Aliases for PEX26 Gene
External Ids for PEX26 Gene
Previous GeneCards Identifiers for PEX26 Gene
This gene belongs to the peroxin-26 gene family. It is probably required for protein import into peroxisomes. It anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Defects in this gene are the cause of peroxisome biogenesis disorder complementation group 8 (PBD-CG8). PBD refers to a group of peroxisomal disorders arising from a failure of protein import into the peroxisomal membrane or matrix. The PBD group is comprised of four disorders: Zellweger syndrome (ZWS), neonatal adrenoleukodystrophy (NALD), infantile Refsum disease (IRD), and classical rhizomelic chondrodysplasia punctata (RCDP). Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for PEX26 Gene
PEX26 (Peroxisomal Biogenesis Factor 26) is a Protein Coding gene. Diseases associated with PEX26 include Peroxisome Biogenesis Disorder 7B and Peroxisome Biogenesis Disorder 7A. Among its related pathways are Peroxisome. Gene Ontology (GO) annotations related to this gene include protein complex binding and ATPase binding.
UniProtKB/Swiss-Prot for PEX26 Gene
Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence.