapMap Linkage Disequilibrium report
PRKCG
Human Gene Mutation Database (HGMD)
PRKCG
Locus Specific Mutation Databases (LSDB)
PRKCG

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCG Gene

Disorders for PRKCG Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for PRKCG Gene including...

Search for PRKCG Gene in MalaCards »

(1) OMIM Diseases for PRKCG Gene (176980)

UniProtKB/Swiss-Prot

KPCG_HUMAN
  • Spinocerebellar ataxia 14 (SCA14) [MIM:605361]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA14 is an autosomal dominant cerebellar ataxia (ADCA). {ECO:0000269 PubMed:12644968}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(2) University of Copenhagen DISEASES for PRKCG Gene

(4) Novoseek inferred disease relationships for PRKCG Gene

Disease -log(P) Hits PubMed IDs
sca14 96.9 34
spinocerebellar ataxias 85.2 16
neurodegenerative diseases 41.5 3
tumors 3.21 1

Relevant External Links for PRKCG

GeneTests
PRKCG
GeneReviews
PRKCG
Genetic Association Database (GAD)
PRKCG
Human Genome Epidemiology (HuGE) Navigator
PRKCG
genes like me logo Genes that share disorders with PRKCG: view

Publications for PRKCG Gene

  1. Missense mutations in the regulatory domain of PKC gamma: a new mechanism for dominant nonepisodic cerebellar ataxia. (PMID: 12644968) Chen D.-H. … Raskind W.H. (Am. J. Hum. Genet. 2003) 3 4 23
  2. New mutations in protein kinase Cgamma associated with spinocerebellar ataxia type 14. (PMID: 16193476) Klebe S. … Stevanin G. (Ann. Neurol. 2005) 3 23 48
  3. The human protein kinase C gamma gene (PRKCG) as a susceptibility locus for behavioral disinhibition. (PMID: 17508994) Schlaepfer I.R. … Ehringer M.A. (Addict Biol 2007) 3 23 48
  4. Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways. (PMID: 3755548) Coussens L. … Ullrich A. (Science 1986) 2 3 4
  5. Protein kinase C gamma, a protein causative for dominant ataxia, negatively regulates nuclear import of recessive-ataxia-related aprataxin. (PMID: 19561170) Asai H. … Ueno S. (Hum. Mol. Genet. 2009) 3 23

Products for PRKCG Gene

  • Addgene plasmids for PRKCG

Sources for PRKCG Gene

Back to Top

Content