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Aliases for PRKAR2B Gene

Aliases for PRKAR2B Gene

  • Protein Kinase, CAMP-Dependent, Regulatory, Type II, Beta 2 3
  • CAMP-Dependent Protein Kinase Type II-Beta Regulatory Subunit 3
  • CAMP-Dependent Protein Kinase Type II-Beta Regulatory Chain 3
  • WUGSC:H_RG363E19.2 3
  • H_RG363E19.2 3
  • RII-BETA 3
  • PRKAR2 3

External Ids for PRKAR2B Gene

Previous Symbols for PRKAR2B Gene

  • PRKAR2

Summaries for PRKAR2B Gene

Entrez Gene Summary for PRKAR2B Gene

  • cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKAR2B Gene

PRKAR2B (Protein Kinase, CAMP-Dependent, Regulatory, Type II, Beta) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include protein domain specific binding and cAMP-dependent protein kinase regulator activity. An important paralog of this gene is PRKAR2A.

UniProtKB/Swiss-Prot for PRKAR2B Gene

  • Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

Tocris Summary for PRKAR2B Gene

  • Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).

Gene Wiki entry for PRKAR2B Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAR2B Gene

Genomics for PRKAR2B Gene

Genomic Location for PRKAR2B Gene

107,044,649 bp from pter
107,161,811 bp from pter
117,163 bases
Plus strand

Genomic View for PRKAR2B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKAR2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAR2B Gene

Regulatory Elements for PRKAR2B Gene

Proteins for PRKAR2B Gene

  • Protein details for PRKAR2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    cAMP-dependent protein kinase type II-beta regulatory subunit
    Protein Accession:
    Secondary Accessions:
    • A4D0R9

    Protein attributes for PRKAR2B Gene

    418 amino acids
    Molecular mass:
    46302 Da
    Quaternary structure:
    • The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with the phosphorylated form of PJA2.

neXtProt entry for PRKAR2B Gene

Proteomics data for PRKAR2B Gene at MOPED

Post-translational modifications for PRKAR2B Gene

Other Protein References for PRKAR2B Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for PRKAR2B Gene

Domains for PRKAR2B Gene


  • Contains 2 cyclic nucleotide-binding domains.:
    • P31323
  • Belongs to the cAMP-dependent kinase regulatory chain family.:
    • P31323
genes like me logo Genes that share domains with PRKAR2B: view

Function for PRKAR2B Gene

Molecular function for PRKAR2B Gene

GENATLAS Biochemistry: protein kinase,cAMP-dependent,type II,beta subunit,regulatory polypeptide
UniProtKB/Swiss-Prot Function: Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase

Gene Ontology (GO) - Molecular Function for PRKAR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004862 cAMP-dependent protein kinase inhibitor activity IDA 21812984
GO:0005515 protein binding --
GO:0008603 cAMP-dependent protein kinase regulator activity IDA 21812984
GO:0019901 protein kinase binding --
GO:0030552 cAMP binding IEA --
genes like me logo Genes that share ontologies with PRKAR2B: view
genes like me logo Genes that share phenotypes with PRKAR2B: view

Animal Models for PRKAR2B Gene

MGI Knock Outs for PRKAR2B:

miRNA for PRKAR2B Gene

miRTarBase miRNAs that target PRKAR2B

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for PRKAR2B Gene

Localization for PRKAR2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKAR2B Gene

Cytoplasm. Cell membrane. Note=Colocalizes with PJA2 in the cytoplasm and at the cell membrane.

Subcellular locations from

Jensen Localization Image for PRKAR2B Gene COMPARTMENTS Subcellular localization image for PRKAR2B gene
Compartment Confidence
cytoskeleton 5
plasma membrane 5
cytosol 4
mitochondrion 2
nucleus 2
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for PRKAR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 21423175
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA 21423175
GO:0005952 cAMP-dependent protein kinase complex IEA --
genes like me logo Genes that share ontologies with PRKAR2B: view

Pathways for PRKAR2B Gene

SuperPathways for PRKAR2B Gene

Superpath Contained pathways
1 Ca-dependent events
2 Signaling by FGFR
3 Regulation of PLK1 Activity at G2/M Transition
4 G-Beta Gamma Signaling
5 GPCR Pathway
genes like me logo Genes that share pathways with PRKAR2B: view

Gene Ontology (GO) - Biological Process for PRKAR2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000278 mitotic cell cycle TAS --
GO:0001932 regulation of protein phosphorylation --
GO:0003091 renal water homeostasis TAS --
GO:0006112 energy reserve metabolic process TAS --
genes like me logo Genes that share ontologies with PRKAR2B: view

Compounds for PRKAR2B Gene

(5) Tocris Compounds for PRKAR2B Gene

Compound Action Cas Number
cAMPS-Sp, triethylammonium salt Cell-permeable cAMP analog [71774-13-5]
H 89 dihydrochloride Protein kinase A inhibitor [127243-85-0]
KT 5720 Selective protein kinase A inhibitor [108068-98-0]
PKA inhibitor fragment (6-22) amide Potent protein kinase A inhibitor [121932-06-7]
PKI 14-22 amide, myristoylated Cell-permeable protein kinase A inhibitor [201422-03-9]

(1) HMDB Compounds for PRKAR2B Gene

Compound Synonyms Cas Number PubMed IDs
Cyclic AMP
  • Cyclic AMP

(1) Drugbank Compounds for PRKAR2B Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Cyclic Adenosine Monophosphate
  • 3'-5'-cyclic adenosine monophosphate
60-92-4 target

(2) Novoseek inferred chemical compound relationships for PRKAR2B Gene

Compound -log(P) Hits PubMed IDs
cyclic amp 38.6 1
forskolin 32.6 3
genes like me logo Genes that share compounds with PRKAR2B: view

Transcripts for PRKAR2B Gene

mRNA/cDNA for PRKAR2B Gene

Unigene Clusters for PRKAR2B Gene

Protein kinase, cAMP-dependent, regulatory, type II, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAR2B Gene

No ASD Table

Relevant External Links for PRKAR2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for PRKAR2B Gene

mRNA expression in normal human tissues for PRKAR2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKAR2B Gene

This gene is overexpressed in Adipose - Visceral (Omentum) (6.7) and Adipose - Subcutaneous (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKAR2B Gene

SOURCE GeneReport for Unigene cluster for PRKAR2B Gene Hs.433068

mRNA Expression by UniProt/SwissProt for PRKAR2B Gene

Tissue specificity: Four types of regulatory chains are found: I-alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible
genes like me logo Genes that share expressions with PRKAR2B: view

Orthologs for PRKAR2B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKAR2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia PRKAR2B 36
  • 99.76 (n)
  • 99.52 (a)
  • 100 (a)
(Bos Taurus)
Mammalia PRKAR2B 36
  • 93.22 (n)
  • 97.37 (a)
  • 97 (a)
(Canis familiaris)
Mammalia PRKAR2B 36
  • 92.33 (n)
  • 96.88 (a)
  • 97 (a)
(Mus musculus)
Mammalia Prkar2b 36
  • 91.11 (n)
  • 97.36 (a)
Prkar2b 16
Prkar2b 37
  • 98 (a)
(Monodelphis domestica)
Mammalia PRKAR2B 37
  • 88 (a)
(Ornithorhynchus anatinus)
Mammalia PRKAR2B 37
  • 91 (a)
(Rattus norvegicus)
Mammalia Prkar2b 36
  • 90.95 (n)
  • 97.12 (a)
(Gallus gallus)
Aves PRKAR2B 36
  • 84.49 (n)
  • 92.09 (a)
  • 90 (a)
(Anolis carolinensis)
Reptilia PRKAR2B 37
  • 79 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.23734 36
tropical clawed frog
(Silurana tropicalis)
Amphibia prkar2b 36
  • 76.3 (n)
  • 80.25 (a)
(Danio rerio)
Actinopterygii LOC100331387 36
  • 68.03 (n)
  • 77.04 (a)
  • 74 (a)
fruit fly
(Drosophila melanogaster)
Insecta Pka-R2 37
  • 47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BCY1 37
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8307 37
  • 50 (a)
Species with no ortholog for PRKAR2B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for PRKAR2B Gene

Gene Tree for PRKAR2B (if available)
Gene Tree for PRKAR2B (if available)

Paralogs for PRKAR2B Gene

Paralogs for PRKAR2B Gene

Selected SIMAP similar genes for PRKAR2B Gene using alignment to 4 proteins: Pseudogenes for PRKAR2B Gene

genes like me logo Genes that share paralogs with PRKAR2B: view

Variants for PRKAR2B Gene

Sequence variations from dbSNP and Humsavar for PRKAR2B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs14748 -- 107,161,423(-) ATTTA(C/T)AGCCT utr-variant-3-prime
rs257371 -- 107,154,598(+) ATACA(A/C)CCTAT intron-variant
rs257372 -- 107,156,532(+) cgggc(G/T)cggtg intron-variant
rs257373 -- 107,157,845(+) TGCAG(A/G)CATCT intron-variant
rs257374 -- 107,158,200(+) AGAAA(G/T)AGTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKAR2B Gene

Variant ID Type Subtype PubMed ID
nsv831087 CNV Gain 17160897
esv274079 CNV Insertion 20981092
esv2675749 CNV Deletion 23128226
esv32754 CNV Loss 17666407

Relevant External Links for PRKAR2B Gene

HapMap Linkage Disequilibrium report

Disorders for PRKAR2B Gene

(1) University of Copenhagen DISEASES for PRKAR2B Gene

(5) Novoseek inferred disease relationships for PRKAR2B Gene

Disease -log(P) Hits PubMed IDs
promyelocytic leukemia 44.8 1
colon carcinoma 28.8 1
leukemia 0 1
tumors 0 3
cancer 0 3

Relevant External Links for PRKAR2B

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with PRKAR2B: view

No data available for UniProtKB/Swiss-Prot for PRKAR2B Gene

Publications for PRKAR2B Gene

  1. Mapping of the regulatory subunits RI beta and RII beta of cAMP-dependent protein kinase genes on human chromosome 7. (PMID: 1358799) Solberg R. … de la Chapelle A. (Genomics 1992) 2 3 23
  2. Identification of a high affinity binding protein for the regulatory subunit RII beta of cAMP-dependent protein kinase in Golgi enriched membranes of human lymphoblasts. (PMID: 1582408) Rios R.M. … Keryer G. (EMBO J. 1992) 3 23
  3. An antisense oligodeoxynucleotide targeted against the type II beta regulatory subunit mRNA of protein kinase inhibits cAMP-induced differentiation in HL-60 leukemia cells without affecting phorbol ester effects. (PMID: 1689049) Tortora G. … Cho-Chung Y.S. (Proc. Natl. Acad. Sci. U.S.A. 1990) 3 23
  4. Mutagenesis of the regulatory subunit (RII beta) of cAMP-dependent protein kinase II beta reveals hydrophobic amino acids that are essential for RII beta dimerization and/or anchoring RII beta to the cytoskeleton. (PMID: 7829531) Li Y. … Rubin C.S. (J. Biol. Chem. 1995) 3 23
  5. Protein kinase A (PKA) isoform RIIbeta mediates the synergistic killing effect of cAMP and glucocorticoid in acute lymphoblastic leukemia cells. (PMID: 18544528) Ji Z. … Cheng X. (J. Biol. Chem. 2008) 3 23

Products for PRKAR2B Gene

Sources for PRKAR2B Gene

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