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Aliases for PRKCA Gene

Aliases for PRKCA Gene

  • Protein Kinase C, Alpha 2 3
  • PKCA 3 4 6
  • EC 2.7.11.13 4 63
  • PKC-Alpha 3 4
  • PRKACA 3 4
  • PKC-A 3 4
  • Protein Kinase C Alpha Type 3
  • Aging-Associated Gene 6 3
  • EC 2.7.11 63
  • AAG6 3

External Ids for PRKCA Gene

Previous HGNC Symbols for PRKCA Gene

  • PKCA

Previous GeneCards Identifiers for PRKCA Gene

  • GC17M063614
  • GC17M066678
  • GC17P064716
  • GC17P064849
  • GC17P061729
  • GC17P064298
  • GC17P059689

Summaries for PRKCA Gene

Entrez Gene Summary for PRKCA Gene

  • Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKCA Gene

PRKCA (Protein Kinase C, Alpha) is a Protein Coding gene. Diseases associated with PRKCA include myotonic dystrophy 1. Among its related pathways are PI3K-Akt signaling pathway and PI-3K cascade. GO annotations related to this gene include enzyme binding and protein kinase C activity. An important paralog of this gene is PRKCB.

UniProtKB/Swiss-Prot for PRKCA Gene

  • Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Tocris Summary for PRKCA Gene

  • Protein kinase C (PKC) refers to a family of serine/threonine protein kinases grouped by their activation mechanism. Classical or conventional PKCs (cPKC alpha-, betaI- , betaII- and gamma-) are activated by phosphatidylserine in a calcium dependent manner and can bind diacylglycerol (DAG). The Ca2+ insensitive novel PKCs (nPKCs epsilon-, delta-, theta- and eta- isotypes) are also activated by DAG and phosphatidylserine. The atypical PKCs (aPKCs iota- and zeta-) are insensitive to Ca2+, DAG and phorbol esters. All PKCs isoforms consist of a highly conserved catalytic domain connected to a regulatory domain via a hinge region. The physiological roles of PKCs are vast. This due to PKC phosphorylation and activation of multiple target proteins, which are involved in signal transduction pathways including, but not limited to, receptor desensitization, modulation of membrane structure events, regulation of transcription, regulation of cell growth, immune responses, and in learning and memory.

Gene Wiki entry for PRKCA Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKCA Gene

Genomics for PRKCA Gene

Regulatory Elements for PRKCA Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKCA Gene

Start:
66,302,636 bp from pter
End:
66,810,744 bp from pter
Size:
508,109 bases
Orientation:
Plus strand

Genomic View for PRKCA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKCA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKCA Gene

Proteins for PRKCA Gene

  • Protein details for PRKCA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P17252-KPCA_HUMAN
    Recommended name:
    Protein kinase C alpha type
    Protein Accession:
    P17252
    Secondary Accessions:
    • B5BU22
    • Q15137
    • Q32M72
    • Q96RE4

    Protein attributes for PRKCA Gene

    Size:
    672 amino acids
    Molecular mass:
    76750 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domain.;
    Quaternary structure:
    • Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and GNB2L1/RACK1 (By similarity). Interacts with ADAP1/CENTA1, CSPG4 and PRKCABP. Binds to SDPR in the presence of phosphatidylserine. Interacts with PICK1 (via PDZ domain). Interacts with TRIM41.

    Three dimensional structures from OCA and Proteopedia for PRKCA Gene

neXtProt entry for PRKCA Gene

Proteomics data for PRKCA Gene at MOPED

Post-translational modifications for PRKCA Gene

  • Ubiquitination at Lys45, Lys76, Lys388, Lys621, and Lys628
  • Modification sites at PhosphoSitePlus

Other Protein References for PRKCA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for PRKCA (PKCA)

Domains for PRKCA Gene

Suggested Antigen Peptide Sequences for PRKCA Gene

Graphical View of Domain Structure for InterPro Entry

P17252

UniProtKB/Swiss-Prot:

KPCA_HUMAN :
  • P17252
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 C2 domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.
Similarity:
  • Contains 2 phorbol-ester/DAG-type zinc fingers.
genes like me logo Genes that share domains with PRKCA: view

Function for PRKCA Gene

Molecular function for PRKCA Gene

GENATLAS Biochemistry:
protein kinase C,alpha polypeptide
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Classical (or conventional) PKCs (PRKCA, PRKCB and PRKCG) are activated by calcium and diacylglycerol (DAG) in the presence of phosphatidylserine. Three specific sites; Thr-497 (activation loop of the kinase domain), Thr-638 (turn motif) and Ser-657 (hydrophobic region), need to be phosphorylated for its full activation
UniProtKB/Swiss-Prot Function:
Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that is involved in positive and negative regulation of cell proliferation, apoptosis, differentiation, migration and adhesion, tumorigenesis, cardiac hypertrophy, angiogenesis, platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involving MAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation and cell growth arrest by positive and negative regulation of the cell cycle. Can promote cell growth by phosphorylating and activating RAF1, which mediates the activation of the MAPK/ERK signaling cascade, and/or by up-regulating CDKN1A, which facilitates active cyclin-dependent kinase (CDK) complex formation in glioma cells. In intestinal cells stimulated by the phorbol ester PMA, can trigger a cell cycle arrest program which is associated with the accumulation of the hyper-phosphorylated growth-suppressive form of RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B. Exhibits anti-apoptotic function in glioma cells and protects them from apoptosis by suppressing the p53/TP53-mediated activation of IGFBP3, and in leukemia cells mediates anti-apoptotic action by phosphorylating BCL2. During macrophage differentiation induced by macrophage colony-stimulating factor (CSF1), is translocated to the nucleus and is associated with macrophage development. After wounding, translocates from focal contacts to lamellipodia and participates in the modulation of desmosomal adhesion. Plays a role in cell motility by phosphorylating CSPG4, which induces association of CSPG4 with extensive lamellipodia at the cell periphery and polarization of the cell accompanied by increases in cell motility. Is highly expressed in a number of cancer cells where it can act as a tumor promoter and is implicated in malignant phenotypes of several tumors such as gliomas and breast cancers. Negatively regulates myocardial contractility and positively regulates angiogenesis, platelet aggregation and thrombus formation in arteries. Mediates hypertrophic growth of neonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is required to induce cardiomyocyte hypertrophy up to heart failure and death, by increasing protein synthesis, protein-DNA ratio and cell surface area. Regulates cardiomyocyte function by phosphorylating cardiac troponin T (TNNT2/CTNT), which induces significant reduction in actomyosin ATPase activity, myofilament calcium sensitivity and myocardial contractility. In angiogenesis, is required for full endothelial cell migration, adhesion to vitronectin (VTN), and vascular endothelial growth factor A (VEGFA)-dependent regulation of kinase activation and vascular tube formation. Involved in the stabilization of VEGFA mRNA at post-transcriptional level and mediates VEGFA-induced cell proliferation. In the regulation of calcium-induced platelet aggregation, mediates signals from the CD36/GP4 receptor for granule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response to lipopolysaccharides (LPS), may regulate selective LPS-induced macrophage functions involved in host defense and inflammation. But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1, which modulates EIF4G1 binding to MKNK1 and may be involved in the regulation of EIF4E phosphorylation. Phosphorylates KIT, leading to inhibition of KIT activity. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription.

Enzyme Numbers (IUBMB) for PRKCA Gene

Gene Ontology (GO) - Molecular Function for PRKCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity IDA 10770950
GO:0004674 protein serine/threonine kinase activity TAS --
GO:0004697 protein kinase C activity ISS --
GO:0004698 calcium-dependent protein kinase C activity IEA --
GO:0004713 protein tyrosine kinase activity --
genes like me logo Genes that share ontologies with PRKCA: view
genes like me logo Genes that share phenotypes with PRKCA: view

Animal Models for PRKCA Gene

MGI Knock Outs for PRKCA:

Animal Model Products

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for PRKCA Gene

Localization for PRKCA Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKCA Gene

Cytoplasm. Cell membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKCA Gene COMPARTMENTS Subcellular localization image for PRKCA gene
Compartment Confidence
cytosol 5
mitochondrion 5
nucleus 5
plasma membrane 5
endoplasmic reticulum 4

Gene Ontology (GO) - Cellular Components for PRKCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001750 photoreceptor outer segment IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IDA --
GO:0005739 mitochondrion IDA 20833797
genes like me logo Genes that share ontologies with PRKCA: view

Pathways for PRKCA Gene

SuperPathways for PRKCA Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 IL-2 Pathway
4 Circadian entrainment
5 Regulation of PLK1 Activity at G2/M Transition
genes like me logo Genes that share pathways with PRKCA: view

Pathways by source for PRKCA Gene

PCR Array Products

Gene Ontology (GO) - Biological Process for PRKCA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000188 inactivation of MAPK activity IEA --
GO:0000278 mitotic cell cycle TAS --
GO:0001525 angiogenesis IEA --
GO:0001933 negative regulation of protein phosphorylation --
GO:0001934 positive regulation of protein phosphorylation IEA --
genes like me logo Genes that share ontologies with PRKCA: view

