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Aliases for PRKCD Gene

Aliases for PRKCD Gene

  • Protein Kinase C, Delta 2 3
  • Tyrosine-Protein Kinase PRKCD 3 4
  • EC 2.7.11.13 4 63
  • NPKC-Delta 3 4
  • CVID9 3 6
  • Protein Kinase C Delta VIII 3
  • Protein Kinase C Delta Type 3
  • EC 2.7.10.2 4
  • EC 2.7.11 63
  • ALPS3 3
  • MAY1 3
  • PKCD 3

External Ids for PRKCD Gene

Previous GeneCards Identifiers for PRKCD Gene

  • GC03P052287
  • GC03P052446
  • GC03P053050
  • GC03P053152
  • GC03P053170

Summaries for PRKCD Gene

Entrez Gene Summary for PRKCD Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCD Gene

PRKCD (Protein Kinase C, Delta) is a Protein Coding gene. Diseases associated with PRKCD include autoimmune lymphoproliferative syndrome, type iii and autosomal recessive systemic lupus erythematosus. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include identical protein binding and protein kinase binding. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCD Gene

  • Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity).

Tocris Summary for PRKCD Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCD Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCD Gene

Genomics for PRKCD Gene

Regulatory Elements for PRKCD Gene

Transcription factor binding sites by QIAGEN in the PRKCD gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKCD Gene

Start:
53,156,009 bp from pter
End:
53,192,717 bp from pter
Size:
36,709 bases
Orientation:
Plus strand

Genomic View for PRKCD Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKCD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCD Gene

Proteins for PRKCD Gene

  • Protein details for PRKCD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05655-KPCD_HUMAN
    Recommended name:
    Protein kinase C delta type
    Protein Accession:
    Q05655
    Secondary Accessions:
    • B0KZ81
    • B2R834
    • Q15144
    • Q86XJ6

    Protein attributes for PRKCD Gene

    Size:
    676 amino acids
    Molecular mass:
    77505 Da
    Quaternary structure:
    • Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.

    Three dimensional structures from OCA and Proteopedia for PRKCD Gene

    Alternative splice isoforms for PRKCD Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for PRKCD Gene

Proteomics data for PRKCD Gene at MOPED

Post-translational modifications for PRKCD Gene

  • Autophosphorylated and/or phosphorylated at Thr-507, within the activation loop; phosphorylation at Thr-507 is not a prerequisite for enzymatic activity. Autophosphorylated at Ser-299, Ser-302 and Ser-304. Upon TNFSF10/TRAIL treatment, phosphorylated at Tyr-155; phosphorylation is required for its translocation to the endoplasmic reticulum and cleavage by caspase-3. Phosphorylated at Tyr-313, Tyr-334 and Tyr-567; phosphorylation of Tyr-313 and Tyr-567 following thrombin stimulation potentiates its kinase activity. Phosphorylated by protein kinase PDPK1; phosphorylation is inhibited by the apoptotic C-terminal cleavage product of PKN2.
  • Proteolytically cleaved into a catalytic subunit and a regulatory subunit by caspase-3 during apoptosis which results in kinase activation.
  • Ubiquitination at Lys184, Lys362, and Lys613
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKCD Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCD (PKCD)

Domains for PRKCD Gene

Suggested Antigen Peptide Sequences for PRKCD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q05655

UniProtKB/Swiss-Prot:

KPCD_HUMAN :
  • Q05655
Domain:
  • The C1 domain, containing the phorbol ester/DAG-type region 1 (C1A) and 2 (C1B), is the diacylglycerol sensor
  • The C2 domain is a non-calcium binding domain. It binds proteins containing phosphotyrosine in a sequence-specific manner
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 C2 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKCD: view

