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Aliases for SLC39A4 Gene

Aliases for SLC39A4 Gene

  • Solute Carrier Family 39 Member 4 2 3 4 5
  • Solute Carrier Family 39 (Zinc Transporter), Member 4 2 3
  • Zrt- And Irt-Like Protein 4 3 4
  • ZIP4 3 4
  • Acrodermatitis Enteropathica, Zinc-Deficiency Type 2
  • Zinc Transporter ZIP4 3
  • AWMS2 3
  • ZIP-4 4
  • AEZ 3

External Ids for SLC39A4 Gene

Previous HGNC Symbols for SLC39A4 Gene

  • AEZ

Previous GeneCards Identifiers for SLC39A4 Gene

  • GC08M143241
  • GC08M145675
  • GC08M145239
  • GC08M145642
  • GC08M145608
  • GC08M145637
  • GC08M140751

Summaries for SLC39A4 Gene

Entrez Gene Summary for SLC39A4 Gene

  • This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]

GeneCards Summary for SLC39A4 Gene

SLC39A4 (Solute Carrier Family 39 Member 4) is a Protein Coding gene. Diseases associated with SLC39A4 include Acrodermatitis Enteropathica and Acrodermatitis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Senescence and Autophagy in Cancer. GO annotations related to this gene include metal ion transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A12.

UniProtKB/Swiss-Prot for SLC39A4 Gene

  • Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity).

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for SLC39A4 Gene

Genomics for SLC39A4 Gene

Regulatory Elements for SLC39A4 Gene

Enhancers for SLC39A4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08G144412 1.3 ENCODE dbSUPER 17.1 +1.8 1803 7.3 HDGF PKNOX1 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 YY1 SLC30A9 VPS28 SLC39A4 CPSF1 TONSL C8orf82 LOC105375803 HGH1 ZNF252P ENSG00000272115
GH08G143914 2.2 FANTOM5 Ensembl ENCODE dbSUPER 4.9 +480.9 480904 45.2 CREB3L1 MLX AGO1 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 PLEC ZNF251 ZNF517 ZNF250 LOC105375803 LRRC14 ZNF696 ZNF34 ZNF623 CYHR1
GH08G145051 1.1 ENCODE 6.7 -634.4 -634422 2.4 PKNOX1 CREB3L1 AGO1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 C8orf33 MAF1 ZNF252P SLC39A4 RPL8 GC08P145056 PIR53567
GH08G143607 1.1 ENCODE 6.4 +808.4 808413 3.5 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 FEZF1 YY1 NAPRT LOC105375798 ENSG00000255050 TOP1MT GSDMD SLC39A4 PYCR3 EEF1D
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around SLC39A4 on UCSC Golden Path with GeneCards custom track

Genomic Location for SLC39A4 Gene

144,409,742 bp from pter
144,418,034 bp from pter
8,293 bases
Minus strand

Genomic View for SLC39A4 Gene

Genes around SLC39A4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
SLC39A4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for SLC39A4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for SLC39A4 Gene

Proteins for SLC39A4 Gene

  • Protein details for SLC39A4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Zinc transporter ZIP4
    Protein Accession:
    Secondary Accessions:
    • Q7L5S5
    • Q9H6T8
    • Q9NXC4

    Protein attributes for SLC39A4 Gene

    647 amino acids
    Molecular mass:
    68408 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAA91091.1; Type=Frameshift; Positions=573, 598, 618; Evidence={ECO:0000305};

    Alternative splice isoforms for SLC39A4 Gene


neXtProt entry for SLC39A4 Gene

Post-translational modifications for SLC39A4 Gene

  • Glycosylation at Asn261
  • Modification sites at PhosphoSitePlus

Other Protein References for SLC39A4 Gene

No data available for DME Specific Peptides for SLC39A4 Gene

Domains & Families for SLC39A4 Gene

Gene Families for SLC39A4 Gene

Protein Domains for SLC39A4 Gene


Suggested Antigen Peptide Sequences for SLC39A4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the ZIP transporter (TC 2.A.5) family.
  • Belongs to the ZIP transporter (TC 2.A.5) family.
genes like me logo Genes that share domains with SLC39A4: view

Function for SLC39A4 Gene

Molecular function for SLC39A4 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity).

