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Aliases for DDX27 Gene

Aliases for DDX27 Gene

  • DEAD-Box Helicase 27 2 3 5
  • DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 27 2 3
  • DEAD (Asp-Glu-Ala-Asp) Box Polypeptide 27 2 3
  • DEAD Box Protein 27 3 4
  • RHLP 3 4
  • Deficiency Of Ribosomal Subunits Protein 1 Homolog 3
  • Probable ATP-Dependent RNA Helicase DDX27 3
  • RNA Helicase-Like Protein 3
  • EC 3.6.4.13 4
  • DJ686N3.1 3
  • EC 3.6.1 61
  • HSPC259 3
  • CPERP-F 4
  • PP3241 3
  • Drs1p 3
  • DRS1 3

External Ids for DDX27 Gene

Previous GeneCards Identifiers for DDX27 Gene

  • GC20P047564
  • GC20P048474
  • GC20P048521
  • GC20P047269
  • GC20P047835
  • GC20P044584

Summaries for DDX27 Gene

Entrez Gene Summary for DDX27 Gene

  • DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. [provided by RefSeq, Jan 2017]

GeneCards Summary for DDX27 Gene

DDX27 (DEAD-Box Helicase 27) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and hydrolase activity.

UniProtKB/Swiss-Prot for DDX27 Gene

  • Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3 end formation of ribosomal 47S rRNA (PubMed:25825154).

Gene Wiki entry for DDX27 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DDX27 Gene

Genomics for DDX27 Gene

Regulatory Elements for DDX27 Gene

Enhancers for DDX27 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH20G049184 1.5 FANTOM5 ENCODE 12 -32.7 -32710 4.7 MLX CREB3L1 ZFP64 YBX1 YY1 SLC30A9 ZNF143 SP3 NFYC SSRP1 ARFGEF2 DDX27 CSE1L SNORD12B ZFAS1 STAU1 PREX1 PIR47119
GH20G049179 1.2 Ensembl ENCODE 12.4 -39.3 -39337 1.4 HNRNPUL1 PKNOX1 FOXA2 ARID4B YY1 ZNF121 FOS MIER2 PPARG TBX21 DDX27 CSE1L STAU1 PIR47119
GH20G049134 0.5 FANTOM5 12.9 -84.8 -84810 0.1 ZNF623 CSE1L DDX27 STAU1 ZNFX1 ARPC3P1 PIR47119
GH20G049180 0.5 Ensembl 12.4 -38.4 -38395 0.2 SCRT2 INSM2 CEBPG WT1 DDX27 STAU1 PIR47119
GH20G049183 0.5 ENCODE 12 -35.6 -35557 0.2 FOSL1 ATF3 ZKSCAN8 ZNF600 RBFOX2 DDX27 STAU1 PIR47119
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DDX27 on UCSC Golden Path with GeneCards custom track

Promoters for DDX27 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000138206 305 1201 HDGF FOXA2 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for DDX27 Gene

Chromosome:
20
Start:
49,219,295 bp from pter
End:
49,244,077 bp from pter
Size:
24,783 bases
Orientation:
Plus strand

Genomic View for DDX27 Gene

Genes around DDX27 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DDX27 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DDX27 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DDX27 Gene

Proteins for DDX27 Gene

  • Protein details for DDX27 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96GQ7-DDX27_HUMAN
    Recommended name:
    Probable ATP-dependent RNA helicase DDX27
    Protein Accession:
    Q96GQ7
    Secondary Accessions:
    • A0AVB6
    • B7ZLY1
    • Q5VXM7
    • Q8WYG4
    • Q969N7
    • Q96F57
    • Q96L97
    • Q9BWY9
    • Q9BXF0
    • Q9H990
    • Q9NWU3
    • Q9P0C2
    • Q9UGD6

    Protein attributes for DDX27 Gene

    Size:
    796 amino acids
    Molecular mass:
    89835 Da
    Quaternary structure:
    • Associates with PeBoW complex, composed of BOP1, PES1 and WDR12 (PubMed:25825154). Interacts directly with BOP1 and PES1 (PubMed:25825154).
    SequenceCaution:
    • Sequence=AAF28937.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF28937.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=AAG22482.1; Type=Frameshift; Positions=208, 427, 434, 532; Evidence={ECO:0000305}; Sequence=AAH16060.2; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA91284.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14343.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for DDX27 Gene

Selected DME Specific Peptides for DDX27 Gene

Q96GQ7:
  • RVGRTAR
  • VAARGLDI
  • GRSVSLVGE
  • DEADRML
  • IQKACIP
  • GTGKTAAF
  • GRTARAGR
  • LVATDVAARGL
  • YVHRVGRT
  • TPGRLID
  • RQTMLFSAT
  • LVPTREL
  • LFSATMT
  • GKTAAFALP
  • IATPGRL
  • TDVAARGLD

Post-translational modifications for DDX27 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DDX27 Gene

Domains & Families for DDX27 Gene

Gene Families for DDX27 Gene

Suggested Antigen Peptide Sequences for DDX27 Gene

Graphical View of Domain Structure for InterPro Entry

Q96GQ7

UniProtKB/Swiss-Prot:

DDX27_HUMAN :
  • The C-terminal domain regulates nucleolar localization (PubMed:25825154).
  • Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
Domain:
  • The C-terminal domain regulates nucleolar localization (PubMed:25825154).
Family:
  • Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.
genes like me logo Genes that share domains with DDX27: view

Function for DDX27 Gene

Molecular function for DDX27 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + H(2)O = ADP + phosphate.
UniProtKB/Swiss-Prot Function:
Probable ATP-dependent RNA helicase. Component of the nucleolar ribosomal RNA (rRNA) processing machinery that regulates 3 end formation of ribosomal 47S rRNA (PubMed:25825154).