Compounds for PRKCA Gene

Compound Products

(5) Tocris Compounds for PRKCA Gene

Compound Action Cas Number
GF 109203X Protein kinase C inhibitor [133052-90-1]
Go 6976 Potent protein kinase C inhibitor; selective for alpha and beta isozymes [136194-77-9]
Go 6983 Broad spectrum PKC inhibitor [133053-19-7]
Phorbol 12-myristate 13-acetate Protein kinase C activator [16561-29-8]
ZIP Cell-permeable inhibitor of atypical PKC isozyme PKMzeta [863987-12-6]

(13) ApexBio Compounds for PRKCA Gene

Compound Action Cas Number
(-)-Epigallocatechin gallate (EGCG) "Antioxidant, antiangiogenic and antitumor agent" [989-51-5]
[Ser25] Protein Kinase C (19-31) PKC substrate [136795-05-6]
Chelerythrine Chloride PKC antagonist [34316-15-9]
Dequalinium Chloride [522-51-0]
Enzastaurin (LY317615) "PKC beta inhibitor,potent and selective" [170364-57-5]
GF 109203X "Protein kinase C,MLCK,PKG and PKA inhibitor" [133052-90-1]
Go 6976 PKCα/PKCβ1 inhibitor [136194-77-9]
Go 6983 pan-PKC inhibitor [133053-19-7]
K-252c Protein kinase inhibitor [85753-43-1]
Ro 31-8220 Mesylate Pan-PKC inhibitor [138489-18-6]
Sotrastaurin (AEB071) PKC inhibitor [425637-18-9]
Staurosporine "Protein kinase inhibitor,potent and cell permeable" [62996-74-1]
ZIP PKMζ inhibitor [863987-12-6]

(970) HMDB Compounds for PRKCA Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available

(4) Drugbank Compounds for PRKCA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Ellagic Acid
476-66-4 target inhibitor, competitive
Ingenol Mebutate
  • 3-Ingenyl Angelate
75567-37-2 target ligand
Phosphatidylserine
  • 3-O-sn-Phosphatidyl-L-serine
8002-43-5 target
Vitamin E
  • alpha-Tocopherol
59-02-9 target

(120) Novoseek inferred chemical compound relationships for PRKCA Gene

Compound -log(P) Hits PubMed IDs
pkcs 89.3 25
go 6976 88.1 26
phorbol 82.4 39
rottlerin 82.4 13
bryostatin 1 81 47

(1) PharmGKB related drug/compound annotations for PRKCA Gene

Drug/compound Annotation
hydrochlorothiazide CA
genes like me logo Genes that share compounds with PRKCA: view

Transcripts for PRKCA Gene

Unigene Clusters for PRKCA Gene

Protein kinase C, alpha:
Representative Sequences:

miRNA Products

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKCA Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18
SP1: - -
SP2:

Relevant External Links for PRKCA Gene

GeneLoc Exon Structure for
PRKCA
ECgene alternative splicing isoforms for
PRKCA

Expression for PRKCA Gene

mRNA expression in normal human tissues for PRKCA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for PRKCA Gene

This gene is overexpressed in Peripheral blood mononuclear cells (9.8) and Lymph node (6.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKCA Gene

SOURCE GeneReport for Unigene cluster for PRKCA Gene Hs.531704

genes like me logo Genes that share expressions with PRKCA: view

Expression partners for PRKCA Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for PRKCA Gene

Orthologs for PRKCA Gene

This gene was present in the common ancestor of animals.

Orthologs for PRKCA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRKCA 35
  • 88.1 (n)
  • 97.77 (a)
PRKCA 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKCA 35
  • 92.16 (n)
  • 99.34 (a)
PRKCA 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkca 35
  • 91.02 (n)
  • 99.55 (a)
Prkca 16
Prkca 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKCA 35
  • 99.55 (n)
  • 99.85 (a)
PRKCA 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkca 35
  • 91.35 (n)
  • 99.37 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKCA 36
  • 97 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKCA 36
  • 94 (a)
OneToOne
chicken
(Gallus gallus)
Aves PRKCA 35
  • 83.23 (n)
  • 94.2 (a)
-- 36
  • 91 (a)
OneToMany
PRKCA 36
  • 94 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia PRKCA 36
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkca 35
  • 79.42 (n)
  • 91.93 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14976 35
zebrafish
(Danio rerio)
Actinopterygii prkca 35
  • 74.94 (n)
  • 85.11 (a)
prkca 36
  • 85 (a)
OneToMany
PRKCA (2 of 3) 36
  • 82 (a)
OneToMany
PRKCA (3 of 3) 36
  • 86 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta inaC 37
  • 52 (a)
Pkc53E 37
  • 70 (a)
Pkc53E 35
  • 66.88 (n)
  • 70.75 (a)
inaC 36
  • 48 (a)
ManyToMany
Pkc53E 36
  • 66 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012252 35
  • 65.57 (n)
  • 69.54 (a)
worm
(Caenorhabditis elegans)
Secernentea pkc-2 37
  • 68 (a)
pkc-2 35
  • 64.6 (n)
  • 70.65 (a)
pkc-2 36
  • 49 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1705 35
Species with no ortholog for PRKCA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKCA Gene