Gene Ontology (GO) - Molecular Function for SLC39A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005385 zinc ion transmembrane transporter activity TAS --
GO:0046873 metal ion transmembrane transporter activity IEA --
genes like me logo Genes that share ontologies with SLC39A4: view
genes like me logo Genes that share phenotypes with SLC39A4: view

Human Phenotype Ontology for SLC39A4 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for SLC39A4 Gene

MGI Knock Outs for SLC39A4:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for SLC39A4 Gene

Localization for SLC39A4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for SLC39A4 Gene

Cell membrane; Multi-pass membrane protein. Recycling endosome membrane; Multi-pass membrane protein. Note=Colocalized with TFRC in the recycling endosomes. Cycles between endosomal compartments and the plasma membrane in response to zinc availability.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for SLC39A4 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endosome 3
peroxisome 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for SLC39A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IEA --
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with SLC39A4: view

Pathways & Interactions for SLC39A4 Gene

genes like me logo Genes that share pathways with SLC39A4: view

Gene Ontology (GO) - Biological Process for SLC39A4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0006811 ion transport IEA --
GO:0006829 zinc II ion transport IEA --
GO:0006882 cellular zinc ion homeostasis IEA,IBA --
GO:0007165 signal transduction IBA --
genes like me logo Genes that share ontologies with SLC39A4: view

No data available for SIGNOR curated interactions for SLC39A4 Gene

Drugs & Compounds for SLC39A4 Gene

(1) Drugs for SLC39A4 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with SLC39A4: view

Transcripts for SLC39A4 Gene

Unigene Clusters for SLC39A4 Gene

Solute carrier family 39 (zinc transporter), member 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for SLC39A4 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b · 12c ^ 13
SP1: - -
SP2: -
SP3: -
SP4: -
SP5: - -
SP7: -

Relevant External Links for SLC39A4 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for SLC39A4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for SLC39A4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for SLC39A4 Gene

This gene is overexpressed in Small Intestine - Terminal Ileum (x10.7), Colon - Transverse (x9.2), and Kidney - Cortex (x5.4).

Protein differential expression in normal tissues from HIPED for SLC39A4 Gene

This gene is overexpressed in Fetal gut (52.4) and CD8 Tcells (16.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for SLC39A4 Gene

Protein tissue co-expression partners for SLC39A4 Gene

NURSA nuclear receptor signaling pathways regulating expression of SLC39A4 Gene:


SOURCE GeneReport for Unigene cluster for SLC39A4 Gene:


mRNA Expression by UniProt/SwissProt for SLC39A4 Gene:

Tissue specificity: Highly expressed in kidney, small intestine, stomach, colon, jejunum and duodenum.

Evidence on tissue expression from TISSUES for SLC39A4 Gene

  • Lung(4.1)
  • Intestine(2.6)
  • Kidney(2.3)
  • Pancreas(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for SLC39A4 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • endocrine
  • immune
  • integumentary
  • lymphatic
  • nervous
  • reproductive
  • skeletal muscle
Head and neck:
  • brain
  • cranial nerve
  • eye
  • face
  • forehead
  • head
  • lip
  • mouth
  • pituitary gland
  • scalp
  • tongue
  • breast
  • intestine
  • large intestine
  • liver
  • small intestine
  • spleen
  • stomach
  • ovary
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vulva
  • digit
  • finger
  • foot
  • hand
  • lower limb
  • nail
  • toe
  • upper limb
  • blood
  • blood vessel
  • bone marrow
  • hair
  • peripheral nerve
  • peripheral nervous system
  • skin
  • sweat gland
  • white blood cell
genes like me logo Genes that share expression patterns with SLC39A4: view

Primer Products

Orthologs for SLC39A4 Gene

This gene was present in the common ancestor of animals.

Orthologs for SLC39A4 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia SLC39A4 34 35
  • 99.04 (n)
(Canis familiaris)
Mammalia SLC39A4 34 35
  • 81.46 (n)
(Bos Taurus)
Mammalia SLC39A4 34 35
  • 81.26 (n)
(Rattus norvegicus)
Mammalia Slc39a4 34
  • 77.29 (n)
(Mus musculus)
Mammalia Slc39a4 34 16 35
  • 76.48 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
-- 35
  • 56 (a)
(Ornithorhynchus anatinus)
Mammalia SLC39A4 35
  • 55 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10006 35
  • 24 (a)
(Caenorhabditis elegans)
Secernentea tag-141 35
  • 26 (a)
Species where no ortholog for SLC39A4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for SLC39A4 Gene

Gene Tree for SLC39A4 (if available)
Gene Tree for SLC39A4 (if available)

Paralogs for SLC39A4 Gene

(3) SIMAP similar genes for SLC39A4 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with SLC39A4: view

Variants for SLC39A4 Gene

Sequence variations from dbSNP and Humsavar for SLC39A4 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs2977838 Acrodermatitis enteropathica, zinc-deficiency type (AEZ) [MIM:201100] 144,415,027(-) GCAGC(C/T)GGGAC upstream-variant-2KB, reference, missense
VAR_023628 Acrodermatitis enteropathica, zinc-deficiency type (AEZ) [MIM:201100]
VAR_023629 Acrodermatitis enteropathica, zinc-deficiency type (AEZ) [MIM:201100]
VAR_023630 Acrodermatitis enteropathica, zinc-deficiency type (AEZ) [MIM:201100]
VAR_023632 Acrodermatitis enteropathica, zinc-deficiency type (AEZ) [MIM:201100]

Structural Variations from Database of Genomic Variants (DGV) for SLC39A4 Gene

Variant ID Type Subtype PubMed ID
dgv12434n54 CNV loss 21841781
dgv12437n54 CNV loss 21841781
dgv907n27 CNV loss 19166990
esv2738065 CNV deletion 23290073
esv2759652 CNV gain+loss 17122850
nsv428208 CNV gain 18775914
nsv470249 CNV loss 18288195
nsv515809 CNV gain+loss 19592680
nsv612935 CNV loss 21841781
nsv612936 CNV loss 21841781
nsv824805 CNV gain 20364138
nsv831489 CNV loss 17160897

Variation tolerance for SLC39A4 Gene

Residual Variation Intolerance Score: 95.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 17.51; 98.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for SLC39A4 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for SLC39A4 Gene

Disorders for SLC39A4 Gene

MalaCards: The human disease database

(5) MalaCards diseases for SLC39A4 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
acrodermatitis enteropathica
  • acrodermatitis enteropathica, zinc-deficiency type
metal metabolism disorder
  • inborn metal metabolism disorder
autosomal recessive disease
  • autosomal recessive disorder
- elite association - COSMIC cancer census association via MalaCards


  • Acrodermatitis enteropathica, zinc-deficiency type (AEZ) [MIM:201100]: A rare autosomal recessive disease caused by the inability to absorb sufficient zinc. The clinical features are growth retardation, immune-system dysfunction, alopecia, severe dermatitis, diarrhea and occasionally mental disorders. {ECO:0000269 PubMed:12032886, ECO:0000269 PubMed:12068297, ECO:0000269 PubMed:12787121, ECO:0000269 PubMed:14702039}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for SLC39A4

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with SLC39A4: view

No data available for Genatlas for SLC39A4 Gene

Publications for SLC39A4 Gene

  1. Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane. (PMID: 14612438) Kim B.-E. … Petris M.J. (J. Biol. Chem. 2004) 3 4 22 64
  2. Acrodermatitis enteropathica mutations affect transport activity, localization and zinc-responsive trafficking of the mouse ZIP4 zinc transporter. (PMID: 14709598) Wang F. … Eide D.J. (Hum. Mol. Genet. 2004) 2 3 22 64
  3. Novel SLC39A4 mutations in acrodermatitis enteropathica. (PMID: 12787121) Nakano A. … Hanada K. (J. Invest. Dermatol. 2003) 3 4 22 64
  4. The acrodermatitis enteropathica gene ZIP4 encodes a tissue-specific, zinc-regulated zinc transporter in mice. (PMID: 12801924) Dufner-Beattie J. … Andrews G.K. (J. Biol. Chem. 2003) 2 3 22 64
  5. Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection. (PMID: 20587610) Ucisik-Akkaya E. … Dorak M.T. (Mol. Hum. Reprod. 2010) 3 46 64

Products for SLC39A4 Gene

Sources for SLC39A4 Gene

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