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Aliases for ARFGAP1 Gene

Aliases for ARFGAP1 Gene

  • ADP Ribosylation Factor GTPase Activating Protein 1 2 3 5
  • ARF1-Directed GTPase-Activating Protein 3 4
  • ARF1GAP 3 4
  • ADP-Ribosylation Factor 1 GTPase Activating Protein 2
  • ADP-Ribosylation Factor GTPase-Activating Protein 1 3
  • ADP-Ribosylation Factor 1 GTPase-Activating Protein 4
  • HRIHFB2281 3
  • ARF GAP 1 4
  • ARF1 GAP 4

External Ids for ARFGAP1 Gene

Previous HGNC Symbols for ARFGAP1 Gene

  • ARF1GAP

Previous GeneCards Identifiers for ARFGAP1 Gene

  • GC20P061781
  • GC20P062583
  • GC20P062630
  • GC20P061374
  • GC20P061904
  • GC20P058629

Summaries for ARFGAP1 Gene

Entrez Gene Summary for ARFGAP1 Gene

  • The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for ARFGAP1 Gene

ARFGAP1 (ADP Ribosylation Factor GTPase Activating Protein 1) is a Protein Coding gene. Among its related pathways are Arf1 pathway and PAK Pathway. GO annotations related to this gene include GTPase activator activity. An important paralog of this gene is ARFGAP2.

UniProtKB/Swiss-Prot for ARFGAP1 Gene

  • GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicles fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).

Gene Wiki entry for ARFGAP1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for ARFGAP1 Gene

Genomics for ARFGAP1 Gene

Regulatory Elements for ARFGAP1 Gene

Enhancers for ARFGAP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G062352 2 FANTOM5 Ensembl ENCODE dbSUPER 15.5 -910.7 -910670 19.1 HDGF FOXA2 MLX CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 LAMA5 LAMA5-AS1 ARFGAP1 MTG2 CABLES2 OSBPL2 BHLHE23 MRGBP ADRM1 RPS21
GH20G064062 1.7 Ensembl ENCODE dbSUPER 15.5 +792.1 792062 5.3 MLX CREB3L1 AGO1 ZFP64 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC RGS19 RTEL1 TNFRSF6B ARFGAP1 MIR647 ZNF512B PRPF6 UCKL1 TCEA2 C20orf204
GH20G062471 1.6 Ensembl ENCODE dbSUPER 15.5 -791.4 -791351 20.0 HDGF PKNOX1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B ZNF766 FOS GATA5 ARFGAP1 MTG2 LOC105372711 GC20M062490
GH20G062425 1.5 Ensembl ENCODE dbSUPER 15.5 -843.8 -843775 6.4 HDGF PKNOX1 ATF1 SIN3A ZBTB7B ZNF207 FOS SP5 REST ZNF592 CABLES2 LOC105372710 ARFGAP1 LAMA5 MIR1-1 C20orf166-AS1 MIR1-1HG RBBP8NL GATA5
GH20G062708 1.4 Ensembl ENCODE dbSUPER 15.5 -561.9 -561859 4.3 PKNOX1 ATF1 SIN3A YY1 ZNF766 GLIS2 REST ZNF592 CREB3 SMARCA4 RTEL1 ARFGAP1 TNFRSF6B ENSG00000223669 OGFR OGFR-AS1 SLCO4A1-AS1 SLCO4A1 MRGBP ENSG00000229882
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around ARFGAP1 on UCSC Golden Path with GeneCards custom track

Promoters for ARFGAP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000139876 115 1801 PKNOX1 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9 ZNF143 SP5

Genomic Location for ARFGAP1 Gene

Chromosome:
20
Start:
63,272,785 bp from pter
End:
63,289,793 bp from pter
Size:
17,009 bases
Orientation:
Plus strand

Genomic View for ARFGAP1 Gene

Genes around ARFGAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
ARFGAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for ARFGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for ARFGAP1 Gene

Proteins for ARFGAP1 Gene

  • Protein details for ARFGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N6T3-ARFG1_HUMAN
    Recommended name:
    ADP-ribosylation factor GTPase-activating protein 1
    Protein Accession:
    Q8N6T3
    Secondary Accessions:
    • B7Z3U0
    • B7Z8H8
    • B7ZBI3
    • E1P5I9
    • E7EV62
    • Q6PK71
    • Q96KC4
    • Q96T02
    • Q9NSU3
    • Q9NVF6
    • Q9UIL0

    Protein attributes for ARFGAP1 Gene

    Size:
    406 amino acids
    Molecular mass:
    44668 Da
    Quaternary structure:
    • Interacts with ARF1. Interacts with the COPI coat proteins, KDELR1 and TMED2. The interaction with TMED2 inhibits the GAP activity (By similarity).
    SequenceCaution:
    • Sequence=BAB55009.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB55113.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAB70901.1; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for ARFGAP1 Gene

    Alternative splice isoforms for ARFGAP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for ARFGAP1 Gene

Post-translational modifications for ARFGAP1 Gene

  • Ubiquitination at Lys102 and posLast=278278
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for ARFGAP1 (ARF GAP1)
  • Abcam antibodies for ARFGAP1

