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Aliases for RUFY2 Gene

Aliases for RUFY2 Gene

  • RUN And FYVE Domain Containing 2 2 3 5
  • Rab4-Interacting Protein Related 3 4
  • RABIP4R 3 4
  • Run- And FYVE-Domain Containing Protein 3
  • RUN And FYVE Domain-Containing 2 3
  • Antigen MU-RMS-40.17 3
  • KIAA1537 4
  • ZFYVE13 3

External Ids for RUFY2 Gene

Previous GeneCards Identifiers for RUFY2 Gene

  • GC10M069186
  • GC10M069993
  • GC10M069445
  • GC10M069770
  • GC10M070100
  • GC10M064103

Summaries for RUFY2 Gene

GeneCards Summary for RUFY2 Gene

RUFY2 (RUN And FYVE Domain Containing 2) is a Protein Coding gene. An important paralog of this gene is RUNDC3B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RUFY2 Gene

Genomics for RUFY2 Gene

Regulatory Elements for RUFY2 Gene

Enhancers for RUFY2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around RUFY2 on UCSC Golden Path with GeneCards custom track

Promoters for RUFY2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around RUFY2 on UCSC Golden Path with GeneCards custom track

Genomic Location for RUFY2 Gene

Chromosome:
10
Start:
68,341,107 bp from pter
End:
68,407,294 bp from pter
Size:
66,188 bases
Orientation:
Minus strand

Genomic View for RUFY2 Gene

Genes around RUFY2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RUFY2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RUFY2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RUFY2 Gene

Proteins for RUFY2 Gene

  • Protein details for RUFY2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WXA3-RUFY2_HUMAN
    Recommended name:
    RUN and FYVE domain-containing protein 2
    Protein Accession:
    Q8WXA3
    Secondary Accessions:
    • B3KXB2
    • B4DFR0
    • Q5TC48
    • Q8IW33
    • Q96P51
    • Q9P1Z1

    Protein attributes for RUFY2 Gene

    Size:
    655 amino acids
    Molecular mass:
    75055 Da
    Quaternary structure:
    • Interacts with BMX.
    SequenceCaution:
    • Sequence=CAI17232.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for RUFY2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RUFY2 Gene

Proteomics data for RUFY2 Gene at MOPED

Post-translational modifications for RUFY2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RUFY2 Gene

Domains & Families for RUFY2 Gene

Gene Families for RUFY2 Gene

Protein Domains for RUFY2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8WXA3

UniProtKB/Swiss-Prot:

RUFY2_HUMAN :
  • Contains 1 RUN domain.
  • Contains 1 FYVE-type zinc finger.
Domain:
  • Contains 1 RUN domain.
Similarity:
  • Contains 1 FYVE-type zinc finger.
genes like me logo Genes that share domains with RUFY2: view

Function for RUFY2 Gene

genes like me logo Genes that share phenotypes with RUFY2: view

Animal Models for RUFY2 Gene

MGI Knock Outs for RUFY2:

Animal Model Products

miRNA for RUFY2 Gene

miRTarBase miRNAs that target RUFY2

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RUFY2 Gene

Localization for RUFY2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RUFY2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for RUFY2 Gene COMPARTMENTS Subcellular localization image for RUFY2 gene
Compartment Confidence
nucleus 4
cytosol 3
mitochondrion 2
endosome 1
extracellular 1
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for RUFY2 Gene

Pathways & Interactions for RUFY2 Gene

SuperPathways for RUFY2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for RUFY2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for RUFY2 Gene

Drugs & Compounds for RUFY2 Gene

(1) Drugs for RUFY2 Gene - From: PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Tenofovir Approved, Investigational Pharma HIV reverse transcriptase inhibitor 701
genes like me logo Genes that share compounds with RUFY2: view

Transcripts for RUFY2 Gene

Unigene Clusters for RUFY2 Gene

RUN and FYVE domain containing 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for RUFY2 Gene

No ASD Table

Relevant External Links for RUFY2 Gene

GeneLoc Exon Structure for
RUFY2
ECgene alternative splicing isoforms for
RUFY2

Expression for RUFY2 Gene

mRNA expression in normal human tissues for RUFY2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RUFY2 Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x4.2).

