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Aliases for LRIF1 Gene

Aliases for LRIF1 Gene

  • Ligand Dependent Nuclear Receptor Interacting Factor 1 2 3
  • RIF1 3 4 6
  • Receptor Interacting Factor 1 2 3
  • Receptor-Interacting Factor 1 3 4
  • C1orf103 3 4
  • Ligand-Dependent Nuclear Receptor-Interacting Factor 1 3
  • Chromosome 1 Open Reading Frame 103 2

External Ids for LRIF1 Gene

Previous Symbols for LRIF1 Gene

  • C1orf103

Summaries for LRIF1 Gene

GeneCards Summary for LRIF1 Gene

LRIF1 (Ligand Dependent Nuclear Receptor Interacting Factor 1) is a Protein Coding gene. Among its related pathways are Transcriptional Regulatory Network in Embryonic Stem Cell. GO annotations related to this gene include retinoic acid receptor binding.

UniProtKB/Swiss-Prot for LRIF1 Gene

  • Represses the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA). This repression may occur through direct recruitment of histone deacetylases.

Gene Wiki entry for LRIF1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for LRIF1 Gene

Genomics for LRIF1 Gene

Genomic Location for LRIF1 Gene

Start:
110,877,276 bp from pter
End:
110,964,197 bp from pter
Size:
86,922 bases
Orientation:
Minus strand

Genomic View for LRIF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for LRIF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for LRIF1 Gene

No data available for Regulatory Elements for LRIF1 Gene

Proteins for LRIF1 Gene

  • Protein details for LRIF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T3J3-LRIF1_HUMAN
    Recommended name:
    Ligand-dependent nuclear receptor-interacting factor 1
    Protein Accession:
    Q5T3J3
    Secondary Accessions:
    • Q86XS4
    • Q8N3B6
    • Q96HT4
    • Q9NUM5
    • Q9NV32

    Protein attributes for LRIF1 Gene

    Size:
    769 amino acids
    Molecular mass:
    84568 Da
    Quaternary structure:
    • Interacts with RARA.
    SequenceCaution:
    • Sequence=AAH08115.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAO43631.1; Type=Frameshift; Positions=23; Evidence={ECO:0000305}; Sequence=BAA92097.1; Type=Frameshift; Positions=667; Evidence={ECO:0000305};

    Alternative splice isoforms for LRIF1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for LRIF1 Gene

Proteomics data for LRIF1 Gene at MOPED

Post-translational modifications for LRIF1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys11, Lys134, Lys252, Lys259, Lys279, Lys290, Lys418, Lys427, Lys470, Lys543, and Lys578

Other Protein References for LRIF1 Gene

No data available for DME Specific Peptides for LRIF1 Gene

Domains for LRIF1 Gene

Protein Domains for LRIF1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for LRIF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T3J3

UniProtKB/Swiss-Prot:

LRIF1_HUMAN
Family:
  • Belongs to the LRIF1 family.:
    • Q5T3J3
genes like me logo Genes that share domains with LRIF1: view

No data available for Gene Families for LRIF1 Gene

Function for LRIF1 Gene

Molecular function for LRIF1 Gene

UniProtKB/Swiss-Prot Function: Represses the ligand-induced transcriptional activity of retinoic acid receptor alpha (RARA). This repression may occur through direct recruitment of histone deacetylases.

Gene Ontology (GO) - Molecular Function for LRIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15383276
GO:0042974 retinoic acid receptor binding IEA --
genes like me logo Genes that share ontologies with LRIF1: view

Phenotypes for LRIF1 Gene

GenomeRNAi human phenotypes for LRIF1:
genes like me logo Genes that share phenotypes with LRIF1: view

miRNA for LRIF1 Gene

miRTarBase miRNAs that target LRIF1

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for LRIF1 Gene

Localization for LRIF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for LRIF1 Gene

Nucleus matrix.