ENSEMBL:
Gene Tree for PRKCA (if available)
TreeFam:
Gene Tree for PRKCA (if available)

Paralogs for PRKCA Gene

Paralogs for PRKCA Gene

genes like me logo Genes that share paralogs with PRKCA: view

Variants for PRKCA Gene

Sequence variations from dbSNP and Humsavar for PRKCA Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs8464 -- 66,810,598(+) TATAT(A/C)GCAGA utr-variant-3-prime
rs59816 -- 66,491,148(+) GTGTC(A/G)TCCGT intron-variant
rs116187 -- 66,501,619(+) TTTGA(A/G)TTGGT intron-variant
rs170585 -- 66,572,442(-) tggcc(C/T)agact intron-variant
rs170586 -- 66,611,609(-) aatgt(A/G)gagac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKCA Gene

Variant ID Type Subtype PubMed ID
nsv510721 CNV Loss 20534489
nsv833520 CNV Gain 17160897
nsv526542 CNV Loss 19592680
nsv523847 CNV Loss 19592680
nsv519825 CNV Gain 19592680
esv272620 CNV Insertion 20981092
esv267744 CNV Insertion 20981092
esv2675034 CNV Deletion 23128226
nsv457881 CNV Loss 19166990
nsv470597 CNV Loss 18288195
nsv457882 CNV Loss 19166990
nsv457887 CNV Loss 19166990
esv274286 CNV Insertion 20981092
esv22631 CNV Loss 19812545
nsv528595 CNV Loss 19592680
nsv517904 CNV Loss 19592680
esv2716116 CNV Deletion 23290073
esv2716118 CNV Deletion 23290073
esv2716119 CNV Deletion 23290073
esv2160844 CNV Deletion 18987734
esv2716120 CNV Deletion 23290073
nsv2126 CNV Insertion 18451855
esv268759 CNV Insertion 20981092
esv274427 CNV Insertion 20981092
nsv510441 CNV Loss 20534489
nsv516184 CNV Loss 19592680
nsv111836 CNV Loss 16902084
nsv512499 CNV Loss 21212237
esv2716121 CNV Deletion 23290073

Relevant External Links for PRKCA Gene

HapMap Linkage Disequilibrium report
PRKCA
Human Gene Mutation Database (HGMD)
PRKCA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKCA Gene

Disorders for PRKCA Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for PRKCA Gene in MalaCards »

(1) Diseases for PRKCA Gene including...

(95) Novoseek inferred disease relationships for PRKCA Gene

Disease -log(P) Hits PubMed IDs
glioma 42.3 32
erythroleukemia 37.2 3
tumors 32.8 79
breast carcinoma 28.2 12
melanoma 24.5 39

Relevant External Links for PRKCA

Genetic Association Database (GAD)
PRKCA
Human Genome Epidemiology (HuGE) Navigator
PRKCA
genes like me logo Genes that share disorders with PRKCA: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for PRKCA Gene

Publications for PRKCA Gene

  1. A functional role for mitochondrial protein kinase Calpha in Bcl2 phosphorylation and suppression of apoptosis. (PMID: 9738012) Ruvolo P.P. … May W.S. (J. Biol. Chem. 1998) 3 4 23
  2. Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression. (PMID: 10848585) Besson A. … Yong V.W. (Mol. Cell. Biol. 2000) 3 4 23
  3. Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo. (PMID: 11909826) Wang A. … Ware J.A. (Circ. Res. 2002) 3 4 23
  4. Association of protein kinase C alpha (PRKCA) gene with multiple sclerosis in a UK population. (PMID: 15155525) Barton A. … Worthington J. (Brain 2004) 3 23 48
  5. Phosphorylation of NG2 proteoglycan by protein kinase C-alpha regulates polarized membrane distribution and cell motility. (PMID: 15504744) Makagiansar I.T. … Stallcup W.B. (J. Biol. Chem. 2004) 3 4 23

Products for PRKCA Gene

  • Addgene plasmids for PRKCA

Sources for PRKCA Gene

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