Protein differential expression in normal tissues from HIPED for RUFY2 Gene

This gene is overexpressed in Bone (20.3), NK cells (16.5), and Pancreatic juice (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for RUFY2 Gene



SOURCE GeneReport for Unigene cluster for RUFY2 Gene Hs.653144

mRNA Expression by UniProt/SwissProt for RUFY2 Gene

Q8WXA3-RUFY2_HUMAN
Tissue specificity: Expressed in brain, lung and testis.
genes like me logo Genes that share expression patterns with RUFY2: view

Primer Products

In Situ Assay Products

No data available for Protein tissue co-expression partners for RUFY2 Gene

Orthologs for RUFY2 Gene

This gene was present in the common ancestor of animals.

Orthologs for RUFY2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RUFY2 35
  • 94.22 (n)
  • 96.86 (a)
RUFY2 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RUFY2 35
  • 93.74 (n)
  • 97.09 (a)
RUFY2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Rufy2 35
  • 86.96 (n)
  • 94.88 (a)
Rufy2 16
Rufy2 36
  • 95 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RUFY2 35
  • 99.74 (n)
  • 100 (a)
RUFY2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rufy2 35
  • 88.5 (n)
  • 95.87 (a)
oppossum
(Monodelphis domestica)
Mammalia RUFY2 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 99 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
chicken
(Gallus gallus)
Aves RUFY2 35
  • 81.68 (n)
  • 89.6 (a)
RUFY2 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RUFY2 36
  • 81 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rufy2 35
  • 71.31 (n)
  • 78.94 (a)
rufy2 36
  • 69 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9356 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003431 35
  • 52.76 (n)
  • 50.27 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG31064 35
  • 51.27 (n)
  • 46.19 (a)
CG31064 36
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for RUFY2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RUFY2 Gene

ENSEMBL:
Gene Tree for RUFY2 (if available)
TreeFam:
Gene Tree for RUFY2 (if available)

Paralogs for RUFY2 Gene

Paralogs for RUFY2 Gene

(3) SIMAP similar genes for RUFY2 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with RUFY2: view

Variants for RUFY2 Gene

Sequence variations from dbSNP and Humsavar for RUFY2 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11816774 - 68,345,872(+) AGAGC(A/T)GGCAT nc-transcript-variant, downstream-variant-500B, reference, missense
rs3781567 -- 68,345,421(+) GAGAA(C/T)TGCAG intron-variant, utr-variant-3-prime
rs3781568 -- 68,345,529(+) CTGCT(A/C)TCTGG intron-variant, downstream-variant-500B, utr-variant-3-prime
rs3831018 -- 68,343,882(+) ACTTA(-/CTTA)AAGGA intron-variant, utr-variant-3-prime
rs3927445 -- 68,370,006(+) AGGCC(A/G)GGCAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for RUFY2 Gene

Variant ID Type Subtype PubMed ID
nsv895690 CNV Loss 21882294
nsv895691 CNV Loss 21882294
nsv895692 CNV Loss 21882294
nsv6988 CNV Insertion 18451855
esv2670140 CNV Deletion 23128226

Variation tolerance for RUFY2 Gene

Residual Variation Intolerance Score: 27.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for RUFY2 Gene

HapMap Linkage Disequilibrium report
RUFY2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RUFY2 Gene

Disorders for RUFY2 Gene

Relevant External Links for RUFY2

Genetic Association Database (GAD)
RUFY2
Human Genome Epidemiology (HuGE) Navigator
RUFY2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
RUFY2

No disorders were found for RUFY2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RUFY2 Gene

Publications for RUFY2 Gene

  1. Interaction between tyrosine kinase Etk and a RUN-domain and FYVE- domain containing protein RUFY1. A possible role of Etk in regulation of vesicle trafficking. (PMID: 11877430) Yang J. … Qiu Y. (J. Biol. Chem. 2002) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  4. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  5. A directed protein interaction network for investigating intracellular signal transduction. (PMID: 21900206) Vinayagam A. … Wanker E.E. (Sci Signal 2011) 3

Products for RUFY2 Gene

Sources for RUFY2 Gene

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