Aliases for SLC39A4 Gene
External Ids for SLC39A4 Gene
Previous HGNC Symbols for SLC39A4 Gene
Previous GeneCards Identifiers for SLC39A4 Gene
This gene encodes a member of the zinc/iron-regulated transporter-like protein (ZIP) family. The encoded protein localizes to cell membranes and is required for zinc uptake in the intestine. Mutations in this gene result in acrodermatitis enteropathica. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
GeneCards Summary for SLC39A4 Gene
SLC39A4 (Solute Carrier Family 39 Member 4) is a Protein Coding gene. Diseases associated with SLC39A4 include Acrodermatitis Enteropathica, Zinc-Deficiency Type and Acrodermatitis. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds and Metal ion SLC transporters. Gene Ontology (GO) annotations related to this gene include metal ion transmembrane transporter activity and zinc ion transmembrane transporter activity. An important paralog of this gene is SLC39A12.
UniProtKB/Swiss-Prot for SLC39A4 Gene
Plays an important role in cellular zinc homeostasis as a zinc transporter. Regulated in response to zinc availability (By similarity).