Gene Ontology (GO) - Cellular Components for LRIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005815 microtubule organizing center IDA --
GO:0015629 actin cytoskeleton IDA --
GO:0016363 nuclear matrix IEA --
genes like me logo Genes that share ontologies with LRIF1: view

No data available for Subcellular locations from COMPARTMENTS for LRIF1 Gene

Pathways for LRIF1 Gene

genes like me logo Genes that share pathways with LRIF1: view

Pathways by source for LRIF1 Gene

Gene Ontology (GO) - Biological Process for LRIF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with LRIF1: view

Transcripts for LRIF1 Gene

Unigene Clusters for LRIF1 Gene

Ligand dependent nuclear receptor interacting factor 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for LRIF1 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3
SP1: -
SP2:

Relevant External Links for LRIF1 Gene

GeneLoc Exon Structure for
LRIF1
ECgene alternative splicing isoforms for
LRIF1

Expression for LRIF1 Gene

mRNA expression in normal human tissues for LRIF1 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for LRIF1 Gene

SOURCE GeneReport for Unigene cluster for LRIF1 Gene Hs.25245

mRNA Expression by UniProt/SwissProt for LRIF1 Gene

Q5T3J3-LRIF1_HUMAN
Tissue specificity: Widely expressed, with the highest expression levels in heart, liver and placenta.
genes like me logo Genes that share expressions with LRIF1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for LRIF1 Gene

Orthologs for LRIF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for LRIF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LRIF1 35
  • 99.83 (n)
  • 99.61 (a)
LRIF1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LRIF1 35
  • 91.05 (n)
  • 85.26 (a)
LRIF1 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LRIF1 35
  • 91.51 (n)
  • 86.74 (a)
LRIF1 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Lrif1 35
  • 82.93 (n)
  • 70.78 (a)
Lrif1 16
Lrif1 36
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia LRIF1 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia LRIF1 36
  • 45 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Lrif1 35
  • 82.39 (n)
  • 69.22 (a)
chicken
(Gallus gallus)
Aves LRIF1 35
  • 58.04 (n)
  • 42.94 (a)
LRIF1 36
  • 32 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia LRIF1 36
  • 29 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100492192 35
  • 52.28 (n)
  • 41.55 (a)
zebrafish
(Danio rerio)
Actinopterygii LRIF1 (1 of 2) 36
  • 18 (a)
OneToMany
LRIF1 (2 of 2) 36
  • 18 (a)
OneToMany
Species with no ortholog for LRIF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for LRIF1 Gene

ENSEMBL:
Gene Tree for LRIF1 (if available)
TreeFam:
Gene Tree for LRIF1 (if available)

Paralogs for LRIF1 Gene

No data available for Paralogs for LRIF1 Gene

Variants for LRIF1 Gene

Sequence variations from dbSNP and Humsavar for LRIF1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs953232 -- 110,964,647(+) GCTGT(C/G)CATTG upstream-variant-2KB
rs1046260 -- 110,947,279(-) TTTTT(G/T)GGGAC utr-variant-3-prime, intron-variant
rs1282006 -- 110,943,146(+) tgcta(C/T)tgaca intron-variant
rs1282007 -- 110,943,348(+) AAGGC(A/G)CATTT intron-variant
rs1282008 -- 110,943,831(+) GATCT(A/C)AGTTC intron-variant

Relevant External Links for LRIF1 Gene

HapMap Linkage Disequilibrium report
LRIF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for LRIF1 Gene

Disorders for LRIF1 Gene

No disorders were found for LRIF1 Gene.

No data available for UniProtKB/Swiss-Prot for LRIF1 Gene

Publications for LRIF1 Gene

  1. RIF-1, a novel nuclear receptor corepressor that associates with the nuclear matrix. (PMID: 17455211) Li H.J. … Mendelsohn M. (J. Cell. Biochem. 2007) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for LRIF1 Gene

Sources for LRIF1 Gene

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