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Aliases for PRKCE Gene

Aliases for PRKCE Gene

  • Protein Kinase C Epsilon 2 3
  • Protein Kinase C, Epsilon 2 3 5
  • NPKC-Epsilon 3 4
  • EC 2.7.11.13 4 63
  • PKCE 3 4
  • EC 2.7.11 63

External Ids for PRKCE Gene

Previous GeneCards Identifiers for PRKCE Gene

  • GC02P045897
  • GC02P046047
  • GC02P045853
  • GC02P045790

Summaries for PRKCE Gene

Entrez Gene Summary for PRKCE Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCE Gene

PRKCE (Protein Kinase C Epsilon) is a Protein Coding gene. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCE Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

Tocris Summary for PRKCE Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol.

Gene Wiki entry for PRKCE Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCE Gene

Genomics for PRKCE Gene

Regulatory Elements for PRKCE Gene

Promoters for PRKCE Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around PRKCE on UCSC Golden Path with GeneCards custom track

Genomic Location for PRKCE Gene

Chromosome:
2
Start:
45,651,315 bp from pter
End:
46,187,990 bp from pter
Size:
536,676 bases
Orientation:
Plus strand

Genomic View for PRKCE Gene

Genes around PRKCE on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
PRKCE Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for PRKCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCE Gene

Proteins for PRKCE Gene

  • Protein details for PRKCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02156-KPCE_HUMAN
    Recommended name:
    Protein kinase C epsilon type
    Protein Accession:
    Q02156
    Secondary Accessions:
    • B0LPH7
    • Q32MQ3
    • Q53SL4
    • Q53SM5
    • Q9UE81

    Protein attributes for PRKCE Gene

    Size:
    737 amino acids
    Molecular mass:
    83674 Da
    Quaternary structure:
    • Forms a ternary complex with TRIM63 and GN2BL1. Can form a complex with PDLIM5 and N-type calcium channel. Interacts with COPB1 and YWHAB (By similarity). Interacts with DGKQ and STAT3.

    Three dimensional structures from OCA and Proteopedia for PRKCE Gene

neXtProt entry for PRKCE Gene

Proteomics data for PRKCE Gene at MOPED

Post-translational modifications for PRKCE Gene

  • Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. Phosphorylation in the hinge domain at Ser-350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKCE Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCE (PKCE)

Domains & Families for PRKCE Gene

Suggested Antigen Peptide Sequences for PRKCE Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q02156

UniProtKB/Swiss-Prot:

KPCE_HUMAN :
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain.
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 C2 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKCE: view

Function for PRKCE Gene

Molecular function for PRKCE Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein.
UniProtKB/Swiss-Prot EnzymeRegulation:
Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation.
UniProtKB/Swiss-Prot Function:
Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

Enzyme Numbers (IUBMB) for PRKCE Gene

Gene Ontology (GO) - Molecular Function for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004697 protein kinase C activity IEA,TAS --
GO:0004699 calcium-independent protein kinase C activity IEA --
genes like me logo Genes that share ontologies with PRKCE: view
genes like me logo Genes that share phenotypes with PRKCE: view

Animal Models for PRKCE Gene

MGI Knock Outs for PRKCE:

Animal Model Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for PRKCE Gene

Localization for PRKCE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCE Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cytoplasm, perinuclear region. Nucleus. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCE Gene COMPARTMENTS Subcellular localization image for PRKCE gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
plasma membrane 5
nucleus 4
cytoskeleton 3
mitochondrion 3
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for PRKCE Gene

Pathways & Interactions for PRKCE Gene

SuperPathways for PRKCE Gene

Superpath Contained pathways
1 Interleukin-3, 5 and GM-CSF signaling
2 IL-2 Pathway
3 fMLP Pathway
4 Development Angiotensin activation of ERK
5 DAG and IP3 signaling
genes like me logo Genes that share pathways with PRKCE: view

Pathways by source for PRKCE Gene

SIGNOR curated interactions for PRKCE Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA,IDA 18556656
GO:0006915 apoptotic process TAS 10438519
GO:0007155 cell adhesion IEA --
GO:0007173 epidermal growth factor receptor signaling pathway TAS --
GO:0010634 positive regulation of epithelial cell migration IMP 17603037
genes like me logo Genes that share ontologies with PRKCE: view

