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Aliases for PRKAA2 Gene

Aliases for PRKAA2 Gene

  • Protein Kinase, AMP-Activated, Alpha 2 Catalytic Subunit 2 3
  • AMPK 3 4 6
  • Hydroxymethylglutaryl-CoA Reductase Kinase 3 4
  • Acetyl-CoA Carboxylase Kinase 3 4
  • AMPK Subunit Alpha-2 3 4
  • ACACA Kinase 3 4
  • HMGCR Kinase 3 4
  • EC 2.7.11.1 4 64
  • AMPK2 3 4
  • 5-AMP-Activated Protein Kinase Catalytic Subunit Alpha-2 3
  • 5-AMP-Activated Protein Kinase, Catalytic Alpha-2 Chain 3
  • AMP-Activated Protein Kinase Alpha-2 Subunit Variant 2 3
  • AMP-Activated Protein Kinase Alpha-2 Subunit Variant 3 3
  • AMPK-Alpha-2 Chain 3
  • AMPK Alpha 2 3
  • EC 2.7.11.27 4
  • EC 2.7.11.31 4
  • EC 2.7.11 64
  • AMPKa2 3
  • PRKAA 3

External Ids for PRKAA2 Gene

Previous Symbols for PRKAA2 Gene

  • PRKAA

Summaries for PRKAA2 Gene

Entrez Gene Summary for PRKAA2 Gene

  • The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia. [provided by RefSeq, Jul 2008]

GeneCards Summary for PRKAA2 Gene

PRKAA2 (Protein Kinase, AMP-Activated, Alpha 2 Catalytic Subunit) is a Protein Coding gene. Diseases associated with PRKAA2 include wolff-parkinson-white syndrome and ischemia. Among its related pathways are PI3K-Akt signaling pathway and Signaling by GPCR. GO annotations related to this gene include chromatin binding and protein kinase activity. An important paralog of this gene is NUAK1.

UniProtKB/Swiss-Prot for PRKAA2 Gene

  • Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates Ser-36 of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1. Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation. Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity).

Tocris Summary for PRKAA2 Gene

  • AMP-activated protein kinase (AMPK) is a heterodimeric protein serine/threonine kinase that is composed of alpha- (catalytic) and beta/gamma- (regulatory) subunits. AMPK acts as a sensor of the energy status of cells and ensures survival at times of metabolic stress. AMPK phosphorylates many metabolic enzymes to stimulate catabolic pathways, such as ketogenesis, and inhibit anabolic pathways, such as protein synthesis. The long-term activation of AMPK increases the capacity of cells to produce ATP. AMPK is regulated by phosphorylation at the Thr-172 residue of the alpha-subunit by AMPKK and by phosphorylation by calmodulin-dependent protein kinase kinase-beta (CamKKbeta). In addition, the ratio of AMP:ATP mediates allosteric activation of the enzyme. AMPK is found throughout the body with high concentrations in metabolically active tissues such as the skeletal muscles and liver.

Gene Wiki entry for PRKAA2 Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for PRKAA2 Gene

Genomics for PRKAA2 Gene

Genomic Location for PRKAA2 Gene

Start:
56,645,317 bp from pter
End:
56,715,335 bp from pter
Size:
70,019 bases
Orientation:
Plus strand

Genomic View for PRKAA2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for PRKAA2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for PRKAA2 Gene

Regulatory Elements for PRKAA2 Gene

Proteins for PRKAA2 Gene

  • Protein details for PRKAA2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54646-AAPK2_HUMAN
    Recommended name:
    5-AMP-activated protein kinase catalytic subunit alpha-2
    Protein Accession:
    P54646
    Secondary Accessions:
    • Q9H1E8
    • Q9UD43

    Protein attributes for PRKAA2 Gene

    Size:
    552 amino acids
    Molecular mass:
    62320 Da
    Cofactor:
    Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
    Quaternary structure:
    • AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non-catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2.

    Three dimensional structures from OCA and Proteopedia for PRKAA2 Gene

neXtProt entry for PRKAA2 Gene

Proteomics data for PRKAA2 Gene at MOPED

Post-translational modifications for PRKAA2 Gene

  • Phosphorylated at Thr-172 by STK11/LKB1 in complex with STE20-related adapter-alpha (STRADA) pseudo kinase and CAB39. Also phosphorylated at Thr-172 by CAMKK2; triggered by a rise in intracellular calcium ions, without detectable changes in the AMP/ATP ratio. CAMKK1 can also phosphorylate Thr-172, but at much lower level. Dephosphorylated by protein phosphatase 2A and 2C (PP2A and PP2C). Phosphorylated by ULK1; leading to negatively regulate AMPK activity and suggesting the existence of a regulatory feedback loop between ULK1 and AMPK. Dephosphorylated by PPM1A and PPM1B at Thr-172 (mediated by STK11/LKB1).
  • Ubiquitinated.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for PRKAA2 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Domains for PRKAA2 Gene