No data available for DME Specific Peptides for ARFGAP1 Gene

Domains & Families for ARFGAP1 Gene

Gene Families for ARFGAP1 Gene

Protein Domains for ARFGAP1 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N6T3

UniProtKB/Swiss-Prot:

ARFG1_HUMAN :
  • The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity).
Domain:
  • The region downstream of Arf-GAP domain is essential to GAP activity in vivo. This region may be required for its targeting to Golgi membranes (By similarity).
genes like me logo Genes that share domains with ARFGAP1: view

Function for ARFGAP1 Gene

Molecular function for ARFGAP1 Gene

UniProtKB/Swiss-Prot Function:
GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicles fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, as when ARF1 is deactivated. Its activity is stimulated by phosphoinosides and inhibited by phosphatidylcholine (By similarity).

Gene Ontology (GO) - Molecular Function for ARFGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IDA 22423108
GO:0005515 protein binding IPI 22363216
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with ARFGAP1: view
genes like me logo Genes that share phenotypes with ARFGAP1: view

Animal Model Products

CRISPR Products

miRNA for ARFGAP1 Gene

miRTarBase miRNAs that target ARFGAP1

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for ARFGAP1 Gene

Localization for ARFGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for ARFGAP1 Gene

Cytoplasm. Golgi apparatus. Note=Associates with the Golgi complex. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for ARFGAP1 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 4

Gene Ontology (GO) - Cellular Components for ARFGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005829 cytosol TAS --
GO:0014069 postsynaptic density IEA --
GO:0045202 synapse IEA --
genes like me logo Genes that share ontologies with ARFGAP1: view

Pathways & Interactions for ARFGAP1 Gene

genes like me logo Genes that share pathways with ARFGAP1: view

Pathways by source for ARFGAP1 Gene

1 Cell Signaling Technology pathway for ARFGAP1 Gene
1 BioSystems pathway for ARFGAP1 Gene
1 KEGG pathway for ARFGAP1 Gene
2 Qiagen pathways for ARFGAP1 Gene

SIGNOR curated interactions for ARFGAP1 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for ARFGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with ARFGAP1: view

Drugs & Compounds for ARFGAP1 Gene

(2) Drugs for ARFGAP1 Gene - From: ApexBio and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
HJC 0350 Pharma 0

(5) Additional Compounds for ARFGAP1 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
PC(18:1(9Z)e/2:0)
  • (2-acetyloxy-3-octadec-9-enoxypropyl) 2-trimethylazaniumylethyl phosphate
  • 2-Acetyl-1-(9Z-octadecenyl)-sn-glycero-3-phosphocholine
  • PC(O-18:1(9Z)/2:0)
Phosphatidylcholines Group A
  • (Z,Z)-(1)-(7-Oleoyl-4-oxido-10-oxo-3,5,9-trioxa-4-phosphaheptacos-18-enyl)trimethylammonium 4-oxide
  • (Z,Z)-4-hydroxy-N,N,N-trimethyl-10-oxo-7-[(1-oxo-9-octadecenyl)oxy]-3,5,9-Trioxa-4-phosphaheptacos-18-en-1-aminium 4-oxide hydroxide inner salt
  • 1,2-Dioleoyl-rac-glycero-3-phosphocholine
  • 1,2-Dioleoylglycerol-3-phosphorylcholine
  • 1,2-Dioleoylglyceryl-3-phosphorylcholine
68737-67-7
Phosphatidylcholines Group B
  • 1-(1-Enyl-vaccenoyl)-2-stearidonoyl-sn-glycero-3-phosphocholine
  • GPCho(18:1/18:4)
  • GPCho(18:1n7/18:4n3)
  • GPCho(18:1w7/18:4w3)
  • GPCho(36:5)
88542-95-4

(1) ApexBio Compounds for ARFGAP1 Gene

Compound Action Cas Number
HJC 0350 885434-70-8
genes like me logo Genes that share compounds with ARFGAP1: view

Drug Products

Transcripts for ARFGAP1 Gene

Unigene Clusters for ARFGAP1 Gene

ADP-ribosylation factor GTPase activating protein 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for ARFGAP1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ·
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - -
SP7: - - -
SP8: - -
SP9: -
SP10:
SP11: - - - - - - - - - - - - - - - - - - -
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 15c · 15d ^ 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20a · 20b ^ 21a · 21b ^ 22a · 22b ^ 23
SP1: - - - - -
SP2: - - - - -
SP3: - - -
SP4: - - - - -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10: - - -
SP11: - - - - - -
SP12:
SP13: - - -
SP14:
SP15:
SP16:
SP17:

Relevant External Links for ARFGAP1 Gene

GeneLoc Exon Structure for
ARFGAP1
ECgene alternative splicing isoforms for
ARFGAP1

Expression for ARFGAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for ARFGAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for ARFGAP1 Gene

This gene is overexpressed in Bone (14.3), Peripheral blood mononuclear cells (6.6), and Bone marrow stromal cell (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB,