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Aliases for TMEM127 Gene

Aliases for TMEM127 Gene

  • Transmembrane Protein 127 2 3 5

External Ids for TMEM127 Gene

Previous GeneCards Identifiers for TMEM127 Gene

  • GC02M096280
  • GC02M096916
  • GC02M090877

Summaries for TMEM127 Gene

Entrez Gene Summary for TMEM127 Gene

  • This gene encodes a transmembrane protein with 3 predicted transmembrane domains. The protein is associated with a subpopulation of vesicular organelles corresponding to early endosomal structures, with the Golgi, and with lysosomes, and may participate in protein trafficking between these structures. Mutations in this gene and several other genes cause pheochromocytomas. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Aug 2010]

GeneCards Summary for TMEM127 Gene

TMEM127 (Transmembrane Protein 127) is a Protein Coding gene. Diseases associated with TMEM127 include pheochromocytoma and tmem127-related susceptibility to pheochromocytoma. GO annotations related to this gene include Rab GTPase binding.

UniProtKB/Swiss-Prot for TMEM127 Gene

  • Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM127 Gene

Genomics for TMEM127 Gene

Regulatory Elements for TMEM127 Gene

Enhancers for TMEM127 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM127 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM127 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM127 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM127 Gene

Chromosome:
2
Start:
96,248,516 bp from pter
End:
96,266,013 bp from pter
Size:
17,498 bases
Orientation:
Minus strand

Genomic View for TMEM127 Gene

Genes around TMEM127 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM127 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM127 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM127 Gene

Proteins for TMEM127 Gene

  • Protein details for TMEM127 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75204-TM127_HUMAN
    Recommended name:
    Transmembrane protein 127
    Protein Accession:
    O75204
    Secondary Accessions:
    • D3DXH0

    Protein attributes for TMEM127 Gene

    Size:
    238 amino acids
    Molecular mass:
    25842 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • Consistent with the observation that mTORC1 signaling regulates cell growth and size in many species, TMEM127 knockdown cells are larger and proliferate at higher rates compared to control cell lines. In contrast, cell proliferation is reduced in cells overexpressing TMEM127 (PubMed:20154675).

neXtProt entry for TMEM127 Gene

Proteomics data for TMEM127 Gene at MOPED

Post-translational modifications for TMEM127 Gene

  • Ubiquitination at Lys 25
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM127 Gene

Antibody Products

No data available for DME Specific Peptides for TMEM127 Gene

Domains & Families for TMEM127 Gene

Protein Domains for TMEM127 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM127 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O75204

UniProtKB/Swiss-Prot:

TM127_HUMAN :
  • Belongs to the TMEM127 family.
Family:
  • Belongs to the TMEM127 family.
genes like me logo Genes that share domains with TMEM127: view

No data available for Gene Families for TMEM127 Gene

Function for TMEM127 Gene

Molecular function for TMEM127 Gene

UniProtKB/Swiss-Prot Function:
Controls cell proliferation acting as a negative regulator of TOR signaling pathway mediated by mTORC1. May act as a tumor suppressor.
genes like me logo Genes that share phenotypes with TMEM127: view

Human Phenotype Ontology for TMEM127 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TMEM127 Gene

MGI Knock Outs for TMEM127:

Animal Model Products

CRISPR Products

miRNA for TMEM127 Gene

miRTarBase miRNAs that target TMEM127

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Transcription Factor Targets and HOMER Transcription for TMEM127 Gene

Localization for TMEM127 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM127 Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm. Note=Association of TMEM127 with the cell membrane is enhanced by inhibition of endocytosis. In the cytoplasm, it colocalizes with markers of early endosomal structures, Golgi apparatus and lysosomes. {ECO:0000269 PubMed:20154675, ECO:0000269 PubMed:21156949}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM127 Gene COMPARTMENTS Subcellular localization image for TMEM127 gene
Compartment Confidence
endosome 5
plasma membrane 5
cytosol 1
endoplasmic reticulum 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM127 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 20154675
GO:0005886 plasma membrane IDA 20154675
genes like me logo Genes that share ontologies with TMEM127: view

Pathways & Interactions for TMEM127 Gene

SuperPathways for TMEM127 Gene

No Data Available

Interacting Proteins for TMEM127 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000258439%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000258439 for TMEM127 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM127 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032006 regulation of TOR signaling IEA --
genes like me logo Genes that share ontologies with TMEM127: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM127 Gene

Drugs & Compounds for TMEM127 Gene

No Compound Related Data Available

Transcripts for TMEM127 Gene

Unigene Clusters for TMEM127 Gene

Transmembrane protein 127:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM127 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e
SP1: - - - -
SP2: - - - - - -
SP3: - - -
SP4: - - -
SP5: - - - - - -
SP6: -
SP7: - -

Relevant External Links for TMEM127 Gene

GeneLoc Exon Structure for
TMEM127
ECgene alternative splicing isoforms for
TMEM127

Expression for TMEM127 Gene

mRNA expression in normal human tissues for TMEM127 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM127 Gene



SOURCE GeneReport for Unigene cluster for TMEM127 Gene Hs.164303

mRNA Expression by UniProt/SwissProt for TMEM127 Gene

O75204-TM127_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TMEM127: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues and Protein tissue co-expression partners for TMEM127 Gene

Orthologs for TMEM127 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM127 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM127 35
  • 91.04 (n)
  • 99.58 (a)
TMEM127 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM127 35
  • 92.58 (n)
  • 100 (a)
TMEM127 36
  • 95 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem127 35
  • 90.06 (n)
  • 98.74 (a)
Tmem127 16
Tmem127 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM127 35
  • 99.3 (n)
  • 100 (a)
TMEM127 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem127 35
  • 89.64 (n)
  • 99.16 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM127 36
  • 98 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM127 35
  • 83.13 (n)
  • 95.68 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM127 36
  • 94 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.1183 35
tmem127 35
  • 75.93 (n)
  • 89.81 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem127 35
  • 76.19 (n)
  • 87.1 (a)
tmem127 36
  • 85 (a)
OneToOne
Species with no ortholog for TMEM127:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM127 Gene

ENSEMBL:
Gene Tree for TMEM127 (if available)
TreeFam:
Gene Tree for TMEM127 (if available)

Paralogs for TMEM127 Gene

No data available for Paralogs for TMEM127 Gene

Variants for TMEM127 Gene

Sequence variations from dbSNP and Humsavar for TMEM127 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs121908823 Pheochromocytoma (PCC) 96,254,974(-) AGACA(A/G)TGCTG reference, missense
VAR_072273 Pheochromocytoma (PCC)
VAR_072274 Pheochromocytoma (PCC)
VAR_072275 Pheochromocytoma (PCC)
VAR_072276 Pheochromocytoma (PCC)

Structural Variations from Database of Genomic Variants (DGV) for TMEM127 Gene

Variant ID Type Subtype PubMed ID
dgv650e201 CNV Deletion 23290073
esv5003 CNV Complex 18987735
nsv874677 CNV Loss 21882294
nsv834305 CNV Gain 17160897
nsv874679 CNV Gain 21882294

Variation tolerance for TMEM127 Gene

Residual Variation Intolerance Score: 54.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.10; 22.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM127 Gene

HapMap Linkage Disequilibrium report
TMEM127
Human Gene Mutation Database (HGMD)
TMEM127

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM127 Gene

Disorders for TMEM127 Gene

MalaCards: The human disease database

(10) MalaCards diseases for TMEM127 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
pheochromocytoma
  • pheochromocytoma, modifier of
tmem127-related susceptibility to pheochromocytoma
phaeochromocytoma
  • pheochromocytoma
hereditary paraganglioma-pheochromocytoma syndromes
  • paragangliomas 4
adrenal gland pheochromocytoma
  • pheochromocytoma
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

TM127_HUMAN
  • Pheochromocytoma (PCC) [MIM:171300]: A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent. {ECO:0000269 PubMed:20154675, ECO:0000269 PubMed:21156949}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for TMEM127

Genetic Association Database (GAD)
TMEM127
Human Genome Epidemiology (HuGE) Navigator
TMEM127
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM127
genes like me logo Genes that share disorders with TMEM127: view

No data available for Genatlas for TMEM127 Gene

Publications for TMEM127 Gene

  1. Germline mutations in TMEM127 confer susceptibility to pheochromocytoma. (PMID: 20154675) Qin Y. … Dahia P.L. (Nat. Genet. 2010) 3 4 48 67
  2. Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. (PMID: 10493829) Loftus B.J. … Adams M.D. (Genomics 1999) 2 3
  3. Familial pheochromocytoma and renal cell carcinoma syndrome: TMEM127 as a novel candidate gene for the association. (PMID: 25800244) Hernandez K.G. … Mete O. (Virchows Arch. 2015) 3
  4. [Hereditary pheochromocytoma-associated syndromes. Part 1]. (PMID: 26591561) Yukina M.Y. … Beltsevich D.G. (Ter. Arkh. 2015) 3
  5. The tumor susceptibility gene TMEM127 is mutated in renal cell carcinomas and modulates endolysosomal function. (PMID: 24334765) Qin Y. … Dahia P.L. (Hum. Mol. Genet. 2014) 3

Products for TMEM127 Gene

Sources for TMEM127 Gene

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