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Aliases for PRKACB Gene

Aliases for PRKACB Gene

  • Protein Kinase, CAMP-Dependent, Catalytic, Beta 2 3
  • EC 2.7.11.11 4 63
  • PKA C-Beta 3 4
  • CAMP-Dependent Protein Kinase Catalytic Beta Subunit Isoform 4ab 3
  • Protein Kinase A Catalytic Subunit Beta 3
  • EC 2.7.11 63
  • PKACB 3

External Ids for PRKACB Gene

Previous GeneCards Identifiers for PRKACB Gene

  • GC01P084937
  • GC01P083681
  • GC01P083832
  • GC01P083966
  • GC01P084255
  • GC01P084316
  • GC01P084543
  • GC01P082654

Summaries for PRKACB Gene

Entrez Gene Summary for PRKACB Gene

  • The protein encoded by this gene is a member of the serine/threonine protein kinase family. The encoded protein is a catalytic subunit of cAMP (cyclic AMP)-dependent protein kinase, which mediates signalling though cAMP. cAMP signaling is important to a number of processes, including cell proliferaton and differentiation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2014]

GeneCards Summary for PRKACB Gene

PRKACB (Protein Kinase, CAMP-Dependent, Catalytic, Beta) is a Protein Coding gene. Diseases associated with PRKACB include carney complex variant and primary pigmented nodular adrenocortical disease. Among its related pathways are MAPK signaling pathway and Immune System. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is PRKACA.

UniProtKB/Swiss-Prot for PRKACB Gene

  • Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.

Tocris Summary for PRKACB Gene

  • Protein kinase A (PKA, aka cAMP-dependent protein kinase) is involved in the regulation of lipid and glucose metabolism and is a component of the signal transduction mechanism of certain GPCRs. PKA is composed of two regulatory subunits and two catalytic subunits.

Gene Wiki entry for PRKACB Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKACB Gene

Genomics for PRKACB Gene

Regulatory Elements for PRKACB Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for PRKACB Gene

Chromosome:
1
Start:
84,077,975 bp from pter
End:
84,238,498 bp from pter
Size:
160,524 bases
Orientation:
Plus strand

Genomic View for PRKACB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKACB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKACB Gene

Proteins for PRKACB Gene

  • Protein details for PRKACB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P22694-KAPCB_HUMAN
    Recommended name:
    cAMP-dependent protein kinase catalytic subunit beta
    Protein Accession:
    P22694
    Secondary Accessions:
    • B1APG4
    • B4DKB0
    • B4E2Q1
    • Q14VH1
    • Q59GC0
    • Q5BNE9
    • Q5BNF0
    • Q5BNF1
    • Q5BNF2
    • Q5BNF3
    • Q5CZ92
    • Q5T1K3
    • Q7Z3M1
    • Q8IYR5
    • Q8IZQ0
    • Q96B09

    Protein attributes for PRKACB Gene

    Size:
    351 amino acids
    Molecular mass:
    40623 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • A number of inactive tetrameric holoenzymes are produced by the combination of homo- or heterodimers of the different regulatory subunits associated with two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. The cAMP-dependent protein kinase catalytic subunit binds PJA2 (By similarity).
    SequenceCaution:
    • Sequence=BAD92426.1; Type=Frameshift; Positions=322; Evidence={ECO:0000305};

    Alternative splice isoforms for PRKACB Gene

neXtProt entry for PRKACB Gene

Proteomics data for PRKACB Gene at MOPED

Post-translational modifications for PRKACB Gene

  • Asn-3 is partially deaminated to Asp giving rise to 2 major isoelectric variants, called CB and CA respectively.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains & Families for PRKACB Gene

Graphical View of Domain Structure for InterPro Entry

P22694

UniProtKB/Swiss-Prot:

KAPCB_HUMAN :
  • Contains 1 AGC-kinase C-terminal domain.
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
Domain:
  • Contains 1 AGC-kinase C-terminal domain.
  • Contains 1 protein kinase domain.
Family:
  • Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily.
genes like me logo Genes that share domains with PRKACB: view

Function for PRKACB Gene

Molecular function for PRKACB Gene

GENATLAS Biochemistry:
protein kinase,cAMP-dependent,catalytic,beta subunit
UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by cAMP
UniProtKB/Swiss-Prot Function:
Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.

Enzyme Numbers (IUBMB) for PRKACB Gene

Gene Ontology (GO) - Molecular Function for PRKACB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000287 magnesium ion binding IDA 12420224
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity --
GO:0004691 cAMP-dependent protein kinase activity IDA 12420224
GO:0005515 protein binding IPI 21880142
genes like me logo Genes that share ontologies with PRKACB: view
genes like me logo Genes that share phenotypes with PRKACB: view

Animal Models for PRKACB Gene

MGI Knock Outs for PRKACB:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKACB

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for PRKACB Gene

Localization for PRKACB Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKACB Gene

Cytoplasm. Cell membrane. Nucleus. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKACB Gene COMPARTMENTS Subcellular localization image for PRKACB gene
Compartment Confidence
cytoskeleton 5
extracellular 5
cytosol 4
nucleus 4
plasma membrane 3

Gene Ontology (GO) - Cellular Components for PRKACB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm --
GO:0005813 centrosome IDA 21399614
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with PRKACB: view

Pathways & Interactions for PRKACB Gene

SuperPathways for PRKACB Gene

Superpath Contained pathways
1 DAG and IP3 signaling
2 Interleukin receptor SHC signaling
3 Circadian entrainment
4 G-Beta Gamma Signaling
5 Aquaporin-mediated transport
genes like me logo Genes that share pathways with PRKACB: view

PCR Array Products

SIGNOR curated interactions for PRKACB Gene

Activates:
Inactivates:

Gene Ontology (GO) - Biological Process for PRKACB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0002223 stimulatory C-type lectin receptor signaling pathway TAS --
GO:0003091 renal water homeostasis TAS --
GO:0005975 carbohydrate metabolic process TAS --
GO:0006006 glucose metabolic process TAS --
genes like me logo Genes that share ontologies with PRKACB: view

Drugs & Compounds for PRKACB Gene

(7) Drugs for PRKACB Gene - From: HMDB, DrugBank, ApexBio, and Tocris

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine triphosphate Approved Nutra 0
Phosphonothreonine Experimental Pharma Target 0
cyclic amp Experimental Pharma 0
PKA inhibitor fragment (6-22) amide Pharma Potent protein kinase A inhibitor 0
H 89 2HCl Pharma Potent PKA inhibitor 0

(4) Additional Compounds for PRKACB Gene - From: HMDB and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Antagonist, Gating inhibitor 58-64-0
cAMPS-Sp, triethylammonium salt
93602-66-5
H 89 dihydrochloride
130964-39-5
PKI 14-22 amide, myristoylated
201422-03-9
genes like me logo Genes that share compounds with PRKACB: view

Transcripts for PRKACB Gene

Unigene Clusters for PRKACB Gene

Protein kinase, cAMP-dependent, catalytic, beta:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for PRKACB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for PRKACB Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b
SP1: - - - -
SP2: -
SP3:
SP4: - - - -
SP5:
SP6:

Relevant External Links for PRKACB Gene

GeneLoc Exon Structure for
PRKACB
ECgene alternative splicing isoforms for
PRKACB

Expression for PRKACB Gene

mRNA expression in normal human tissues for PRKACB Gene

mRNA differential expression in normal tissues according to GTEx for PRKACB Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.4) and Brain - Anterior cingulate cortex (BA24) (x4.0).

Protein differential expression in normal tissues from HIPED for PRKACB Gene

This gene is overexpressed in Fetal Brain (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKACB Gene



SOURCE GeneReport for Unigene cluster for PRKACB Gene Hs.487325

mRNA Expression by UniProt/SwissProt for PRKACB Gene

P22694-KAPCB_HUMAN
Tissue specificity: Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain.
genes like me logo Genes that share expression patterns with PRKACB: view

Protein tissue co-expression partners for PRKACB Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for PRKACB Gene