Drugs & Compounds for PRKCE Gene

(37) Drugs for PRKCE Gene - From: Novoseek, ApexBio, HMDB, DGIdb, Tocris, PharmGKB, DrugBank, and FDA Approved Drugs

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tamoxifen Approved Pharma Antagonist, Target ER antagonist, Anti-Estrogens 350
Ingenol Mebutate Approved Pharma 0
nolvadex Approved October 1998 Pharma 0
Adenosine triphosphate Approved Nutra 0
Staurosporine Experimental Pharma Positive, Allosteric regulator Protein kinase inhibitor,potent and cell permeable 21

(16) Additional Compounds for PRKCE Gene - From: HMDB, Tocris, and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(5) Tocris Compounds for PRKCE Gene

Compound Action Cas Number
Phorbol 12-myristate 13-acetate Protein kinase C activator 16561-29-8
PKC fragment (530-558) Potent activator of protein kinase C 122613-29-0
Pseudo RACK1 Protein kinase C activator peptide (attached to cell permeable vector)
SC-10 Protein kinase C activator 102649-79-6
SC-9 Protein kinase C activator 102649-78-5

(12) ApexBio Compounds for PRKCE Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) Antioxidant, antiangiogenic and antitumor agent 989-51-5
Chelerythrine Chloride PKC antagonist 34316-15-9
Dequalinium Chloride 522-51-0
Enzastaurin (LY317615) PKC beta inhibitor,potent and selective 170364-57-5
GF 109203X Protein kinase C,MLCK,PKG and PKA inhibitor 133052-90-1
Go 6976 PKCα/PKCβ1 inhibitor 136194-77-9
Go 6983 pan-PKC inhibitor 133053-19-7
K-252c Protein kinase inhibitor 85753-43-1
Ro 31-8220 Mesylate Pan-PKC inhibitor 138489-18-6
Sotrastaurin (AEB071) PKC inhibitor 425637-18-9
Staurosporine Protein kinase inhibitor,potent and cell permeable 62996-74-1
ZIP PKMζ inhibitor 863987-12-6
genes like me logo Genes that share compounds with PRKCE: view

Drug Products

Transcripts for PRKCE Gene

Unigene Clusters for PRKCE Gene

Protein kinase C, epsilon:
Representative Sequences:

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - - - - -
SP2:
SP3: - - -
SP4:
SP5:

ExUns: 23
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for PRKCE Gene

GeneLoc Exon Structure for
PRKCE
ECgene alternative splicing isoforms for
PRKCE

Expression for PRKCE Gene

mRNA expression in normal human tissues for PRKCE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCE Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x5.6) and Brain - Anterior cingulate cortex (BA24) (x4.9).

Protein differential expression in normal tissues from HIPED for PRKCE Gene

This gene is overexpressed in Frontal cortex (50.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCE Gene



SOURCE GeneReport for Unigene cluster for PRKCE Gene Hs.580351

genes like me logo Genes that share expression patterns with PRKCE: view

Protein tissue co-expression partners for PRKCE Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PRKCE Gene

Orthologs for PRKCE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCE Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRKCE 35
  • 92.54 (n)
  • 99.19 (a)
PRKCE 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCE 35
  • 93.17 (n)
  • 98.91 (a)
PRKCE 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkce 35
  • 91.09 (n)
  • 97.96 (a)
Prkce 16
Prkce 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKCE 35
  • 99.64 (n)
  • 100 (a)
PRKCE 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkce 35
  • 90.86 (n)
  • 98.1 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKCE 36
  • 96 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCE 35
  • 81.95 (n)
  • 95.93 (a)
PRKCE 36
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCE 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkce 35
  • 79.25 (n)
  • 91.96 (a)
Str.13025 35
zebrafish
(Danio rerio)
Actinopterygii Dr.12470 35
prkceb 35
  • 76.34 (n)
  • 86.92 (a)
prkcea 36
  • 85 (a)
OneToMany
prkceb 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Pkc98E 37
  • 59 (a)
Pkc98E 35
  • 60.64 (n)
  • 59.94 (a)
Pkc98E 36
  • 57 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002748 35
  • 60.6 (n)
  • 60.97 (a)
worm
(Caenorhabditis elegans)
Secernentea F48G7.10 37
  • 44 (a)
R12G8.1 37
  • 43 (a)
tpa-1 37
  • 42 (a)
pkc-1 35
  • 58.64 (n)
  • 62.26 (a)
pkc-1 36
  • 55 (a)
OneToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR191C 35
  • 49.83 (n)
  • 40.48 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06447g 35
  • 49.46 (n)
  • 39.45 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 35
  • 49.68 (n)
  • 41.09 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9021 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06544 35
  • 55.08 (n)
  • 44.53 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pck2 35
  • 50 (n)
  • 41.72 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2703 36
  • 54 (a)
OneToMany
Species with no ortholog for PRKCE:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCE Gene

