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Aliases for NUP133 Gene

Aliases for NUP133 Gene

  • Nucleoporin 133kDa 2 3
  • 133 KDa Nucleoporin 3 4
  • Nucleoporin Nup133 3 4
  • Nucleoporin 133kD 2 3
  • Nuclear Pore Complex Protein Nup133 3
  • HNUP133 3

External Ids for NUP133 Gene

Summaries for NUP133 Gene

Entrez Gene Summary for NUP133 Gene

  • The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. The nucleoporin protein encoded by this gene displays evolutionarily conserved interactions with other nucleoporins. This protein, which localizes to both sides of the nuclear pore complex at interphase, remains associated with the complex during mitosis and is targeted at early stages to the reforming nuclear envelope. This protein also localizes to kinetochores of mitotic cells. [provided by RefSeq, Jul 2008]

GeneCards Summary for NUP133 Gene

NUP133 (Nucleoporin 133kDa) is a Protein Coding gene. Among its related pathways are Disease and Cell Cycle, Mitotic. GO annotations related to this gene include nucleocytoplasmic transporter activity.

UniProtKB/Swiss-Prot for NUP133 Gene

  • Involved in poly(A)+ RNA transport.

Gene Wiki entry for NUP133 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for NUP133 Gene

Genomics for NUP133 Gene

Genomic Location for NUP133 Gene

Start:
229,440,260 bp from pter
End:
229,508,341 bp from pter
Size:
68,082 bases
Orientation:
Minus strand

Genomic View for NUP133 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for NUP133 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for NUP133 Gene

Regulatory Elements for NUP133 Gene

Proteins for NUP133 Gene

  • Protein details for NUP133 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUM0-NU133_HUMAN
    Recommended name:
    Nuclear pore complex protein Nup133
    Protein Accession:
    Q8WUM0
    Secondary Accessions:
    • B2RAZ8
    • Q5T8N0
    • Q9H9W2
    • Q9NV71
    • Q9NVC4

    Protein attributes for NUP133 Gene

    Size:
    1156 amino acids
    Molecular mass:
    128979 Da
    Quaternary structure:
    • Forms part of the Nup160 subcomplex in the nuclear pore which is composed of NUP160, NUP133, NUP107 and Nup96. This complex plays a role in RNA export and in tethering Nup98 and NUP153 to the nucleus.
    SequenceCaution:
    • Sequence=BAA91885.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14106.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for NUP133 Gene

neXtProt entry for NUP133 Gene

Proteomics data for NUP133 Gene at MOPED

Post-translational modifications for NUP133 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys35, Lys523, Lys674, Lys787, Lys842, and Lys1110

Other Protein References for NUP133 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for NUP133 Gene

Domains for NUP133 Gene

UniProtKB/Swiss-Prot:

NU133_HUMAN
Family:
  • Belongs to the nucleoporin Nup133 family.:
    • Q8WUM0
genes like me logo Genes that share domains with NUP133: view

No data available for Gene Families for NUP133 Gene

Function for NUP133 Gene

Molecular function for NUP133 Gene

UniProtKB/Swiss-Prot Function: Involved in poly(A)+ RNA transport.

Gene Ontology (GO) - Molecular Function for NUP133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005487 nucleocytoplasmic transporter activity IDA 11684705
GO:0005515 protein binding IPI 11564755
genes like me logo Genes that share ontologies with NUP133: view
genes like me logo Genes that share phenotypes with NUP133: view

miRNA for NUP133 Gene

miRTarBase miRNAs that target NUP133

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for NUP133 Gene

Localization for NUP133 Gene

Subcellular locations from UniProtKB/Swiss-Prot for NUP133 Gene

Nucleus, nuclear pore complex. Chromosome, centromere, kinetochore. Note=Located on both the cytoplasmic and nuclear sides of the nuclear pore. During mitosis, localizes to the kinetochores.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for NUP133 Gene COMPARTMENTS Subcellular localization image for NUP133 gene
Compartment Confidence
nucleus 5
cytosol 4
mitochondrion 2

Gene Ontology (GO) - Cellular Components for NUP133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000777 colocalizes_with condensed chromosome kinetochore IDA 17098863
GO:0000940 colocalizes_with condensed chromosome outer kinetochore IDA 17363900
GO:0005635 nuclear envelope TAS --
GO:0005643 nuclear pore IDA 11564755
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with NUP133: view

