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Aliases for RBM22 Gene

Aliases for RBM22 Gene

  • RNA Binding Motif Protein 22 2 3 5
  • Zinc Finger CCCH Domain-Containing Protein 16 3 4
  • Functional Spliceosome-Associated Protein 47 2 3
  • ZC3H16 3 4
  • Pre-MRNA-Splicing Factor RBM22 3
  • RNA-Binding Motif Protein 22 4
  • FSAP47 3
  • Cwc2 3

External Ids for RBM22 Gene

Previous GeneCards Identifiers for RBM22 Gene

  • GC05M150099
  • GC05M150050
  • GC05M145216

Summaries for RBM22 Gene

Entrez Gene Summary for RBM22 Gene

  • This gene encodes an RNA binding protein. The encoded protein may play a role in cell division and may be involved in pre-mRNA splicing. Related pseudogenes exist on chromosomes 6, 7, 9, 13, 16, 18, and X. [provided by RefSeq, Mar 2009]

GeneCards Summary for RBM22 Gene

RBM22 (RNA Binding Motif Protein 22) is a Protein Coding gene. Among its related pathways are mRNA Splicing - Major Pathway and Gene Expression. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for RBM22 Gene

  • Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5 splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.

Gene Wiki entry for RBM22 Gene

Additional gene information for RBM22 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RBM22 Gene

Genomics for RBM22 Gene

Regulatory Elements for RBM22 Gene

Enhancers for RBM22 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H150447 1.4 ENCODE dbSUPER 18.9 +252.2 252155 3 DMAP1 YY1 SLC30A9 ZNF143 SP3 MEF2D ZNF610 GLIS1 RCOR2 NBN HMGXB3 TCOF1 RBM22 RPS14 RPL7P1 GC05P150449 GC05M150442
GH05H150777 1.8 FANTOM5 ENCODE dbSUPER 13.4 -80.0 -80010 8 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 SLC30A9 RPL7P1 RBM22 TCOF1 HMGXB3 G3BP1 SMIM3 ZNF300 TNIP1 RPS14 CCDC69
GH05H149999 1.7 FANTOM5 ENCODE dbSUPER 11.5 +700.0 700037 3 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9 HMGXB3 TCOF1 ZNF300P1 ZNF300 TIGD6 CARMN RPS20P4 RPL7P1 RBM22 CAMK2A
GH05H150496 1.6 Ensembl ENCODE dbSUPER 10.3 +193.0 193048 24 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 ZNF143 NDST1 TCOF1 NDST1-AS1 RPS14 HMGXB3 SYNPO ENSG00000253852 RBM22 MYOZ3 ENSG00000250309
GH05H150460 1.6 FANTOM5 Ensembl ENCODE dbSUPER 10.2 +239.6 239632 1 HDAC1 HDGF PKNOX1 TBL1XR1 RB1 SIN3A ZNF366 IKZF2 SMARCA5 ELF1 NDST1 SYNPO RPS14 NDST1-AS1 SMIM3 RBM22 ENSG00000253852 ZNF300 GC05P150482
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around RBM22 on UCSC Golden Path with GeneCards custom track

Promoters for RBM22 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000189035 307 2001 PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 ZNF207 ZNF143

Genomic Location for RBM22 Gene

Chromosome:
5
Start:
150,690,790 bp from pter
End:
150,701,107 bp from pter
Size:
10,318 bases
Orientation:
Minus strand

Genomic View for RBM22 Gene

Genes around RBM22 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RBM22 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RBM22 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RBM22 Gene

Proteins for RBM22 Gene

  • Protein details for RBM22 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NW64-RBM22_HUMAN
    Recommended name:
    Pre-mRNA-splicing factor RBM22
    Protein Accession:
    Q9NW64
    Secondary Accessions:
    • A6NDM5
    • B4DLI9
    • O95607

