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Aliases for PRKCG Gene

Aliases for PRKCG Gene

  • Protein Kinase C Gamma 2 3 5
  • PKC-Gamma 2 3 4
  • EC 2.7.11.13 4 61
  • PKCG 3 4
  • Protein Kinase C Gamma Type 3
  • Protein Kinase C, Gamma 2
  • EC 2.7.11 61
  • SCA14 3
  • PKCC 3

External Ids for PRKCG Gene

Previous HGNC Symbols for PRKCG Gene

  • PKCG
  • SCA14

Previous GeneCards Identifiers for PRKCG Gene

  • GC19P055031
  • GC19P054810
  • GC19P059061
  • GC19P059077
  • GC19P054382
  • GC19P050704

Summaries for PRKCG Gene

Entrez Gene Summary for PRKCG Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

GeneCards Summary for PRKCG Gene

PRKCG (Protein Kinase C Gamma) is a Protein Coding gene. Diseases associated with PRKCG include Spinocerebellar Ataxia 14 and Spinocerebellar Ataxia Type14. Among its related pathways are CCR5 Pathway in Macrophages and Development VEGF signaling via VEGFR2 - generic cascades. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCA.

UniProtKB/Swiss-Prot for PRKCG Gene

  • Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity).

Tocris Summary for PRKCG Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCG Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCG Gene

Genomics for PRKCG Gene

Regulatory Elements for PRKCG Gene

Enhancers for PRKCG Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G053907 1.5 FANTOM5 Ensembl ENCODE 18.8 +30.1 30098 2.6 CREB3L1 ZNF133 ZNF76 DEAF1 GLI4 YBX1 ZNF48 ETS1 ZNF766 ZNF143 PRKCG ZNF845 ENSG00000235681 ZNF665 LENG8-AS1 ZNF347 ENSG00000232220 LOC105372457 PRPF31 ZNF765
GH19G053851 1.3 FANTOM5 Ensembl ENCODE 12.3 -27.4 -27350 1.1 PTBP1 NFIA MIER1 NFIB BHLHE40 MAX EP300 NFIC PRDM4 MYC ENSG00000232220 PRKCG MIR935 CACNG6 MYADM VSTM1 LILRA5 OSCAR NLRP12 LILRB2
GH19G053840 1.3 Ensembl ENCODE 12.1 -37.1 -37062 2.7 PKNOX1 ATF1 ARNT ARID4B SIN3A YBX1 GATA2 ZNF143 FOS SP3 LOC105372457 ENSG00000232220 PRKCG MIR935 CACNG6 MIR1283-1 MIR520A MIR515-2 MIR519C MIR515-1
GH19G053864 1.8 FANTOM5 ENCODE dbSUPER 8.6 -10.3 -10276 9.8 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 ZNF845 ZNF765 ZNF816 ENSG00000269001 ENSG00000235681 ZNF813 TPM3P6 LENG8-AS1 MYADM ZNF525
GH19G053848 1.2 FANTOM5 Ensembl ENCODE 12.3 -29.8 -29817 1.6 MEF2D ZNF146 SMARCA4 POLR2A IKZF1 CREM LOC105372457 PRKCG ENSG00000232220 MIR935 CACNG6 MYADM VSTM1 OSCAR NLRP12 LILRA5
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around PRKCG on UCSC Golden Path with GeneCards custom track

Promoters for PRKCG Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111416 210 801 CREB3L1 ARID4B GLI4 ZNF2 ZNF48 ZBTB7B ETS1 SLC30A9 ELK1 ZNF143

Genomic Location for PRKCG Gene

Chromosome:
19
Start:
53,879,190 bp from pter
End:
53,907,652 bp from pter
Size:
28,463 bases
Orientation:
Plus strand

Genomic View for PRKCG Gene

Genes around PRKCG on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCG Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCG Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCG Gene

Proteins for PRKCG Gene

  • Protein details for PRKCG Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P05129-KPCG_HUMAN
    Recommended name:
    Protein kinase C gamma type
    Protein Accession:
    P05129
    Secondary Accessions:
    • B7Z8Q0

    Protein attributes for PRKCG Gene

    Size:
    697 amino acids
    Molecular mass:
    78448 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    • Interacts with GRIA4 (By similarity). Interacts with CDCP1. Interacts with TP53INP1 and p53/TP53. Interacts with ARNTL/BMAL1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for PRKCG Gene

    Alternative splice isoforms for PRKCG Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCG Gene

Selected DME Specific Peptides for PRKCG Gene

P05129:
  • FYAAEIAIGLF
  • GIIYRDLK
  • TTRTFCGT
  • VLGKGSFGKV
  • GKGSFGKV
  • KLLNQEEGE
  • EAVAICKG
  • GVLLYEMLAGQ
  • CKGFLTK
  • EKRVLAL
  • RFFKQPTFCSHC
  • GVLLYEM
  • DFGMCKE
  • GQPPFDGEDE
  • VKLKLIPD
  • RCHEFVTF
  • MNVHRRC
  • RKGALRQK
  • LNPVWNE
  • FYAAEIA
  • FQGFTYVNPDFVHPDARSP
  • TSRNDFMG
  • YRDLKLDN
  • DDPRNKHKF
  • KRLGSGPDGEPTIRAHGFFRWIDW
  • IKITDFG
  • TFCDHCGSLL
  • DRLYFVME
  • FGKVMLAE
  • DHTERRGR
  • PMDPNGL
  • GTPDYIAPE
  • EGEYYNVP
  • TFCGTPDYIAPEI
  • VDWWSFGVLLYEML
  • PYGKSVD
  • FIWGIGKQG
  • ENFDKFFTR
  • RDLKLDN
  • LLQKFEACNYPLELYERVR