ENSEMBL:
Gene Tree for PRKCE (if available)
TreeFam:
Gene Tree for PRKCE (if available)

Paralogs for PRKCE Gene

Paralogs for PRKCE Gene

genes like me logo Genes that share paralogs with PRKCE: view

Variants for PRKCE Gene

Sequence variations from dbSNP and Humsavar for PRKCE Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_035466 A colorectal cancer sample
rs55989965 - 46,004,573(+) GCCTG(C/T)TTCTG nc-transcript-variant, reference, missense
rs55767130 - 46,007,564(+) GAGCC(C/G)CGGTG nc-transcript-variant, reference, missense
rs34077350 - 46,145,188(+) TGTGA(C/T)GACCA reference, missense
rs35777875 - 46,159,645(-) CGATG(C/T)CACAC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for PRKCE Gene

Variant ID Type Subtype PubMed ID
esv2751894 CNV Gain 17911159
nsv528112 CNV Loss 19592680
esv2720010 CNV Deletion 23290073
esv269618 CNV Insertion 20981092
nsv2713 CNV Loss 18451855
esv2720011 CNV Deletion 23290073
nsv457318 CNV Loss 19166990
esv2668866 CNV Deletion 23128226
nsv829130 CNV Gain 20364138
esv2720012 CNV Deletion 23290073
esv273768 CNV Insertion 20981092
esv267472 CNV Insertion 20981092
nsv518264 CNV Loss 19592680
esv2674913 CNV Deletion 23128226
esv3096 CNV Deletion 18987735
esv2720013 CNV Deletion 23290073
esv2671600 CNV Deletion 23128226
nsv213629 CNV Loss 16902084
esv9518 CNV Loss 19470904
nsv517015 CNV Loss 19592680
nsv521205 CNV Loss 19592680
nsv829142 CNV Gain 20364138

Variation tolerance for PRKCE Gene

Residual Variation Intolerance Score: 11.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.73; 46.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKCE Gene

HapMap Linkage Disequilibrium report
PRKCE

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCE Gene

Disorders for PRKCE Gene

Relevant External Links for PRKCE

Genetic Association Database (GAD)
PRKCE
Human Genome Epidemiology (HuGE) Navigator
PRKCE
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKCE

No disorders were found for PRKCE Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for PRKCE Gene

Publications for PRKCE Gene

  1. Sequence and expression of human protein kinase C-epsilon. (PMID: 1382605) Basta P. … Burns D.J. (Biochim. Biophys. Acta 1992) 2 3 4 23 67
  2. Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function. (PMID: 7877991) Lehel C. … Anderson W.B. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 23
  3. The divergent roles of protein kinase C epsilon and delta in simulated ischaemia-reperfusion injury in human myocardium. (PMID: 19248786) Sivaraman V. … Yellon D.M. (J. Mol. Cell. Cardiol. 2009) 3 23
  4. MATER protein as substrate of PKCepsilon in human cumulus cells. (PMID: 19542546) Maraldi T. … De Pol A. (Mol. Hum. Reprod. 2009) 3 23
  5. Protein kinase C epsilon is involved in ionizing radiation induced bystander response in human cells. (PMID: 19577658) Hu B. … Balajee A.S. (Int. J. Biochem. Cell Biol. 2009) 3 23

Products for PRKCE Gene