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Aliases for SCN3B Gene

Aliases for SCN3B Gene

  • Sodium Channel, Voltage Gated, Type III Beta Subunit 2 3
  • Sodium Channel, Voltage-Gated, Type III, Beta Subunit 2 3
  • SCNB3 3 6
  • Sodium Channel, Voltage-Gated, Type III, Beta 2
  • Voltage-Gated Sodium Channel Beta-3 Subunit 3
  • Sodium Channel Subunit Beta-3 3
  • HSA243396 3
  • KIAA1158 4
  • ATFB16 3
  • BRGDA7 3

External Ids for SCN3B Gene

Previous GeneCards Identifiers for SCN3B Gene

  • GC11M125013
  • GC11M123533
  • GC11M123037
  • GC11M123039
  • GC11M123005
  • GC11M119441
  • GC11M123500

Summaries for SCN3B Gene

Entrez Gene Summary for SCN3B Gene

  • Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]

GeneCards Summary for SCN3B Gene

SCN3B (Sodium Channel, Voltage Gated, Type III Beta Subunit) is a Protein Coding gene. Diseases associated with SCN3B include brugada syndrome 7 and brugada syndrome. Among its related pathways are L1CAM interactions and Activation of cAMP-Dependent PKA. GO annotations related to this gene include ion channel binding and voltage-gated sodium channel activity. An important paralog of this gene is SCN1B.

UniProtKB/Swiss-Prot for SCN3B Gene

  • Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).

Tocris Summary for SCN3B Gene

  • Voltage-gated sodium channels (NaV) are responsible for action potential initiation and propagation in excitable cells, including nerve, muscle, and neuroendocrine cell types. They are also expressed at low levels in non-excitable cells, where their physiological role is unclear. Structurally, Nav channels are composed of one pore-forming alpha-subunit, which may be associated with either one or more beta-subunits. alpha-subunits are composed for four homologous domains, each of which contains six transmembrane segments. The fourth transmembrane loop (S4) acts as the 'voltage sensor' and is activated by changes in membrane potential. S4 is also involved in channel gating.

Gene Wiki entry for SCN3B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SCN3B Gene

Genomics for SCN3B Gene

Regulatory Elements for SCN3B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for SCN3B Gene

Start:
123,629,187 bp from pter
End:
123,655,244 bp from pter
Size:
26,058 bases
Orientation:
Minus strand

Genomic View for SCN3B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for SCN3B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SCN3B Gene

Proteins for SCN3B Gene

  • Protein details for SCN3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NY72-SCN3B_HUMAN
    Recommended name:
    Sodium channel subunit beta-3
    Protein Accession:
    Q9NY72
    Secondary Accessions:
    • A5H1I5
    • Q17RL3
    • Q9ULR2

    Protein attributes for SCN3B Gene

    Size:
    215 amino acids
    Molecular mass:
    24702 Da
    Quaternary structure:
    • The voltage-sensitive sodium channel consists of an ion conducting pore forming alpha-subunit regulated by one or more beta-1, beta-2, beta-3 and/or beta-4 subunits. Beta-1 and beta-3 are non-covalently associated with alpha, while beta-2 and beta-4 are covalently linked by disulfide bonds (By similarity).
    SequenceCaution:
    • Sequence=BAA86472.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for SCN3B Gene

neXtProt entry for SCN3B Gene

Proteomics data for SCN3B Gene at MOPED

Post-translational modifications for SCN3B Gene

  • Glycosylation at Asn95, Asn109, Asn113, and Asn121
  • Modification sites at PhosphoSitePlus

Other Protein References for SCN3B Gene

Antibody Products

No data available for DME Specific Peptides for SCN3B Gene

Domains for SCN3B Gene

Gene Families for SCN3B Gene

HGNC:
  • SC :Sodium channels
  • SCN :Voltage-gated ion channels / Sodium channels
  • VSET :Immunoglobulin superfamily / V-set domain containing

Suggested Antigen Peptide Sequences for SCN3B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NY72

UniProtKB/Swiss-Prot:

SCN3B_HUMAN :
  • Q9NY72
Domain:
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Family:
  • Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.
genes like me logo Genes that share domains with SCN3B: view

Function for SCN3B Gene

Molecular function for SCN3B Gene

UniProtKB/Swiss-Prot Function:
Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with neurofascin may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).

