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Aliases for PRKCE Gene

Aliases for PRKCE Gene

  • Protein Kinase C, Epsilon 2 3
  • PKCE 3 4 6
  • NPKC-Epsilon 3 4
  • EC 2.7.11.13 4 64
  • Protein Kinase C Epsilon Type 3
  • EC 2.7.11 64

External Ids for PRKCE Gene

Summaries for PRKCE Gene

Entrez Gene Summary for PRKCE Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCE Gene

PRKCE (Protein Kinase C, Epsilon) is a Protein Coding gene. Diseases associated with PRKCE include ischemia and rift valley fever. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include signal transducer activity and enzyme activator activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCE Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

Tocris Summary for PRKCE Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCE Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCE Gene

Genomics for PRKCE Gene

Genomic Location for PRKCE Gene

Start:
45,651,315 bp from pter
End:
46,187,990 bp from pter
Size:
536,676 bases
Orientation:
Plus strand

Genomic View for PRKCE Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKCE Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCE Gene

Regulatory Elements for PRKCE Gene

Proteins for PRKCE Gene

  • Protein details for PRKCE Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q02156-KPCE_HUMAN
    Recommended name:
    Protein kinase C epsilon type
    Protein Accession:
    Q02156
    Secondary Accessions:
    • B0LPH7
    • Q32MQ3
    • Q53SL4
    • Q53SM5
    • Q9UE81

    Protein attributes for PRKCE Gene

    Size:
    737 amino acids
    Molecular mass:
    83674 Da
    Quaternary structure:
    • Forms a ternary complex with TRIM63 and GN2BL1. Can form a complex with PDLIM5 and N-type calcium channel. Interacts with COPB1 and YWHAB (By similarity). Interacts with DGKQ and STAT3.

    Three dimensional structures from OCA and Proteopedia for PRKCE Gene

neXtProt entry for PRKCE Gene

Proteomics data for PRKCE Gene at MOPED

Post-translational modifications for PRKCE Gene

  • Phosphorylation on Thr-566 by PDPK1 triggers autophosphorylation on Ser-729. Phosphorylation in the hinge domain at Ser-350 by MAPK11 or MAPK14, Ser-346 by GSK3B and Ser-368 by autophosphorylation is required for interaction with YWHAB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKCE Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PRKCE Gene

UniProtKB/Swiss-Prot:

KPCE_HUMAN
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor and the C2 domain is a non-calcium binding domain:
    • Q02156
  • Contains 1 AGC-kinase C-terminal domain.:
    • Q02156
  • Contains 1 C2 domain.:
    • Q02156
  • Contains 1 protein kinase domain.:
    • Q02156
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.:
    • Q02156
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.:
    • Q02156
genes like me logo Genes that share domains with PRKCE: view