UniProtKB/Swiss-Prot:

AAPK2_HUMAN
Domain:
  • The AIS (autoinhibitory sequence) region shows some sequence similarity with the ubiquitin-associated domains and represses kinase activity:
    • P54646
  • Contains 1 protein kinase domain.:
    • P54646
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.:
    • P54646
genes like me logo Genes that share domains with PRKAA2: view

Function for PRKAA2 Gene

Molecular function for PRKAA2 Gene

GENATLAS Biochemistry: protein kinase,cAMP-activated,alpha 2 catalytic subunit,involved in fatty acid and cholesterol metabolism,expressed in skeletal muscle,complexing with beta 2 and gamma 1subunits
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [hydroxymethylglutaryl-CoA reductase (NADPH)] = ADP + [hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate
UniProtKB/Swiss-Prot CatalyticActivity: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate
UniProtKB/Swiss-Prot EnzymeRegulation: Activated by phosphorylation on Thr-172. Binding of AMP to non-catalytic gamma subunit (PRKAG1, PRKAG2 or PRKAG3) results in allosteric activation, inducing phosphorylation on Thr-172. AMP-binding to gamma subunit also sustains activity by preventing dephosphorylation of Thr-172. ADP also stimulates Thr-172 phosphorylation, without stimulating already phosphorylated AMPK. ATP promotes dephosphorylation of Thr-172, rendering the enzyme inactive. Under physiological conditions AMPK mainly exists in its inactive form in complex with ATP, which is much more abundant than AMP. AMPK is activated by antihyperglycemic drug metformin, a drug prescribed to patients with type 2 diabetes: in vivo, metformin seems to mainly inhibit liver gluconeogenesis. However, metformin can be used to activate AMPK in muscle and other cells in culture or ex vivo (PubMed:11602624). Selectively inhibited by compound C (6-[4-(2-Piperidin-1-yl-ethoxy)-phenyl)]-3-pyridin-4-yl-pyyrazolo[1,5-a] pyrimidine. Activated by resveratrol, a natural polyphenol present in red wine, and S17834, a synthetic polyphenol. Salicylate/aspirin directly activates kinase activity, primarily by inhibiting Thr-172 dephosphorylation.
UniProtKB/Swiss-Prot Function: Catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Regulates lipid synthesis by phosphorylating and inactivating lipid metabolic enzymes such as ACACA, ACACB, GYS1, HMGCR and LIPE; regulates fatty acid and cholesterol synthesis by phosphorylating acetyl-CoA carboxylase (ACACA and ACACB) and hormone-sensitive lipase (LIPE) enzymes, respectively. Regulates insulin-signaling and glycolysis by phosphorylating IRS1, PFKFB2 and PFKFB3. AMPK stimulates glucose uptake in muscle by increasing the translocation of the glucose transporter SLC2A4/GLUT4 to the plasma membrane, possibly by mediating phosphorylation of TBC1D4/AS160. Regulates transcription and chromatin structure by phosphorylating transcription regulators involved in energy metabolism such as CRTC2/TORC2, FOXO3, histone H2B, HDAC5, MEF2C, MLXIPL/ChREBP, EP300, HNF4A, p53/TP53, SREBF1, SREBF2 and PPARGC1A. Acts as a key regulator of glucose homeostasis in liver by phosphorylating CRTC2/TORC2, leading to CRTC2/TORC2 sequestration in the cytoplasm. In response to stress, phosphorylates Ser-36 of histone H2B (H2BS36ph), leading to promote transcription. Acts as a key regulator of cell growth and proliferation by phosphorylating TSC2, RPTOR and ATG1/ULK1: in response to nutrient limitation, negatively regulates the mTORC1 complex by phosphorylating RPTOR component of the mTORC1 complex and by phosphorylating and activating TSC2. In response to nutrient limitation, promotes autophagy by phosphorylating and activating ATG1/ULK1. AMPK also acts as a regulator of circadian rhythm by mediating phosphorylation of CRY1, leading to destabilize it. May regulate the Wnt signaling pathway by phosphorylating CTNNB1, leading to stabilize it. Also phosphorylates CFTR, EEF2K, KLC1, NOS3 and SLC12A1. Plays an important role in the differential regulation of pro-autophagy (composed of PIK3C3, BECN1, PIK3R4 and UVRAG or ATG14) and non-autophagy (composed of PIK3C3, BECN1 and PIK3R4) complexes, in response to glucose starvation. Can inhibit the non-autophagy complex by phosphorylating PIK3C3 and can activate the pro-autophagy complex by phosphorylating BECN1 (By similarity).

Enzyme Numbers (IUBMB) for PRKAA2 Gene

Gene Ontology (GO) - Molecular Function for PRKAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding ISS --
GO:0004672 protein kinase activity TAS 7959015
GO:0004674 protein serine/threonine kinase activity ISS --
GO:0004679 AMP-activated protein kinase activity IDA 18439900
GO:0004712 protein serine/threonine/tyrosine kinase activity IDA 22797923
genes like me logo Genes that share ontologies with PRKAA2: view
genes like me logo Genes that share phenotypes with PRKAA2: view

Animal Models for PRKAA2 Gene

MGI Knock Outs for PRKAA2:

miRNA for PRKAA2 Gene

No data available for Transcription Factor Targeting and HOMER Transcription for PRKAA2 Gene

Localization for PRKAA2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for PRKAA2 Gene

Cytoplasm. Nucleus. Note=In response to stress, recruited by p53/TP53 to specific promoters.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for PRKAA2 Gene COMPARTMENTS Subcellular localization image for PRKAA2 gene
Compartment Confidence
nucleus 5
cytosol 4
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for PRKAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA --
GO:0005829 cytosol TAS --
GO:0031588 AMP-activated protein kinase complex IBA --
genes like me logo Genes that share ontologies with PRKAA2: view

Pathways for PRKAA2 Gene

genes like me logo Genes that share pathways with PRKAA2: view

Gene Ontology (GO) - Biological Process for PRKAA2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006112 energy reserve metabolic process TAS --
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006367 transcription initiation from RNA polymerase II promoter TAS --
GO:0006468 protein phosphorylation TAS 7959015
genes like me logo Genes that share ontologies with PRKAA2: view

Compounds for PRKAA2 Gene

(4) Tocris Compounds for PRKAA2 Gene

Compound Action Cas Number
A 769662 Potent AMPK activator [844499-71-4]
Dorsomorphin dihydrochloride Potent and selective AMPK inhibitor [1219168-18-9]
Metformin hydrochloride Activator of LKB1/AMPK; antidiabetic agent [1115-70-4]
PT 1 AMPK activator [331002-70-1]

(4) HMDB Compounds for PRKAA2 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
ADP
  • adenosindiphosphorsaeure
58-64-0
Calcium
  • Ca
7440-70-2
Magnesium
  • Magnesium
7439-95-4

(56) Novoseek inferred chemical compound relationships for PRKAA2 Gene

Compound -log(P) Hits PubMed IDs
acetyl-coa 81.7 40
acadesine 79.4 14
metformin 77.5 70
glycogen 73 58
phenformin 71 7
genes like me logo Genes that share compounds with PRKAA2: view

Transcripts for PRKAA2 Gene

mRNA/cDNA for PRKAA2 Gene

Unigene Clusters for PRKAA2 Gene

Protein kinase, AMP-activated, alpha 2 catalytic subunit:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for PRKAA2 Gene

No ASD Table

Relevant External Links for PRKAA2 Gene

GeneLoc Exon Structure for
PRKAA2
ECgene alternative splicing isoforms for
PRKAA2

Expression for PRKAA2 Gene

mRNA expression in normal human tissues for PRKAA2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for PRKAA2 Gene

This gene is overexpressed in Muscle - Skeletal (9.9), Heart - Left Ventricle (7.9), and Heart - Atrial Appendage (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for PRKAA2 Gene

SOURCE GeneReport for Unigene cluster for PRKAA2 Gene Hs.437039

genes like me logo Genes that share expressions with PRKAA2: view

Orthologs for PRKAA2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for PRKAA2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia PRKAA2 36
  • 99.58 (n)
  • 100 (a)
PRKAA2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia PRKAA2 36
  • 95.05 (n)
  • 98.37 (a)
PRKAA2 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia PRKAA2 36
  • 95.53 (n)
  • 98.66 (a)
PRKAA2 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Prkaa2 36
  • 90.34 (n)
  • 97.83 (a)
Prkaa2 16
Prkaa2 37
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia PRKAA2 37
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia PRKAA2 37
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Prkaa2 36
  • 90.46 (n)
  • 98.19 (a)
chicken
(Gallus gallus)
Aves PRKAA2 36
  • 79.64 (n)
  • 94.36 (a)
PRKAA2 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia PRKAA2 37
  • 88 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia prkaa2 36
  • 81.37 (n)
  • 93.83 (a)
zebrafish
(Danio rerio)
Actinopterygii prkaa2 36
  • 75.39 (n)
  • 89.82 (a)
prkaa2 37
  • 86 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002686 36
  • 59.03 (n)
  • 67.99 (a)
fruit fly
(Drosophila melanogaster)
Insecta SNF1A 36
  • 59.86 (n)
  • 69.07 (a)
SNF1A 37
  • 61 (a)
OneToMany
CG3105 38
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea aak-1 37
  • 42 (a)
ManyToMany
aak-2 36
  • 58.33 (n)
  • 62.78 (a)
aak-2 37
  • 53 (a)
ManyToMany
T01C8.1b 38
  • 57 (a)
DC2.7a 38
  • 32 (a)
Y38H8A.4 38
  • 35 (a)
T01C8.1a 38
  • 57 (a)
B0511.4 38
  • 36 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL230W 36
  • 53.95 (n)
  • 50.55 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SNF1 36
  • 54.91 (n)
  • 51.56 (a)
SNF1 37
  • 38 (a)
OneToMany
SNF1 39
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A03806g 36
  • 56.81 (n)
  • 50.99 (a)
rice
(Oryza sativa)
Liliopsida Os08g0484600 36
  • 56.87 (n)
  • 56.53 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU04566 36
  • 52.78 (n)
  • 50.24 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes ssp2 36
  • 53.05 (n)
  • 46.58 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 59 (a)
OneToMany
Species with no ortholog for PRKAA2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for PRKAA2 Gene

ENSEMBL:
Gene Tree for PRKAA2 (if available)
TreeFam:
Gene Tree for PRKAA2 (if available)

Paralogs for PRKAA2 Gene

Paralogs for PRKAA2 Gene

genes like me logo Genes that share paralogs with PRKAA2: view

Variants for PRKAA2 Gene

Sequence variations from dbSNP and Humsavar for PRKAA2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs706466 -- 56,715,194(-) GTAAC(C/T)ATGAA utr-variant-3-prime
rs706467 -- 56,715,565(-) AATAA(A/G)ATAAT downstream-variant-500B
rs706468 -- 56,715,709(-) TGGAA(C/T)GAAAT downstream-variant-500B
rs715404 -- 56,676,259(-) TACAT(A/G)ATCCA intron-variant
rs715405 -- 56,676,026(-) CAAAG(A/G)TCAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for PRKAA2 Gene

Variant ID Type Subtype PubMed ID
nsv523032 CNV Gain 19592680
nsv520726 CNV Loss 19592680

Relevant External Links for PRKAA2 Gene

HapMap Linkage Disequilibrium report
PRKAA2
Human Gene Mutation Database (HGMD)
PRKAA2

Disorders for PRKAA2 Gene

(28) Novoseek inferred disease relationships for PRKAA2 Gene

Disease -log(P) Hits PubMed IDs
peutz-jeghers syndrome 73.3 1
insulin resistance 61.4 20
insulin sensitivity 57.9 13
wolff-parkinson-white syndrome 54.7 4
metabolic disorder 49.1 9

Relevant External Links for PRKAA2

Genetic Association Database (GAD)
PRKAA2
Human Genome Epidemiology (HuGE) Navigator
PRKAA2
genes like me logo Genes that share disorders with PRKAA2: view

No data available for UniProtKB/Swiss-Prot for PRKAA2 Gene

Publications for PRKAA2 Gene

  1. Characterization and chromosomal localization of the human homologue of a rat AMP-activated protein kinase-encoding gene: a major regulator of lipid metabolism in mammals. (PMID: 7959015) Aguan K. … Sarkar N.H. (Gene 1994) 2 3 4 23
  2. AMP-kinase alpha2 subunit gene PRKAA2 variants are associated with total cholesterol, low-density lipoprotein-cholesterol and high-density lipoprotein-cholesterol in normal women. (PMID: 16801347) Spencer-Jones N.J. … O'Dell S.D. (J. Med. Genet. 2006) 3 23 49
  3. A polymorphism in the AMPKalpha2 subunit gene is associated with insulin resistance and type 2 diabetes in the Japanese population. (PMID: 16567511) Horikoshi M. … Kadowaki T. (Diabetes 2006) 3 23 49
  4. Oral glucose ingestion attenuates exercise-induced activation of 5'-AMP-activated protein kinase in human skeletal muscle. (PMID: 16598851) Akerstrom T.C. … Wojtaszewski J. (Biochem. Biophys. Res. Commun. 2006) 3 23
  5. Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy. (PMID: 16275868) Ahmad F. … Seidman J.G. (Circulation 2005) 3 23

Products for PRKAA2 Gene

Sources for PRKAA2 Gene

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