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Aliases for OSGEP Gene

Aliases for OSGEP Gene

  • O-Sialoglycoprotein Endopeptidase 2 3 4
  • T(6)A37 Threonylcarbamoyladenosine Biosynthesis Protein OSGEP 3 4
  • TRNA Threonylcarbamoyladenosine Biosynthesis Protein OSGEP 3 4
  • N6-L-Threonylcarbamoyladenine Synthase 3 4
  • T(6)A Synthase 3 4
  • HOSGEP 3 4
  • GCPL1 3 4
  • Probable TRNA Threonylcarbamoyladenosine Biosynthesis Protein OSGEP 3
  • Probable TRNA N6-Adenosine Threonylcarbamoyltransferase 3
  • Probable O-Sialoglycoprotein Endopeptidase 3
  • EC 3.4.24.57 63
  • EC 2.3.1.234 4
  • FLJ20411 6
  • OSGEP1 3
  • PRSMG1 3
  • KAE1 3

External Ids for OSGEP Gene

Previous GeneCards Identifiers for OSGEP Gene

  • GC14M018285
  • GC14M014702
  • GC14M018904
  • GC14M018905
  • GC14M019985
  • GC14M020915
  • GC14M001036

Summaries for OSGEP Gene

GeneCards Summary for OSGEP Gene

OSGEP (O-Sialoglycoprotein Endopeptidase) is a Protein Coding gene. Diseases associated with OSGEP include pasteurellosis and shipyard eye.

UniProtKB/Swiss-Prot for OSGEP Gene

  • Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

Gene Wiki entry for OSGEP Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for OSGEP Gene

Genomics for OSGEP Gene

Regulatory Elements for OSGEP Gene

Transcription factor binding sites by QIAGEN in the OSGEP gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for OSGEP Gene

Start:
20,446,411 bp from pter
End:
20,455,108 bp from pter
Size:
8,698 bases
Orientation:
Minus strand

Genomic View for OSGEP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for OSGEP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for OSGEP Gene

Proteins for OSGEP Gene

  • Protein details for OSGEP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NPF4-OSGEP_HUMAN
    Recommended name:
    Probable tRNA N6-adenosine threonylcarbamoyltransferase
    Protein Accession:
    Q9NPF4
    Secondary Accessions:
    • Q6IAC3

    Protein attributes for OSGEP Gene

    Size:
    335 amino acids
    Molecular mass:
    36427 Da
    Cofactor:
    Name=a divalent metal cation; Xref=ChEBI:CHEBI:60240; Note=Binds 1 divalent metal cation per subunit.;
    Quaternary structure:
    • Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes. Interacts with PRAME.

neXtProt entry for OSGEP Gene

Proteomics data for OSGEP Gene at MOPED

Post-translational modifications for OSGEP Gene

  • Ubiquitination at Lys185
  • Modification sites at PhosphoSitePlus

Other Protein References for OSGEP Gene

Domains for OSGEP Gene

Protein Domains for OSGEP Gene

Suggested Antigen Peptide Sequences for OSGEP Gene

Graphical View of Domain Structure for InterPro Entry

Q9NPF4

UniProtKB/Swiss-Prot:

OSGEP_HUMAN :
  • Q9NPF4
Family:
  • Belongs to the KAE1 / TsaD family.
genes like me logo Genes that share domains with OSGEP: view

No data available for Gene Families for OSGEP Gene

Function for OSGEP Gene

Molecular function for OSGEP Gene

UniProtKB/Swiss-Prot CatalyticActivity: L-threonylcarbamoyladenylate + adenine(37) in tRNA = AMP + N(6)-L-threonylcarbamoyladenine(37) in tRNA
UniProtKB/Swiss-Prot Function: Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.

Enzyme Numbers (IUBMB) for OSGEP Gene

Gene Ontology (GO) - Molecular Function for OSGEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016746 transferase activity, transferring acyl groups IEA --
GO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with OSGEP: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSGEP

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for OSGEP Gene

Localization for OSGEP Gene

Subcellular locations from UniProtKB/Swiss-Prot for OSGEP Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for OSGEP Gene COMPARTMENTS Subcellular localization image for OSGEP gene
Compartment Confidence
cytosol 2
endoplasmic reticulum 2
nucleus 2
plasma membrane 2
cytoskeleton 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for OSGEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000408 EKC/KEOPS complex IBA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with OSGEP: view

Pathways for OSGEP Gene

SuperPathways for OSGEP Gene

No Data Available

Gene Ontology (GO) - Biological Process for OSGEP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070526 threonylcarbamoyladenosine biosynthetic process IBA --
genes like me logo Genes that share ontologies with OSGEP: view

No data available for Pathways by source for OSGEP Gene

Transcripts for OSGEP Gene

Unigene Clusters for OSGEP Gene

O-sialoglycoprotein endopeptidase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for OSGEP

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for OSGEP Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^
SP1: - - - - - - - - -
SP2: - -
SP3: - - -
SP4: - - - - - -
SP5: - - - - - - - - - - -
SP6: - - - - -
SP7: -
SP8:
SP9:
SP10: -
SP11: -
SP12:

ExUns: 12a · 12b · 12c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for OSGEP Gene

GeneLoc Exon Structure for
OSGEP
ECgene alternative splicing isoforms for
OSGEP

Expression for OSGEP Gene

mRNA expression in normal human tissues for OSGEP Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for OSGEP Gene

SOURCE GeneReport for Unigene cluster for OSGEP Gene Hs.525196

mRNA Expression by UniProt/SwissProt for OSGEP Gene

Q9NPF4-OSGEP_HUMAN
Tissue specificity: Widely expressed at low level. Expressed in heart, placenta, liver, kidney, lung, brain, skeletal muscle and pancreas.
genes like me logo Genes that share expressions with OSGEP: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for OSGEP Gene

Orthologs for OSGEP Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for OSGEP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia OSGEP 35
  • 100 (n)
  • 100 (a)
OSGEP 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia OSGEP 35
  • 92.74 (n)
  • 97.31 (a)
OSGEP 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia OSGEP 35
  • 89.05 (n)
  • 96.12 (a)
OSGEP 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Osgep 35
  • 86.87 (n)
  • 93.43 (a)
Osgep 16
Osgep 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia OSGEP 36
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia OSGEP 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Osgep 35
  • 87.96 (n)
  • 94.93 (a)
lizard
(Anolis carolinensis)
Reptilia OSGEP 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia osgep-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia osgep 35
  • 72.44 (n)
  • 84.48 (a)
Str.3476 35
zebrafish
(Danio rerio)
Actinopterygii osgep 35
  • 73.63 (n)
  • 83.88 (a)
osgep 36
  • 84 (a)
OneToOne
wufj38e02 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006952 35
  • 66.57 (n)
  • 73.73 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4933 35
  • 66.67 (n)
  • 72.24 (a)
CG4933 36
  • 70 (a)
OneToOne
CG4933 37
  • 69 (a)
worm
(Caenorhabditis elegans)
Secernentea Y71H2AM.1 35
  • 62.69 (n)
  • 69.85 (a)
Y71H2AM.1 36
  • 69 (a)
OneToOne
Y71H2AM.1 37
  • 70 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL316W 35
  • 61.53 (n)
  • 68.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes KAE1 35
  • 62.64 (n)
  • 68.28 (a)
KAE1 36
  • 59 (a)
OneToOne
KAE1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F21450g 35
  • 61.13 (n)
  • 67.37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G22720 35
  • 63.34 (n)
  • 70.69 (a)
rice
(Oryza sativa)
Liliopsida Os.25488 35
Os05g0194600 35
  • 63.67 (n)
  • 70.36 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU03836 35
  • 64.85 (n)
  • 70.69 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes pgp2 35
  • 59.82 (n)
  • 65.86 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5464 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6759 36
  • 75 (a)
OneToOne
Species with no ortholog for OSGEP:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for OSGEP Gene

ENSEMBL:
Gene Tree for OSGEP (if available)
TreeFam:
Gene Tree for OSGEP (if available)

Paralogs for OSGEP Gene

No data available for Paralogs for OSGEP Gene

Variants for OSGEP Gene

Sequence variations from dbSNP and Humsavar for OSGEP Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs883037 -- 20,449,585(-) AAGCC(A/G)GTTAC intron-variant
rs938881 -- 20,449,283(-) TGGAC(A/T)TCCTC intron-variant
rs938882 -- 20,448,828(-) TCGTA(C/T)GCTTA intron-variant
rs938883 -- 20,448,799(-) AAGCT(A/G)GTTGA reference, synonymous-codon
rs938884 -- 20,448,557(-) TGCCA(C/G)ATGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for OSGEP Gene

Variant ID Type Subtype PubMed ID
esv23438 CNV Gain+Loss 19812545

Relevant External Links for OSGEP Gene

HapMap Linkage Disequilibrium report
OSGEP

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for OSGEP Gene

Disorders for OSGEP Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for OSGEP Gene including...

Search for OSGEP Gene in MalaCards »

(4) University of Copenhagen DISEASES for OSGEP Gene

Relevant External Links for OSGEP

Genetic Association Database (GAD)
OSGEP
Human Genome Epidemiology (HuGE) Navigator
OSGEP
genes like me logo Genes that share disorders with OSGEP: view

No data available for UniProtKB/Swiss-Prot for OSGEP Gene

Publications for OSGEP Gene

  1. Sequencing analysis of a putative human O-sialoglycoprotein endopeptidase gene (OSGEP) and analysis of a bidirectional promoter between the OSGEP and APEX genes. (PMID: 12039036) Seki Y. … Matsui H. (Gene 2002) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Haplotype-based case-control study on human apurinic/apyrimidinic endonuclease 1/redox effector factor-1 gene and essential hypertension. (PMID: 20010699) Naganuma T. … Usami R. (Am. J. Hypertens. 2010) 3 48
  5. The human EKC/KEOPS complex is recruited to Cullin2 ubiquitin ligases by the human tumour antigen PRAME. (PMID: 22912744) Costessi A. … Stunnenberg H.G. (PLoS ONE 2012) 3 4

Products for OSGEP Gene

Sources for OSGEP Gene

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