Orthologs for PRKACB Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for PRKACB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia PRKACB 35
  • 95.25 (n)
  • 98.52 (a)
PRKACB 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia LOC479975 35
  • 95.3 (n)
  • 97.73 (a)
PRKACB 36
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkacb 35
  • 85.01 (n)
  • 92.46 (a)
Prkacb 16
Prkacb 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia PRKACB 35
  • 99.92 (n)
  • 100 (a)
PRKACB 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkacb 35
  • 87.34 (n)
  • 97.03 (a)
oppossum
(Monodelphis domestica)
Mammalia PRKACB 36
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 98 (a)
OneToMany
-- 36
  • 80 (a)
OneToMany
-- 36
  • 95 (a)
OneToMany
chicken
(Gallus gallus)
Aves PRKACB 35
  • 85.51 (n)
  • 90.2 (a)
PRKACB 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKACB 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkacb 35
  • 84.17 (n)
  • 94.07 (a)
Str.3970 35
African clawed frog
(Xenopus laevis)
Amphibia kin-1-prov 35
zebrafish
(Danio rerio)
Actinopterygii prkacbb 35
  • 78.93 (n)
  • 91.99 (a)
zgc64054 35
prkacba 36
  • 80 (a)
OneToMany
prkacbb 36
  • 89 (a)
OneToMany
prkacbb 36
  • 89 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12069 37
  • 48 (a)
Pka-C1 37
  • 82 (a)
Pka-C2 37
  • 49 (a)
Pka-C3 37
  • 56 (a)
Pka-C1 35
  • 70.03 (n)
  • 83.38 (a)
Pka-C1 36
  • 81 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001384 35
  • 67.46 (n)
  • 82.49 (a)
worm
(Caenorhabditis elegans)
Secernentea F47F2.1a 37
  • 51 (a)
F47F2.1b 37
  • 49 (a)
kin-1 35
  • 70.13 (n)
  • 83.68 (a)
kin-1 36
  • 47 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes TPK1 35
  • 54.92 (n)
  • 51.11 (a)
TPK1 36
  • 41 (a)
ManyToMany
TPK2 36
  • 44 (a)
ManyToMany
TPK3 36
  • 39 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3274 35
bread mold
(Neurospora crassa)
Ascomycetes NCU06240 35
  • 55.45 (n)
  • 55.45 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 75 (a)
OneToMany
Species with no ortholog for PRKACB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKACB Gene

ENSEMBL:
Gene Tree for PRKACB (if available)
TreeFam:
Gene Tree for PRKACB (if available)

Paralogs for PRKACB Gene

Paralogs for PRKACB Gene

genes like me logo Genes that share paralogs with PRKACB: view

Variants for PRKACB Gene

Sequence variations from dbSNP and Humsavar for PRKACB Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs582201 -- 84,175,008(+) TCATT(G/T)TCTAA intron-variant
rs588518 -- 84,227,477(+) ATCTT(C/T)TCATA intron-variant
rs589373 -- 84,182,902(+) ATGTG(A/T)ACAGT intron-variant
rs589918 -- 84,227,800(+) TAACC(A/G)TTTGT intron-variant
rs594631 -- 84,220,882(+) ctcag(A/T)gatgt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKACB Gene

Variant ID Type Subtype PubMed ID
nsv1732 CNV Loss 18451855
nsv871655 CNV Loss 21882294
nsv871731 CNV Loss 21882294
nsv871656 CNV Loss 21882294
nsv871375 CNV Loss 21882294
dgv263n71 CNV Loss 21882294
nsv830414 CNV Gain 17160897

Variation tolerance for PRKACB Gene

Residual Variation Intolerance Score: 22.35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.72; 15.30% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for PRKACB Gene

HapMap Linkage Disequilibrium report
PRKACB
Human Gene Mutation Database (HGMD)
PRKACB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for PRKACB Gene

Disorders for PRKACB Gene

MalaCards: The human disease database

(2) MalaCards diseases for PRKACB Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
carney complex variant
  • carney complex, type 1
primary pigmented nodular adrenocortical disease
  • pigmented nodular adrenocortical disease, primary, 2
- elite association

Relevant External Links for PRKACB

Genetic Association Database (GAD)
PRKACB
Human Genome Epidemiology (HuGE) Navigator
PRKACB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
PRKACB
genes like me logo Genes that share disorders with PRKACB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for PRKACB Gene

Publications for PRKACB Gene

  1. Protein kinase A is a target for aging and the aging heart. (PMID: 20448293) Enns L.C. … Ladiges W. (Aging (Albany NY) 2010) 23 67
  2. Protein kinases A and C in post-mortem prefrontal cortex from persons with major depression and normal controls. (PMID: 19573263) Shelton R.C. … Lewis D.A. (Int. J. Neuropsychopharmacol. 2009) 23 67
  3. Two different global gene expression profiles in cancer cell lines established from etiologically different oral carcinomas. (PMID: 16273247) Ruutu M. … SyrjAonen S. (Oncol. Rep. 2005) 23 67
  4. Localization of the IGHG, PRKACB, and TNP2 genes in pigs by in situ hybridization. (PMID: 8012108) Gu F. … Gustavsson I. (Mamm. Genome 1994) 23 67
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67

Products for PRKACB Gene

Sources for PRKACB Gene

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