Pathways for NUP133 Gene

SuperPathways for NUP133 Gene

genes like me logo Genes that share pathways with NUP133: view

Pathways by source for NUP133 Gene

47 Reactome pathways for NUP133 Gene
1 KEGG pathway for NUP133 Gene

Gene Ontology (GO) - Biological Process for NUP133 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000278 mitotic cell cycle TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006406 mRNA export from nucleus IDA 11684705
GO:0006999 nuclear pore organization IMP 15146057
GO:0007077 mitotic nuclear envelope disassembly TAS --
genes like me logo Genes that share ontologies with NUP133: view

Transcripts for NUP133 Gene

mRNA/cDNA for NUP133 Gene

Unigene Clusters for NUP133 Gene

Nucleoporin 133kDa:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for NUP133 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b · 21c ^
SP1: - - - - -
SP2: - - - - -
SP3:
SP4: -
SP5:
SP6:
SP7: -
SP8:

ExUns: 22a · 22b ^ 23 ^ 24a · 24b ^ 25 ^ 26 ^ 27a · 27b ^ 28 ^ 29 ^ 30a · 30b · 30c
SP1: -
SP2: - - - -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:

Relevant External Links for NUP133 Gene

GeneLoc Exon Structure for
NUP133
ECgene alternative splicing isoforms for
NUP133

Expression for NUP133 Gene

mRNA expression in normal human tissues for NUP133 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for NUP133 Gene

SOURCE GeneReport for Unigene cluster for NUP133 Gene Hs.12457

genes like me logo Genes that share expressions with NUP133: view

Orthologs for NUP133 Gene

This gene was present in the common ancestor of animals.

Orthologs for NUP133 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia NUP133 36
  • 99.48 (n)
  • 99.31 (a)
NUP133 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia NUP133 36
  • 89.07 (n)
  • 90.05 (a)
NUP133 37
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia NUP133 36
  • 90.43 (n)
  • 91.09 (a)
NUP133 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Nup133 36
  • 80.38 (n)
  • 83.29 (a)
Nup133 16
Nup133 37
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia NUP133 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia NUP133 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Nup133 36
  • 78.48 (n)
  • 80.37 (a)
chicken
(Gallus gallus)
Aves NUP133 36
  • 74.32 (n)
  • 73.74 (a)
NUP133 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia NUP133 37
  • 67 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.9485 36
tropical clawed frog
(Silurana tropicalis)
Amphibia nup133 36
  • 66.02 (n)
  • 66.02 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12743 36
zebrafish
(Danio rerio)
Actinopterygii nup133 36
  • 60.82 (n)
  • 59.52 (a)
nup133 37
  • 59 (a)
OneToOne
wufa04e09 36
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003503 36
  • 42.21 (n)
  • 30.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta Nup133 36
  • 42.05 (n)
  • 29.4 (a)
Nup133 37
  • 26 (a)
OneToOne
CG6958 38
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1223 37
  • 32 (a)
OneToOne
Species with no ortholog for NUP133:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for NUP133 Gene

ENSEMBL:
Gene Tree for NUP133 (if available)
TreeFam:
Gene Tree for NUP133 (if available)

Paralogs for NUP133 Gene

No data available for Paralogs for NUP133 Gene

Variants for NUP133 Gene

Sequence variations from dbSNP and Humsavar for NUP133 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs2904 -- 229,464,589(+) TCAGC(A/C)AATTT intron-variant
rs168346 -- 229,496,491(+) CAAAA(A/C)AAACC intron-variant
rs186995 -- 229,505,687(-) ctggt(C/T)ttgaa intron-variant
rs189431 -- 229,505,625(-) acagg(C/G)gtgag intron-variant
rs348331 -- 229,492,820(+) acact(C/G)ctcag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for NUP133 Gene

Variant ID Type Subtype PubMed ID
esv259426 OTHER Complex 20981092
esv259749 OTHER Complex 20981092

Relevant External Links for NUP133 Gene

HapMap Linkage Disequilibrium report
NUP133
Locus Specific Mutation Databases (LSDB)
NUP133

Disorders for NUP133 Gene

Relevant External Links for NUP133

Genetic Association Database (GAD)
NUP133
Human Genome Epidemiology (HuGE) Navigator
NUP133
genes like me logo Genes that share disorders with NUP133: view

No data available for UniProtKB/Swiss-Prot for NUP133 Gene

Publications for NUP133 Gene

  1. Novel vertebrate nucleoporins Nup133 and Nup160 play a role in mRNA export. (PMID: 11684705) Vasu S. … Forbes D.J. (J. Cell Biol. 2001) 2 3 4 23
  2. An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. (PMID: 11564755) Belgareh N. … Doye V. (J. Cell Biol. 2001) 3 4 23
  3. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PMID: 16964243) Beausoleil S.A. … Gygi S.P. (Nat. Biotechnol. 2006) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for NUP133 Gene

Sources for NUP133 Gene

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