Function for PRKCD Gene

Molecular function for PRKCD Gene

GENATLAS Biochemistry: protein kinase C,delta polypeptide,involved in proheparin-binding EGF-like growth factor (HBEGF) ectodomain shedding upon TPA stimulation
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot EnzymeRegulation: Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine. Three specific sites; Thr-507 (activation loop of the kinase domain), Ser-645 (turn motif) and Ser-664 (hydrophobic region), need to be phosphorylated for its full activation. Activated by caspase-3 (CASP3) cleavage during apoptosis. After cleavage, the pseudosubstrate motif in the regulatory subunit is released from the substrate recognition site of the catalytic subunit, which enables PRKCD to become constitutively activated. The catalytic subunit which displays properties of a sphingosine-dependent protein kinase is activated by D-erythro-sphingosine (Sph) or N,N-dimethyl-D-erythrosphingosine (DMS) or N,N,N-trimethyl-D-erythrosphingosine (TMS), but not by ceramide or Sph-1-P and is strongly inhibited by phosphatidylserine (By similarity).
UniProtKB/Swiss-Prot Function: Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction. Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53. In cytosol can trigger apoptosis by activating MAPK11 or MAPK14, inhibiting AKT1 and decreasing the level of X-linked inhibitor of apoptosis protein (XIAP), whereas in nucleus induces apoptosis via the activation of MAPK8 or MAPK9. Upon ionizing radiation treatment, is required for the activation of the apoptosis regulators BAX and BAK, which trigger the mitochondrial cell death pathway. Can phosphorylate MCL1 and target it for degradation which is sufficient to trigger for BAX activation and apoptosis. Is required for the control of cell cycle progression both at G1/S and G2/M phases. Mediates phorbol 12-myristate 13-acetate (PMA)-induced inhibition of cell cycle progression at G1/S phase by up-regulating the CDK inhibitor CDKN1A/p21 and inhibiting the cyclin CCNA2 promoter activity. In response to UV irradiation can phosphorylate CDK1, which is important for the G2/M DNA damage checkpoint activation. Can protect glioma cells from the apoptosis induced by TNFSF10/TRAIL, probably by inducing increased phosphorylation and subsequent activation of AKT1. Is highly expressed in a number of cancer cells and promotes cell survival and resistance against chemotherapeutic drugs by inducing cyclin D1 (CCND1) and hyperphosphorylation of RB1, and via several pro-survival pathways, including NF-kappa-B, AKT1 and MAPK1/3 (ERK1/2). Can also act as tumor suppressor upon mitogenic stimulation with PMA or TPA. In N-formyl-methionyl-leucyl-phenylalanine (fMLP)-treated cells, is required for NCF1 (p47-phox) phosphorylation and activation of NADPH oxidase activity, and regulates TNF-elicited superoxide anion production in neutrophils, by direct phosphorylation and activation of NCF1 or indirectly through MAPK1/3 (ERK1/2) signaling pathways. May also play a role in the regulation of NADPH oxidase activity in eosinophil after stimulation with IL5, leukotriene B4 or PMA. In collagen-induced platelet aggregation, acts a negative regulator of filopodia formation and actin polymerization by interacting with and negatively regulating VASP phosphorylation. Downstream of PAR1, PAR4 and CD36/GP4 receptors, regulates differentially platelet dense granule secretion; acts as a positive regulator in PAR-mediated granule secretion, whereas it negatively regulates CD36/GP4-mediated granule release. Phosphorylates MUC1 in the C-terminal and regulates the interaction between MUC1 and beta-catenin. The catalytic subunit phosphorylates 14-3-3 proteins (YWHAB, YWHAZ and YWHAH) in a sphingosine-dependent fashion (By similarity).

Enzyme Numbers (IUBMB) for PRKCD Gene

Gene Ontology (GO) - Molecular Function for PRKCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IDA 10770950
GO:0004697 protein kinase C activity ISS --
GO:0004699 calcium-independent protein kinase C activity TAS 14583092
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with PRKCD: view
genes like me logo Genes that share phenotypes with PRKCD: view

Animal Models for PRKCD Gene

MGI Knock Outs for PRKCD:

Animal Model Products

CRISPR Products

miRNA for PRKCD Gene

miRTarBase miRNAs that target PRKCD

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PRKCD Gene

Localization for PRKCD Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCD Gene

Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Endoplasmic reticulum. Mitochondrion. Cell membrane; Peripheral membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCD Gene COMPARTMENTS Subcellular localization image for PRKCD gene
Compartment Confidence
cytosol 5
endoplasmic reticulum 5
mitochondrion 5
nucleus 5
plasma membrane 5

Gene Ontology (GO) - Cellular Components for PRKCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 15632189
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA 15632189
GO:0005739 mitochondrion IEA --
GO:0005783 endoplasmic reticulum IDA 15774464
genes like me logo Genes that share ontologies with PRKCD: view

Pathways for PRKCD Gene

SuperPathways for PRKCD Gene

Superpath Contained pathways
1 Signaling by FGFR
2 Ca-dependent events
3 IL-2 Pathway
4 fMLP Pathway
5 Development Endothelin-1/EDNRA signaling
genes like me logo Genes that share pathways with PRKCD: view

Pathways by source for PRKCD Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for PRKCD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0006468 protein phosphorylation IDA 16611985
GO:0006915 apoptotic process TAS --
GO:0006921 cellular component disassembly involved in execution phase of apoptosis TAS --
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with PRKCD: view

Compounds for PRKCD Gene

Compound Products

(10) ApexBio Compounds for PRKCD Gene

Compound Action Cas Number
CX-4945 (Silmitasertib) potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor [1009820-21-6]
Dequalinium Chloride PKC inhibitor [522-51-0]
Enzastaurin (LY317615) potent PKC beta inhibitor [170364-57-5]
GF 109203X Very potent and selective inhibitor of PKC [133052-90-1]
Go 6976 PKC inhibitor [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
K-252c PKC inhibitor [85753-43-1]
Ro 31-8220 cell-permeable inhibitor of PKC [125314-64-9]
Sotrastaurin (AEB071) Potent and specific inhibitor of PKC [425637-18-9]
Staurosporine (CGP 41251) inhibitor of a broad spectrum of protein kinases [62996-74-1]

(5) Tocris Compounds for PRKCD Gene

Compound Action Cas Number
GF 109203X Protein kinase C inhibitor [133052-90-1]
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
Phorbol 12-myristate 13-acetate Protein kinase C activator [16561-29-8]
ZIP Cell-permeable inhibitor of atypical PKC isozyme PKMzeta [863987-12-6]

(846) HMDB Compounds for PRKCD Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(2) Drugbank Compounds for PRKCD Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
13-Acetylphorbol
target
Ingenol Mebutate
  • 3-Ingenyl Angelate
75567-37-2 target ligand

(44) Novoseek inferred chemical compound relationships for PRKCD Gene

Compound -log(P) Hits PubMed IDs
rottlerin 96.1 31
n-benzyladriamycin-14-valerate 82.7 1
nsc-606985 82.6 2
pkcs 82.5 2
bryostatin 1 70.4 5
genes like me logo Genes that share compounds with PRKCD: view

Transcripts for PRKCD Gene

Unigene Clusters for PRKCD Gene

Protein kinase C, delta:
Representative Sequences:

CRISPR Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCD Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^ 19 ^ 20a · 20b
SP1: - - -
SP2: - - - -
SP3: -
SP4:
SP5:

Relevant External Links for PRKCD Gene

GeneLoc Exon Structure for
PRKCD
ECgene alternative splicing isoforms for
PRKCD

Expression for PRKCD Gene

mRNA expression in normal human tissues for PRKCD Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKCD Gene

This gene is overexpressed in Whole Blood (11.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCD Gene

SOURCE GeneReport for Unigene cluster for PRKCD Gene Hs.155342

genes like me logo Genes that share expressions with PRKCD: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for PRKCD Gene

Orthologs for PRKCD Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKCD 35
  • 99.38 (n)
  • 99.59 (a)
PRKCD 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKCD 35
  • 87.46 (n)
  • 88.3 (a)
PRKCD 36
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCD 35
  • 89.48 (n)
  • 91.65 (a)
PRKCD 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkcd 35
  • 87.27 (n)
  • 90.79 (a)
Prkcd 16
Prkcd 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKCD 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCD 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkcd 35
  • 87.67 (n)
  • 89.9 (a)
chicken
(Gallus gallus)
Aves PRKCD 35
  • 76.93 (n)
  • 85.57 (a)
PRKCD 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKCD 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkcd 35
  • 75.69 (n)
  • 82.89 (a)
Str.11010 35
zebrafish
(Danio rerio)
Actinopterygii prkcda 35
  • 71.47 (n)
  • 78.68 (a)
prkcda 36
  • 76 (a)
OneToMany
prkcdb 36
  • 76 (a)
OneToMany
wufb09d10 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000418 35
  • 60.45 (n)
  • 55.03 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pkcdelta 35
  • 60.22 (n)
  • 57.47 (a)
Pkcdelta 36
  • 15 (a)
OneToMany
Pkcdgr 37
  • 55 (a)
worm
(Caenorhabditis elegans)
Secernentea tpa-1 35
  • 55.4 (n)
  • 51.26 (a)
tpa-1 36
  • 46 (a)
OneToMany
tpa-1 37
  • 48 (a)
F48G7.10 37
  • 39 (a)
R12G8.1 37
  • 42 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for PRKCD:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCD Gene