Gene Ontology (GO) - Molecular Function for SCN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005248 voltage-gated sodium channel activity NAS 10688874
GO:0005515 protein binding --
GO:0017080 sodium channel regulator activity IMP 20042427
GO:0044325 ion channel binding IPI 20042427
GO:0086006 voltage-gated sodium channel activity involved in cardiac muscle cell action potential IMP 21051419
genes like me logo Genes that share ontologies with SCN3B: view

Phenotypes for SCN3B Gene

MGI mutant phenotypes for SCN3B:
inferred from 1 alleles
GenomeRNAi human phenotypes for SCN3B:
genes like me logo Genes that share phenotypes with SCN3B: view

Animal Model Products

miRNA for SCN3B Gene

miRTarBase miRNAs that target SCN3B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCN3B

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for SCN3B Gene

Localization for SCN3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for SCN3B Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for SCN3B Gene COMPARTMENTS Subcellular localization image for SCN3B gene
Compartment Confidence
plasma membrane 4
cytosol 1
extracellular 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for SCN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001518 voltage-gated sodium channel complex TAS 21895525
GO:0005886 plasma membrane IDA --
GO:0016021 integral component of membrane NAS 10688874
GO:0030018 Z disc ISS --
genes like me logo Genes that share ontologies with SCN3B: view

Pathways for SCN3B Gene

genes like me logo Genes that share pathways with SCN3B: view

Gene Ontology (GO) - Biological Process for SCN3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006814 sodium ion transport NAS 10688874
GO:0007399 nervous system development IEA --
GO:0007411 axon guidance --
GO:0010460 positive regulation of heart rate ISS --
GO:0010765 positive regulation of sodium ion transport IMP 21051419
genes like me logo Genes that share ontologies with SCN3B: view

Compounds for SCN3B Gene

(5) Tocris Compounds for SCN3B Gene

Compound Action Cas Number
Flecainide acetate Cardiac Na+ channel blocker. Antiarrhythmic [54143-56-5]
QX 314 bromide Na+ channel blocker [24003-58-5]
QX 314 chloride Na+ channel blocker [5369-03-9]
Tetrodotoxin Na+ channel blocker [4368-28-9]
Tetrodotoxin citrate Na+ channel blocker; citrate salt of tetrodotoxin (Cat. No. 1078) [18660-81-6]

(1) HMDB Compounds for SCN3B Gene

Compound Synonyms Cas Number PubMed IDs
Sodium
  • Sodium
7440-23-5

(1) Drugbank Compounds for SCN3B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Zonisamide
  • Zonisamida [Spanish]
68291-97-4 target inhibitor
genes like me logo Genes that share compounds with SCN3B: view

Transcripts for SCN3B Gene

Unigene Clusters for SCN3B Gene

Sodium channel, voltage-gated, type III, beta subunit:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for SCN3B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for SCN3B Gene

No ASD Table

Relevant External Links for SCN3B Gene

GeneLoc Exon Structure for
SCN3B
ECgene alternative splicing isoforms for
SCN3B

Expression for SCN3B Gene

mRNA expression in normal human tissues for SCN3B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SCN3B Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (7.5), Brain - Frontal Cortex (BA9) (6.8), Brain - Cortex (6.6), Brain - Hippocampus (6.2), and Brain - Amygdala (4.2).

Protein differential expression in normal tissues for SCN3B Gene

This gene is overexpressed in Fetal Brain (56.3) and Frontal cortex (11.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for SCN3B Gene

SOURCE GeneReport for Unigene cluster for SCN3B Gene Hs.4865

mRNA Expression by UniProt/SwissProt for SCN3B Gene

Q9NY72-SCN3B_HUMAN
Tissue specificity: Expressed in the atrium.
genes like me logo Genes that share expressions with SCN3B: view

Expression partners for SCN3B Gene

In Situ Assay Products

Orthologs for SCN3B Gene

This gene was present in the common ancestor of chordates.