    Protein attributes for RBM22 Gene

    Size:
    420 amino acids
    Molecular mass:
    46896 Da
    Quaternary structure:
    • Identified in the spliceosome C complex. Interacts with PDCD6; the interaction induces translocation of PDCD6 in the cytoplasm.
    SequenceCaution:
    • Sequence=AAC99998.1; Type=Miscellaneous discrepancy; Note=Chimera.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RBM22 Gene

    Alternative splice isoforms for RBM22 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RBM22 Gene

Post-translational modifications for RBM22 Gene

  • Ubiquitination at Lys78, isoforms=2114, and Lys149
  • Modification sites at PhosphoSitePlus

Other Protein References for RBM22 Gene

No data available for DME Specific Peptides for RBM22 Gene

Domains & Families for RBM22 Gene

Gene Families for RBM22 Gene

Suggested Antigen Peptide Sequences for RBM22 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NW64

UniProtKB/Swiss-Prot:

RBM22_HUMAN :
  • The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.
  • Belongs to the SLT11 family.
Domain:
  • The C-terminus RRM domain and the zinc finger motif are necessary for RNA-binding.
Family:
  • Belongs to the SLT11 family.
genes like me logo Genes that share domains with RBM22: view

Function for RBM22 Gene

Molecular function for RBM22 Gene

UniProtKB/Swiss-Prot Function:
Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5 splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses.

Phenotypes From GWAS Catalog for RBM22 Gene

Gene Ontology (GO) - Molecular Function for RBM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA,IEA 22658674
GO:0005487 nucleocytoplasmic transporter activity IDA 21122810
GO:0005515 protein binding IPI 25416956
GO:0017070 U6 snRNA binding IDA 22246180
genes like me logo Genes that share ontologies with RBM22: view
genes like me logo Genes that share phenotypes with RBM22: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBM22
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RBM22 Gene

Localization for RBM22 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RBM22 Gene

Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RBM22 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RBM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000974 Prp19 complex IBA --
GO:0005634 nucleus IDA 11278427
GO:0005654 nucleoplasm TAS --
GO:0005681 spliceosomal complex IEA --
GO:0005737 cytoplasm IEA,IDA 21122810
genes like me logo Genes that share ontologies with RBM22: view

Pathways & Interactions for RBM22 Gene

genes like me logo Genes that share pathways with RBM22: view

Pathways by source for RBM22 Gene

Gene Ontology (GO) - Biological Process for RBM22 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000060 protein import into nucleus, translocation IDA 17045351
GO:0000387 spliceosomal snRNP assembly IBA --
GO:0000398 mRNA splicing, via spliceosome TAS --
GO:0006397 mRNA processing IEA --
GO:0006810 transport IEA --
genes like me logo Genes that share ontologies with RBM22: view

No data available for SIGNOR curated interactions for RBM22 Gene

Drugs & Compounds for RBM22 Gene

No Compound Related Data Available

Transcripts for RBM22 Gene

Unigene Clusters for RBM22 Gene

RNA binding motif protein 22:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for RBM22
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for RBM22 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10 ^ 11
SP1: - -
SP2:
SP3:
SP4:

Relevant External Links for RBM22 Gene

GeneLoc Exon Structure for
RBM22
ECgene alternative splicing isoforms for
RBM22

Expression for RBM22 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RBM22 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RBM22 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RBM22 Gene



Protein tissue co-expression partners for RBM22 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RBM22 Gene:

RBM22

SOURCE GeneReport for Unigene cluster for RBM22 Gene:

Hs.713564

Evidence on tissue expression from TISSUES for RBM22 Gene

  • Nervous system(4.8)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with RBM22: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RBM22 Gene