Function for PRKCE Gene

Molecular function for PRKCE Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-566 (activation loop of the kinase domain), Thr-710 (turn motif) and Ser-729 (hydrophobic region), need to be phosphorylated for its full activation
UniProtKB/Swiss-Prot Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin-dependent signaling, by mediating angiotensin-2-induced activation of integrin beta-1 (ITGB1) in cardiac fibroblasts. Phosphorylates MARCKS, which phosphorylates and activates PTK2/FAK, leading to the spread of cardiomyocytes. Involved in the control of the directional transport of ITGB1 in mesenchymal cells by phosphorylating vimentin (VIM), an intermediate filament (IF) protein. In epithelial cells, associates with and phosphorylates keratin-8 (KRT8), which induces targeting of desmoplakin at desmosomes and regulates cell-cell contact. Phosphorylates IQGAP1, which binds to CDC42, mediating epithelial cell-cell detachment prior to migration. In HeLa cells, contributes to hepatocyte growth factor (HGF)-induced cell migration, and in human corneal epithelial cells, plays a critical role in wound healing after activation by HGF. During cytokinesis, forms a complex with YWHAB, which is crucial for daughter cell separation, and facilitates abscission by a mechanism which may implicate the regulation of RHOA. In cardiac myocytes, regulates myofilament function and excitation coupling at the Z-lines, where it is indirectly associated with F-actin via interaction with COPB1. During endothelin-induced cardiomyocyte hypertrophy, mediates activation of PTK2/FAK, which is critical for cardiomyocyte survival and regulation of sarcomere length. Plays a role in the pathogenesis of dilated cardiomyopathy via persistent phosphorylation of troponin I (TNNI3). Involved in nerve growth factor (NFG)-induced neurite outgrowth and neuron morphological change independently of its kinase activity, by inhibition of RHOA pathway, activation of CDC42 and cytoskeletal rearrangement. May be involved in presynaptic facilitation by mediating phorbol ester-induced synaptic potentiation. Phosphorylates gamma-aminobutyric acid receptor subunit gamma-2 (GABRG2), which reduces the response of GABA receptors to ethanol and benzodiazepines and may mediate acute tolerance to the intoxicating effects of ethanol. Upon PMA treatment, phosphorylates the capsaicin- and heat-activated cation channel TRPV1, which is required for bradykinin-induced sensitization of the heat response in nociceptive neurons. Is able to form a complex with PDLIM5 and N-type calcium channel, and may enhance channel activities and potentiates fast synaptic transmission by phosphorylating the pore-forming alpha subunit CACNA1B (CaV2.2). In prostate cancer cells, interacts with and phosphorylates STAT3, which increases DNA-binding and transcriptional activity of STAT3 and seems to be essential for prostate cancer cell invasion. Downstream of TLR4, plays an important role in the lipopolysaccharide (LPS)-induced immune response by phosphorylating and activating TICAM2/TRAM, which in turn activates the transcription factor IRF3 and subsequent cytokines production. In differentiating erythroid progenitors, is regulated by EPO and controls the protection against the TNFSF10/TRAIL-mediated apoptosis, via BCL2. May be involved in the regulation of the insulin-induced phosphorylation and activation of AKT1.

Enzyme Numbers (IUBMB) for PRKCE Gene

Gene Ontology (GO) - Molecular Function for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003785 actin monomer binding ISS --
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 15695813
GO:0004697 protein kinase C activity IDA 18556656
GO:0004699 calcium-independent protein kinase C activity IEA --
genes like me logo Genes that share ontologies with PRKCE: view
genes like me logo Genes that share phenotypes with PRKCE: view

Animal Models for PRKCE Gene

MGI Knock Outs for PRKCE:

No data available for Transcription Factor Targeting and HOMER Transcription for PRKCE Gene

Localization for PRKCE Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCE Gene

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane. Cytoplasm, perinuclear region. Nucleus. Note=Translocated to plasma membrane in epithelial cells stimulated by HGF. Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity). In passaging cells, translocated to the cell periphery (By similarity). Translocated to the nucleus in PMA-treated cells (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCE Gene COMPARTMENTS Subcellular localization image for PRKCE gene
Compartment Confidence
cytoskeleton 5
cytosol 5
plasma membrane 5
endoplasmic reticulum 4
golgi apparatus 2
mitochondrion 2
nucleus 2

Gene Ontology (GO) - Cellular Components for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IDA 15632189
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA 18556656
GO:0005794 colocalizes_with Golgi apparatus ISS --
genes like me logo Genes that share ontologies with PRKCE: view

Pathways for PRKCE Gene

SuperPathways for PRKCE Gene

genes like me logo Genes that share pathways with PRKCE: view

Pathways by source for PRKCE Gene

Gene Ontology (GO) - Biological Process for PRKCE Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002281 macrophage activation involved in immune response IEA --
GO:0006468 protein phosphorylation IDA 18556656
GO:0006915 apoptotic process TAS 10438519
GO:0007049 cell cycle IEA --
GO:0007155 cell adhesion IEA --
genes like me logo Genes that share ontologies with PRKCE: view