Post-translational modifications for PRKCG Gene

Other Protein References for PRKCG Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCG (PKCG)

Domains & Families for PRKCG Gene

Graphical View of Domain Structure for InterPro Entry

P05129

UniProtKB/Swiss-Prot:

KPCG_HUMAN :
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
genes like me logo Genes that share domains with PRKCG: view

Function for PRKCG Gene

Molecular function for PRKCG Gene

GENATLAS Biochemistry:
protein kinase C,gamma polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-514 (activation loop of the kinase domain), Thr-655 (turn motif) and Thr-674 (hydrophobic region), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but may be not necessary for the process of synaptic plasticity. May be involved in desensitization of mu-type opioid receptor-mediated G-protein activation in the spinal cord, and may be critical for the development and/or maintenance of morphine-induced reinforcing effects in the limbic forebrain. May modulate the functionality of mu-type-opioid receptors by participating in a signaling pathway which leads to the phosphorylation and degradation of opioid receptors. May also contributes to chronic morphine-induced changes in nociceptive processing. Plays a role in neuropathic pain mechanisms and contributes to the maintenance of the allodynia pain produced by peripheral inflammation. Plays an important role in initial sensitivity and tolerance to ethanol, by mediating the behavioral effects of ethanol as well as the effects of this drug on the GABA(A) receptors. During and after cerebral ischemia modulate neurotransmission and cell survival in synaptic membranes, and is involved in insulin-induced inhibition of necrosis, an important mechanism for minimizing ischemic injury. Required for the elimination of multiple climbing fibers during innervation of Purkinje cells in developing cerebellum. Is activated in lens epithelial cells upon hydrogen peroxide treatment, and phosphorylates connexin-43 (GJA1/CX43), resulting in disassembly of GJA1 gap junction plaques and inhibition of gap junction activity which could provide a protective effect against oxidative stress (By similarity). Phosphorylates p53/TP53 and promotes p53/TP53-dependent apoptosis in response to DNA damage. Involved in the phase resetting of the cerebral cortex circadian clock during temporally restricted feeding. Stabilizes the core clock component ARNTL/BMAL1 by interfering with its ubiquitination, thus suppressing its degradation, resulting in phase resetting of the cerebral cortex clock (By similarity).

Enzyme Numbers (IUBMB) for PRKCG Gene

Gene Ontology (GO) - Molecular Function for PRKCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 15808853
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004697 protein kinase C activity TAS 3755548
GO:0004698 calcium-dependent protein kinase C activity TAS --
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
genes like me logo Genes that share ontologies with PRKCG: view
genes like me logo Genes that share phenotypes with PRKCG: view

Human Phenotype Ontology for PRKCG Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for PRKCG Gene

MGI Knock Outs for PRKCG:

Animal Model Products

CRISPR Products

miRNA for PRKCG Gene

miRTarBase miRNAs that target PRKCG

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for PRKCG

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PRKCG Gene

Localization for PRKCG Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCG Gene

Cytoplasm. Cytoplasm, perinuclear region. Cell membrane; Peripheral membrane protein. Cell junction, synapse, synaptosome. Cell projection, dendrite. Note=Translocates to synaptic membranes on stimulation. {ECO:0000250 UniProtKB:P63318}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for PRKCG gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 4
cytoskeleton 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for PRKCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IBA,IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane ISS --
genes like me logo Genes that share ontologies with PRKCG: view

Pathways & Interactions for PRKCG Gene

genes like me logo Genes that share pathways with PRKCG: view

Pathways by source for PRKCG Gene

SIGNOR curated interactions for PRKCG Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for PRKCG Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation TAS 3755548
GO:0006950 response to stress IEA --
GO:0007268 chemical synaptic transmission IEA --
GO:0007611 learning or memory IEA --
GO:0007635 chemosensory behavior IEA --
genes like me logo Genes that share ontologies with PRKCG: view

Drugs & Compounds for PRKCG Gene

(35) Drugs for PRKCG Gene - From: DrugBank, ApexBio, DGIdb, FDA Approved Drugs, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Target TGF-β modulatory and PKC inhibitory effects, ER antagonist, Anti-Estrogens 390
Ingenol Mebutate Approved Pharma 0
nolvadex Approved October 1998 Pharma 0
Adenosine triphosphate Approved Nutra 0
Staurosporine Experimental Pharma Positive, Allosteric regulator Protein kinase inhibitor,potent and cell permeable 47

(13) Additional Compounds for PRKCG Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Hexadecanoyl-3-(11-eicosenoyl)-sn-glycerol
  • 1-Palmitoyl-3-eicosenoyl-sn-glycerol
  • DAG(16:0/0:0/20:1)
  • DAG(16:0/0:0/20:1n9)
  • DAG(16:0/0:0/20:1w9)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCG Gene

Compound Action Cas Number
Enzastaurin Potent PKCbeta inhibitor 170364-57-5
GF 109203X Protein kinase C inhibitor 133052-90-1
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes 136194-77-9
Go 6983 Broad spectrum PKC inhibitor 133053-19-7
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8

(15) ApexBio Compounds for PRKCG Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
[Ser25] Protein Kinase C (19-31) PKC substrate 136795-05-6
Chelerythrine Chloride PKC antagonist 34316-15-9
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
Midostaurin (PKC412) PKC inhibitor 120685-11-2
Ro 31-8220 pan-PKC inhibitor 125314-64-9
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
ZIP PKMζ inhibitor 863987-12-6
genes like me logo Genes that share compounds with PRKCG: view