Enzyme Numbers (IUBMB) for DDX27 Gene

Gene Ontology (GO) - Molecular Function for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding IDA 22658674
GO:0004004 ATP-dependent RNA helicase activity IBA --
GO:0004386 helicase activity IEA --
GO:0005515 protein binding IPI 25825154
genes like me logo Genes that share ontologies with DDX27: view
genes like me logo Genes that share phenotypes with DDX27: view

Animal Model Products

CRISPR Products

miRNA for DDX27 Gene

miRTarBase miRNAs that target DDX27

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DDX27 Gene

Localization for DDX27 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DDX27 Gene

Nucleus, nucleolus. Chromosome. Note=Associates with 60S and 90S pre-ribosomal particles (PubMed:25825154). {ECO:0000269 PubMed:25825154}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DDX27 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005694 chromosome IEA,IDA 20813266
GO:0005730 nucleolus IDA,IEA 25825154
genes like me logo Genes that share ontologies with DDX27: view

Pathways & Interactions for DDX27 Gene

SuperPathways for DDX27 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DDX27 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006364 rRNA processing IMP 25825154
GO:0010501 RNA secondary structure unwinding IBA --
GO:0042254 ribosome biogenesis IEA --
genes like me logo Genes that share ontologies with DDX27: view

No data available for Pathways by source and SIGNOR curated interactions for DDX27 Gene

Drugs & Compounds for DDX27 Gene

(3) Drugs for DDX27 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Water Approved Pharma 0
Adenosine triphosphate Approved Nutra 0

(1) Additional Compounds for DDX27 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with DDX27: view

Transcripts for DDX27 Gene

Unigene Clusters for DDX27 Gene

DEAD (Asp-Glu-Ala-Asp) box polypeptide 27:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DDX27 Gene

No ASD Table

Relevant External Links for DDX27 Gene

GeneLoc Exon Structure for
DDX27
ECgene alternative splicing isoforms for
DDX27

Expression for DDX27 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DDX27 Gene

Protein differential expression in normal tissues from HIPED for DDX27 Gene

This gene is overexpressed in Lung (50.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DDX27 Gene



Protein tissue co-expression partners for DDX27 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DDX27 Gene:

DDX27

SOURCE GeneReport for Unigene cluster for DDX27 Gene:

Hs.65234

Evidence on tissue expression from TISSUES for DDX27 Gene

  • Nervous system(4.8)
  • Skin(4.5)
  • Liver(4.4)
  • Muscle(4.3)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with DDX27: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DDX27 Gene

Orthologs for DDX27 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DDX27 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DDX27 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia DDX27 34 35
  • 91.99 (n)
cow
(Bos Taurus)
Mammalia DDX27 34 35
  • 91.55 (n)
oppossum
(Monodelphis domestica)
Mammalia DDX27 35
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ddx27 34 16 35
  • 87.94 (n)
rat
(Rattus norvegicus)
Mammalia Ddx27 34
  • 87.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DDX27 35
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves DDX27 34 35
  • 74.73 (n)
lizard
(Anolis carolinensis)
Reptilia DDX27 35
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ddx27 34
  • 70.14 (n)
Str.11808 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.29976 34
zebrafish
(Danio rerio)
Actinopterygii ddx27 34 35
  • 70.2 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4514 34
fruit fly
(Drosophila melanogaster)
Insecta Rs1 36 34 35
  • 62.45 (n)
Dbp45A 36
  • 32 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP011084 34
  • 59.29 (n)
worm
(Caenorhabditis elegans)
Secernentea Y71G12B.8 36 34 35
  • 55.36 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DRS1 35 37
  • 33 (a)
OneToOne
rice
(Oryza sativa)
Liliopsida Os.27674 34
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8743 35
  • 60 (a)
OneToOne
Species where no ortholog for DDX27 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DDX27 Gene

ENSEMBL:
Gene Tree for DDX27 (if available)
TreeFam:
Gene Tree for DDX27 (if available)

Paralogs for DDX27 Gene

(13) SIMAP similar genes for DDX27 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DDX27: view

No data available for Paralogs for DDX27 Gene

Variants for DDX27 Gene

Sequence variations from dbSNP and Humsavar for DDX27 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs1000097641 -- 49,229,324(+) CGCAC(C/T)CAGCC intron-variant
rs1000213839 -- 49,242,248(+) GTTTT(C/T)CCTGA intron-variant
rs1000230241 -- 49,238,301(+) CTTGA(C/G)CCACT intron-variant
rs1000376657 -- 49,244,196(+) ACAGG(A/G)TATGG downstream-variant-500B
rs1000406975 -- 49,229,183(+) CCGCC(A/G)CCACG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DDX27 Gene

Variant ID Type Subtype PubMed ID
nsv1064443 CNV gain 25217958
nsv1067146 CNV loss 25217958

Variation tolerance for DDX27 Gene

Residual Variation Intolerance Score: 17.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.80; 94.75% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DDX27 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DDX27

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DDX27 Gene

Disorders for DDX27 Gene

Relevant External Links for DDX27

Genetic Association Database (GAD)
DDX27
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DDX27

No disorders were found for DDX27 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DDX27 Gene

Publications for DDX27 Gene

  1. DEAD-box helicase DDX27 regulates 3' end formation of ribosomal 47S RNA and stably associates with the PeBoW-complex. (PMID: 25825154) Kellner M. … Eick D. (Exp. Cell Res. 2015) 3 4 64
  2. The protein composition of mitotic chromosomes determined using multiclassifier combinatorial proteomics. (PMID: 20813266) Ohta S. … Rappsilber J. (Cell 2010) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D. … Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004) 3 4 64

Products for DDX27 Gene

Sources for DDX27 Gene

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