Compounds for PRKCE Gene

(10) ApexBio Compounds for PRKCE Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor [1009820-21-6]
Dequalinium Chloride PKC inhibitor [522-51-0]
Enzastaurin (LY317615) potent PKC beta inhibitor [170364-57-5]
GF 109203X Very potent and selective inhibitor of PKC [133052-90-1]
Go 6976 PKC inhibitor [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
K-252c PKC inhibitor [85753-43-1]
Ro 31-8220 cell-permeable inhibitor of PKC [125314-64-9]
Sotrastaurin (AEB071) Potent and specific inhibitor of PKC [425637-18-9]
Staurosporine (CGP 41251) inhibitor of a broad spectrum of protein kinases [62996-74-1]

(5) Tocris Compounds for PRKCE Gene

Compound Action Cas Number
GF 109203X Protein kinase C inhibitor [133052-90-1]
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
Phorbol 12-myristate 13-acetate Protein kinase C activator [16561-29-8]
ZIP Cell-permeable inhibitor of atypical PKC isozyme PKMzeta [863987-12-6]

(846) HMDB Compounds for PRKCE Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(19) Novoseek inferred chemical compound relationships for PRKCE Gene

Compound -log(P) Hits PubMed IDs
phorbol 63.4 6
12-o-tetradecanoylphorbol 13-acetate 51.3 3
threonine 48.7 3
serine 43.3 4
okadaic acid 32 2
genes like me logo Genes that share compounds with PRKCE: view

Transcripts for PRKCE Gene

Unigene Clusters for PRKCE Gene

Protein kinase C, epsilon:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCE Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20 ^ 21a · 21b ^ 22a · 22b ^
SP1: - - - - - - - - -
SP2:
SP3: - - -
SP4:
SP5:

ExUns: 23
SP1:
SP2:
SP3:
SP4:
SP5:

Relevant External Links for PRKCE Gene

GeneLoc Exon Structure for
PRKCE
ECgene alternative splicing isoforms for
PRKCE

Expression for PRKCE Gene

mRNA expression in normal human tissues for PRKCE Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCE Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (5.6) and Brain - Anterior cingulate cortex (BA24) (4.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCE Gene

SOURCE GeneReport for Unigene cluster for PRKCE Gene Hs.580351

genes like me logo Genes that share expressions with PRKCE: view

Orthologs for PRKCE Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKCE Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCE 36
  • 99.64 (n)
  • 100 (a)
PRKCE 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCE 36
  • 92.54 (n)
  • 99.19 (a)
PRKCE 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCE 36
  • 93.17 (n)
  • 98.91 (a)
PRKCE 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkce 36
  • 91.09 (n)
  • 97.96 (a)
Prkce 16
Prkce 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKCE 37
  • 96 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkce 36
  • 90.86 (n)
  • 98.1 (a)
chicken
(Gallus gallus)
Aves PRKCE 36
  • 81.95 (n)
  • 95.93 (a)
PRKCE 37
  • 95 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCE 37
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkce 36
  • 79.25 (n)
  • 91.96 (a)
Str.13025 36
zebrafish
(Danio rerio)
Actinopterygii Dr.12470 36
prkcea 37
  • 85 (a)
OneToMany
prkceb 36
  • 76.34 (n)
  • 86.92 (a)
prkceb 37
  • 86 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002748 36
  • 60.6 (n)
  • 60.97 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pkc98E 36
  • 60.64 (n)
  • 59.94 (a)
Pkc98E 37
  • 57 (a)
OneToMany
Pkc98E 38
  • 59 (a)
worm
(Caenorhabditis elegans)
Secernentea pkc-1 36
  • 58.64 (n)
  • 62.26 (a)
pkc-1 37
  • 55 (a)
OneToMany
tpa-1 38
  • 42 (a)
F48G7.10 38
  • 44 (a)
R12G8.1 38
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR191C 36
  • 49.83 (n)
  • 40.48 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PKC1 36
  • 49.68 (n)
  • 41.09 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E06447g 36
  • 49.46 (n)
  • 39.45 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU06544 36
  • 55.08 (n)
  • 44.53 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pck2 36
  • 50 (n)
  • 41.72 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.9021 36
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2703 37
  • 54 (a)
OneToMany
Species with no ortholog for PRKCE:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCE Gene

ENSEMBL:
Gene Tree for PRKCE (if available)
TreeFam:
Gene Tree for PRKCE (if available)

Paralogs for PRKCE Gene

Paralogs for PRKCE Gene

genes like me logo Genes that share paralogs with PRKCE: view

Variants for PRKCE Gene

Sequence variations from dbSNP and Humsavar for PRKCE Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs10472 -- 46,187,632(+) TTCTT(C/T)TGTGT utr-variant-3-prime
rs13843 -- 46,187,979(-) TTAAC(A/G)TCATT utr-variant-3-prime
rs14138 -- 46,187,307(+) AGGCA(A/G)CCAGT utr-variant-3-prime
rs17077 -- 45,992,325(-) TCGGC(C/T)GCTTG intron-variant
rs20462 -- 45,748,758(+) CCTGA(A/G)GGAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCE Gene

Variant ID Type Subtype PubMed ID
esv2751894 CNV Gain 17911159
nsv528112 CNV Loss 19592680
esv2720010 CNV Deletion 23290073
esv269618 CNV Insertion 20981092
nsv2713 CNV Loss 18451855
esv2720011 CNV Deletion 23290073
nsv457318 CNV Loss 19166990
esv2668866 CNV Deletion 23128226
nsv829130 CNV Gain 20364138
esv2720012 CNV Deletion 23290073
esv273768 CNV Insertion 20981092
esv267472 CNV Insertion 20981092
nsv518264 CNV Loss 19592680
esv2674913 CNV Deletion 23128226
esv3096 CNV Deletion 18987735
esv2720013 CNV Deletion 23290073
esv2671600 CNV Deletion 23128226
nsv213629 CNV Loss 16902084
esv9518 CNV Loss 19470904
nsv517015 CNV Loss 19592680
nsv521205 CNV Loss 19592680
nsv829142 CNV Gain 20364138

Relevant External Links for PRKCE Gene

HapMap Linkage Disequilibrium report
PRKCE

Disorders for PRKCE Gene

(2) MalaCards Diseases for PRKCE Gene

Search for PRKCE Gene in MalaCards »

(15) Novoseek inferred disease relationships for PRKCE Gene

Disease -log(P) Hits PubMed IDs
astrocytoma 40.8 3
glioma 19.9 1
thymoma 12.8 1
necrosis 11 3
brain tumors 2.72 1

Relevant External Links for PRKCE

Genetic Association Database (GAD)
PRKCE
Human Genome Epidemiology (HuGE) Navigator
PRKCE
genes like me logo Genes that share disorders with PRKCE: view

No data available for UniProtKB/Swiss-Prot for PRKCE Gene

Publications for PRKCE Gene

  1. Sequence and expression of human protein kinase C-epsilon. (PMID: 1382605) Basta P. … Burns D.J. (Biochim. Biophys. Acta 1992) 2 3 4 23
  2. Protein kinase C epsilon is localized to the Golgi via its zinc-finger domain and modulates Golgi function. (PMID: 7877991) Lehel C. … Anderson W.B. (Proc. Natl. Acad. Sci. U.S.A. 1995) 2 3 23
  3. Regulation of novel protein kinase C epsilon by phosphorylation. (PMID: 11964154) Cenni V. … Toker A. (Biochem. J. 2002) 3 4 23
  4. Protein kinase C-epsilon promotes survival of lung cancer cells by suppressing apoptosis through dysregulation of the mitochondrial caspase pathway. (PMID: 12121973) Ding L. … Xiao L. (J. Biol. Chem. 2002) 3 23
  5. Overexpression of protein kinase C-epsilon enhances the stimulatory effect of ethanol on phospholipase C-mediated hydrolysis of phosphatidylethanolamine in NIH 3T3 fibroblasts. (PMID: 8224184) Kiss Z. … Garamszegi N. (FEBS Lett. 1993) 3 23

Products for PRKCE Gene

  • Addgene plasmids for PRKCE

Sources for PRKCE Gene

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