Orthologs for SCN3B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia SCN3B 35
  • 92.09 (n)
  • 98.6 (a)
SCN3B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia SCN3B 35
  • 92.09 (n)
  • 97.67 (a)
SCN3B 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Scn3b 35
  • 89.46 (n)
  • 97.67 (a)
Scn3b 16
Scn3b 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia SCN3B 35
  • 99.38 (n)
  • 100 (a)
SCN3B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Scn3b 35
  • 89.15 (n)
  • 98.14 (a)
oppossum
(Monodelphis domestica)
Mammalia SCN3B 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia SCN3B 36
  • 88 (a)
OneToOne
chicken
(Gallus gallus)
Aves SCN3B 35
  • 73.18 (n)
  • 76.74 (a)
SCN3B 36
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia SCN3B 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia scn3b 35
  • 65.12 (n)
  • 66.05 (a)
zebrafish
(Danio rerio)
Actinopterygii scn3b 35
  • 59.38 (n)
  • 53.49 (a)
scn3b 36
  • 46 (a)
OneToOne
Species with no ortholog for SCN3B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for SCN3B Gene

ENSEMBL:
Gene Tree for SCN3B (if available)
TreeFam:
Gene Tree for SCN3B (if available)

Paralogs for SCN3B Gene

Paralogs for SCN3B Gene

Selected SIMAP similar genes for SCN3B Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SCN3B: view

Variants for SCN3B Gene

Sequence variations from dbSNP and Humsavar for SCN3B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs947908 -- 123,653,196(-) TAGGC(A/C)ACTGT intron-variant
rs947913 -- 123,652,135(-) TGAGA(C/T)TCTGC intron-variant
rs947915 -- 123,643,897(+) TCTCC(A/G)CTGGT intron-variant
rs947916 -- 123,644,113(+) CTGCT(C/G)TTAGA intron-variant
rs1148085 -- 123,656,361(+) aagga(C/T)tttca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for SCN3B Gene

Variant ID Type Subtype PubMed ID
dgv443e1 CNV Complex 17122850

Relevant External Links for SCN3B Gene

HapMap Linkage Disequilibrium report
SCN3B
Human Gene Mutation Database (HGMD)
SCN3B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SCN3B Gene

Disorders for SCN3B Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for SCN3B Gene in MalaCards »

(3) Diseases for SCN3B Gene including...

(1) OMIM Diseases for SCN3B Gene (608214)

UniProtKB/Swiss-Prot

SCN3B_HUMAN
  • Brugada syndrome 7 (BRGDA7) [MIM:613120]: A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. {ECO:0000269 Ref.8}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Atrial fibrillation, familial, 16 (ATFB16) [MIM:613120]: A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure. {ECO:0000269 PubMed:20558140, ECO:0000269 PubMed:21051419}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for SCN3B Gene

Relevant External Links for SCN3B

Genetic Association Database (GAD)
SCN3B
Human Genome Epidemiology (HuGE) Navigator
SCN3B
genes like me logo Genes that share disorders with SCN3B: view

No data available for Novoseek inferred disease relationships and Genatlas for SCN3B Gene

Publications for SCN3B Gene

  1. Beta3: an additional auxiliary subunit of the voltage-sensitive sodium channel that modulates channel gating with distinct kinetics. (PMID: 10688874) Morgan K. … Jackson A.P. (Proc. Natl. Acad. Sci. U.S.A. 2000) 2 3 4
  2. Functional dominant-negative mutation of sodium channel subunit gene SCN3B associated with atrial fibrillation in a Chinese GeneID population. (PMID: 20558140) Wang P. … Wang Q.K. (Biochem. Biophys. Res. Commun. 2010) 3 4 48
  3. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. (PMID: 10574461) Hirosawa M. … Ohara O. (DNA Res. 1999) 3 4
  4. Mutations in sodium channel I^-subunit SCN3B are associated with early-onset lone atrial fibrillation. (PMID: 21051419) Olesen M.S. … Svendsen J.H. (Cardiovasc. Res. 2011) 3 4
  5. High throughput SNP and expression analyses of candidate genes for non-syndromic oral clefts. (PMID: 16415175) Park J.W. … Beaty T.H. (J. Med. Genet. 2006) 3 48

Products for SCN3B Gene

Sources for SCN3B Gene

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