Orthologs for RBM22 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RBM22 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RBM22 33 34
  • 99.6 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 98 (a)
OneToMany
-- 34
  • 91 (a)
OneToMany
-- 34
  • 63 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia RBM22 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RBM22 33 34
  • 93.73 (n)
cow
(Bos Taurus)
Mammalia RBM22 33 34
  • 92.7 (n)
mouse
(Mus musculus)
Mammalia Rbm22 33 16 34
  • 90 (n)
rat
(Rattus norvegicus)
Mammalia Rbm22 33
  • 89.52 (n)
chicken
(Gallus gallus)
Aves RBM22 33 34
  • 82.94 (n)
lizard
(Anolis carolinensis)
Reptilia RBM22 34
  • 98 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rbm22 33
  • 76.68 (n)
MGC76229 33
African clawed frog
(Xenopus laevis)
Amphibia cg14641-prov 33
zebrafish
(Danio rerio)
Actinopterygii RBM22 (3 of 3) 34
  • 84 (a)
OneToMany
rbm22 33 34 34
  • 75.18 (n)
wufc62e03 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004509 33
  • 60.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14641 33 34
  • 60.29 (n)
worm
(Caenorhabditis elegans)
Secernentea T11G6.8 33 34
  • 62.17 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ECM2 34 36
  • 21 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G07360 33
  • 57.79 (n)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.1512 33
rice
(Oryza sativa)
Liliopsida Os07g0281000 33
  • 59.57 (n)
Os.14314 33
barley
(Hordeum vulgare)
Liliopsida Hv.2670 33
wheat
(Triticum aestivum)
Liliopsida Ta.14515 33
corn
(Zea mays)
Liliopsida Zm.4129 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8471 34
  • 66 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2969 33
Species where no ortholog for RBM22 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RBM22 Gene

ENSEMBL:
Gene Tree for RBM22 (if available)
TreeFam:
Gene Tree for RBM22 (if available)

Paralogs for RBM22 Gene

No data available for Paralogs for RBM22 Gene

Variants for RBM22 Gene

Sequence variations from dbSNP and Humsavar for RBM22 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000310509 -- 150,694,652(+) TTACA(C/G)CGAAA intron-variant
rs1000705188 -- 150,699,633(+) AAGAA(A/G)TAGAG intron-variant
rs1000731922 -- 150,699,412(+) CAAAA(A/C)CCAAA intron-variant
rs1000990844 -- 150,696,376(+) TATTC(A/G)TGCTC intron-variant
rs1001221382 -- 150,693,522(+) AAGGA(C/T)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RBM22 Gene

Variant ID Type Subtype PubMed ID
esv2759386 CNV loss 17122850
esv29484 CNV loss 19812545
esv33898 CNV loss 17666407
nsv428129 CNV loss 18775914

Variation tolerance for RBM22 Gene

Residual Variation Intolerance Score: 29.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RBM22 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RBM22

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RBM22 Gene

Disorders for RBM22 Gene

Relevant External Links for RBM22

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RBM22

No disorders were found for RBM22 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RBM22 Gene

Publications for RBM22 Gene

  1. The influence of calcium signaling on the regulation of alternative splicing. (PMID: 19133299) Krebs J (Biochimica et biophysica acta 2009) 2 3 4 60
  2. Cwc2 and its human homologue RBM22 promote an active conformation of the spliceosome catalytic centre. (PMID: 22246180) Rasche N … Lührmann R (The EMBO journal 2012) 3 4 60
  3. Stress induced subcellular distribution of ALG-2, RBM22 and hSlu7. (PMID: 21122810) Janowicz A … Krebs J (Biochimica et biophysica acta 2011) 3 4 60
  4. RNA-binding motif protein RBM22 is required for normal development of zebrafish embryos. (PMID: 20013661) He F … Gou LT (Genetics and molecular research : GMR 2009) 2 3 60
  5. Nuclear translocation of the calcium-binding protein ALG-2 induced by the RNA-binding protein RBM22. (PMID: 17045351) Montaville P … Krebs J (Biochimica et biophysica acta 2006) 3 4 60

Products for RBM22 Gene

Sources for RBM22 Gene

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