Aliases for PRKAR1B Gene
External Ids for PRKAR1B Gene
Previous GeneCards Identifiers for PRKAR1B Gene
Cyclic AMP-dependent protein kinase A (PKA) is an essential enzyme in the signaling pathway of the second messenger cAMP. Through phosphorylation of target proteins, PKA controls many biochemical events in the cell including regulation of metabolism, ion transport, and gene transcription. The PKA holoenzyme is composed of 2 regulatory and 2 catalytic subunits and dissociates from the regulatory subunits upon binding of cAMP.[supplied by OMIM, Jun 2009]
GeneCards Summary for PRKAR1B Gene
PRKAR1B (Protein Kinase, CAMP-Dependent, Regulatory, Type I, Beta) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by FGFR. GO annotations related to this gene include cAMP-dependent protein kinase regulator activity and protein kinase A catalytic subunit binding. An important paralog of this gene is PRKAR2B.
UniProtKB/Swiss-Prot for PRKAR1B Gene
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.
Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. Protein kinase A is composed of two regulatory subunits and two catalytic subunits. There are multiple isoforms of the regulatory subunit (RIalpha- and RIbeta-, RIIalpha- and RIIbeta-). Binding of cAMP to the regulatory subunit releases the catalytic subunits, which then phosphorylate a diverse set of proteins including the transcription factor CREB, ion channels and metabolic enzymes. Protein kinase A is localized to specific sites near these substrates within cells by scaffold proteins known as A kinase anchoring proteins (AKAPs).