ENSEMBL:
Gene Tree for PRKCD (if available)
TreeFam:
Gene Tree for PRKCD (if available)

Paralogs for PRKCD Gene

Paralogs for PRKCD Gene

Selected SIMAP similar genes for PRKCD Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with PRKCD: view

Variants for PRKCD Gene

Sequence variations from dbSNP and Humsavar for PRKCD Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs750170 -- 53,167,882(-) ACCTA(C/T)TGAAC intron-variant, upstream-variant-2KB
rs750527 -- 53,175,933(-) TCGCA(C/T)ATGTG intron-variant
rs750528 -- 53,175,857(-) GCTTG(C/T)CCCTG intron-variant
rs900495 -- 53,189,986(+) CCACC(C/T)TTCAG synonymous-codon, reference
rs1056998 - 53,186,204(+) GTACT(C/T)TGCCA missense, reference

Structural Variations from Database of Genomic Variants (DGV) for PRKCD Gene

Variant ID Type Subtype PubMed ID
nsv460553 CNV Loss 19166990
nsv834699 CNV Loss 17160897
nsv517233 CNV Loss 19592680
nsv460554 CNV Loss 19166990
nsv470583 CNV Loss 18288195

Relevant External Links for PRKCD Gene

HapMap Linkage Disequilibrium report
PRKCD
Human Gene Mutation Database (HGMD)
PRKCD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCD Gene

Disorders for PRKCD Gene

(1) OMIM Diseases for PRKCD Gene (176977)

UniProtKB/Swiss-Prot

KPCD_HUMAN
  • Autoimmune lymphoproliferative syndrome 3 (ALPS3) [MIM:615559]: A primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antigen. The defect results from a failure of B-cell differentiation and impaired secretion of immunoglobulins; the numbers of circulating B-cells is usually in the normal range, but can be low. CVID9 patients have B-cell deficiency and severe autoimmunity. {ECO:0000269 PubMed:23319571}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(20) Novoseek inferred disease relationships for PRKCD Gene

Disease -log(P) Hits PubMed IDs
glioma 27.2 6
tumors 22.4 17
colon cancer 15.4 3
mammary tumor 6.55 1
parkinson disease 4.59 3

Relevant External Links for PRKCD

Genetic Association Database (GAD)
PRKCD
Human Genome Epidemiology (HuGE) Navigator
PRKCD
genes like me logo Genes that share disorders with PRKCD: view

Publications for PRKCD Gene

  1. Assignment of the protein kinase C delta polypeptide gene (PRKCD) to human chromosome 3 and mouse chromosome 14. (PMID: 8188219) Huppi K. … Mischak H. (Genomics 1994) 2 3 23
  2. Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. (PMID: 11877440) Ren J. … Kufe D. (J. Biol. Chem. 2002) 3 4 23
  3. Novel phosphorylation site markers of protein kinase C delta activation. (PMID: 17603046) Durgan J. … Parker P.J. (FEBS Lett. 2007) 3 4 23
  4. Phosphorylation of mitochondrial phospholipid scramblase 3 by protein kinase C-delta induces its activation and facilitates mitochondrial targeting of tBid. (PMID: 17226776) He Y. … Lee R.M. (J. Cell. Biochem. 2007) 3 23
  5. Essential role of protein kinase C delta in platelet signaling, alpha IIb beta 3 activation, and thromboxane A2 release. (PMID: 16895913) Yacoub D. … Merhi Y. (J. Biol. Chem. 2006) 3 23

Products for PRKCD Gene

  • Addgene plasmids for PRKCD

Sources for PRKCD Gene

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